Associate Scientist in United States Massachusetts Cambridge

Use Your Power for Purpose At Pfizer, our purpose is to deliver breakthroughs that change patients’ lives. In this role, you will contribute to the discovery and advancement of innovative medicines for patients worldwide by applying rigorous science, modern pharmacology, and cutting-edge technologies. Your work will help transform promising therapeutic ideas into high-quality experimental data that enable confident decisions across the drug discovery process. What You Will Achieve A key strategic focus within the Internal Medicine Research Unit (IMRU) is the discovery of novel therapies for obesity, cardiovascular disease, and related cardiometabolic conditions. As an Associate Scientist in the In Vitro Pharmacology group, you will contribute to early drug discovery programs by generating rigorous, reproducible pharmacology data that support target validation, assay development, compound profiling, and mechanism-of-action studies. This role is well suited for a collaborative, hands-on scientist with experience in cell-based assay execution, mammalian cell culture, quantitative data analysis, and an interest in receptor pharmacology within cardiometabolic drug discovery. How You Will Achieve It Develop, optimize, and execute cell-based signaling, ligand-binding, and other in vitro pharmacology assays to generate high-quality data that support project decisions. Support compound profiling and mechanism-of-action studies through careful experimental design, troubleshooting, and quantitative data analysis. Maintain mammalian cell cultures and prepare fit-for-purpose cellular or membrane-based assay reagents to support screening, binding, and functional assay workflows. Apply core pharmacology concepts, including ligand potency, efficacy and affinity to interpret experimental results. Work collaboratively with pharmacology colleagues and cross-functional pr

ROLE SUMMARY: The key strategic focus within the Internal Medicine Research Unit (IMRU) is identifying novel therapies to prevent or treat metabolic diseases such as obesity and cardiovascular disease. Our goal is to build a world-class research team of dedicated scientists committed to developing a deep mechanistic understanding of the metabolic pathways underlying disease pathogenesis. As a senior scientific leader and member of the obesity discovery biology team, this individual will play a significant role in shaping the scientific direction for the obesity therapeutic area and influencing broader IMRU research strategy and portfolio priorities. The individual will help create and drive discovery research strategy across multiple programs, including target ideation, validation, translational biomarker strategy, hypothesis testing, and early clinical development within the IMRU obesity portfolio. The successful candidate will lead through both direct team leadership and influence across multidisciplinary partners, helping align scientific decisions across discovery biology, translational sciences, clinical, computational, and external collaborators. The individual will identify emerging therapeutic opportunities, advance portfolio programs with scientific rigor and urgency, and represent research strategies to internal leadership and the external scientific community. Knowledge and experience in the study of metabolic pathways are essential, and familiarity with the pathophysiology of dysmetabolic states would be advantageous. Strong self-motivation, excellent communication and interpersonal skills, and the ability to lead, mentor, and build scientific capability in a highly collaborative environment are essential. ROLE RESPONSIBILITIES: Shape and influence the scientific direction for discovery research programs aligned with IMRU therapeutic area and portfolio strategy. Ap

ROLE SUMMARY Exciting opportunity in Clinical Pharmacology! Our Clinical Pharmacology Team is looking for an Associate Director to support the exciting portfolio in Internal Medicine. Our team members champion the innovative use of MIDD for efficient drug development and robust decision-making. A great environment for learning and professional growth! Our Clinical Pharmacology Leads have key roles to play in influencing the discovery and development of drugs. Pfizer is a leader in model informed drug discovery and development (MIDD), and we are expanding in influence and impact. We have an open position as Clinical Pharmacology Lead supporting our End-to-End Internal Medicine portfolio. The ideal candidate is responsible for providing the clinical pharmacology and MIDD components of clinical plans and provide clinical pharmacology expertise to the project team and regulatory interactions. Working with multifunctional study team, Clinical Pharmacology Leads utilize innovative methods to integrate knowledge of pharmacokinetics, pharmacodynamics, patient characteristics and diseases for rational development strategies and decisions, as well as optimal study designs and dosage regimen selections. ROLE RESPONSIBILITIES Act as Clinical Pharmacology representative on Clinical Sub Team and Development Team and other multifunctional teams as appropriate. Responsible for providing expertise, leadership, and deliverables of clinical pharmacology for the assigned projects within sphere of influence. Design and execute clinical pharmacology plans and implement clinical pharmacology best practices on project teams. Work closely with other disciplines to ensure that sufficient preclinical PK/PD knowledge exists to underwrite safe human administration and to establish the structure of a predictive model prior to FIH. Responsible for planning and overseeing clinical pharmacolo