Ai Oncology Portfolio Lead Jobs

For over 20 years, Smartsheet has empowered teams to manage work seamlessly and scale solutions smarter. Now, in our most ambitious chapter yet, we are uniting human teams with AI agents. By orchestrating the work agents do best, automating manual tasks and uncovering insights at scale, we create the space for people to focus on what truly matters: judgment, creativity, and big thinking. That is magic at work, and it’s what we show up for every day. We are looking for an experienced Principal Product Manager to join our Product Organization at Smartsheet. In this role, you will own the intersection of AI-powered creation and product-led growth, driving investments that help customers get to value faster through intelligent content generation, AI-assisted onboarding, and self-serve activation. You will be accountable for setting strategy and making high-impact investments in areas of high ambiguity, aligned to customer demands and business goals. You will report into a leader in Product Management, and can be based in our Bellevue, WA office or work remotely from anywhere in the US where Smartsheet is a registered employer. You Will: Own the AI creation product surface: drive AI-powered asset generation, intelligent template recommendations, and the overall experience that turns a blank canvas into a working solution Define and drive the activation strategy: set the vision for how AI reduces time-to-value for new and expanding users, with a clear north star metric and a roadmap to move it Improve AI output quality: define standards for AI-generated content in Smartsheet, and work with engineering and design to improve the accuracy and usefulness of outputs over time Build the PLG feedback loop: optimize creation flows to understand what drives users to their "aha moment," use that signal to iterate fast, and turn activation wins into expansion Partner deeply across the org: work with engineering, design, data science, and platform teams to ship capabilities that are

About Us At Cloudflare, we are on a mission to help build a better Internet. Today the company runs one of the world’s largest networks that powers millions of websites and other Internet properties for customers ranging from individual bloggers to SMBs to Fortune 500 companies. Cloudflare protects and accelerates any Internet application online without adding hardware, installing software, or changing a line of code. Internet properties powered by Cloudflare all have web traffic routed through its intelligent global network, which gets smarter with every request. As a result, they see significant improvement in performance and a decrease in spam and other attacks. Cloudflare was named to Entrepreneur Magazine’s Top Company Cultures list and ranked among the World’s Most Innovative Companies by Fast Company. At Cloudflare, we’re not looking for people who wait for a polished roadmap; we’re looking for the builders who see the cracks in the Internet that everyone else has simply learned to live with. We value candidates who have the instinct to spot a "normalized" problem and the AI-native curiosity to create a solution using the latest tools. Our culture is built on iteration, leveraging AI to ship faster today to make it better tomorrow, while ensuring that every improvement, no matter how small, is shared across the team to lift everyone up. If you’re the type of person who values curiosity over bureaucracy, and that AI is a partner in solving tough problems to keep the Internet moving forward, you’ll fit right in. Available Location: NYC Metro About the role The Enterprise AI and Digital Natives segment is Cloudflare's fastest growing and highest visibility market. This segment is dedicated exclusively to the largest organizations in the modern tech economy including premier SaaS platforms, hyperscale digital marketplaces, and leading AI labs. This is a deep infrastructure, developer centric play where technical alignment and deep engineering partnerships a

About Us At Cloudflare, we are on a mission to help build a better Internet. Today the company runs one of the world’s largest networks that powers millions of websites and other Internet properties for customers ranging from individual bloggers to SMBs to Fortune 500 companies. Cloudflare protects and accelerates any Internet application online without adding hardware, installing software, or changing a line of code. Internet properties powered by Cloudflare all have web traffic routed through its intelligent global network, which gets smarter with every request. As a result, they see significant improvement in performance and a decrease in spam and other attacks. Cloudflare was named to Entrepreneur Magazine’s Top Company Cultures list and ranked among the World’s Most Innovative Companies by Fast Company. At Cloudflare, we’re not looking for people who wait for a polished roadmap; we’re looking for the builders who see the cracks in the Internet that everyone else has simply learned to live with. We value candidates who have the instinct to spot a "normalized" problem and the AI-native curiosity to create a solution using the latest tools. Our culture is built on iteration, leveraging AI to ship faster today to make it better tomorrow, while ensuring that every improvement, no matter how small, is shared across the team to lift everyone up. If you’re the type of person who values curiosity over bureaucracy, and that AI is a partner in solving tough problems to keep the Internet moving forward, you’ll fit right in. Available Locations Los Angeles We are only considering locally based candidates and are not offering relocation. Senior Customer Engineer - (AI & Start-Ups) About the Role Digital Native SEs at Cloudflare work with the most innovative and cutting-edge companies on the planet — the startups and high-growth, cloud-native businesses that are building the next generation of Internet products. These are companies where the developers&n

