Supervisor, Oncology RUO

As the Associate/Laboratory Director, Oncology and one of our Laboratory Directors, you have clinical oversight of Natera’s laboratory testing. You ensure that testing is properly performed, and applicable regulatory standards are met. You are responsible for ensuring that the laboratory implements testing while consistently providing accurate and reliable patient test results. PRIMARY RESPONSIBILITIES: Review, approve, and sign-out reports for a variety of clinical molecular/cytogenetic and/or oncologic results, including the Signatera MRD assay and other Next Generation Sequencing based assays. Oversee the review of genetic and CNV variant data: interpret NGS results in the context of medical literature, online variant databases and other references along with relevant patient demographic data. Provide clinical and technical support for genetic counselors and other laboratory personnel. Set standards for laboratory testing and acceptable levels of analytic performance and ensure these are maintained. Analyze lab data, contribute to or write publications for high-quality scientific journals. May serve as Technical Supervisor. The Technical Supervisor is responsible for ensuring: appropriate test method selection; adequate method verification to determine the accuracy and precision of the test; enrollment of the laboratory in a CMS-approved proficiency testing (PT) program for the test performed; PT samples are tested in accordance with the CLIA requirements; PT results are returned within the time frames established by the PT program; PT reports are reviewed by the appropriate staff; corrective action plans are followed when PT results are found to be unacceptable or unsatisfactory; quality assessment and quality control programs are established and maintained; acceptable analytical test performance is established and maintained for each test system; remedial actions are taken and documented when significant deviations from the laboratory’s established

As the Associate/Laboratory Director, you have clinical oversight of Natera’s laboratory testing. You ensure that testing is properly performed, and applicable regulatory standards are met. You are responsible for ensuring that the laboratory implements testing while consistently providing accurate and reliable patient test results. PRIMARY RESPONSIBILITIES: Review, approve, and sign-out reports for a variety of clinical molecular/cytogenetic and/or oncologic results, including NIPT, carrier screening, PGD/PGS, products of conception and rare disease testing on platforms including SNP array analysis, NGS, and other methodologies. Oversee the review of genetic and CNV variant data: interpret NGS and microarray results in the context of medical literature, online variant databases and other references along with relevant patient demographic data. Provide clinical and technical support for genetic counselors and other laboratory personnel. Set standards for laboratory testing and acceptable levels of analytic performance and ensure these are maintained. Analyze lab data, contribute to or write publications for high-quality scientific journals. May serve as Technical Supervisor. The Technical Supervisor is responsible for ensuring: appropriate test method selection; adequate method verification to determine the accuracy and precision of the test; enrollment of the laboratory in a CMS-approved proficiency testing (PT) program for the test performed; PT samples are tested in accordance with the CLIA requirements; PT results are returned within the time frames established by the PT program; PT reports are reviewed by the appropriate staff; corrective action plans are followed when PT results are found to be unacceptable or unsatisfactory; quality assessment and quality control programs are established and maintained; acceptable analytical test performance is established and maintained for each test system; remedial actions are taken and documented when signific

POSITION SUMMARY The Clinical Lab Supervisor is a leader in Natera’s lab operations whose role is to oversee employees' performance and serve as a liaison between employees and senior management to meet company goals and quality objectives. The supervisor is responsible for daily supervision of lab staff performing duties such as laboratory testing and data review. Duties include but are not limited to coaching, motivating, staffing, evaluating, and training staff. The supervisor works closely with the manager to ensure company and team goals are met while adhering to good manufacturing practices and CLIA/CAP guidelines. The shift timings are from Monday- Friday , 1.00 PM- 9.30 PM PRIMARY RESPONSIBILITIES Responsible for day-to-day staffing/scheduling/setting up sample run schedules. Ensures production work is consistently completed according to department goals. Ensures all case samples are processed and accounted for. Monitors team members to ensure adherence to SOPs and safety procedures Oversees training for new hires: works in conjunction with lead to train new hires. Document nonconformance reports and all corrective actions taken when test systems deviate from the established performance specifications as needed. Escalates protocol deviation to lead/supervisor. Assists manager in initiating and completing CAPAs. Handles employee issues. Collaborates with Manager and/or Human Resources to resolve issues. Ensures alignment with team for reasoning behind instructions/processes and changes Meets regularly with individual team members to discuss goals and progress. Responsible for staff performance reviews. Plans and leads shift meetings Maintains team morale and professionalism of team members, including by acting as role model. Adheres to Departmental Expectations Ensures compliance with all regulatory agency requirements through documentation, audits, and corrective action. Go-to person when manager is not present. May assist lab team in day to day

