Jobs in United States

Ai Senior Systems Engineer in United States

5,246 active opportunities · Updated October 2026

Explore current ai senior systems engineer jobs across United States. Filter by work mode, employment type, experience, department, date posted and distance.

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📍 New York, New York, United States· Full-time
✓ High-confidence listingCompany trend -90.6%

From $192K/yr

Quick readStrong listing-quality and freshness signals

Applied AI is where Datadog's ambitious AI bets get built and shipped ( Bits Chat , updog ). We sit at the intersection of research and product: turning promising capabilities from Datadog AI Research lab and the research community into production systems that reach real customers. The team builds the foundations for agentic systems capable of operating at scale in complex production environments. Current bets span agents that run autonomously at scale, context and memory layers that make those agents more intelligent over time, and tools that help customers build and validate AI-native services in production. The mandate is to move fast from idea to customer impact, and when a product finds its footing, to set it up for growth. As an Engineering Manager I in Applied AI, you will lead a team of engineers and applied scientists working on one of these challenges. You will define technical direction, run short feedback loops, make deliberate decisions about what to pursue or stop, and work closely with product managers, research teams, and cross-functional partners to ship AI capabilities that matter. At Datadog, we place value in our office culture, the relationships and collaboration it builds and the creativity it brings. We operate as a hybrid workplace to ensure our Datadogs can create a work-life harmony that best fits them. What You'll Do Lead and develop a team of engineers and applied scientists focused on building the foundations for agents operating at scale Work closely with product managers, research teams, and cross-functional partners to shape the team's bets from initial framing through to broader adoption, with a clear definition of success criteria at each stage Own end-to-end delivery of high-quality AI systems, from early research exploration to production-grade reliability, with high standards for operational excellence, system reliability, and technical quality Navigate the unique challenges of shipping AI-powered products: balancing quali

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📍 United States· Full-time· Remote
✓ High-confidence listingCompany trend -90.5%

From $157K/yr

Quick readStrong listing-quality and freshness signals

We're transforming the grocery industry At Instacart, we invite the world to share love through food because we believe everyone should have access to the food they love and more time to enjoy it together. Where others see a simple need for grocery delivery, we see exciting complexity and endless opportunity to serve the varied needs of our community. We work to deliver an essential service that customers rely on to get their groceries and household goods, while also offering safe and flexible earnings opportunities to Instacart Personal Shoppers. Instacart has become a lifeline for millions of people, and we’re building the team to help push our shopping cart forward. If you’re ready to do the best work of your life, come join our table. Instacart is a Flex First team There’s no one-size fits all approach to how we do our best work. Our employees have the flexibility to choose where they do their best work—whether it’s from home, an office, or your favorite coffee shop—while staying connected and building community through regular in-person events. Learn more about our flexible approach to where we work. Overview The Commercial Scaled Intelligence (CSI) team is an AI-first team dedicated to delivering actionable commercial insights and scalable automation to drive revenue growth and operational efficiency across the company. The team focuses on intelligence generation, predictive analytics, and workflow automation to enable data-driven decision-making and optimize commercial performance. As an Ads AI Analytics Lead II, you will own the intelligence behind our Ads agents. You will design the Ads semantic/context layer and build vertical AI agents that analyze campaigns, diagnose performance, and recommend actions that improve ROAS, pacing, and partner outcomes. You will partner with Ads GTM, Product, Data Science, and Engineering to ship production agents with measurable lift. About the Job Define Ads ontologies and metrics for campaigns, budgets, bids

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📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -88%

About the Team GTM Growth Engineering builds AI-native products that help OpenAI's go-to-market and B2B marketing organizations scale with greater speed, intelligence, and operational effectiveness. We apply OpenAI models to real business workflows and build the systems that make those applications useful and dependable: customer context, agent behavior, feedback, evaluation, experimentation, and appropriate human oversight. Our work brings together software engineering, applied AI, product, data, and GTM operations. We measure success through the quality of customer engagement, pipeline, conversion, and the effectiveness of our sales and marketing teams. About the Role We're looking for an Applied AI Engineer to build production systems that help AI-powered go-to-market workflows improve over time. You will connect agent behavior, customer and operator feedback, evaluation, experimentation, and business outcomes to make these systems more effective, reliable, and responsive to evolving customer needs. This is a deeply technical, cross-functional role with end-to-end ownership of the agent improvement loop: understand production behavior, identify failure modes, improve how the system decides or acts, and validate the resulting impact. You will partner with Engineering, Product, Data Science, Sales, and B2B Marketing to turn real-world signals into safer, more effective agent behavior and measurable improvements in customer engagement, conversion, qualified pipeline, and team productivity. In this role, you will: Own the production improvement loop across agent behavior, customer and operator feedback, evaluation, experimentation, and verified business outcomes. Instrument agent workflows so model interactions, tool use, decisions, failures, human edits, and downstream outcomes can be understood in context. Define meaningful quality standards, representative evaluation datasets, regression coverage, and production monitoring for real GTM workflows. Investigate why a

