Jobs in United States

Ai Senior Systems Engineer in United States

5,158 active opportunities · Updated October 2026

Explore current ai senior systems engineer jobs across United States. Filter by work mode, employment type, experience, department, date posted and distance.

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📍 San Francisco Bay Area, California, United States· Full-time
✓ Quality checkedCompany trend -100%

About Ema Ema is building the world’s leading Agentic AI platform to transform enterprise productivity. We enable organizations to delegate repetitive tasks to Ema, the Universal AI Employee, delivering 10x gains in workforce efficiency, across functions. Founded by former executives from Google, Coinbase, Flipkart, and Okta, our team includes engineers from premier tech companies and graduates of Stanford, MIT, UC Berkeley, CMU, and IITs. We are backed by industry leading investors including Accel, Naspers/Prosus, Section32, and angels like Sheryl Sandberg and Dustin Moskovitz. Headquartered in Silicon Valley and with offices in London, Bangalore and Vancouver, Ema is at the frontier of what Agentic AI can do in production — we ship real systems that run real business processes at scale. Role Overview We are seeking a seasoned AI Strategist to lead strategic enterprise accounts and play a pivotal role in shaping high-impact AI engagements. This role will work closely with our Executive Leadership Team, providing leverage on our most important deals and helping drive transformative AI adoption across major enterprises. The ideal candidate has previously served as a Senior Engagement Manager (or equivalent) at a top-tier consulting firm such as McKinsey, BCG, Bain, or comparable management consulting firms, and is familiar with complex enterprise sales motions. You must be comfortable engaging at C-level, shaping AI strategy for customers, and partnering cross-functionally to orchestrate successful outcomes. Key Responsibilities Strategic Account Leadership Own and drive AI strategy for high-value enterprise accounts Partner with executive sponsors, customer success, solution engineering, and product to deliver winning AI solutions. Act as the strategic advisor to client leadership, helping define AI transformation roadmaps and business cases. Deal Strategy & Executive Leverage Work closely with the CEO, CRO, and broader leadership team to influence deal strategy

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📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -83.9%

About the Team OpenAI’s mission is to ensure that artificial general intelligence benefits all of humanity. Safely delivering increasingly capable AI systems requires scalable technical safeguards, clear ownership of emerging risks, rigorous deployment readiness, and close coordination across research, engineering, product, operations, legal, policy, and external partners. Our Technical Program Managers lead complex, high-stakes initiatives that turn safety commitments into deployed systems and measurable outcomes. We work across model development, infrastructure, product, and operational response to help ensure our technology is deployed responsibly and cannot be used to cause serious real-world harm. About the Role We’re seeking Technical Program Managers to drive complex product, platform, and safety initiatives across ChatGPT, API, enterprise, and related deployment environments. These roles operate at the intersection of technical strategy and execution: you will turn safety and product priorities into actionable plans, influence architectural and operational decisions, and deliver durable capabilities across model, infrastructure, application, and platform layers. Depending on the role, you may enable sensitive or high-impact model deployments, integrate safeguards into cloud and API platforms, prevent violent misuse and other serious harms, improve detection and enforcement systems, create platform solutions for safety or establish new programs as risks evolve. You will partner deeply with engineers, researchers, product managers, and operational teams while communicating technical tradeoffs and program decisions to senior leadership. You bring technical fluency, product judgment, and a strong execution record. You’re comfortable navigating ambiguity, advocating for users and developers, balancing safety with model usefulness, and leading cross-functional work with urgency, rigor, and empathy. Specific focus areas and scope will vary by opening and level. Thi

AWSRestMachine LearningAI
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📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -83.9%

