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System Engineer in San Francisco

249 active opportunities · Updated October 2026

Explore current system engineer jobs in San Francisco. Filter by work mode, employment type, experience, department, date posted and distance.

L
📍 San Francisco, Canada· Full-time
✓ High-confidence listingCompany trend -74%

$1.6M – $2M/yr

Quick readStrong listing-quality and freshness signals

At Lyft, our purpose is to serve and connect. We aim to achieve this by cultivating a work environment where all team members belong and have the opportunity to thrive. We are building out Finance business operations to drive disciplined execution of both organic and inorganic initiatives, including M&A integration, strategic programs (AVs, Luxury), and other new product initiatives (NPIs). This is a strategy-to-execution role that requires strong judgment, cross-functional leadership, and the ability to drive outcomes in ambiguous, high-stakes environments. We are seeking a high-impact Finance BizOps leader to sit at the center of this effort, owning finance integration execution (in partnership with Lyft’s Corp Dev IMO), NPI financial readiness, and the intake/governance layer that connects Finance to the company’s most strategic initiatives. This role is the operating backbone for Finance – ensuring acquisitions integrate seamlessly, new products launch cleanly, and Finance work is prioritized with rigor and transparency. As the company scales, the volume and complexity of strategic initiatives—M&A, new products, and cross-functional programs—continues to increase. This role establishes a centralized operating model that ensures: Strategic initiatives are executed with discipline and completeness Finance is embedded early and effectively ensuring strong planning to execution across multiple teams to deliver strong customer and business results The organization scales without accumulating operational debt or technical debt Responsibilities: Strategic program Readiness Act as the central Finance lead for new product initiatives and large strategic programs Build strong working relationships with key product and business leaders and stay “in the know” on planned launches Partner with Finance SMEs, Product, Engineering, and GTM teams to ensure: Financial workflows and requirements are defined Systems, processes, and financ

L
📍 San Francisco, Canada· Full-time
✓ High-confidence listingCompany trend -74%
Quick readStrong listing-quality and freshness signals

At Lyft, our purpose is to serve and connect. We aim to achieve this by cultivating a work environment where all team members belong and have the opportunity to thrive. The Pricing team is a centerpiece of Lyft’s marketplace, determining prices for all rideshare products and supporting new initiatives. Dynamic Pricing & Offer Selection sits at the heart of Pricing, focused on determining optimal prices and ETAs in real-time and balancing supply and demand for our two-sided marketplace to drive both short-term and long-term conversion and retention. As an Applied Scientist specializing in Machine Learning and Operations Research on this team, you will develop mathematical models and launch algorithms that power these key pricing and ETA decisions. You will leverage your skills to build ML and optimization models and productionalize pipelines that can scale to millions of calls per day while solving critical business problems that have a big impact on the marketplace and rider experience. You will get exposure to a diverse set of real-world problems across optimization, prediction, machine learning, and inference and collaborate closely with teammates and stakeholders across Pricing, from Product Managers to Engineers and Analysts. We are looking for someone who is excited about working in a fast-paced, innovative, and impactful environment, and is adept at balancing complexity and efficiency to translate real world business problems into reliable solutions, systems and decision frameworks. Responsibilities Partner with Data Scientists, Engineers, Product Managers, and Business Partners to frame problems mathematically and within the business context Write production quality code. Design, build and deploy production-grade ML and Optimization models. Able to build custom methods and tooling beyond off-the-shelf libraries. Perform data analysis and build proof-of-concepts to explore and propose ML and Optimization solutions to both new and existing problems.&n

PythonMachine LearningAIGo
AT
📍 San Francisco, Canada· Full-time
✓ High-confidence listing