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Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -88%

About the team The Agent Enablement AI Deployment Engineering (ADE) team works across engineering, product, design, partnerships, and strategic customers to grow an open ecosystem of agent-enabled sites and services. We help partners adopt the OpenAI tech stack related to identity, permissioning, agent-auth primitives so users can safely connect ChatGPT and Codex to the tools, services, and workflows they already use. Our team also works with external partners on defining the standards for agent access, marketplace offerings as well as other agent enablement initiatives to ensure users of ChatGPT and Codex go from intent to task completion seamlessly. About the role We are looking for an AI Deployment Engineer to help strategic partners design, build, validate, launch, and operate agent enablement integrations across web applications, connectors, APIs, CLIs, MCP servers, and developer tools. This is a hands-on, partner-facing product engineering role for someone who can contribute to the platform itself, lead sophisticated technical engagements, and turn ambiguous identity and agent-workflow requirements into secure, production-ready integrations. You will work across partner product and engineering teams and OpenAI’s product, engineering, design, partnerships, legal, policy, security, support, and go-to-market teams. You will identify high-value user journeys, choose the right integration path, prototype and review architectures, write code, run evaluations and dogfood, trace failures end to end, guide launch and rollout, and support post-launch iteration. The best person for this role moves fluidly between full-stack code, OAuth/OIDC and identity systems, product judgment, project leadership, and clear communication with engineers and executives. This role is a fit for a product-minded engineer who wants to stay close to users and partners while going deep on authentication, permissions, reliability, safety, and developer experience. The principle objective is to

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Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -88%

About the Team The Ecosystem AI Deployment Engineering (ADE) team supports strategic partners as they build high-quality technical integrations into ChatGPT and Codex. Our goal is to create products users depend on, drive adoption and retention, and build an ecosystem where partners win when OpenAI wins. About the Role We are looking for an AI Deployment Engineer to help strategic partners design, build, evaluate, submit, launch, and maintain high-utility plugins for ChatGPT and Codex. This is a hands-on, partner-facing product engineering role for someone who can contribute to the platform itself, lead sophisticated partner engagements, and translate ambiguous product needs into production-ready integrations. You will work across partner product and engineering teams and OpenAI's product, engineering, partnerships, legal, policy, design, and go-to-market teams. You will identify the right use cases, prototype and review implementations, run evaluations, debug issues across systems, guide partners through submission and review, and support launch and post-launch iteration. The best person for this role moves fluidly between code, product judgment, project leadership, and clear communication with engineers and executives. This role is a fit for a product minded engineer who wants to stay close to users and partners while still going deep on code, reliability, evaluations, and developer experience. The goal is to help partners ship plugins that are not merely technically functional, but genuinely useful in ChatGPT and Codex. This role is based in our San Francisco office. We use a hybrid work model of 3 days in the office per week and offer relocation assistance to new employees. In this role, you will: Own the technical partner journey for priority B2B plugins—from pitch and readiness assessment through architecture, build, evaluation, submission, launch, and ongoing maintenance. Identify strong plugin use cases, define crisp user journeys and expected behaviors, and

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📍 New York, New York, United States· Full-time
✓ Quality checkedCompany trend -88%

About the Team The AI Deployment Engineering team is responsible for ensuring the safe and effective deployment of Generative AI applications for developers and startups. We act as a trusted advisor and thought partner for our customers, working to build an effective backlog of GenAI use cases for their industry and drive them to production through strong technical guidance. As an AI Deployment Engineer (ADE) in the OpenAI for Global Affairs team, you’ll help government and non-profit agencies transform their organization through solutions such as automated content generation, contextual search, and novel applications that make use of our newest, most exciting models and technology. About the Role OpenAI’s mission is to ensure that general-purpose artificial intelligence benefits all of humanity. We believe that achieving our goal requires effective engagement with public policy stakeholders and the broader community impacted by AI. The Global Affairs team builds authentic, collaborative relationships with public officials and the broader AI policymaking community to inform and support our shared work in these domains. We ensure that insights from policymakers inform our work and - in collaboration with our colleagues and external stakeholders - help shape policy guardrails, industry standards, and safe and beneficial development of AI tools. We are looking for an AI Deployment Engineer to collaborate directly with our Global Affairs team to help public sector actors unlock the benefits of OpenAI tools and products, aiming to broadly benefit humanity. This includes supporting a workforce organization deploying Certifications programs or advising a government partner on responsible implementation practices. Your role will integrate technical expertise with our mission to ensure that artificial general intelligence benefits all of humanity. In this role, you will: Technical Enablement & Deployment Serve as the primary technical advisor for Global Affairs partnersh