About the Team The Product & Platform teams at OpenAI are responsible for delivering the company’s most impactful offerings—such as ChatGPT, our API platform, and new enterprise capabilities—to a global and diverse customer base. These systems must perform at scale and deliver exceptional experiences to developers, consumers, and businesses alike. Technical Program Managers at OpenAI play a key leadership role in scaling these efforts, partnering deeply with product, engineering, design, and go-to-market teams to bring ambitious ideas to life and ensure clarity and discipline in execution. About the Role We are hiring a Technical Program Manager to support OpenAI's critical AI deployments across strategic cloud partners. This role is designed for a candidate who can operate as an end-to-end owner across internal engineering teams and external partner organizations. This role will drive the technical strategy and execution required to bring OpenAI models and platform capabilities into partner environments responsibly and at scale. The work spans engineering deliverables, shared roadmaps, model launch pipelines, technical integration, launch readiness, and post-launch follow-through. You will work closely with senior leaders across OpenAI engineering, infrastructure, product, safety, security, legal, finance, and go-to-market, as well as technical counterparts at our partners. The job is to turn broad partnership commitments into concrete execution plans, align both sides on what must land, and build repeatable mechanisms for launching OpenAI capabilities on third-party platforms. This role is based in San Francisco, CA. We use a hybrid work model of 3 days in the office per week and offer relocation assistance to new employees. In this role, you will: Lead end-to-end execution for major cloud partner programs spanning model deployment, product integration, operational readiness, launch follow-through, and partner-platform adoption. Own integrated technical roadma

AWSRestAIGo
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📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -83.9%

About the Team OpenAI’s GTM Data Science team helps shape how our products are adopted, monetized, and scaled across organizations. We work at the intersection of Product, Go-to-Market, Finance, Research, and Data, turning product usage, customer evidence, and market signals into decisions that grow durable enterprise value. We’re looking for a senior Data Scientist to own the analytical strategy for enterprise knowledge-worker adoption. As ChatGPT Work and Codex become capable of research, analysis, document creation, spreadsheets, presentations, internal knowledge synthesis, and other agentic workflows, you will help determine how these products become embedded in everyday work—not merely tried once. About the Role You will define how we measure activation, retained usage, workflow depth, and value across ChatGPT Work, Codex, and connected enterprise systems. You will explain why adoption succeeds or stalls and identify the product, enablement, and commercial interventions most likely to create durable usage. This is a hands-on, zero-to-one role. You will work through imperfect telemetry, overlapping product surfaces, evolving definitions, and ambiguous business questions. You will partner closely with GTM, Product, Finance, Research, Customer Deployment, Analytics Engineering, and Data Science. Your work is successful when it changes a product, GTM, or investment decision. In This Role, You Will Define a trusted measurement framework for knowledge-worker adoption, including identity, eligible populations, activation, retained usage, penetration, workflow depth, feature adoption, and monetization. Map the knowledge-worker journey from initial exposure through first successful task, repeated workflows, multi-surface usage, and durable adoption. Identify which personas, functions, use cases, product capabilities, and account conditions are associated with deep and retained usage. Design and evaluate experiments and quasi-experiments across onboarding, enablement, wo

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📍 Austin, Texas, United States· Full-time
✓ High-confidence listing
Quick readStrong listing-quality and freshness signals

About DevRev At DevRev, we're building the future of work with Computer – your AI teammate. Unlike traditional tools, Computer unifies all your data sources, tools, and workflows into a single AI-ready platform, giving employees real-time insights, proactive suggestions, and powerful agentic actions. It extends your existing software with AI-native apps and agents that work alongside your teams and customers – updating workflows, coordinating across teams, and eliminating repetitive work. We call this Team Intelligence: human-AI collaboration that breaks down silos, brings people back together, and frees you to solve bigger problems. Backed by Khosla Ventures and Mayfield with $150M+ raised, DevRev is trusted by global companies across industries. About the team The Applied AI Engineering team ensures our customers get the optimal experience from DevRev. As customers go through their DevRev journey, they may identify needs for integration with existing enterprise systems and services, workflow and process automation, or customization of the DevRev platform to achieve their business objectives. Our team works with customers to understand requirements and design, develop, and implement solutions to meet customer goals. Your mission is to systematically help customers find value with DevRev by developing a thorough understanding of their needs, owning coordination between internal and external stakeholders, and engineering the solution to get the job done. You are a product expert and will use your application development and AI/ML skills to ensure our customers get the most out of the DevRev platform. About the role As a Forward Deployed Architect, you will serve as a hands-on senior technical architect on the Applied AI Engineering team, owning the end-to-end design and delivery of AI-driven business transformation projects. You will work closely with pre-sales teams to scope technical integration and implementation strategies, translating business requirement

