Upstream Process Development Lead Jobs

ROLE SUMMARY This laboratory-based leadership role will lead upstream process development for both mammalian cell culture and microbial fermentation platforms within Vaccines Early Bioprocess Development (EBPD). The incumbent will provide scientific and people leadership for the design, planning, execution, and interpretation of experiments supporting recombinant protein and vaccine antigen production. The role requires strong expertise in upstream process development, including host and cell-line evaluation, media and feed optimization, bioreactor process development, and integration of product yield and quality considerations. The successful candidate is expected to bring deep expertise in at least one platform, mammalian cell culture or microbial fermentation, together with demonstrated knowledge of and ability to lead programs across the other platform. Responsibilities include application of high-throughput and scale-down models, Design of Experiments (DOE), process characterization and modeling, scale-up, technology transfer, and development of processes suitable for good manufacturing practice (GMP) manufacture. Experience with automated and conventional bioreactor systems, such as ambr, stirred-tank bioreactors, and rocking-motion bioreactors, is highly valued. The role requires rigorous documentation, clear communication of data and recommendations, effective cross-functional collaboration, and a proven record of scientific and team leadership. ROLE RESPONSIBILITIES · Provide scientific and people leadership for the upstream process development workstream spanning mammalian cell culture and microbial fermentation within the Vaccines EBPD Process Development group. · Lead the design, prioritization, execution, documentation, and communication of complex studies to improve cell growth, recombinant protein expression, prod

We anticipate the application window for this opening will close on - 5 Oct 2026 Careers that change lives start here. Medtronic is a global leader in healthcare technology with a Mission to alleviate pain, restore health, and extend life. Our 95,000 employees work across more than 150 countries to put patients first — developing innovative medical technologies that improve the lives of 72+ million patients each year. Your unique talents will help shape the future of healthcare while building a career grounded in purpose, growth, and impact. A Day in the Life In this role, you will help bring innovative medical technologies from concept into commercialization by leading manufacturing engineering efforts for metal additive manufacturing processes within New Product Introduction. The Principal Manufacturing Engineer will support both upstream and later-stage NPI activities, partnering closely with cross-functional teams to develop robust, scalable, and compliant manufacturing solutions that enable successful product launches and long-term operational performance. This position requires deep technical expertise in metal additive manufacturing, strong process development capabilities, and experience operating within a regulated environment. The ideal candidate will be equally comfortable supporting early feasibility and design collaboration as well as process validation, design transfer, and production readiness activities. At Medtronic, we bring bold ideas forward with speed and decisiveness to put patients first in everything we do. In-person exchanges are invaluable to our work. We’re working a minimum of 5 days a week onsite as part of our commitment to fostering a culture of professional growth and cross-functional collaboration as we work together to engineer the extraordinary. Responsi

What You Will Achieve A Senior Scientist (R 4 ) position is available in the Upstream Process Development group within the Bioprocess R&D organization. The successful applicant will join a team of scientists and engineers focused on developing and optimizing manufacturing processes for recombinant proteins and other modalities for early- and late-phase human clinical trials. In this role, the candidate will be responsible for designing and executing laboratory experiments in bench-top bioreactors and associated scale-down equipment with the goal of developing robust, scalable, and high productivity processes. The work will also involve collaborating with pilot, clinical, and commercial production facilities to ensure accurate technology transfer, successful large-scale production and associated regulatory filing activities. The candidate may also be involved in cutting edge technology development projects that seek to improve production processes and control strategies leveraging various process analytical technologies. How You Will Achieve It Design and execute

Job Details: Job Description: The Thin Films Senior Process Engineer will support PVD, CVD, and ALD technologies for dielectric and metal thin-film deposition in a high-volume manufacturing environment. Key Responsibilities Apply advanced expertise in thin-film deposition processes to drive continuous improvement in process performance, sustainment, and technology development. Collaborate with upstream and downstream partners to deliver manufacturing improvements through strong cross-functional engagement and stakeholder management. Own manufacturing processes and/or equipment, ensuring achievement of key performance indicators (KPIs) including safety, quality, cost, productivity, defect reduction, and yield improvement. Develop and execute strategic plans for complex projects, coordinating timelines and dependencies across multiple teams and initiatives. Support manufacturing capacity expansion and technology transfer activities to enable successful ramp-to-volume production. Partner with equipment vendors and cross-functional stakeholders to troubleshoot technical challenges, improve tool performance, and enhance operational efficiency. Lead process development initiatives that support current and next-generation high-volume manufacturing technologies. Design and optimize excursion prevention and detection systems to strengthen process control and minimize manufacturing risk. Lead equipment installation, conversion, qualification, and readiness activities during factory ramps, ensuring all tools are deployed safely, on schedule, and in compliance with quality and manufacturing standards. Drive root cause analysis and implement corrective actions to resolve process and equipment-related issues while improving overall manufacturing stability and performance. <p st