About Us At Cloudflare, we are on a mission to help build a better Internet. Today the company runs one of the world’s largest networks that powers millions of websites and other Internet properties for customers ranging from individual bloggers to SMBs to Fortune 500 companies. Cloudflare protects and accelerates any Internet application online without adding hardware, installing software, or changing a line of code. Internet properties powered by Cloudflare all have web traffic routed through its intelligent global network, which gets smarter with every request. As a result, they see significant improvement in performance and a decrease in spam and other attacks. Cloudflare was named to Entrepreneur Magazine’s Top Company Cultures list and ranked among the World’s Most Innovative Companies by Fast Company. At Cloudflare, we’re not looking for people who wait for a polished roadmap; we’re looking for the builders who see the cracks in the Internet that everyone else has simply learned to live with. We value candidates who have the instinct to spot a "normalized" problem and the AI-native curiosity to create a solution using the latest tools. Our culture is built on iteration, leveraging AI to ship faster today to make it better tomorrow, while ensuring that every improvement, no matter how small, is shared across the team to lift everyone up. If you’re the type of person who values curiosity over bureaucracy, and that AI is a partner in solving tough problems to keep the Internet moving forward, you’ll fit right in. Available Locations San Francisco, US We are only considering locally based candidates Senior Customer Engineer - (AI & Start-Ups) About the Role Digital Native SEs at Cloudflare work with the most innovative and cutting-edge companies on the planet — the startups and high-growth, cloud-native businesses that are building the next generation of Internet products. These are companies where the developers are the decision

Every day, tens of millions of people come to Roblox to explore, create, play, learn, and connect with friends in 3D immersive digital experiences– all created by our global community of developers and creators. At Roblox, we’re building the tools and platform that empower our community to bring any experience that they can imagine to life. Our vision is to reimagine the way people come together, from anywhere in the world, and on any device. We’re on a mission to connect a billion people with optimism and civility, and looking for amazing talent to help us get there. A career at Roblox means you’ll be working to shape the future of human interaction, solving unique technical challenges at scale, and helping to create safer, more civil shared experiences for everyone. As a member of the Infrastructure Foundation Hardware Engineering team, you will play a key role in enabling our mission to deliver a reliable, high-performing, and cost-efficient infrastructure that powers the world’s play. In this specialized role, you will be the technical lead for our GPU and AI accelerator ecosystem. You will be responsible for the full lifecycle of GPU hardware, from initial architectural evaluation and firmware qualification to large-scale fleet integration and performance tuning. You will ensure that Roblox’s massive-scale rendering and ML workloads run on the most optimized and stable hardware possible. You Will: Architect & Prototype: Prototype next-generation GPU-accelerated hardware platforms, ensuring seamless integration between high-density compute nodes, high-speed interconnects (NVLink/PCIe Gen5/6), and system firmware. GPU Optimization: Drive the integration, performance testing, and debugging of GPUs in our fleet, focusing specifically on hardware-level optimizations, driver tuning, and thermal/power management. Validation & Certification: Develop and execute rigorous evaluation and stress-testing strategies for GPU-heavy server platforms to ensur

Every day, tens of millions of people come to Roblox to explore, create, play, learn, and connect with friends in 3D immersive digital experiences– all created by our global community of developers and creators. At Roblox, we’re building the tools and platform that empower our community to bring any experience that they can imagine to life. Our vision is to reimagine the way people come together, from anywhere in the world, and on any device. We’re on a mission to connect a billion people with optimism and civility, and looking for amazing talent to help us get there. A career at Roblox means you’ll be working to shape the future of human interaction, solving unique technical challenges at scale, and helping to create safer, more civil shared experiences for everyone. About the role: Roblox Studio is the creation engine behind millions of immersive 3D games built by creators around the world. We are entering a major platform transition, evolving Studio into an AI-Native IDE where intelligent systems plan, act, validate, and iterate alongside creators to amplify their output. We are seeking a Technical Director, Applied AI to own the technical direction of the agentic AI systems embedded deeply into Roblox Studio. This is a hands-on individual-contributor role operating at the intersection of platform engineering, AI systems, and developer experience, where you will set the technical direction, design the architecture, and write the code. You will: Design and build the agentic AI systems at the core of the AI-Native IDE (planning, execution, validation, evaluation) so they are production-grade and reliable. Decide how Studio uses coding models, agents, retrieval, tool calling, and context management across the Assistant and the broader creator workflow. Own the quality bar and evaluation strategy , standing up quantitative and qualitative eval pipelines, including human-in-the-loop, so we ship with confidence. Optimize these systems for latency, throughpu