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📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -83.9%

About the team ​​Preparedness is a critical Safety Research team at OpenAI, which is focused on mitigating AI threats to global security that could scale to an extreme level of severity. Our work involves: Measurement. Monitoring and predicting the evolving capabilities of frontier AI systems. Mitigation. Keeping misuse safeguards, alignment tools, and security measures on track to adequately address extreme threats that might arise in the future. Coordination. Setting mitigation targets by maintaining OpenAI’s preparedness framework , and partnering with other staff to achieve these targets. This is urgent, fast-paced work that has far-reaching implications for the company and for society. About the role Models are becoming increasingly capable—moving from tools that assist humans to agents that can plan, execute, and adapt in the real world. As we push toward AGI, cybersecurity becomes one of the most important and urgent frontiers: the same systems that can accelerate productivity can also accelerate exploitation. As a Researcher for cybersecurity risks, you will help design and implement an end-to-end mitigation stack to reduce severe cyber misuse across OpenAI’s products. This role requires strong technical depth and close cross-functional collaboration to ensure safeguards are enforceable, scalable, and effective. You’ll contribute directly to building protections that remain robust as products, model capabilities, and attacker behaviors evolve. In this role, you will: Design and implement mitigation components for model-enabled cybersecurity misuse—spanning prevention, monitoring, detection, and enforcement—under the guidance of senior technical and risk leadership. Integrate safeguards across product surfaces in partnership with product and engineering teams, helping ensure protections are consistent, low-latency, and scale with usage and new model capabilities. Evaluate technical trade-offs within the cybersecurity risk domain (coverage, latency, model util

AWSRestAIGo
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📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -83.9%

About the Team The Growth team drives user and revenue growth across ChatGPT’s consumer and business segments as well as other OpenAI products worldwide. We operate across the full funnel - from awareness and acquisition through activation, retention, and expansion - using a combination of global performance marketing, AI-powered workflows, in-product optimization, insights, experimentation, and creative ops engineering. About the Role We are hiring a Lifecycle Lead to build the company-wide owned-channel capability that helps teams reach users with relevant, timely, and trustworthy experiences. This senior, hands-on leader will set the lifecycle strategy, partner with Engineering to build the orchestration and deployment platform, and establish the operating model that allows teams across the company to launch and improve evergreen programs safely at scale. You will sit at the intersection of platform, product, and campaign strategy. You will partner with Engineering, Product, Data Science, and Analytics on the underlying systems, and with Product Marketing Managers and other client teams to design journeys that help new, active, and returning users reach value and build durable habits. In this role, you will: Partner with product to set the company-wide vision, roadmap, and operating model for lifecycle and owned-channel engagement. Partner with Engineering, Product, Data Science, and Analytics to shape the tooling and infrastructure for identity, audiences, eligibility, consent, triggers, orchestration, decisioning, frequency, experimentation, localization, quality assurance, and observability. Define scalable deployment workflows—including self-service and centrally supported paths, intake, templates, approvals, governance, service levels, and incident response—so teams across the company can launch safely and efficiently. Partner with Product Marketing Managers and other client teams to translate audience, product, and business goals into evergreen journey stra

AWSRestAIGo
E(
📍 United States· Full-time
✓ High-confidence listingCompany trend -100%

