Become a part of our caring community Every large organization is making critical decisions today about how it will leverage AI over the next decade. Few have leaders who can both define that vision and demonstrate its viability through hands-on engineering. This role requires both. We build the platform that transforms millions of clinical documents into trusted, actionable data. Our systems use large language models (LLMs) to read medical records, extract structured facts, answer complex questions with citations to source documents, and route difficult cases to human experts. These capabilities support decisions that impact real healthcare outcomes for members. As a Principal AI Applied Engineer, you will define the technical strategy, architectural standards, and long-term vision for AI-enabled products across the organization. You will influence enterprise-wide decisions regarding AI platforms, model strategies, engineering standards, and technology investments while remaining deeply hands-on in prototyping, experimentation, architecture, and software development. This is the highest-level individual contributor role within the AI Applied Engineering organization. Success requires exceptional technical depth, organizational influence, strategic thinking, and the ability to translate emerging AI capabilities into scalable, reliable, and responsible production systems. Why Join Us Shape the long-term AI architecture and engineering direction for a large enterprise healthcare organization. Influence how AI-enabled products are designed, built, evaluated, deployed, and governed across multiple teams. Drive strategic decisions involving models, vendors, platforms, infrastructure, and shared capabilities. Prototype and validate emerging technologies before the organization invests at scale.</
Role overview
Job description
Here at Appian, our values of Intensity and Excellence define who we are. We set high standards and live up to them, ensuring that everything we do is done with care and quality. We approach every challenge with ambition and commitment, holding ourselves and each other accountable to achieve the best results. When you join Appian, you’ll be part of a passionate team dedicated to accomplishing hard things, together. Principal Applied AI Engineer Location: Remote (US) Lead the engineering of software that matters — driving AI automation for the world's largest enterprises. ABOUT THE TEAM Appian Engineering spans the full depth of our platform: from the foundational layers that power enterprise scale, to the AI capabilities redefining what automation can do. We operate in a highly collaborative, fast-paced environment focused on technical precision, continuous learning, and high code qual
…What they are looking for
Skills & requirements
Qualification
Minimum of a Bachelor of Science degree in Computer Science or a related technical/analytical discipline. (Equivalent experience is not accepted in lieu of a degree).
Department · Engineering

Hiring company
Appian Corporation
AI automation for critical processes. Appian orchestrates AI agents, systems, and people on an enterprise platform, without replacing your systems.
Related opportunities
Similar active roles
Relevant, currently active roles for this market.
$224K – $308K/yr
🔔 Get job alerts
New Principal Applied AI Engineer jobs in United States, straight to your inbox.
No spam · Unsubscribe anytime