$120K – $185K/yr

Quick readStrong listing-quality and freshness signals

Axsome Therapeutics is a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) conditions. We deliver scientific breakthroughs by identifying critical gaps in care and develop differentiated products with a focus on novel mechanisms of action that enable meaningful advancements in patient outcomes. Our industry-leading neuroscience portfolio includes FDA-approved treatments for major depressive disorder, agitation associated with dementia due to Alzheimer’s disease, excessive daytime sleepiness associated with narcolepsy and obstructive sleep apnea, and migraine, as well as multiple novel product candidates addressing a broad range of serious neurological and psychiatric conditions that impact over 150 million people in the United States. Together, we are on a mission to solve some of the brain’s biggest problems so patients and their loved ones can flourish. For more information, please visit us at www.axsome.com and follow us on LinkedIn and X . About This Role Axsome Therapeutics is currently searching for a field based Long-Term Care (LTC) Specialty Account Manager (SAM) to drive LTC commercial activities for an assigned geography by executing marketing strategies to ensure a successful launch and make a meaningful difference through the execution of commercial activities. SAMs will be responsible for product performance at a territory level and expected to be a disease state expert, product champion and an account specialist. The SAM will provide account management support and exhibit business knowledge of the local landscape to assess key stakeholders plus future trends within the marketplace. Job Responsibilities and Duties include, but are not limited to, the following: Drive product adoption in LTC facilities Proficient in both virtual and live customer engagements Effectively call on LTC Care teams, building meaningful relationships across the entire LTC ecosystem: Psychiatrists

GitAIGoMarketing
AT
📍 San Francisco, Canada· Full-time
✓ High-confidence listing

$140K – $160K/yr

Quick readStrong listing-quality and freshness signals

Axsome Therapeutics is a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) conditions. We deliver scientific breakthroughs by identifying critical gaps in care and develop differentiated products with a focus on novel mechanisms of action that enable meaningful advancements in patient outcomes. Our industry-leading neuroscience portfolio includes FDA-approved treatments for major depressive disorder, excessive daytime sleepiness associated with narcolepsy and obstructive sleep apnea, and migraine, and multiple late-stage development programs addressing a broad range of serious neurological and psychiatric conditions that impact over 150 million people in the United States. Together, we are on a mission to solve some of the brain’s biggest problems so patients and their loved ones can flourish. For more information, please visit us at www.axsome.com and follow us on LinkedIn and X . About This Role: Axsome Therapeutics is seeking a National Training Manager to lead and conduct training programs for our Specialty Account Managers. This role is pivotal in ensuring our sales teams are equipped with the knowledge and skills necessary to effectively communicate our product offerings to healthcare professionals. This is a hybrid role that includes both remote and field-based work. This position requires up to 50% travel based on reoccurring national, regional and HQ-based training events, as well as travel to customer field rides with our specialty account team. Job Responsibilities and Duties include, but are not limited to, the following: Conduct all foundational new hire and advanced sales training classes virtually with some in-person sessions Coach and support new specialty account managers in their onboarding Partnering with the HQ based training team and cross functional teams, manage all aspects of training logistics for assigned classes to ensure a se

AIMarketingLogisticsRecruitment
AT
📍 San Francisco, Canada· Full-time
✓ High-confidence listing

$140K – $160K/yr

Quick readStrong listing-quality and freshness signals

Axsome Therapeutics is a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) conditions. We deliver scientific breakthroughs by identifying critical gaps in care and develop differentiated products with a focus on novel mechanisms of action that enable meaningful advancements in patient outcomes. Our industry-leading neuroscience portfolio includes FDA-approved treatments for major depressive disorder, excessive daytime sleepiness associated with narcolepsy and obstructive sleep apnea, and migraine, and multiple late-stage development programs addressing a broad range of serious neurological and psychiatric conditions that impact over 150 million people in the United States. Together, we are on a mission to solve some of the brain’s biggest problems so patients and their loved ones can flourish. For more information, please visit us at www.axsome.com and follow us on LinkedIn and X . About This Role: Axsome Therapeutics is seeking a National Training Manager to lead and conduct training programs for our Specialty Account Managers. This role is pivotal in ensuring our sales teams are equipped with the knowledge and skills necessary to effectively communicate our product offerings to healthcare professionals. This is a hybrid role that includes both remote and field-based work. This position requires up to 50% travel based on reoccurring national, regional and HQ-based training events, as well as travel to customer field rides with our specialty account team. Job Responsibilities and Duties include, but are not limited to, the following: Conduct all foundational new hire and advanced sales training classes virtually with some in-person sessions Coach and support new specialty account managers in their onboarding Partnering with the HQ based training team and cross functional teams, manage all aspects of training logistics for assigned classes to ensure a se

AIMarketingLogisticsRecruitment
DU
📍 San Francisco, Canada· Full-time
✓ High-confidence listing