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Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -88%

About the Team OpenAI’s Applied AI Engineering team helps organizations turn frontier AI capabilities into safe, reliable, and high-impact production systems. We work with customer executives, product and engineeriIng teams, security leaders, and transformation teams to identify valuable opportunities, accelerate technical implementation, and scale what works. Enterprise deployments are defined by complexity rather than any one industry: existing architectures, diverse data environments, security and governance requirements, multiple stakeholder groups, and organization-wide change. We turn lessons from these deployments into better products and reusable patterns for customers everywhere. About the Role As an Enterprise Applied AI Engineer you will partner directly with leading organizations to design, build, and deploy AI systems that deliver measurable business outcomes. You will combine deep technical judgment, hands-on engineering, and customer leadership to take ambitious ideas from use-case selection and architecture through prototyping, evaluation, production launch, and scale. You will write and debug code, build evaluation systems, resolve complex integrations, and guide decisions involving model behavior, reliability, latency, cost, safety, security, governance, and operational readiness. Success is measured by production systems, sustained adoption, and meaningful customer impact—not simply activity or successful demonstrations. This is a rare opportunity to work on consequential real-world deployments at the frontier of AI while directly influencing how OpenAI’s products evolve. This role is based in our SF or NYC office. We use a hybrid work model of 3 days in the office per week and offer relocation assistance to new employees. In this role, you will: Partner directly with enterprise customers to identify high-value opportunities and translate them into technical architectures, implementation plans, evaluation strategies, and measurable success criteri

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Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -88%

About the team The Technical Success team is responsible for ensuring the safe and effective deployment of ChatGPT and OpenAI API applications for developers and enterprises. We act as a trusted advisor and thought partner for our customers, ensuring developers and enterprises maximize value from our models and products. The Ecosystem team builds and scales third-party integrations around ChatGPT and Codex. We work across product, engineering, partnerships, safety, legal, policy, and go-to-market to create integrations that are useful, trustworthy, and technically sound. About the role We’re looking for an Applied Deployment Engineer to help build and deepen ChatGPT integrations with third-party messaging platforms. The initial focus will be on partner work as well as future opportunities with other messaging apps around the world. This is a hands-on, partner-facing engineering role. You’ll work closely with external product and engineering teams to improve existing integrations, expand capabilities such as image generation, increase retention, and translate partner needs back into OpenAI’s product and engineering roadmap. You should be comfortable writing code daily, making changes across platform or monorepo surfaces when needed, and moving fluidly between technical discovery, product tradeoffs, prototyping, debugging, and executive-level communication. This role is best suited for a strong product-minded engineer with excellent communication skills, sound technical judgment, and the ability to work across cultures, time zones, and organizations. This role is based in our San Francisco office. We use a hybrid work model of 3 days in the office per week and offer relocation assistance to new employees. In this role, you will: Partner with messenger app product and engineering teams to design ChatGPT-powered experiences that fit naturally into chat, group, contact, and app-tab surfaces. Deepen existing partner integrations, with an initial focus on improving user ex

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Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -88%

About the team The Applied AI Engineering team is responsible for ensuring the safe and effective deployment of Generative AI applications for developers and startups. We act as a trusted advisor and thought partner for our customers, working to build an effective backlog of GenAI use cases for their industry and drive them to production through strong technical guidance. OpenAI's customers represent a range of diverse backgrounds and maturity, from early-stage startups to late-stage startups. About the Role We are seeking a technically proficient, business-minded Applied AI Engineer to help push the frontier of advanced AI with our strategic startup customers. You'll work with some of the most exciting AI startups in the world, guiding them through ideation, development, delivery, and scaling to accelerate and maximize the value of what they build on our platform. You will have the opportunity to work on the most novel and creative use cases being built on our API, serving as a critical partner in collecting and delivering high-fidelity product and model feedback internally. You will collaborate closely with Sales, Solutions Engineering, Applied Research, and Product teams, and you will report to the Startups Applied AI Lead. This role is based in our San Francisco or New York offices. We use a hybrid work model of 3 days in the office per week and offer relocation assistance to new employees. In this role, you will: Partner closely with strategic startup customers as their technical thought partner to build novel applications on our API, helping them rapidly move from ideation to scale. Provide proactive guidance to maximize business impact and accelerate application development. Experiment and prototype alongside customers, demonstrating practical use cases. Contribute to open-source resources and scale the function by sharing knowledge, codifying best practices, and publishing useful resources. Synthesize and deliver valuable feedback to the Product and Research