About Supabase Supabase is the Postgres development platform, built by developers for developers. We provide a complete backend solution including Database, Auth, Storage, Edge Functions, Realtime, and Vector Search. All services are deeply integrated and designed for growth. About the role We're looking for an engineer to drive the evolution of OrioleDB and its collaboration with the upstream PostgreSQL community. OrioleDB is a next-generation storage engine for PostgreSQL, and this role sits at the intersection of database internals, open source community work, and Supabase's managed Postgres platform. This role requires strong working overlap with Americas time zones due to production support and on-call responsibilities. What you'll work on New OrioleDB features. Design and implement new capabilities in OrioleDB — for example, native index access methods (GiST, GIN, HNSW for pgvector), disaster recovery tooling, and other storage-engine-level features that expand what OrioleDB can do. Stability. Strengthen OrioleDB's reliability through deeper test coverage, fault injection, crash and recovery testing, and improvements to CI infrastructure. Ensure regressions are caught early and that OrioleDB behaves predictably under stress, replication, and failure scenarios. Upstream collaboration. Contribute changes directly to PostgreSQL core. Part of OrioleDB lives as a patch on top of PostgreSQL — moving the right pieces upstream shrinks what we maintain ourselves and benefits the wider community. This happens through PostgreSQL's open development process: the pgsql-hackers mailing list, public code review, and commitfests. Supabase integration. Work with Supabase's Postgres team to ensure OrioleDB fits naturally into Supabase's managed offering and roadmap. You Will: Design, implement, and test new OrioleDB features and integrate them cleanly with PostgreSQL's planner, executor, and surrounding subsystems. Build out and maintain test infrastructure: regression suites, f

Work Flexibility: Onsite What You Will Do: This role is on the Electrical Engineering team at Stryker Medical division's Acute Care business unit. We primarily work with patient handling and patient care equipment within the hospital space such as stretchers, hospital beds, and support surfaces. This role falls under the team addressing the high-acuity market, with a focus on products that often come into direct contact with patients. It includes gaining a deep understanding of customer needs through research and partnership with upstream marketing and through direct interactions with customers. Working with a diverse team, you will design, develop, modify, evaluate, and verify electrical components and sub-systems for medical devices. The role includes the full development process from research to product launch. Design and develop electrical circuits and subsystems for medical devices. Coordinate engineering changes and complete documentation in accordance with quality management system requirements. Review and modify C/C&#43;&#43; code to support product functionality and performance Apply electrical system and circuit test methods to evaluate product designs. Build and support prototypes and conduct bench testing activities. Collaborate with manufacturing, sourcing, and cross-functional teams to support ongoing production activities. Analyze and test designs for electromagnetic compatibility, reliability, safety, manufacturability, and testability. Support

Our vision is to transform how the world uses information to enrich life for all . Micron Technology is a world leader in innovating memory and storage solutions that accelerate the transformation of information into intelligence, inspiring the world to learn, communicate and advance faster than ever. Responsibilities and Tasks: Identify yield gain opportunities and successfully implement strategies to achieve yield targets. Plan and implement a baseline improvement program to drive yield enhancements. Ensure process control charts are set up accurately, with strict adherence to limits and reaction mechanisms. Collaborate with Process Integration, Production, and other process areas, determining the best approaches to meet and exceed goals. Follow up on all defects related to SWRs, ensuring timely updates to the defect library. Set up contamination, defect, and performance qualification procedures and frequencies. Characterize process responses to parameters and define process margins with respect to upstream and downstream steps. Qualify conversions and new processes, working tirelessly to reduce scrap and excursions. Study new methods for defect analysis to maintain and improve world-class standards. Study new methods for defect analysis to maintain and improve world-class standards. AI Relevant Job Responsibilities: - Integrates AI-assisted tools and insights into daily work to improve efficiency, quality, or effectiveness, exercising sound judgment and complying with organizational standards and legal requirements. - Contributes to a culture of continuous improvement by identifying, testing, and sharing AI-enabled enhancements within one’s scope of work. - Ability to apply baseline digital fluency and role‑a