Who we are At Twilio, we’re shaping the future of communications, all from the comfort of our homes. We deliver innovative solutions to hundreds of thousands of businesses and empower millions of developers worldwide to craft personalized customer experiences. Our dedication to remote-first work , and strong culture of connection and global inclusion means that no matter your location, you’re part of a vibrant team with diverse experiences making a global impact each day. As we continue to revolutionize how the world interacts, we’re acquiring new skills and experiences that make work feel truly rewarding. Your career at Twilio is in your hands. . Hiring and how we work We use Artificial Intelligence (AI) to help make our hiring process efficient. That said, every hiring decision is made by real Twilions! Also, while we are a remote-first company, you may be asked to report in person on an ad-hoc basis for team gatherings, functional off-sites or customer meetings. . See yourself at Twilio Join the team as Twilio’s next Senior Principal Field Architect - AI Agents About the job The Senior Principal Field Engineer is a critical, highly visible leader on the Field CTO team who bridges the gap between Twilio's product vision and our customers' needs. In the rapidly evolving era of AI, Twilio takes an open and flexible approach: we want developers to use their preferred AI coding tools and agent builder platforms to get up and running extremely quickly with our platform of APIs across a variety of services that address many use cases. In this P7 Distinguished Engineer role, you will be in R&D and partner with Product, Engineering, Sales and GTM teams to spearhead the launch and adoption of our AI-native platform services. You will be the field engineering linchpin ensuring that the newly launched Twilio Conversations suite and Twilio Agent Connect (TAC) integrate flawlessly with the industry's top AI tools. Your mission is to ensure tha

Who we are At Twilio, we’re shaping the future of communications, all from the comfort of our homes. We deliver innovative solutions to hundreds of thousands of businesses and empower millions of developers worldwide to craft personalized customer experiences. Our dedication to remote-first work , and strong culture of connection and global inclusion means that no matter your location, you’re part of a vibrant team with diverse experiences making a global impact each day. As we continue to revolutionize how the world interacts, we’re acquiring new skills and experiences that make work feel truly rewarding. Your career at Twilio is in your hands. . Hiring and how we work We use Artificial Intelligence (AI) to help make our hiring process efficient. That said, every hiring decision is made by real Twilions! Also, while we are a remote-first company, you may be asked to report in person on an ad-hoc basis for team gatherings, functional off-sites or customer meetings. . See yourself at Twilio. Join us as our next Staff Product Manager - Enterprise AI on Twilio's Enterprise AI team. About the job Twilio is undergoing a major business transformation powered by Enterprise AI, supported by a dedicated engineering team building the foundations for a unified, secure, and scalable operating system across GTM functions (Sales, Support, Operations, etc.) as well as Internal non-GTM corporate functions (Finance, HR, Legal, etc.) Our platform is designed to support a multitude of business functions by deploying intelligent agentic solutions that automate complex workflows and deliver unprecedented user experiences. We're building the future of work at Twilio, and this role offers the opportunity to be at the forefront of enterprise AI innovation. As Staff Product Manager for Enterprise AI, you will lead the product strategy and execution for AI-powered solutions across both GTM and Corporate Functions. You'll build intelligent agents, automatio

Fin is the AI Customer Agent company on a mission to help businesses provide perfect customer experiences. Our AI Agent Fin is the highest-performing AI Customer Agent on the market today, enabling businesses to deliver impeccable, always-on customer support across the customer journey – from service, to sales, to ecommerce. Powered by our own AI models, Fin resolves complex customer issues end-to-end across every channel, with minimal set-up and integration. Fin can also be combined with our natively integrated Intercom help desk for one single system that is designed to meet the needs of modern day support teams. Founded in 2011, Fin became one of the fastest growing companies and remains one of the largest private software companies in the world with nearly 30,000 global businesses using our products to transform their customer support. Driven by our core values, we push boundaries, build with speed and intensity, and relentlessly deliver incredible value to our customers. What's the opportunity? The Research, Analytics & Data Science (RAD) team turns insight into action. We uncover customer, product, and business insights and translate them into tools and decision systems embedded directly into GTM workflows. AI has unlocked an entirely new generation of internal tools for our GTM teams. We’re evolving from static dashboards to LLM and agent-powered workflows that do the work: auto-researching accounts, summarizing prior interactions, drafting personalized outreach, flagging renewal risk, and assembling decks and docs - enabling Sales and Success to focus on high-value conversations. The RAD team partners closely with GTM Systems to define problems, solutions, and measure impact - from prototype to production. This is a high-ownership role for someone who thrives in ambiguity, is energized by solving complex real-world problems, and is motivated by seeing their work translate into tangible business impact. What will I be doing? Design, evaluate,