From $897.6K/yr

Quick readStrong listing-quality and freshness signals

About the Team As one of DoorDash's core operations teams, Customer Experience ensures that when issues arise across the platform, there is a reliable and effective support system in place. Our team designs, manages, and continuously improves DoorDash's global support network, with the goal of delivering a high-quality and consistent customer experience. This role sits within the Safety Customer Experience team, focused on the most critical and high-risk incidents on the platform. The team owns some of the most sensitive customer interactions at DoorDash, where thoughtful operational and product decisions directly improve customer trust and platform safety. About the Role You'll operate at the intersection of Product, Operations, and Customer Experience to improve how DoorDash prevents, identifies, and responds to the most critical safety incidents on the platform. You'll partner closely with Product, Policy, Analytics, and Operations to design scalable solutions that deliver accurate, timely support during customers' highest-stakes moments. This role requires a detail-oriented operator who can navigate complex problem spaces, design scalable processes, and execute with precision in a fast-paced environment. You’ll be expected to take ownership of ambiguous, high-stakes problems and translate them into structured, actionable solutions. You’re excited about this opportunity because you will… Drive Safety Strategy – Partner with cross-functional teams to identify and execute initiatives that improve how DoorDash prevents, identifies, and responds to safety incidents. Own End-to-End Experience – Design and optimize the full lifecycle of safety incident handling, including reporting, workflows, support execution, and tooling. Drive Data-Driven Decisions – Leverage data and case-level insights to identify root causes, measure performance, and prioritize opportunities to improve the safety customer experience. Influence Cross-Functionally – Collaborate with Product, Engin

AWSGitRestAI
DU
📍 San Francisco, Canada
✓ High-confidence listing
Quick readStrong listing-quality and freshness signals

About the Role At DoorDash we are redefining what it means to be a designer. We are building towards a team of makers, builders, and doers. Between 2005 and 2015, "web designer" became "product designer" and the scope widened. The same shift is happening now — LLMs are expanding the T again, toward strategy on one end and direct execution on the other. As a Staff Product Designer, you will lead this shift across your team: not just practicing build-first design, but multiplying it through the people and systems around you. We're seeking an ambitious and system design minded Staff Product Designer to lead “Meals for Work” within DoorDash for Business , a strategic area at the heart of redefining workplace dining and company perks. You’ll craft transformative consumer and enterprise experiences, from tools that make team lunch ordering effortless to scalable solutions for catering, company paid recurring meals, and grocery benefits. This role offers a unique opportunity to design powerful systems that help workplace admins plan, manage, and operate food programs with confidence, while pioneering new offerings in an evolving market. This position is open for candidates in San Francisco, Seattle, or New York City, and will report to the Head of New Bets Design within our Consumer organization. You will work in a hybrid model, working from one of our offices 1-2 times a week with the rest working from home. Your primary impact is making the team faster and more autonomous. You build reusable workflows, shared tools, and decision frameworks that let every designer on your team operate at a higher level with less coordination overhead. Your secondary impact is revenue: the speed and quality gains you unlock translate directly into more experiments shipped, faster iteration cycles, and measurable business outcomes across your team and adjacent teams. You're excited about this opportunity because you will... Define projects with a clear point of view on what to build,

AIExcelLogisticsRecruitment
SA
📍 San Francisco, Canada· Full-time
✓ High-confidence listing

From $165.6K/yr

Quick readStrong listing-quality and freshness signals

Overview Scale’s Finance Systems and Automation team is looking for a builder-oriented team member to help design and develop integrations, automations, and AI agents that streamline workflows across Finance, Accounting, People, and Recruiting. In this role, you will work closely with stakeholders across Finance, Accounting, People Operations, and Recruiting to understand their workflows and build integrations, automations, and agentic workflows that reduce manual effort and accelerate execution across these teams. You will leverage our internal data infrastructure, system integration tooling, and emerging AI platforms to architect scalable solutions — from traditional system integrations to intelligent agent-driven workflows — that serve as the foundation for long-term operational efficiency. We’re looking for someone who thrives on connecting systems, automating repetitive processes, and pushing toward more autonomous, AI-assisted operations. You should be comfortable navigating ambiguity, designing solutions that scale, and rigorously validating outcomes end to end. What You’ll Do Design and build agent-driven workflows and automation systems across People Operations, Recruiting, Finance, and Accounting Identify opportunities to replace manual or rules-based processes with agentic workflows Partner with stakeholders to translate business processes into scalable, automated solutions Lead the implementation of end-to-end workflows, from requirements through deployment and validation Automate candidate-to-employee transitions (e.g., Greenhouse → HRIS → provisioning systems) Build workflows to manage employee lifecycle events such as onboarding, transfers, and offboarding Automate approval flows and data synchronization across People, Finance, and Recruiting systems Support accounting and finance workflows through scalable integrations and automation Design and implement the underlying integrations and data flows that enable reliable automation and agent behavior Est

