Histology Lab Operator I

POSITION SUMMARY: Performs histological preparations for Signatera Whole Exome/Genome Sequencing PRIMARY RESPONSIBILITIES: • Perform histological preparations for the tissue whole exome sequencing laboratory with little to no errors • Duties may include, but not limited to: preparation of tissues, stained slides, macrodissection, and supporting workflow tasks • May independently perform testing, reagent, and equipment preparation after completion of training and competency. • Participates in validations • Performs qualifications of reagents • Monitors and performs case management; ensures all cases are processed within department TAT goals and investigates sample processing issues • Actively participate in EH&S initiatives such as safety audits • Participates in updating and creating Standard Operating Procedures • May serve as the general supervisor (Depending on education and years of experience) and perform competencies • Has an understanding of equipment and process troubleshooting • Document all corrective actions taken when test systems deviate from the established performance specifications as needed. Escalates protocol deviation to the supervisor • Provides general oversight of personnel and the daily operations in the lab. Provides guidance to new team members QUALIFICATIONS: • An associate's, or higher, degree in a histotechnician program OR An associate's degree, or higher, in one of the chemical or biological sciences AND - one year of experience and/or training in histology within the past 5 years OR - completion of a course of training of at least nine months in a histotechnician program OR A bachelor's, or higher, degree in one of the chemical or biological sciences, including a combination of thirty (30) hours in biology and chemistry; and either one of the following conditions: - one year of experience and/or training in histology within the past 5 years OR - completion of a course of training of at least nine months in a histotechnician program

POSITION SUMMARY: The Histology Lab Operator I is a member of the Histopathy Department responsible for assisting HT/HTLs in analyzing specimens and maintaining equipment in good condition. PRIMARY RESPONSIBILITIES: • Assists certified/licensed personnel in clinical patient testing in accordance with the SOP • Perform histological preparations for the tissue whole exome sequencing laboratory with little to no errors • Duties may include but not limited to: preparation of tissues, stained slides, macrodissection and supporting workflow tasks • Sets up equipment and assists with automated lab procedures, as applicable • Assist and complete daily tasks • Maintains equipment and instruments in good operating condition • Maintain sufficient inventory of material, supplies, and equipment in the laboratory for the performance of duties • Documents information accurately and in accordance with Good Documentation Practices (GDP) • Performs other duties as assigned QUALIFICATIONS: • 0-2 years of experience • An associate's, or higher, degree in a histotechnician program OR An associate's degree, or higher, in one of the chemical or biological sciences AND one year of experience and/or training in histology within the past 5 years OR - completion of a course of training of at least nine months in a histotechnician program OR A bachelor's, or higher, degree in one of the chemical or biological sciences, including a combination of thirty (30) hours in biology and chemistry; and either one of the following conditions: - one year of experience and/or training in histology within the past 5 years OR - completion of a course of training of at least nine months in a histotechnician program • A copy of the degree is required at the time of hire; the degree must either be from the US or equivalent to a US degree KNOWLEDGE, SKILLS, AND ABILITIES: • Excellent interpersonal, communication, computer, and technical skills • Excellent oral

POSITION SUMMARY: As the Histotechnologist Supervisor you will oversee the activities of the lab and Signatera team that is cutting, staining and preparing tissue samples for the pathologist view. The individual is responsible for supervising and participating in operations of the histology lab. PRIMARY RESPONSIBILITIES: In this position, you will work in a fast paced, customer focused, and challenging environment Supervise the day-to-day operations of the Histology department Ensure laboratory tests are accurately performed and results are reported in a timely manner Directly supervise, train, and mentor laboratory personnel of the department Monitor daily workflow in the lab and schedule adequate assay coverage Responsible for ensuring all shifts in the department are properly staffed Research and resolve any production errors while escalating when necessary Engage in continuous process and service level improvements Ensure all equipment is being properly maintained through Quality Control Prepare and maintain Quality Assurance records and documents Evaluate new process improvements and make appropriate recommendations Meet regularly with direct reports to provide coaching and feedback for their development Perform bench work as needed and maintain proficiency/competency in technical operations Ensure all work is in accordance with state and Federal regulations Responsible for administering and managing policies and procedures Process and maintain payroll and personnel files Perform administrative duties as needed Qualifications Bachelor's Degree required Active ASCP Board of Certification, HT(ASCP), HLT(ASCP) 4+ years Histology laboratory experience required, and minimum 2 years supervisory experience KNOWLEDGE, SKILLS, AND ABILITIES: Excellent written and oral communication skills. Able to accurately understand and convey information to team members Ability to think broadly about the importance of information. A