POSITION SUMMARY: As the Histotechnologist Supervisor you will oversee the activities of the lab and Signatera team that is cutting, staining and preparing tissue samples for the pathologist view. The individual is responsible for supervising and participating in operations of the histology lab. PRIMARY RESPONSIBILITIES: In this position, you will work in a fast paced, customer focused, and challenging environment Supervise the day-to-day operations of the Histology department Ensure laboratory tests are accurately performed and results are reported in a timely manner Directly supervise, train, and mentor laboratory personnel of the department Monitor daily workflow in the lab and schedule adequate assay coverage Responsible for ensuring all shifts in the department are properly staffed Research and resolve any production errors while escalating when necessary Engage in continuous process and service level improvements Ensure all equipment is being properly maintained through Quality Control Prepare and maintain Quality Assurance records and documents Evaluate new process improvements and make appropriate recommendations Meet regularly with direct reports to provide coaching and feedback for their development Perform bench work as needed and maintain proficiency/competency in technical operations Ensure all work is in accordance with state and Federal regulations Responsible for administering and managing policies and procedures Process and maintain payroll and personnel files Perform administrative duties as needed Qualifications Bachelor's Degree required Active ASCP Board of Certification, HT(ASCP), HLT(ASCP) 4+ years Histology laboratory experience required, and minimum 2 years supervisory experience KNOWLEDGE, SKILLS, AND ABILITIES: Excellent written and oral communication skills. Able to accurately understand and convey information to team members Ability to think broadly about the importance of information. A

POSITION SUMMARY: The role of a Laboratory Assistant I has the ability to receive specimens with an ability to exercise independent judgement in the performance of assigned laboratory tasks. This role ensures all workflow stations within the laboratory are given specimens in a timely manner, with turnaround time in consideration. PRIMARY RESPONSIBILITIES: •Assist licensed/certified staff in preparing specimen (i.e. blood tubes, tissue) to be processed for testing •Receive and deliver specimens to the appropriate workflows and/or labs •Maintain organization of samples through physical and electronic sample storage and/or disposal. •Accurately enter patient data into the Laboratory Inventory Management System (LIMS). •Prepares samples for shipment •Maintains organization of inventory, materials, and supplies within the lab •Assists in cleaning lab equipment and benches •Responsible for maintaining an updated understanding and knowledge of methods pertaining to the role •Completes training and other deadlines on time. •Recognizes and escalates issues to the lead/supervisor •Participate in Continuous Improvement Projects (TAG, 5S) •Conducts himself/herself in a professional manner •Adheres to Departmental Expectations •This role works with PHI on a regular basis both in paper and electronic form and has access to various technologies to access PHI (paper and electronic) in order to perform the job •Must maintain a current status on Natera training requirements. •Performs other duties as assigned. QUALIFICATIONS: Provide a list of qualifications that are truly required (e.g. Education and Experience, Equivalent job experience substituted for degree, preferred level to perform principal responsibilities, required certifications to successfully perform principal responsibilities, etc.) • High School Diploma required • Science - related degree preferred • Less than 1 year industry related experience preferred • Employee must complete training relating to HIPAA/PHI pri

POSITION SUMMARY: Performs histological preparations for Signatera Whole Exome/Genome Sequencing PRIMARY RESPONSIBILITIES: • Perform histological preparations for the tissue whole exome sequencing laboratory with little to no errors • Duties may include but not limited to: preparation of tissues, stained slides, microdissection, and supporting workflow tasks • May independently perform testing, reagent and equipment preparation after completion of training and competency. • Participates in validations • Performs qualifications of reagents • Monitors and performs case management; ensures all cases are processed within department TAT goals and investigates sample processing issues • Actively participate in EH&S initiatives such as safety audits • Participates in updating and creating Standard Operating Procedures • May serve as a general supervisor (Depending on education and years of experience) and perform competencies • Trains staff on department procedures • Participates in Projects and initiatives initiated by the department/external departments • May serve as a general supervisor (Depending on education and years of experience) and perform competencies • Extensive knowledge in equipment and process troubleshooting • Document all corrective actions taken when test systems deviate from the established performance specifications as needed. Escalates protocol deviation to lead/supervisor. • Provides general oversight of personnel and the daily operations in the lab. Provides guidance to new team members • Engages with external departments such as Engineering, Biodev, Stats to resolve issues • May work with leaders of the department to streamline processes. QUALIFICATIONS: • A bachelor's, or higher, degree in a histotechnician program OR A bachelor's, or higher, degree in one of the chemical, or biological sciences, including a combination of thirty (30) hours in biology and chemistry; and, either one of the following conditions:-one year of experien