From $250K/yr

Quick readStrong listing-quality and freshness signals

About Ema Ema is building the world’s leading Agentic AI platform to transform enterprise productivity. We enable organizations to delegate repetitive tasks to Ema, the Universal AI Employee, delivering 10x gains in workforce efficiency, across functions. Founded by former executives from Google, Coinbase, Flipkart, and Okta, our team includes engineers from premier tech companies and graduates of Stanford, MIT, UC Berkeley, CMU, and IITs. We are backed by industry leading investors including Accel, Naspers/Prosus, Section32, and angels like Sheryl Sandberg and Dustin Moskovitz. Headquartered in Silicon Valley and with offices in London, Bangalore and Vancouver, Ema is at the frontier of what Agentic AI can do in production — we ship real systems that run real business processes at scale. Skills and Qualifications: Product Knowledge: Deep understanding of product offerings and their real-world applications, particularly in AI technologies, enabling effective communication of value to potential customers. Sales Expertise: Proven track record in building positive relationships, prospecting, and negotiating high-value deals with senior executives. Experience generating pipeline through cold calling and prospecting. Interpersonal Skills: Strong communication and interpersonal abilities, with the capacity to be personable yet persistent, adapting your approach to different customer needs. Technical Acumen: Effective combination of selling skills and technical understanding, focusing on strategic thinking, problem-solving, and value creation tailored to each unique client. Adaptability: Ability to thrive in a fast-paced, dynamic environment, with a high level of flexibility and the capacity to adapt to changing priorities and overcome challenges. Responsibilities: Lead Generation: Responsible for outbound prospecting, generating new leads, and developing comprehensive strategies to expand the company’s presence within targeted institutions or regions. Client Engagement: B

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📍 New York, New York, United States
✓ High-confidence listingCompany trend -86.8%
Quick readStrong listing-quality and freshness signals

About Datadog: Datadog is the essential monitoring and security platform for cloud applications. We bring together end-to-end traces, metrics, and logs to make your applications, infrastructure, and third-party services entirely observable. These capabilities help businesses secure their systems, avoid downtime, and ensure customers are getting the best user experience. The Team: The Financial Planning & Analysis (FP&A) team analyzes company financial data (revenue, customers, headcount, expenses, etc.) in order to support the business’ growth and success. Within FP&A, the R&D Finance team enables the financial strategy behind Datadog’s Engineering and Product organizations. We partner directly with technical leadership to drive decision-making around our most critical investments. Your work will be highly cross-functional and play a pivotal role in connecting the dots across the organization through a financial lens, ensuring operational alignment and informing decision making. The Opportunity: As a part of the R&D Finance team, this person will be key in supporting our product and engineering leadership team. Reporting to the Senior Manager, you will help create our annual budget and financial targets and work with operational leaders to support execution against our goals. Your work will be highly cross-functional and strategic, and you will play a pivotal role in connecting the dots across the organization through a financial lens, in order to help ensure operational alignment and inform decision making. What You’ll Do: Partner with senior business leaders to manage their departmental budgets on a regular basis, including but not limited to the company’s co-founder and CTO Manage financial forecasts and analytics, which include data across revenue, customers, product, company expenses, and headcount / workforce. Help manage significant portions of the company’s spend, including but not limited to AI and GPU spend across the compan

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📍 Foster City, California, United States· Full-time· Remote
✓ High-confidence listingCompany trend -87.5%
Quick readStrong listing-quality and freshness signals

Replit is the agentic software creation platform that enables anyone to build applications using natural language. With millions of users worldwide, Replit is democratizing software development by removing traditional barriers to application creation. About the role: We're hiring a Product Partnerships Manager to own Replit's most important strategic partnerships end-to-end: from identifying the opportunity to shipping the outcome and measuring the impact. This is a product-focused role where you will work with our consumer technology partners, such as Stripe, Shopify, Google, and the broader connector ecosystem. You'll work at the intersection of product strategy, ecosystem thinking, and deal execution. You'll need to be a serious Replit power user. You'll speak credibly with engineers. You'll negotiate with senior partner stakeholders. And you'll be the person accountable for turning ambiguous ecosystem opportunities into shipped product and business outcomes. What You'll Do Develop a clear point of view on Replit's partner landscape and build a prioritized pipeline of high-leverage opportunities across consumer tooling, AI tooling, cloud and infrastructure, and payments technology partners. Lead partner conversations from early exploration through joint product thesis, business case, commercial terms, launch plan, and post-launch iteration. Partner with Product, Engineering, Partner Engineering, Legal, Finance, Marketing, and Sales to turn agreements into shipped outcomes. Work directly with Partner Engineers to scope integrations, demos, prototypes, reference apps, and partner enablement assets. Define success metrics before every launch activation: retained usage, apps created, deployments, revenue, partner-sourced users, and use them to decide when to scale, iterate, or sunset a partnership. Build lightweight operating systems: partner scorecards, launch checklists, partner roadmap tracking, and repeatable frameworks for evaluating new opportunities. Represent

