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Systems Architect in San Francisco

249 active opportunities · Updated October 2026

Explore current systems architect jobs in San Francisco. Filter by work mode, employment type, experience, department, date posted and distance.

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📍 San Francisco, Canada· Full-time
✓ High-confidence listingCompany trend -74%
Quick readStrong listing-quality and freshness signals

At Lyft, our purpose is to serve and connect. We aim to achieve this by cultivating a work environment where all team members belong and have the opportunity to thrive. The Pricing team is a centerpiece of Lyft’s marketplace, determining prices for all rideshare products and supporting new initiatives. Dynamic Pricing & Offer Selection sits at the heart of Pricing, focused on determining optimal prices and ETAs in real-time and balancing supply and demand for our two-sided marketplace to drive both short-term and long-term conversion and retention. As an Applied Scientist specializing in Machine Learning and Operations Research on this team, you will develop mathematical models and launch algorithms that power these key pricing and ETA decisions. You will leverage your skills to build ML and optimization models and productionalize pipelines that can scale to millions of calls per day while solving critical business problems that have a big impact on the marketplace and rider experience. You will get exposure to a diverse set of real-world problems across optimization, prediction, machine learning, and inference and collaborate closely with teammates and stakeholders across Pricing, from Product Managers to Engineers and Analysts. We are looking for someone who is excited about working in a fast-paced, innovative, and impactful environment, and is adept at balancing complexity and efficiency to translate real world business problems into reliable solutions, systems and decision frameworks. Responsibilities Partner with Data Scientists, Engineers, Product Managers, and Business Partners to frame problems mathematically and within the business context Write production quality code. Design, build and deploy production-grade ML and Optimization models. Able to build custom methods and tooling beyond off-the-shelf libraries. Perform data analysis and build proof-of-concepts to explore and propose ML and Optimization solutions to both new and existing problems.&n

PythonMachine LearningAIGo
T
📍 San Francisco, Canada· Full-time
✓ High-confidence listingCompany trend -94.9%

From $151.2K/yr

Quick readStrong listing-quality and freshness signals

About Us Twitch is the world’s biggest live streaming service, with global communities built around gaming, entertainment, music, sports, cooking, and more. It is where thousands of communities come together for whatever, every day. We’re about community, inside and out. You’ll find coworkers who are eager to team up, collaborate, and smash (or elegantly solve) problems together. We’re on a quest to empower live communities, so if this sounds good to you, see what we’re up to on LinkedIn and X , and discover the projects we’re solving on our Blog . Be sure to explore our Interviewing Guide to learn how to ace our interview process. About the Role Platform Core Engineering (PCE) builds the foundational systems, frameworks, and tooling that Twitch's engineers build on every day. As a Senior Product Manager on PCE, your customers are developers, and your success depends on earning their trust. You will own a platform product area and be measured on whether developers actually adopt, rely on, and advocate for what you ship. This is a deeply technical, senior individual-contributor role. You are expected to be hands-on with modern AI development tools, to understand the technology you are shaping at a real level (not just at the surface), and to hold credibility in a room full of engineers. You can be based out of one of the Twitch offices including San Francisco, Seattle, Los Angeles, Irvine, or New York City. You Will: Own the strategy and roadmap for a PCE platform area, balancing near-term developer needs with a 1 to 2 year technical vision. Treat developers as your customers: understand their workflows, earn their trust, and prioritize the capabilities that make them faster and more effective. Work directly with Senior Engineering Managers and Principal Engineers to define technical and organizational needs and build a cohesive platform ecosystem. Define and drive the platform metrics that matter. Drive alignment across dependent

AWSRestAIGo
T
📍 San Francisco, Canada· Full-time
✓ High-confidence listingCompany trend -94.9%