Job title: Liquidity reporting Compliance Finance has mobilised a multi-year Integrity of Regulatory Reporting (IRR) programme to ensure that Regulatory Reporting across the Group is fit for purpose; accurate, timely and complete. The IRR programme is responsible for overseeing the design and implementation of a set of standards and control outcomes that will be consistently applied across the end-to-end Regulatory Reporting Process. IRR will drive the interconnectivity across various strategic transformation programs to ensure linkages and dependencies are well understood and aligned to the IRR standards and control outcomes. The Liquidity Product Based Review (LIQ_PBR) workstream is part of the overall data controls framework for Liquidity Regulatory Reporting. Product Based Reviews enable Finance to develop key assurance that the end to end data flow for Business Data Elements (“BDE’s”), from upstream Primary Booking Systems to downstream Reporting data warehouses (including the Liquidity Reporting Finance Data Application / Platform) complies with the applicable group data standards and controls (‘DMOV’ and ‘DUSE’), is complete and valid for the production of key Liquidity reports and metrics and that data quality or completeness issues discovered through the PBR process are appropriately logged, reported, escalated and managed to resolution. The LIQ_PBR Data Analyst contributes to Global Finance, supporting data flow discovery and documentation, from upstream primary trading and booking systems (PTS) to downstream Liquidity reporting platforms. The role holder will support the Liquidity PBR workstream to undertake quantitative and qualitative data documentation, test case formulation, data test execution and results tabulation, in order to provide the necessary assurance for management with regards to the traceability, lineage, transformation and controls on Liquidity business data elements from source systems to reporting. In this regards, the LIQ PBR d

Become a part of our caring community Services represent one of the organization’s most consequential sources of capability, capacity, transformation and external spend. The Associate Vice President, Services Procurement will lead the enterprise strategy for contingent workforce, outsourcing and offshoring, consulting and clinical services, converting third-party services into measurable business outcomes, workforce agility, operating leverage and sustainable value. The AVP will serve as the senior Procurement partner to leaders across the Insurance segment and Corporate Services, helping shape operating-model, workforce and transformation decisions before sourcing begins or a supplier solution is selected. The leader will bring deep expertise in global business services, business process outsourcing, workforce solutions and complex professional services. The mandate is to strengthen business-case quality, establish clear make, buy, build, automate and partner choices, create fit-for-purpose commercial models, manage transitions and hold providers accountable for committed outcomes. Success will be measured by whether business leaders make better services and workforce decisions, transformations deliver their promised value, and suppliers improve performance and innovation. Key Responsibilities Serve as the Strategic Services Partner to Business Leaders Serve as the senior Procurement relationship leader and trusted commercial advisor to Insurance segment and Corporate Services leadership. Develop a deep understanding of business strategy, operating plans, transformation roadmaps, workforce needs and financial commitments, and translate them into integrated services, workforce and supplier strategies. Engage upstream of supplier selection to frame the problem, test demand and assess make, buy, build, automate, offshore, outsource

Secure Every Identity, from AI to Human Identity is the key to unlocking the potential of AI. Okta secures AI by building the trusted, neutral infrastructure that enables organizations to safely embrace this new era. This work requires a relentless drive to solve complex challenges with real-world stakes. We are looking for builders and owners who operate with speed and urgency and execute with excellence. This is an opportunity to do career-defining work. We're all in on this mission. If you are too, let's talk. Role Overview As the Senior Commission Manager, you will serve as a key operational leader driving execution, calculation integrity, and continuous process optimization across Okta’s end-to-end sales compensation lifecycle. Supporting a high-growth field organization of 2,300+ sellers, this role bridges hands-on commission administration—validations, payment submissions, dispute resolution, and operational modernization—with advanced reporting, enterprise analytics, and AI-driven process automation. With a sharp focus on execution, data and incentive design governance, process engineering, and emerging AI tools, you will eliminate manual bottlenecks, build scalable reporting infrastructure, and guarantee 100% payout accuracy within tight deadlines. Key Responsibilities Commission Execution & Calculation Integrity Oversee the monthly commission calculation and payout lifecycle for 2,300+ global sellers, actively streamlining and operationalizing processes to maintain near-zero error margins. Operationalize data reconciliations between upstream source systems (CRM and Workday) and Xactly Incent, optimizing workflows to safeguard data integrity, maintain accurate crediting rules, and ensure calculation accuracy. Process Engineering, Automation & AI Map core commission workflows to eliminate friction, slash monthly close processing times, and eliminate manual data manipulation. Identify and deploy automation tools, custom scripts, AI-driven effic