AWSRestAIGo
DU
📍 San Francisco, Canada· Full-time
✓ High-confidence listing

From $1.8M/yr

Quick readStrong listing-quality and freshness signals

About the Team Design Program Managers make DoorDash's Design Studio run better. As owner of the Logistics pillar within Design Operations, you're accountable for one of our most important operating outcomes: maximizing the bandwidth of the team. About the Role You'll find where ICs and managers lose time, fragmented workflows, manual processes, meeting overload, unclear rhythms, and you'll define and build the tools and systems that fix it. That might mean shipping a new internal tool, automating a recurring workflow, redesigning how scheduling or reviews work, or establishing a better operating cadence. You own the full loop: diagnose the problem, design the system, build the tool, measure whether it worked. You're excited about this opportunity because you will… Own the Logistics outcome, maximize the bandwidth of the team. ICs and managers have more usable time. Meeting load decreases. The team can focus on high-value work. Identify the biggest sources of operational drag across the Studio and turn them into a prioritized roadmap of tools and process fixes. Define and build the tools, automations, and workflows that reduce manual coordination, including for scheduling, budgets, vendor management, and event logistics. Redesign how the Studio operates: reviews, planning cadences, rhythms for both ICs and managers, information flows, whatever determines how fast teams can move. Measure whether your systems work, usable time for ICs and managers, meeting load, adoption, hours of manual work eliminated, and iterate. Turn recurring requests into scalable solutions. The second time a problem shows up, build the thing that stops a third. Own scheduling, budget, vendor, and logistics programs as a builder, not a permanent executor, your job is to make them need less manual effort every quarter. Partner with (and, as scope grows, help develop) other DPMs on the Logistics pod. We're excited about you because you have… 5+ years in operations, program management, or bu

AWSGitRestAI
N
📍 San Francisco, Canada
✓ Quality checked

POSITION SUMMARY: A Phlebotomist serves patients by identifying the best method for retrieving blood; preparing specimens for laboratory testing; and performing screening procedures. The Phlebotomist will also act as an operations manager for the designated patient service center (PSC) and oversee Natera’s phlebotomy program at the specified location. Depending upon growth opportunities, this role may also require oversight of other phlebotomists as needed to support patient volume growth. *** IF YOUR STATE REQUIRES A PHLEBOTOMY LICENSE, IT MUST BE SENT IN WITH YOUR RESUME WITH YOUR APPLICATION *** PRIMARY RESPONSIBILITIES: Verifies test requisitions by comparing information with orders and requisition documentation; brings discrepancies to the attention of Natera product management leadership. Verifies patient by reading patient identification. Obtains blood specimens by performing venipunctures and finger sticks. Maintains specimen integrity by using aseptic technique, following Natera[KC1] procedures; observes isolation procedures. Tracks collected specimens by initialing, dating, and noting times of collection; maintaining daily tallies of collections performed[MB2] in Natera provided system. Maintains quality results by following Natera procedures and testing schedule; recording results in the quality-control log; identifying and reporting needed changes reporting KPIs to product management leadership on biweekly basis. Maintains safe, secure, and healthy work environment by following standards and procedures; complies with legal regulations. Resolves unusual test orders by contacting the physician, pathologist, nursing station, or reference laboratory; referring unresolved orders back to the originator for further clarification; notifying internal Natera team [MB3] of unresolved orders. Updates job knowledge by participating in educational opportunities; reading professional publications; main

SC
📍 San Francisco, Canada
✓ High-confidence listing
Quick readStrong listing-quality and freshness signals