From $82.7K/yr

Quick readStrong listing-quality and freshness signals

About Us Twitch is the world’s biggest live streaming service, with global communities built around gaming, entertainment, music, sports, cooking, and more. It is where thousands of communities come together for whatever, every day. We’re about community, inside and out. You’ll find coworkers who are eager to team up, collaborate, and smash (or elegantly solve) problems together. We’re on a quest to empower live communities, so if this sounds good to you, see what we’re up to on LinkedIn and X , and discover the projects we’re solving on our Blog . Be sure to explore our Interviewing Guide to learn how to ace our interview process. About the Team Community Trust (CT) exists to foster an environment where streamers and their communities thrive, while proactively reducing harm and ensuring support is accessible when needed. Our organization encompasses safety policy & enforcement, fraud prevention, and customer experience. Within CT, the Business Operations & Integrations team is the operational backbone – encompassing four functions (Business Operations, Financial & Contract Management, Go-to-Market, and Safety by Design) split across two sub-teams: BizOps and Integrations. The Integrations team – which this role sits on – is the connective tissue between Community Trust and the rest of Twitch. We own the CT Readiness Program, ensuring every product, monetization, regulatory, or business development launch is operationally ready before it reaches our community (200+ launches per year). We also co-own Safety By Design, the process by which safety risks are identified and mitigated before products ship. We're building a team that can anticipate what's coming and react to what's arrived – getting CT into planning conversations earlier, simplifying how Twitch launches safely at scale, and building the systems that allow a small team to have outsized impact. About the Role This is a Program Manager II role on the Integration

ReactRestAIGo
T
📍 San Francisco, Canada· Full-time
✓ High-confidence listingCompany trend -94.9%

From $127.1K/yr

Quick readStrong listing-quality and freshness signals

About Us Twitch is the world’s biggest live streaming service, with global communities built around gaming, entertainment, music, sports, cooking, and more. It is where thousands of communities come together for whatever, every day. We’re about community, inside and out. You’ll find coworkers who are eager to team up, collaborate, and smash (or elegantly solve) problems together. We’re on a quest to empower live communities, so if this sounds good to you, see what we’re up to on LinkedIn and X , and discover the projects we’re solving on our Blog . Be sure to explore our Interviewing Guide to learn how to ace our interview process. About the Role The Discovery Team in App Experiences manages a wide array of features and systems to help communities form, grow, and thrive on Twitch. These features let people participate in their favorite communities and discover new ones more efficiently. We work hard to bring novel opportunities to the world of streaming both individually and in collaboration with similar streamers. Our consumer facing features span both web and mobile surfaces, we’re working hard to build fast, reliable, and easy to understand client-side experiences. This position is primarily focused across the entire stack (React and Golang) but will lean initially more toward backend systems, with future efforts moving more client-side. This position is in San Francisco, CA. You Will: Work with product managers, technical leads, and other engineers to design, develop, launch, and operate interactive experiences Investigate, instrument and solve performance problems Build distributed applications at scale Collaborate with both your team and related teams - fostering shared understanding of how to solve common problems and deliver solutions Work backwards from customer problems to drive business impact You Have: 1+ Years experience developing software in a professional environment Prior experience building consumer-f

TypeScriptReactAWSRest
AT
📍 San Francisco, Canada· Full-time
✓ High-confidence listing

$120K – $185K/yr

Quick readStrong listing-quality and freshness signals

Axsome Therapeutics is a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) conditions. We deliver scientific breakthroughs by identifying critical gaps in care and develop differentiated products with a focus on novel mechanisms of action that enable meaningful advancements in patient outcomes. Our industry-leading neuroscience portfolio includes FDA-approved treatments for major depressive disorder, agitation associated with dementia due to Alzheimer’s disease, excessive daytime sleepiness associated with narcolepsy and obstructive sleep apnea, and migraine, as well as multiple novel product candidates addressing a broad range of serious neurological and psychiatric conditions that impact over 150 million people in the United States. Together, we are on a mission to solve some of the brain’s biggest problems so patients and their loved ones can flourish. For more information, please visit us at www.axsome.com and follow us on LinkedIn and X . About This Role Axsome Therapeutics is currently searching for a field based Long-Term Care (LTC) Specialty Account Manager (SAM) to drive LTC commercial activities for an assigned geography by executing marketing strategies to ensure a successful launch and make a meaningful difference through the execution of commercial activities. SAMs will be responsible for product performance at a territory level and expected to be a disease state expert, product champion and an account specialist. The SAM will provide account management support and exhibit business knowledge of the local landscape to assess key stakeholders plus future trends within the marketplace. Job Responsibilities and Duties include, but are not limited to, the following: Drive product adoption in LTC facilities Proficient in both virtual and live customer engagements Effectively call on LTC Care teams, building meaningful relationships across the entire LTC ecosystem: Psychiatrists