Secure Every Identity, from AI to Human Identity is the key to unlocking the potential of AI. Okta secures AI by building the trusted, neutral infrastructure that enables organizations to safely embrace this new era. This work requires a relentless drive to solve complex challenges with real-world stakes. We are looking for builders and owners who operate with speed and urgency and execute with excellence. This is an opportunity to do career-defining work. We're all in on this mission. If you are too, let's talk. Support end-to-end upstream P2P activities from Scout through PO closure , ensuring accurate, timely, and compliant procurement execution. Key Responsibilities Manage PR/PO creation, revision, and closure in Coupa. Support NDA, MSA, SOW/Order Form creation, documentation, and DocuSign execution. Validate supplier, pricing, payment terms, dates, commodity, billing strings, and supporting documentation. Coordinate with Sourcing, Category, Legal, Security, Business Users, and AP to resolve P2P issues and bottlenecks. Support supplier onboarding and respond to stakeholder/supplier queries. Monitor procurement milestones, follow up on pending approvals, and ensure timely completion. Support low-dollar sourcing/procurement activities and Category Procurement as needed. Maintain accurate Scout, Coupa, and contract records, including PO/contract renewal and closure information. Identify process/system improvement opportunities and support P2P transformation initiatives. Ensure compliance with procurement SOPs, controls, and SLA/OLA requirements. Requirements Experience in Procurement, Sourcing, or P2P operations. Strong Coupa and procurement process knowledge; Scout/DocuSign experience preferred. Strong attention to detail, financial acumen, and problem-solving skills. Excellent stakeholder communication and collaboration skills. Ability to work in a fast-paced, global environment and support extended/graveyard shifts. 2-3 Years of AP or Procurement experienc

ABOUT THE ROLE The Senior Manager, Financial Systems & Reporting Transformation is responsible for leading the redesign of the company's financial master data — including the chart of accounts, cost centers, profit centers, product hierarchies, and dimensional reporting structures — with the objective of enhancing profitability insights, standardizing management reporting, and enabling seamless upstream consolidation with the parent company. YOUR DAILY IMPACT AT PELOTON Lead the end-to-end redesign of the company's financial master data structures — chart of accounts, cost centers, profit centers, functional areas, internal orders, product hierarchies, customer/vendor master, and reporting dimensions — to enable enhanced profitability, channel, and product-level reporting Define the target-state data model required for seamless consolidation with the parent company's reporting environment, including alignment of GL accounts, entity structures, intercompany conventions, and dimensional hierarchies Develop and execute the migration plan from the legacy fragmented environment to the redesigned master data model, including data mapping, cleansing, cutover, and validation Establish master data governance (ownership, request/approval workflows, change controls, and audit trails) to preserve data integrity post-implementation Partner with IT and the SAP functional teams to configure and validate master data changes in SAP ECC, ensuring downstream impacts to sub-ledgers, allocations, and reporting are fully understood and controlled Spearhead process optimization efforts within key functional areas, including the month-end close process, consolidations, allocations, and monthly management reporting Drive efficiency and process design improvements within major transaction cycles: Order to Cash (OTC), Procure to Pay (PTP), Inventory, and Fixed Assets — with particular focus on how master data drives accuracy, controls, and reporting granularity Identify, champion, a