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📍 San Francisco Bay Area, California, United States· Full-time
✓ High-confidence listingCompany trend -100%

$200K – $250K/yr

Quick readStrong listing-quality and freshness signals

About Ema Ema is building the world’s leading Agentic AI platform to transform enterprise productivity. We enable organizations to delegate repetitive tasks to Ema, the Universal AI Employee, delivering 10x gains in workforce efficiency, across functions. Founded by former executives from Google, Coinbase, Flipkart, and Okta, our team includes engineers from premier tech companies and graduates of Stanford, MIT, UC Berkeley, CMU, and IITs. We are backed by industry leading investors including Accel, Naspers/Prosus, Section32, and angels like Sheryl Sandberg and Dustin Moskovitz. Headquartered in Silicon Valley and with offices in London, Bangalore and Vancouver, Ema is at the frontier of what Agentic AI can do in production — we ship real systems that run real business processes at scale. Role Overview As Chief of Staff to the CEO, you will be the strategic nerve center of the entire company — a true force-multiplier to Surojit Chatterjee (ex CPO Coinbase, VP Products at Google). Reporting directly to the CEO and based in Mountain View, CA (full co-location required), you will own the translation of the CEO's vision across Sales, Product, and the full organizational agenda — serving as connective tissue between the CEO and every critical function: EPD, GTM, Finance, HR, Legal, and the Board. This is a senior operating role for someone who has already done it — led strategy at scale, driven GTM at a high-growth technology company, and earned their stripes as an Engagement Manager or Associate Principal at a top-tier consulting firm (McKinsey, BCG, Bain) before stepping into industry. You are not here to learn the ropes; you are here to pull them. Ema is backed by top-tier investors (Accel, Section 32, and Prosus) and is building the Universal AI Employee for enterprises worldwide. This is a high-visibility, high-impact role at one of the most consequential AI companies in the world. Key Responsibilities CEO Leverage & Executive Operations Serve as Surojit's strat

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📍 United States· Full-time
✓ Quality checkedCompany trend -100%

What you’ll do Own and evolve the Quality Management System (QMS) to support a regulated medical device development program, including design controls and DHF maintenance. Establish and enforce requirements traceability: user needs → design requirements → verification/validation artifacts and change control. Define and run the program-level V&V strategy (verification, validation, and test coverage), including test plans, protocols, reports, and acceptance criteria. Drive risk management activities (e.g., DFMEA / PFMEA, hazard analyses) and ensure mitigations are reflected in requirements and verification. Lead document control: reviews, approvals, training, retention, and audit readiness. Partner with engineering to make quality “native” to the dev workflow (automated testing, release gates, software configuration management). Prepare the program for audits and inspections, including hands-on audit leadership. What we’re looking for Senior experience leading quality for complex hardware + software products in a regulated environment. Deep familiarity with design controls, DHF, document control, risk management, and verification planning. Strong systems thinking and the ability to translate ambiguous product intent into testable requirements. Comfortable collaborating directly with multidisciplinary engineering (recon/ML, embedded, mechanical, EE, cloud). Useful experience Regulated product quality leadership (ISO 13485 / 21 CFR 820 or equivalent), including audit readiness and FDA-facing work. eQMS + document control fluency (e.g., Greenlight Guru) that integrates cleanly with modern engineering workflows.

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📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -83.9%

