We believe that the way people interact with their finances will drastically improve in the next few years. We’re dedicated to empowering this transformation by building the tools and experiences that thousands of developers use to create their own products. Plaid powers the tools millions of people rely on to live a healthier financial life. We work with thousands of companies like Venmo, SoFi, several of the Fortune 500, and many of the largest banks to make it easy for people to connect their financial accounts to the apps and services they want to use. Plaid’s network covers 12,000 financial institutions across the US, Canada, UK and Europe. Founded in 2013, the company is headquartered in San Francisco with offices in New York, Seattle, Washington D.C., Raleigh, London, and Amsterdam. We are the Fraud Data team within Plaid's Fraud organization. We leverage relationships and activity across Plaid’s network to develop machine learning models that help customers detect and prevent fraud while minimizing friction for legitimate users. Our team owns the full model lifecycle, from data processing and experimentation to feature pipelines, model serving, and monitoring. In this research role, you’ll partner closely with Machine Learning Engineers and Data Scientists to uncover new signals, explore and evaluate innovative modeling approaches, and translate promising research into production-ready solutions that strengthen fraud detection across Plaid’s network. As a Senior Research Scientist, you will lead applied research to develop next-generation fraud detection models across relational graphs, sequential events, images, and video data. You’ll design rigorous experiments and evaluation methodologies that reflect real-world fraud dynamics, while exploring state-of-the-art approaches such as Graph Neural Networks and Transformer-based foundation models. In close partnership with Machine Learning Engineers, you’ll translate promising research into production-ready solu
Senior Research Scientist, High Content Imaging
Role overview
Job description
ROLE SUMMARY
We are seeking a highly motivated individual to join our high content imaging lab within the Discovery Biology and Pharmacology (DBP) group at the vibrant Groton campus in Connecticut. DBP is responsible for hit-identification, lead optimization, and molecular characterization of our small molecules and has teams focused on high-throughput screening, DNA-encoded libraries, pharmacology, protein homeostasis platforms, cellular models, functional genomics, and high-content imaging. The group is highly integrated with other groups in Medicine Design including Chemists, Structural Biologists, and Computational Scientists, and supports the small molecule portfolio across multiple therapeutic areas. The individual in this role will bring in rich experience in high content imaging and high throughput flow cytometry, and apply them to support our diverse small molecule portfolio spanning various therapeutic areas.
ROLE RESPONSIBILITIES
High-content imaging assay design, development, and optimization: Apply a broad range of imaging and flow cytometry assay technologies to address project needs. Independently develop, optimize, and troubleshoot high-content imaging and flow cytometry assays.
Imaging data analysis and interpretation: Design and implement advanced image-analysis workflows, build complex analysis algorithms, and streamline data processing to support medium- to high-throughput screening. Translate imaging data into clear, actionable biological insights.
Imaging infrastructure management and continuous improvement: Partner with team experts to support high-content imaging and flow cytometry instrumentation, implement software solutions that enable advanced imaging applications and data analysis, and continuously improve imaging infrastructure and workflows.
Screening and mechanistic studies: Execute screening campaigns and mechanism-of-action studies using high-content imaging and/or flow cytometry assays to support target validation, small-molecule identification and optimization, and clinical candidate selection.
HTS and automation: Where applicable, partner with our high-throughput screening team to leverage automated systems to execute imaging and flow cytometry screens.
Technology innovation: Stay current with advances in imaging technologies and partner with the broader team to identify, evaluate, and implement novel imaging technologies and instruments that address unmet portfolio needs.
Leverage expertise in image algorithm development and imaging hardware and software to support the infrastructure, in close partnership with our Digital teams, and to support less experienced assay scientists in applying imaging and flow cytometry.
QUALIFICATIONS
Must have
Education: PhD in molecular biology, pharmacology, cell biology, biomedical engineering, or a related discipline (0 to 4 years of work relevant experience), with 2+ years of relevant experience applying fluorescence or confocal microscopy in biological research.
Imaging assay expertise: Hands-on experience developing, optimizing, and troubleshooting high-content imaging assays; familiarity with flow cytometry assay platforms is strongly valued.
Image analysis and data interpretation: Strong familiarity with plate-based imaging systems and flow cytometry instrumentation. Experience using image-analysis software and quantitative data-analysis approaches to extract meaningful biological insights from imaging assay data. Experience with advanced image-analysis platforms, computational workflows, scripting, programming, or computational biology approaches that support algorithm development and data analysis.
Scientific problem solving: Demonstrated ability to apply imaging-based approaches to address biological questions, troubleshoot technical challenges, and deliver fit-for-purpose assay solutions.
Learning agility: Ability to quickly learn new technologies, adapt them to emerging project needs, and contribute to continuous improvement of imaging capabilities in the group.
Communication and collaboration: Strong verbal and written communication skills, with the ability to work effectively in cross-functional teams and clearly present experimental results and scientific rationale.
QUALIFICATIONS
Nice to have
Experience supporting small-molecule discovery programs or pharmacology studies across therapeutic areas such as Internal Medicine, Immunology & Inflammation, or Oncology.
Experience designing and executing cell-based assays to investigate target biology, mechanism of action, or compound activity.
Familiarity with implementing new technologies, instruments, or software tools to improve imaging workflows or expand laboratory capabilities.
PHYSICAL/MENTAL REQUIREMENTS
Ability to perform practical laboratory bench work and work on a computer). Ability to perform mathematical calculations and interpret data.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Candidate may periodically be asked to travel to the Pfizer Cambridge, MA site to meet project team members and to attend appropriate meetings and conferences.
Candidate must comply with all laboratory safety practices.
Other Job Details
Relocation support available
Work Location Assignment: On Premise
Relocation assistance may be available based on business needs and/or eligibility.
Candidates must be authorized to be employed in the U.S. by any employer.
U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.com. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.
To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available on Pfizer Careers.
Research and DevelopmentWhat they are looking for
Skills & requirements
Qualification
PhD in molecular biology, pharmacology, cell biology, biomedical engineering, or a related discipline (0 to 4 years of work relevant experience), with 2+ years of relevant experience applying fluorescence or confocal microscopy in biological research.
Hiring company
Pfizer
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