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📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -88%

OpenAI’s charter calls on us to ensure the benefits of AI are distributed broadly and safely. Our Health AI team focuses on expanding access to high-quality medical expertise and aims to set a high standard for deploying AI responsibly in high-stakes domains. Improving health will be one of the defining impacts of AGI. Today, millions of people lack access to reliable medical information, and clinicians around the world face increasing time and resource constraints. We are building AI systems that support patients, clinicians, and health workers, while meeting the highest standards for safety, reliability, and privacy. We are seeking full stack software engineers to help build and scale products used by consumers and care providers globally. You will work closely with product, design, and research teams to ship real systems in a fast-moving, high-impact environment. In this role, you will: Design and build scalable fullstack systems for consumer and enterprise health. Own end-to-end feature development—from early design and implementation through deployment, monitoring, and iteration. Build and maintain data pipelines and services that meet strict privacy, security, and compliance requirements (e.g., HIPAA). Collaborate closely with researchers and safety teams to integrate reliability, evaluation, and guardrails into production systems. Debug, optimize, and harden systems to support high availability, performance, and global scale. Take ownership of ambiguous problems and drive them to practical, high-quality solutions. You might thrive in this role if you: Are deeply motivated by improving health outcomes and expanding access to medical expertise. Are a strong engineer who enjoys building durable, well-designed systems. Have 5+ years of experience writing maintainable, production-quality code. Can operate with high agency—owning problems end-to-end with minimal supervision. Enjoy working in fast-moving, cross-functional teams with engineers, product managers, desi

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📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -88%

About the team The Intelligence and Investigations team seeks to rapidly identify and mitigate abuse and strategic risks to ensure a safe online ecosystem in close collaboration with our internal and external partners. Our efforts contribute to OpenAI's overarching goal of developing AI that benefits humanity. This role focuses specifically on AI Safety: understanding and mitigating risks created or amplified by increasingly capable AI systems. It is not a cybersecurity, information security, or corporate security role. The Strategic Intelligence & Analysis (SIA) team provides safety intelligence for OpenAI’s products by monitoring, analyzing, and forecasting real-world abuse, geopolitical risks, and strategic threats. Our work informs AI safety mitigations, product decisions, and partnerships, ensuring OpenAI’s tools are deployed responsibly across critical sectors. About the role We are looking for a Frontier AI Risks Lead to help us understand potential harms and misuse of AI in a time of rapid, sustained change. We seek to understand how developments in AI could intersect with misuse and abuse, accelerating existing harm areas and creating novel risks. We seek to scan available signals and use strategic foresight methodologies to enable proactive detection and mitigation of frontier AI risks. This is an AI safety role focused on frontier and systemic risks, including model misalignment, recursive self-improvement (RSI), multi-agent interaction, loss of control, runaway agents, and related emerging failure modes. In this role, you will help provide a strategic-level perspective on a range of frontier AI safety areas, producing actionable understanding of issues relevant to OpenAI’s platforms, systems, and broader mission. Utilizing mixed quantitative and qualitative methodologies, you will spot early warning signs, pull threads on potentially concerning behavior, and turn weak signals into clear, prioritized risk calls. You will focus on upstream ecosystem sc

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📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -88%

About the Team The Codex Core Agent team builds the kernel of Codex. We own making the agent better, accelerating research, and making those improvements real in production for our users. That means working across the systems that make Codex actually function as an agent in the real world: the production performance envelope around tokens, latency, reliability, cost, and capacity; the core execution loop and interfaces that turn models into useful behavior; the shared infrastructure that enables other teams to build on Codex; and the feedback loops that turn real-world usage into better models and better agent behavior over time. About the Role We’re looking for applied AI engineers to help bring Codex agents from impressive demos to dependable tools. This role is about improving agent performance on real software engineering tasks and closing the gap between research capability and real-world usefulness. You’ll work closely with research, infrastructure, and product to ensure agents are not just powerful, but useful, steerable, and reliable in practice. The job is not only to improve model behavior in isolation, but to turn those improvements into measurable gains in solve rate, usefulness, and economic value for users. What You’ll Do Design and iterate on agent behaviors across real-world coding tasks and long-horizon workflows. Work closely with research to develop and run evals to measure agent performance, regressions, failure modes, and edge cases. Improve performance through prompting, tool-use strategies, context construction, and model-facing experimentation. Analyze failures in production and systematically improve robustness and reliability. Build feedback loops and data systems that get better real-task data into evaluation and research. Work with product teams to shape user-facing agent experiences and the interfaces the agent depends on. Help define what “good” looks like for agents completing complex tasks end-to-end. You Might Be a Good Fit If You Ha