Fin is the AI Customer Agent company on a mission to help businesses provide perfect customer experiences. Our AI Agent Fin is the highest-performing AI Customer Agent on the market today, enabling businesses to deliver impeccable, always-on customer support across the customer journey – from service, to sales, to ecommerce. Powered by our own AI models, Fin resolves complex customer issues end-to-end across every channel, with minimal set-up and integration. Fin can also be combined with our natively integrated Intercom help desk for one single system that is designed to meet the needs of modern day support teams. Founded in 2011, Fin became one of the fastest growing companies and remains one of the largest private software companies in the world with nearly 30,000 global businesses using our products to transform their customer support. Driven by our core values, we push boundaries, build with speed and intensity, and relentlessly deliver incredible value to our customers. Fin is the AI Customer Service company on a mission to help businesses provide incredible customer experiences. Our Helpdesk brings together the tools modern support teams need to deliver fast, effective service: an omnichannel inbox, AI-powered ticketing, real-time assistance from Copilot, automation, and Fin AI Agent. We are building a single system where human and AI agents can work together seamlessly, with the context and intelligence to resolve increasingly complex customer issues. What’s the opportunity? The AI Helpdesk is a major next step in the evolution of Intercom’s core product. We are shaping an AI-first Helpdesk that helps support teams work more efficiently, resolve more conversations, and deliver consistently excellent customer experiences. This role sits in a high-impact product organisation where the product vision and technical direction are continuing to evolve. You’ll lead an engineering team working closely with Product, Design, Customer Support, and AI/ML partners to tur

We're building AI Teammates: agents that work like actual users in Asana and integrated apps. They triage bugs, respond to requests, draft project briefs, conduct research, and handle complex knowledge work across your team's workflows. Unlike chatbots, Teammates are shared team resources that build memory and context across all executions. They get smarter as you and your colleagues work with them. Currently in beta with Fortune 500 customers, AI Teammates represents Asana's shift from tracking work to getting work done. We're looking for an Engineering Manager to lead the Agent Orchestration team — the team building the connections to other systems that allow Asana AI to serve the highest-value workloads. This means building the integration capabilities, agent skills, and vertical use cases that make AI Teammates extraordinarily useful across enterprise tools and workflows. You'll manage a senior team of six engineers (ICs up to L6) working at the intersection of systems integration and emerging AI capabilities to architect the foundation that lets AI agents operate seamlessly across customer environments while meeting enterprise requirements for reliability and compliance. This is a rare opportunity to be at the forefront of Agentic AI. You'll work directly with model partners, lead the core team shaping how enterprises collaborate with AI agents across their entire tool ecosystem, and drive the technical direction for one of the most impactful applied AI challenges in the industry. You'll also flex into org-level engineering leadership across the broader Asana AI group, contributing beyond your direct team. About Asana AI Asana AI is the company's number one priority. We're building the future of human/AI collaboration — going beyond chatbots to integrate AI into everyday workflows for some of the biggest companies on the planet. Asana's AI Teammates deliver a secure, multi-player, enterprise-grade agentic experience. They're transforming Asana from a place wher

As organizations rapidly adopt AI applications and agentic systems, security teams need visibility and control over how these technologies are being used. Datadog's AI & Data Security product helps customers discover, secure, and govern AI usage across their environments ensuring sensitive data is properly managed from model training through production. As a Product Manager II for AI & Data Security, you will own capabilities for AI discovery, posture management, and data security; giving customers complete visibility into their AI applications, agents, and enabling ecosystem, with prioritized actions to operate AI systems securely. You'll partner with engineering, design, security research, and GTM teams to define and ship platform capabilities that help organizations adopt AI at scale. At Datadog, we place value in our office culture - the relationships and collaboration it builds and the creativity it brings to the table. We operate as a hybrid workplace to ensure our Datadogs can create a work-life harmony that best fits them. What You’ll Do: Own the roadmap for AI & Data Security capabilities, including AI and data discovery & posture management. Define how security teams can assess and manage the security posture of AI-enabled systems, including configuration risks, sensitive data exposure, and policy violations. Work closely with engineers and designers to deliver new product capabilities end-to-end, from early concept through launch and iteration. Partner with Datadog security researchers to identify emerging risks in AI systems and translate them into actionable product features. Engage with customers to understand how they are adopting AI and validate solutions that help them operate these systems securely. Collaborate with go-to-market teams to enable adoption and communicate the value of AI security capabilities to customers. Who You Are: You have 3+ years of product management experience building technical products, ideally in security,