GitAIGoMarketing
AT
📍 San Francisco, Canada· Full-time
✓ High-confidence listing

$140K – $160K/yr

Quick readStrong listing-quality and freshness signals

Axsome Therapeutics is a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) conditions. We deliver scientific breakthroughs by identifying critical gaps in care and develop differentiated products with a focus on novel mechanisms of action that enable meaningful advancements in patient outcomes. Our industry-leading neuroscience portfolio includes FDA-approved treatments for major depressive disorder, excessive daytime sleepiness associated with narcolepsy and obstructive sleep apnea, and migraine, and multiple late-stage development programs addressing a broad range of serious neurological and psychiatric conditions that impact over 150 million people in the United States. Together, we are on a mission to solve some of the brain’s biggest problems so patients and their loved ones can flourish. For more information, please visit us at www.axsome.com and follow us on LinkedIn and X . About This Role: Axsome Therapeutics is seeking a National Training Manager to lead and conduct training programs for our Specialty Account Managers. This role is pivotal in ensuring our sales teams are equipped with the knowledge and skills necessary to effectively communicate our product offerings to healthcare professionals. This is a hybrid role that includes both remote and field-based work. This position requires up to 50% travel based on reoccurring national, regional and HQ-based training events, as well as travel to customer field rides with our specialty account team. Job Responsibilities and Duties include, but are not limited to, the following: Conduct all foundational new hire and advanced sales training classes virtually with some in-person sessions Coach and support new specialty account managers in their onboarding Partnering with the HQ based training team and cross functional teams, manage all aspects of training logistics for assigned classes to ensure a se

AIMarketingLogisticsRecruitment
AT
📍 San Francisco, Canada· Full-time
✓ High-confidence listing

$140K – $160K/yr

Quick readStrong listing-quality and freshness signals

Axsome Therapeutics is a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) conditions. We deliver scientific breakthroughs by identifying critical gaps in care and develop differentiated products with a focus on novel mechanisms of action that enable meaningful advancements in patient outcomes. Our industry-leading neuroscience portfolio includes FDA-approved treatments for major depressive disorder, excessive daytime sleepiness associated with narcolepsy and obstructive sleep apnea, and migraine, and multiple late-stage development programs addressing a broad range of serious neurological and psychiatric conditions that impact over 150 million people in the United States. Together, we are on a mission to solve some of the brain’s biggest problems so patients and their loved ones can flourish. For more information, please visit us at www.axsome.com and follow us on LinkedIn and X . About This Role: Axsome Therapeutics is seeking a National Training Manager to lead and conduct training programs for our Specialty Account Managers. This role is pivotal in ensuring our sales teams are equipped with the knowledge and skills necessary to effectively communicate our product offerings to healthcare professionals. This is a hybrid role that includes both remote and field-based work. This position requires up to 50% travel based on reoccurring national, regional and HQ-based training events, as well as travel to customer field rides with our specialty account team. Job Responsibilities and Duties include, but are not limited to, the following: Conduct all foundational new hire and advanced sales training classes virtually with some in-person sessions Coach and support new specialty account managers in their onboarding Partnering with the HQ based training team and cross functional teams, manage all aspects of training logistics for assigned classes to ensure a se

AIMarketingLogisticsRecruitment
DU
📍 San Francisco, Canada· Full-time
✓ High-confidence listing