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📍 Menlo Park, California, United States· Full-time
✓ Quality checkedCompany trend -95.6%

At Snowflake, we are powering the era of the agentic enterprise. To usher in this new era, we seek AI-native thinkers across every function who are energized by the opportunity to reinvent how they work. You don’t just use tools; you possess an innate curiosity, treating AI as a high-trust collaborator that is core to how you solve problems and accelerate your impact. We look for low-ego individuals who thrive in dynamic and fast-moving environments and move with an experimental mindset — who rapidly test emerging capabilities to discover simpler, more powerful ways to deliver results. At Snowflake, your role isn't just to execute a function, but to help redefine the future of how work gets done. How do you make the world's most powerful coding agent for data a delight to use? We are the fastest growing software company at this scale in history and looking to push that to new heights by building the best coding agent in the industry. The Cortex Code (CoCo) team is building the future of coding agents for working with data. See our flagship product in action: CoCo Desktop in Action . As a Frontend AI Principal Engineer, you are the cornerstone of delivering the ultimate user experience. You will be entrusted with the highest level of polish, creativity, and interaction design, pushing the boundaries of what's possible in the most innovative areas of our product. This role offers the unique opportunity to have broad creative license, empowering you to lead and create groundbreaking systems and experiences that marry aesthetics with functionality, making data more accessible and actionable for our customers. AS THE FRONTEND AI PRINCIPAL ENGINEER YOU WILL: Design and build exceptional experiences, ensuring the highest level of polish, creativity, and interaction to solve complex customer problems. Define the architectural vision for the CoCo coding agent platform and ensure consistency of design abstractions across the entire product surface Develop innovative platform

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📍 Bellevue, Washington, United States· Full-time
✓ Quality checkedCompany trend -95.6%

At Snowflake, we are powering the era of the agentic enterprise. To usher in this new era, we seek AI-native thinkers across every function who are energized by the opportunity to reinvent how they work. You don’t just use tools; you possess an innate curiosity, treating AI as a high-trust collaborator that is core to how you solve problems and accelerate your impact. We look for low-ego individuals who thrive in dynamic and fast-moving environments and move with an experimental mindset — who rapidly test emerging capabilities to discover simpler, more powerful ways to deliver results. At Snowflake, your role isn't just to execute a function, but to help redefine the future of how work gets done. THE MISSION We are seeking a Staff Research Scientist to serve as a technical pillar within our AI research organization. You will not just execute on roadmaps—you will define them. At the intersection of autonomous agents and large language models (LLMs) , you will build the models and systems that turn enterprise data into self-directed, decision-making agents —shifting from passive data access to autonomous execution. Our team operates at the frontier of enterprise AI, delivering both state-of-the-art models and production systems , including: Arctic LLM : Enterprise foundation models optimized for performance and efficiency Arctic-Text2SQL : Post-trained reasoning models with frontier-level quality at a fraction of cost and latency Snowflake Intelligence : Brought research to production through agentic innovations in multi-step reasoning, Deep Research for structured and unstructured insights, and system optimization Arctic Inference : High-performance LLM serving stack (Shift Parallelism, SwiftKV), open-sourced and powering Snowflake Cortex Arctic Long-Context Training : Enables 1M+ token context training on a single H200 GPU Agent World Models (AWM) : RL training across 1,000+ synthetic environments for tool-using agents We focus on core challenges such as reliable re

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📍 California, Foster City, United States
✓ Quality checkedCompany trend -1.6%

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description Intern - Research - Data Sciences - AI As a Gilead intern you will contribute to high-impact meaningful projects that will not only further advance our company’s mission but will allow you to gain real world experience at one of the most innovative organizations in the world. You will also have opportunities to participate in special events including professional development and leadership presentations, social/network building activities and local community volunteer programs. Key Responsibilities will include, but are not limited to the following: Contribute to the development of a proof-of-concept AI-enabled workflow that integrates biological

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