The Sales Compensation Manager is vital for scaling and operationalizing Sigma's sales compensation process. You will ensure accurate, timely compensation payouts using expert analysis and refine processes, tools, and reporting to align compensation with business results. This role is ideal for a self-starter who thrives on ownership, data integrity, and cross-functional collaboration between Finance, Revenue Operations, and GTM leadership. Key Responsibilities Commission & Incentive Processing Execute end-to-end commission calculation validation and processing for sales commissions and incentive payouts with high accuracy and precision. Identify, troubleshoot, and resolve calculation discrepancies and stakeholder escalations efficiently. Support compensation accruals and roll-up reporting in coordination with Finance close cycles. Systems & Platform Administration Manage Sigma’s compensation platform with the broader team. Lead system updates, user access coordination and UAT Ensure clean data flows between CRM (Salesforce), HRIS, ERP, and comp systems. Plan Governance & Communication Support administration of quota rules, crediting structures, and payout policies. Prepare clear plan documentation, and communication for GTM teams. Cross-Functional Collaboration Partner closely with Finance, Sales Operations, HR/People, and Data to align comp mechanics with business strategy. Identify, prioritize, and implement process improvements that increase accuracy and reduce manual effort. Qualifications: 5+ years of experience in sales compensation, ideally within fast-scaling SaaS orgs. Advanced proficiency with Salesforce CRM, Sigma and spreadsheet tools. Familiarity with consumption-based models and usage-driven GTM strategies. Exceptional attention to detail, robust problem-solving skills, and a strong systems mindset. Effective communication skills with the ability to clearly translate complex compensation lo

PythonSQLArtificial IntelligenceAI
SA
📍 San Francisco, Canada· Full-time
✓ High-confidence listing

From $1.5M/yr

Quick readStrong listing-quality and freshness signals

We are seeking an experienced and detail-oriented US Payroll Specialist to oversee our end-to-end multi-state payroll operations. In this role, you will ensure accurate, timely, and compliant payroll processing for all US-based employees while managing internal payroll initiatives. The ideal candidate is a strategic problem-solver with deep expertise in US labor laws, taxation, and ADP+Workday payroll systems. You will: Full-Cycle Payroll Processing: Oversee the accurate and timely processing of multi-state bi-weekly and semi-monthly payrolls for over a thousand exempt and non-exempt employees across most of the USA. Compliance & Taxation: Ensure strict adherence to federal, state, and local tax laws, as well as FLSA regulations. Monitor regulatory changes and update internal systems accordingly. Year-End Processing: Manage year-end payroll activities, including W-2 and W-2c generation, fringe benefit reporting, and annual tax reconciliations. Cross-Functional Collaboration: Partner closely with HR to ensure accurate data flow for onboarding, offboarding, benefits deductions, and compensation changes. Ability to work with Accounting to ensure accurate general ledger mapping, month-end close procedures, and payroll account reconciliations. System Administration & Optimization: Act as the primary subject matter expert for our payroll system (e.g., Workday, ADP). Identify bottlenecks, recommend process improvements, and lead system upgrades or implementations. Issue Resolution, Continuous Improvement & Auditing: Conduct regular audits of payroll data to identify and resolve discrepancies. Serve as the ultimate point of continuous improvement with AI and other methodologies to ensure Scale’s payroll processes are best in class. Ideally you'd have: 5+ years of payroll experience. Strong organizational skills; the ability to get all priority tasks completed by the end of each day. Confidentiality and integrity. Accuracy under pressure and extreme attention to

AWSRestAIGo
SC
📍 San Francisco, Canada· Full-time
✓ High-confidence listing
Quick readStrong listing-quality and freshness signals