As organizations rapidly adopt AI applications and agentic systems, security teams need visibility and control over how these technologies are being used. Datadog's AI & Data Security product helps customers discover, secure, and govern AI usage across their environments ensuring sensitive data is properly managed from model training through production. As a Product Manager II for AI & Data Security, you will own capabilities for AI discovery, posture management, and data security; giving customers complete visibility into their AI applications, agents, and enabling ecosystem, with prioritized actions to operate AI systems securely. You'll partner with engineering, design, security research, and GTM teams to define and ship platform capabilities that help organizations adopt AI at scale. At Datadog, we place value in our office culture - the relationships and collaboration it builds and the creativity it brings to the table. We operate as a hybrid workplace to ensure our Datadogs can create a work-life harmony that best fits them. What You’ll Do: Own the roadmap for AI & Data Security capabilities, including AI and data discovery & posture management. Define how security teams can assess and manage the security posture of AI-enabled systems, including configuration risks, sensitive data exposure, and policy violations. Work closely with engineers and designers to deliver new product capabilities end-to-end, from early concept through launch and iteration. Partner with Datadog security researchers to identify emerging risks in AI systems and translate them into actionable product features. Engage with customers to understand how they are adopting AI and validate solutions that help them operate these systems securely. Collaborate with go-to-market teams to enable adoption and communicate the value of AI security capabilities to customers. Who You Are: You have 3+ years of product management experience building technical products, ideally in security,

The Behavior AI team builds the AI-based anomaly detection behind Datadog's security products. Our models learn what normal looks like across the billions of logs, events, and telemetry records flowing through the platform every second, and they flag the behavior that does not fit, on every record, in real time, at a cost that makes sense at our scale. What we build does not ship to a single feature. The same models power detection across many of Datadog's security products at once, so the work has impact well beyond any one team. Large general-purpose models are too slow and too expensive to run in that path, so we take the opposite approach: small, custom models, designed for high-throughput stream processing and optimized to run cheaply on every record. We are hiring a Senior Applied Scientist to build these models from start to finish. You will contribute to designing the architecture, training at scale, and the optimization work that takes a model from training to running efficiently on production traffic. This optimization requires a deep understanding of the constraints imposed by both the software and the hardware, together with the applied mathematics to work within them: often it comes down to finding a mathematical reformulation that fits those constraints better, and that judgment can decide whether a model reaches production at all. The work involves a number of open questions. How do you obtain most of the quality of a large model from one that is far smaller and cheap enough to run on the full stream? Where is it worth trading exactness for speed, and how do you reason about the error you accept? How do you make a small model's outputs clear enough that the detection engineers and analysts who rely on it can trust what it reports? If these are the problems you want to work on, we would like to hear from you. At Datadog, we place value in our office culture: the relationships and collaboration it builds, and the creativity it bring

Databases and data stores are at the center of our applications, for legacy applications and modern AI applications alike. Yet most observability and optimization approaches lack a holistic approach or application context. Datadog has been on a mission to revolutionize how databases are operated, flipping what is often seen as a black box of complexity prone to security and performance risks, into a well oiled machine enabling our builders and businesses to move faster and smarter. We’re looking for an experienced product manager passionate about joining this mission to lead this product opportunity. At Datadog, we place value in our office culture - the relationships and collaboration it builds and the creativity it brings to the table. We operate as a hybrid workplace to ensure our Datadogs can create a work-life harmony that best fits them. What You’ll Do: Lead ambitious investments that rethink how customers operate and get value from their databases, diving into ambiguity, working with our customers on new models, and shipping new products and changes to existing products. Develop a deep understanding of our customers and their issues, what problems are really behind those issues, and how we can improve how databases are operationalized across SRE teams, DBAs and application developers. Continuously refine your understanding of database management systems and datastores from SQL and OLTP based to NoSQL e.g. AWS RDS, PostgreSQL, SQL Server, MongoDB, MySQL, etc Define, build and launch the next generation of database monitoring and optimization capabilities for our customers Join a talented engineering team with a record of disrupting observability approaches to further the mission of demystifying and optimizing databases using your team’s creativity, alongside your customers’ problems, as a key resource. Collaborate with other Product teams in Datadog to maintain and improve all Datadog products, improve the seamless integration across th