POSITION SUMMARY: Performs histological preparations for Signatera Whole Exome/Genome Sequencing PRIMARY RESPONSIBILITIES: • Perform histological preparations for the tissue whole exome sequencing laboratory with little to no errors • Duties may include but not limited to: preparation of tissues, stained slides, microdissection, and supporting workflow tasks • May independently perform testing, reagent and equipment preparation after completion of training and competency. • Participates in validations • Performs qualifications of reagents • Monitors and performs case management; ensures all cases are processed within department TAT goals and investigates sample processing issues • Actively participate in EH&S initiatives such as safety audits • Participates in updating and creating Standard Operating Procedures • May serve as a general supervisor (Depending on education and years of experience) and perform competencies • Trains staff on department procedures • Participates in Projects and initiatives initiated by the department/external departments • May serve as a general supervisor (Depending on education and years of experience) and perform competencies • Extensive knowledge in equipment and process troubleshooting • Document all corrective actions taken when test systems deviate from the established performance specifications as needed. Escalates protocol deviation to lead/supervisor. • Provides general oversight of personnel and the daily operations in the lab. Provides guidance to new team members • Engages with external departments such as Engineering, Biodev, Stats to resolve issues • May work with leaders of the department to streamline processes. QUALIFICATIONS: • A bachelor's, or higher, degree in a histotechnician program OR A bachelor's, or higher, degree in one of the chemical, or biological sciences, including a combination of thirty (30) hours in biology and chemistry; and, either one of the following conditions:-one year of experien

POSITION SUMMARY Natera is seeking a highly motivated Scientist, R&D – Immunohistochemistry (IHC) & Histology to join the Oncology Product Development team. This role will focus on the development, optimization, verification, and validation of IHC and tissue-based workflows supporting oncology products and clinical assay development. The ideal candidate will have strong hands-on experience in IHC assay development and optimization, supported by a solid foundation in histology and FFPE tissue workflows. Experience with automated IHC/ISH staining platforms, particularly the Roche BenchMark ULTRA IHC/ISH System, is highly desirable. Experience with NGS and molecular biology workflows is an additional plus. PRIMARY RESPONSIBILITIES Design and execute development, optimization, verification, and validation studies for IHC, histology, and tissue-based workflows. Develop and optimize IHC assays, including antibody selection and titration, antigen retrieval, staining conditions, controls, and assay performance assessment. Evaluate and optimize histology and pre-analytical variables, including tissue fixation, FFPE processing, embedding, sectioning, H&E staining, and slide preparation. Develop and troubleshoot workflows on automated IHC/ISH staining platforms and investigate staining artifacts, reagent performance, tissue quality, and assay variability. Plan and execute moderate- to high-complexity experiments; analyze and interpret results using tools such as Excel, JMP, and image-analysis approaches. Collaborate with Pathology, Clinical Laboratory Operations, Quality, Automation, and other cross-functional teams to transfer R&D methods into robust clinical laboratory workflows. Author study protocols, development/validation reports, SOPs, and transfer documentation, and provide technical guidance and training during implementation. Communicate project progress, experimental findings, risks, and recommendations to project teams and stakeholders. QUALI