About the Team OpenAI is a frontier AI research and deployment company. Frontier research is at the center of how we advance our mission, with researchers, engineers, product leaders, operators, and many other teams working together to turn new capabilities into systems that benefit humanity. The People team helps OpenAI attract, engage, and support the exceptional talent this work requires. Employer Brand sits at the intersection of Research, Recruiting, Communications, Marketing, and Brand. Its mandate is to continue to establish OpenAI in the talent market as the unique and leading frontier research lab—not simply another technology company—and make our distinctive research environment, mission, culture, and opportunity for impact relevant and tangible to every priority talent audience. About the Role We’re hiring an Employer Brand Manager to build and scale the strategy, narrative, and operating system that shape how priority talent understands OpenAI. This senior individual contributor will anchor our employer brand in OpenAI’s identity as a frontier research lab and translate an evidence-backed “why OpenAI / why now” narrative into campaigns, researcher and employee stories, recruiter and hiring manager enablement, and candidate experiences. This role is especially important as OpenAI competes for exceptional talent across research, engineering, product, and other mission-critical functions in a fast-moving field where external perceptions can be incomplete or change quickly. You will develop a clear, credible talent narrative for priority audiences—anchored in frontier research and substantiated by individual agency, world-class infrastructure, research-to-product translation, deployment scale, and a willingness to answer hard questions candidly. This role is responsible for ensuring the external brand resembles our culture and ethos internally, therefore must remain immersed in various OpenAI research and applied branches. This role is based in San Francisco

AWSRestAIRust
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📍 United States· Full-time
✓ Quality checkedCompany trend -83.9%

About the Team OpenAI’s Agentic Data Science team helps shape how AI agents are built, deployed, and improved across our products. We partner with product, engineering, research, and security teams to define meaningful measures of success, understand how our systems behave in the real world, and translate evidence into better decisions. As AI agents become more capable, they can write and execute code, access sensitive systems, and complete increasingly complex tasks with greater autonomy. These capabilities create powerful opportunities to improve cybersecurity, but they also introduce risks that traditional security tools and processes were not designed to address. Meeting this moment requires new ways to measure security, evaluate defenses, and distinguish genuine risk reduction from friction that slows users down. About the Role We are looking for a senior data scientist to help define what effective cybersecurity looks like in the age of AI agents. You will work across OpenAI’s Security organization and cybersecurity product teams to measure emerging risks, improve internal security controls, and shape AI-powered security products. The problems are foundational: How do we know whether an agent’s security controls are effective? Which safeguards meaningfully reduce risk, and which create unnecessary friction? When an AI system identifies a potential vulnerability, how do we determine whether the finding is accurate, actionable, and ultimately resolved? How do we detect anomalous behavior or risky access when the systems themselves are changing rapidly? You will report into Data Science while partnering closely with Security, Cyber Product, Engineering, and Research. This is a high-ownership role for someone who can establish a new analytical discipline, operate across organizational boundaries, and turn ambiguous security challenges into measurable improvements. In This Role You Will Define how we measure AI-agent security. Establish metrics and evaluation frame

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📍 Miami, Florida, United States· Full-time
✓ High-confidence listing
Quick readStrong listing-quality and freshness signals

About Us OpenFX is on a mission to move money as freely as data, unrestricted by time zones, banking hours, or legacy systems. We are building the infrastructure that will power the next generation of cross-border payment systems for institutions. The team's execution has been exceptional, and we're scaling at a remarkable pace. Our stellar early team brings experience at companies such as J.P. Morgan, Goldman Sachs, FalconX, PayPal, Affirm, Polygon, Kraken, Nium & others. We're backed by Accel, Lightspeed, NfX, and other top-tier investors. Role Overview We are seeking an Account Executive, North America to join our dynamic go-to-market team. You'll own the full sales cycle for institutional customers across North America — from prospecting through close, helping banks, fintechs, and other institutions move money faster and more efficiently across borders. Key Responsibilities: New Business Development Build and manage a pipeline of institutional prospects across North America, from initial outreach through qualification Identify and prioritize target accounts — banks, fintechs, and other institutions with cross-border payment needs Full-Cycle Sales Execution Own deals end-to-end: discovery, solution design, negotiation, and close Consistently meet or exceed quarterly and annual revenue targets Maintain accurate pipeline and forecast data in the CRM Client & Stakeholder Relationship Management Develop trusted relationships with senior stakeholders (Treasury, Finance, Payments, and Operations leaders) at prospective and existing clients Serve as a strategic advisor, understanding each client's cross-border payment needs and tailoring OpenFX's value proposition accordingly Cross-Functional Collaboration Partner closely with Product, Engineering, Legal & Compliance, and Marketing to navigate technical integrations and structure deals Work with leadership to refine sales strategy, messaging, and positioning as the go-to-market motion matures Market St

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