From $897.6K/yr

Quick readStrong listing-quality and freshness signals

About the Team As one of DoorDash's core operations teams, Customer Experience ensures that when issues arise across the platform, there is a reliable and effective support system in place. Our team designs, manages, and continuously improves DoorDash's global support network, with the goal of delivering a high-quality and consistent customer experience. This role sits within the Safety Customer Experience team, focused on the most critical and high-risk incidents on the platform. The team owns some of the most sensitive customer interactions at DoorDash, where thoughtful operational and product decisions directly improve customer trust and platform safety. About the Role You'll operate at the intersection of Product, Operations, and Customer Experience to improve how DoorDash prevents, identifies, and responds to the most critical safety incidents on the platform. You'll partner closely with Product, Policy, Analytics, and Operations to design scalable solutions that deliver accurate, timely support during customers' highest-stakes moments. This role requires a detail-oriented operator who can navigate complex problem spaces, design scalable processes, and execute with precision in a fast-paced environment. You’ll be expected to take ownership of ambiguous, high-stakes problems and translate them into structured, actionable solutions. You’re excited about this opportunity because you will… Drive Safety Strategy – Partner with cross-functional teams to identify and execute initiatives that improve how DoorDash prevents, identifies, and responds to safety incidents. Own End-to-End Experience – Design and optimize the full lifecycle of safety incident handling, including reporting, workflows, support execution, and tooling. Drive Data-Driven Decisions – Leverage data and case-level insights to identify root causes, measure performance, and prioritize opportunities to improve the safety customer experience. Influence Cross-Functionally – Collaborate with Product, Engin

AWSGitRestAI
A
📍 San Francisco, Canada· Full-time
✓ High-confidence listing

$165K – $247K/yr

Quick readStrong listing-quality and freshness signals

Amplitude is the leading AI analytics platform, helping over 4,700 customers—including Atlassian, Burger King, NBCUniversal, and Square—build better products and digital experiences. With powerful AI Agents embedded across our platform, teams can analyze, test, and optimize user experiences faster than ever. Ranked #1 across multiple categories in G2’s Winter 2026 Report, Amplitude is the best-in-class solution for product, data, and marketing teams. Learn more at amplitude.com . As an organization, we deliver for our customers by living our values. We operate from a place of humility, take ownership of problems and successes, approach challenges with a growth mindset, and put our customers at the center of everything we do. Amplitude’s Commitment to Diversity Equity & Inclusion (DEI): Amplitude believes that diversity enables the creation of better products, improves the ability to solve complex problems, and drives more powerful solutions. We strive to create an environment of inclusion—one focused on psychological safety, empathy, and human connection—that will allow employees of all backgrounds to thrive. At Amplitude, we’re building the operating system for digital products. While we’re known as the leader in product analytics, our Statsig team is redefining how companies learn, iterate, and ship better experiences. Statsig is one of the fastest-growing and most strategic bets at Amplitude. It sits at the intersection of product, data, and decision-making, and we’re looking for a Product Engineer to help take it to the next level. Why this role matters This isn’t a “take tickets and ship code” role. You’ll operate as an owner, shaping both the product and the technical direction of a system used by some of the most sophisticated product teams in the world. You’ll work across the stack, NextJS and Node.js, to build intuitive, high-performance experiences that make experimentation accessible, powerful, and trustworthy. What you’ll do Own critical product surf

PythonReactNode.jsGit
V
📍 San Francisco, Canada· Full-time
✓ High-confidence listing

$260K – $290K/yr

Quick readStrong listing-quality and freshness signals

About VSCO For years, we've helped photographers create their work. Now we're building what comes next. VSCO exists for photographers. Not as a side feature, not as an afterthought, but as the whole point. We build the connected system photographers rely on, and we've spent over a decade earning the trust of a global creative community that takes the craft seriously. Photography is at an inflection point. AI is reshaping what's possible for creative work, and that's where our mission shines. VSCO is building the full photographer's workflow: from creating and editing your work, to delivering it to clients, to running your business. All of it built thoughtfully, with photographers leading the way. We believe the future of photography tools creates more space for creativity, handling the busy work so photographers can focus on the craft. If you care about craft, community, and what technology can unlock for creative people, this is the work. We're a mission-driven and focused company where your work ships quickly, is meaningful, and reaches tens of millions of people worldwide. You'll have a real say in what we build and how we build it. We hire people who don't wait to be asked, naturally connect the dots, care about the quality of what they ship, and believe the best outcomes come from building together. About The Role VSCO is hiring a Senior Staff Engineer to own Reflex, our production GPU image-processing engine, and the path it takes into Studio Pro on iOS and macOS. This is a critical technical leader. You will deepen a stack that is already in customers’ hands: new capabilities (RAW, large-image export, desktop), production quality (color correctness, memory, performance), and the contracts that let product engineers ship on top of the engine without becoming graphics programmers. You will also lead company-wide engineering mentorship and force-multiplication — tools, workflows, and AI-assisted development that make the rest of the team more effective. In This