Everpure (NYSE: P) has evolved from storage pioneer to data platform, closing fiscal 2026 with $3.7 billion in revenue, its first billion-dollar quarter, and accelerating growth into FY27. Our strategic agenda spans the companies defining the next era of technology - hyperscalers, AI labs, the AI hardware supply chain, data platform providers, and the broader AI ecosystem. This type of work—work that changes the world—is what the tech industry was founded on. So, if you're ready to seize the endless opportunities and leave your mark, come join us. THE ROLE Join Everpure™ as a key operational anchor driving the performance, integrity, and scalability of our HR technology ecosystem. In this business-critical position based out of our Bengaluru office, you will own the end-to-end administration of core HR applications—with an initial primary focus on mastering and optimizing TeamOhana alongside our ATS, LMS, and key internal platforms . You will partner directly with cross-functional leaders across HRIS, HR Operations, Talent Acquisition, Learning, and Finance to ensure seamless data accuracy, role-based security, and system reliability. By translating complex operational requirements into clean system governance, your work directly enables our global workforce to scale efficiently and securely. WHAT YOU'LL DO HR Application & Access Governance: Administer assigned HR software platforms (initially focused on TeamOhana), configuring user roles, permissions, reference data, and onboarding/offboarding workflows to guarantee 100% data integrity and compliance. Workforce Data Integrity & Auditing: Conduct routine data quality reconciliations, system health checks, and security audits across HR systems to eliminate data discrepancies and streamline upstream/downstream integrations. Cross-Functional System Support: Triage, diagnose, and resolve daily administration and data issues submitted by stakeholders, escalating technical anomalies to HR Tech process owners whil

Position Overview The Senior Analyst – Sales Operations will serve as a strategic operational partner responsible for translating sales incentive commission plans into robust back-end data processes and converting complex business requirements into data-backed executive insights. This role requires an analytical professional who combines hands-on expertise in Google Sheets, Advanced Excel, Salesforce CRM, data wrangling, pipeline analysis, and CRM hygiene with an AI-forward mindset to streamline cross-functional operations. Key Responsibilities Commissions & Incentive Management: Thoroughly understand business commission plans and architect back-end processes, automated workflows, and data models to accurately capture required inputs, run monthly/quarterly calculations, execute timely plan rollouts, and resolve participant queries with complete transparency. Business Requirements & Strategic Reporting: Deconstruct complex business requirements into structured analytical frameworks. Build, set up, and maintain reports and dynamic dashboards that drive data-backed decision-making across key commercial initiatives, including pipeline health analysis, revenue trends, and Salesforce CRM data hygiene projects. Data Wrangling & Spreadsheet Modeling: Perform hands-on data manipulation, cleansing, and complex performance/commission modeling using Google Sheets, Advanced Excel and to bridge upstream source data with compensation and reporting systems. Salesforce CRM & Reporting: Design, build, and maintain robust Salesforce reports, analytics dashboards, and operational tracking tools to provide key performance visibility to executive leadership. Process Optimization: Evaluate end-to-end sales and operational workflows, pinpoint operational friction, and propose scalable solutions to streamline business processes. Cross-Functional Stakeholder Management: Serve as a trusted advisor and liaison across Sales, Account Management, Finance, and Business Intelligence

About Us Twitch is the world’s biggest live streaming service, with global communities built around gaming, entertainment, music, sports, cooking, and more. It is where thousands of communities come together for whatever, every day. We’re about community, inside and out. You’ll find coworkers who are eager to team up, collaborate, and smash (or elegantly solve) problems together. We’re on a quest to empower live communities, so if this sounds good to you, see what we’re up to on LinkedIn and X , and discover the projects we’re solving on our Blog . Be sure to explore our Interviewing Guide to learn how to ace our interview process. About the Role Twitch is a globally renowned brand with a dedicated following across the world. Localization is at the heart of our mission to connect creators with their communities on a global scale. We're looking for a Localization Program Manager to own the operational core of our localization program — vendor coordination, content workflows, quality processes, and launch execution across 29 languages. You'll join a lean team of senior professionals who operate as strategic partners to Product and Engineering and focus on bringing global users a native experience. Strong performers can take on increasing scope over time. You can work from San Francisco, CA; Irvine, CA; Seattle, WA. You Will: Manage end-to-end localization into 29 languages, including launches that require creative asset localization, terminology building and testing Monitor continuous localization operations while identifying and implementing opportunities for improvement. Run and evolve localization quality processes: coordinate testing, build LQA workflows and propose improvements based on data. Monitor and improve translation quality output by developing and maintaining linguistic assets Influence upstream content operations for seamless, context-rich translations. Build localization metrics reports (turnaround,