(Sr.) Revenue Accounting Manager Sigma Computing is seeking a Senior Revenue Manager to join our Revenue team and play a key role in managing revenue accounting and revenue operations in a fast-growing SaaS environment. Reporting to the Senior Director of Revenue, this role will own key aspects of the revenue close, revenue recognition, contract review, and related processes. The Senior Revenue Manager will serve as a subject-matter expert on revenue accounting, partnering closely with Sales, Deal Desk, Legal, FP&A, and Finance to assess complex customer arrangements, ensure appropriate revenue treatment, and build scalable processes and controls. Key Responsibilities Own key components of the monthly, quarterly, and annual revenue close, including revenue recognition, deferred revenue, unbilled revenue, and related reconciliations. Ensure compliance with ASC 606 and applicable accounting standards. Review customer contracts and non-standard arrangements to determine appropriate revenue recognition. Partner with Sales, Deal Desk, Legal, FP&A, and Finance to assess the accounting implications of new products, pricing structures, and complex deals. Review and approve revenue-related journal entries, reconciliations, and supporting schedules. Develop, maintain, and improve revenue accounting policies, procedures, and internal controls. Own accurate and timely billing operations, including review and validation of sales tax applied to customer invoices. Own sales tax compliance processes, including periodic reviews of nexus, taxability, and potential exposure across applicable jurisdictions. Support internal and external audits, including preparation of revenue-related schedules and documentation. Identify opportunities to streamline, automate, and scale revenue processes. Partner with Finance Systems and other stakeholders on revenue system enhancements and process improvements. Support the implementation and optimization of revenue-related

PythonSQLAIGo
SA
📍 San Francisco, Canada· Full-time
✓ High-confidence listing

From $1.8M/yr

Quick readStrong listing-quality and freshness signals

We are building the Finance team to help make data-driven and financially sound decisions for Scale. The team is responsible for improving strategic, financial, and operational decisions by partnering with the leadership team in making critical decisions across Scale. The Corporate Finance team is responsible for owning the company’s budget, helping to drive monthly forecasts and annual planning processes, allocating and deploying the company’s resources efficiently, and performing financial analyses in partnership with all departments. As AI reshapes the competitive landscape, Corporate Finance sits at the center of decisions about where Scale invests, how quickly we scale, and which bets we make. You will have a unique opportunity to work closely with department heads on real-time, high-priority business issues and use quantitative insights to drive better decision making across Scale. The ideal candidate will not only have the technical skills to support their recommendations but also strong interpersonal skills to manage various stakeholders. What You’ll Do Provide analysis to support short and long-term decisions regarding workforce planning across the company. Own tools (such as the company's workforce planning system, TeamOhana) to automate and streamline reporting and headcount processes Partner cross-functionally with HR, Recruiting, Compensation, and Analytics teams to drive scalable analyses and insights. Define and maintain KPIs to measure impact on strategic initiatives and resource allocation. Manage the development, implementation, and administration of our financial forecasting system (Pigment) Partner with finance and accounting to drive process improvements (e.g. month-end close and reporting) Implement enhancements to forecasting tools, processes, and reporting deliverables that reduce manual work and improve data integration Support management, Board business, and financial planning, including presentations and key analysis requests Help execute

AWSRestAIGo
DU
📍 San Francisco, Canada· Full-time
✓ High-confidence listing

From $1.5M/yr

Quick readStrong listing-quality and freshness signals

About the Team At DoorDash, design means making experiences for the people who order, the people who prepare, and the people who deliver. As a Designer at DoorDash, you want to build things that matter to real people. You're at your best when you can move from idea to shipped product quickly, bringing experiences to life that reach and influence users at massive scale. You'll care about whether the product you make solved a real problem for real people, or changed how someone experiences their day. About the Role At DoorDash, we’re redefining what it means to be a designer. We’re building a team of makers, builders, and doers. Over the past decade, “web designer” evolved into “product designer” as the scope expanded. Now, that shift is happening again — LLMs are broadening the role further, pushing design toward both strategic thinking and direct execution. As a Staff Product Designer, you’ll help lead this evolution: not only practicing build-first design, but scaling it across people, processes, and systems. In this role, you’ll join the Ads & Promos Design team — one of DoorDash’s fastest-growing businesses — owning end-to-end campaign experience design and shaping the strategic vision for our marketing tooling system. This platform powers both SMB and enterprise restaurants across DoorDash’s global markets and connects local businesses with over 40 million consumers globally. Your impact will span both team effectiveness and business growth. You’ll increase team velocity and autonomy by building reusable workflows, shared tools, and decision frameworks that enable designers to operate at a higher level with less coordination overhead. In parallel, you’ll drive measurable business outcomes by unlocking faster experimentation, shorter iteration cycles, and higher-quality execution across your team and adjacent teams. This role can be based in New York City, San Francisco, or Seattle and reports to the Design Manager for Ads & Promotions (Restaurant Experie

AWSGitRestAI
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