ReactRestAIGo
V
📍 San Francisco, Canada· Full-time
✓ High-confidence listing

$190K – $220K/yr

Quick readStrong listing-quality and freshness signals

About VSCO For years, we've helped photographers create their work. Now we're building what comes next. VSCO exists for photographers. Not as a side feature, not as an afterthought, but as the whole point. We build the connected system photographers rely on, and we've spent over a decade earning the trust of a global creative community that takes the craft seriously. Photography is at an inflection point. AI is reshaping what's possible for creative work, and that's where our mission shines. VSCO is building the full photographer's workflow: from creating and editing your work, to delivering it to clients, to running your business. All of it built thoughtfully, with photographers leading the way. We believe the future of photography tools creates more space for creativity, handling the busy work so photographers can focus on the craft. If you care about craft, community, and what technology can unlock for creative people, this is the work. We're a mission-driven and focused company where your work ships quickly, is meaningful, and reaches tens of millions of people worldwide. You'll have a real say in what we build and how we build it. We hire people who don't wait to be asked, naturally connect the dots, care about the quality of what they ship, and believe the best outcomes come from building together. About The Role VSCO is hiring a Senior Software Engineer to be a primary contributor on Reflex, our production GPU image-processing engine, and significantly guide the path it takes into Studio Pro on iOS and macOS. You will deepen a stack that is already in customers’ hands: new capabilities (RAW, large-image export, desktop), production quality (color correctness, memory, performance), and the contracts that let product engineers ship on top of the engine without becoming graphics programmers. In This Role, You Will Be a primary contributor on the Reflex imaging engine: DAG execution, WGSL operators, GPU resource/memory budgets, and color management (linear workin

ReactAIGoRust
V
📍 San Francisco, Canada· Full-time
✓ High-confidence listing

$230K – $260K/yr

Quick readStrong listing-quality and freshness signals

About VSCO For years, we've helped photographers create their work. Now we're building what comes next. VSCO exists for photographers. Not as a side feature, not as an afterthought, but as the whole point. We build the connected system photographers rely on, and we've spent over a decade earning the trust of a global creative community that takes the craft seriously. Photography is at an inflection point. AI is reshaping what's possible for creative work, and that's where our mission shines. VSCO is building the full photographer's workflow: from creating and editing your work, to delivering it to clients, to running your business. All of it built thoughtfully, with photographers leading the way. We believe the future of photography tools creates more space for creativity, handling the busy work so photographers can focus on the craft. If you care about craft, community, and what technology can unlock for creative people, this is the work. We're a mission-driven and focused company where your work ships quickly, is meaningful, and reaches tens of millions of people worldwide. You'll have a real say in what we build and how we build it. We hire people who don't wait to be asked, naturally connect the dots, care about the quality of what they ship, and believe the best outcomes come from building together. About The Role If you are passionate about iOS development and excited to join a dynamic team of creators, we encourage you to apply for this position and help us empower creators worldwide. At VSCO, you'll have the opportunity to collaborate with talented individuals who share your passion for innovation and creativity. We're building an ecosystem of end-to-end tools for photographers, enhancing our existing product while creating entirely new tools and services. This is a crucial role for someone who will help define and drive that vision forward, shaping the way our users create, connect and earn. Join us in shaping the future of mobile technology and making a me

ReactRestAISwift
DU
📍 San Francisco, Canada· Full-time
✓ High-confidence listing
Quick readStrong listing-quality and freshness signals

About the Team DoorDash Labs is an independent team within DoorDash. We explore robotics and automation to transform last mile logistics in the long term. If you have a passion for applying robotics solutions in a service used by millions of people, then we want to talk to you! About the Role We are hiring a Software Integration Engineer for our Platform Integration team. This is a critical role with impact across the robot lifecycle, from manufacturing to daily operation. The Platform Integration team owns making sure the robot works as one cohesive system. The focus is on the interfaces between subsystems; this role in particular is focused on the software side handling interaction between: OS & software stack; firmware; networking; timing; and calibration. In this role, you will work cross functionally with our electrical, hardware, firmware, and autonomy engineers to support new functionality both in both hardware and software. This includes creating provisioning tools, functional tests, and supporting integration into the autonomy software stack. You will report to the Autonomy Platform Lead on our Autonomy Platform Team at DoorDash Labs. We expect this role to be hybrid with some time in-office and some time remote. You’re excited about this opportunity because you will… Play an integral role on a small and focused team. Lead system-level debug when an issue crosses subsystem boundaries or no single team can isolate it. Support early integration of new sensor and software component designs by identifying interface requirements, risks, dependencies and required checks. Design and maintain integration tests, test setups, and procedures to ensure subsystems, once combined, satisfy requirements and design intent. Build and maintain the mission-readiness checks used before manufacturing signoff, validation, field testing, or mission use for different robot platforms. Create the tools, checks, and debug guidance that Manufacturing Integration, Validation,

PythonAWSGitRest
PE
📍 San Francisco, Canada· Full-time
✓ High-confidence listing
Quick readStrong listing-quality and freshness signals

A Test Program Manager (or Test Engineering Program Manager) leads cross-functional teams to define, plan, and execute product testing strategies, ensuring quality from development to launch. They manage test schedules, budgets, and vendor relations while driving bug resolution and reporting status to leadership. Apple +4 Key Responsibilities Strategy & Planning: Define comprehensive end-to-end testing strategies, covering functional, regression, and system testing. Cross-Functional Leadership: Coordinate with software, hardware, and RF test engineers to align testing with product development. Execution & Monitoring: Drive test readiness reviews, monitor test execution, and manage defect reporting. Vendor & Budget Management: Manage test suppliers, vendors, and development budgets. Risk Management: Proactively identify project risks, inter-dependencies, and bottlenecks to ensure on-time delivery. Apple +6 Required Skills & Qualifications Technical Proficiency: Familiarity with test technologies, CICD, and automation tools. Project Management: Experience with software development lifecycles (SDLC) and complex product testing. Communication: Excellent leadership, presentation, and conflict-resolution skills. Education/Experience: Often requires a degree in Engineering (Software/Electrical) and experience in testing or program management. Apple +4

Project Management
L
📍 San Francisco, Canada· Full-time
✓ High-confidence listingCompany trend -74%
Quick readStrong listing-quality and freshness signals

At Lyft, our purpose is to serve and connect. We aim to achieve this by cultivating a work environment where all team members belong and have the opportunity to thrive. We are hiring a Machine Learning Engineer to join our ETA team. Our team builds and maintains Lyft's system responsible for estimating/predicting ETAs for every ride request on our platform. ETAs play a critical role in matching decisions, pricing estimates and overall user experience. Low latency, high reliability and high accuracy are paramount for our success. If you are a critical thinker with experience in machine learning workflows and writing reliable code, passionate about solving business problems using data and working in a dynamic, creative, and collaborative environment, we are searching for you. Our technology stack runs on AWS, Kubernetes, Go, Spark, Python and Apache Airflow. In this role, you will work with incredibly passionate and talented colleagues from software engineering, machine learning and data science on building rideshare experiences that delight millions of riders and drivers. Responsibilities: Perform data analysis and build proof-of-concept to explore and compare ML and non-ML solutions Be able to make effective tradeoffs between model accuracy, its productization complexity and runtime performance Develop statistical, machine learning, or optimization models Write production quality code that can scale well to serve millions of requests per day Participate in code reviews, design reviews, production on-call support and incident triaging process. Write well-crafted, well-tested, readable, maintainable code Experience: B.S., M.S., or Ph.D. in Computer Science or other quantitative fields or related work experience 3+ years of Machine Learning experience Nice-to-have: Experience with big data processing / distributed data pipelines and tools such as Apache Airflow and Spark Ability to work in distributed teams spread across time zones. (North America and

PythonAWSKubernetesMachine Learning
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