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Ai Systems Engineer in California

75 active opportunities · Updated October 2026

Explore current ai systems engineer jobs in California. Filter by work mode, employment type, experience, department, date posted and distance.

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📍 California, California, United States· Full-time
✓ Quality checkedCompany trend -100%

Who Are We? Postman is the world’s leading API platform, used by more than 45 million+ developers and 500,000 organizations, including 98% of the Fortune 500. Postman is helping developers and professionals across the globe build the API-first world by simplifying each step of the API lifecycle and streamlining collaboration—enabling users to create better APIs, faster. The company is headquartered in San Francisco and has offices in Boston, New York, Austin, Tokyo, London, and Bangalore - where Postman was founded. Postman is privately held, with funding from Battery Ventures, BOND, Coatue, CRV, Insight Partners, and Nexus Venture Partners. Learn more at postman.com or connect with Postman on X via @getpostman. P.S: We highly recommend reading The "API-First World" graphic novel to understand the bigger picture and our vision at Postman. The Opportunity (Summer 2026 AI Internship - Applications Open Now) We're seeking an AI Engineer Intern to work alongside our AI team on large-scale AI and Agentic systems from data pipeline to production deployment. This role is scoped for someone with foundational experience who wants to deepen it: you'll own discrete pieces of real systems under the mentorship of senior engineers, not shadow work or isolated coursework-style projects. What You'll Do You’ll work directly with the AI team, taking responsibility for well-scoped pieces of real systems, with mentorship from senior engineers. Benchmarks & Evaluation Contribute to APIFlow-Bench , our open-source benchmark for real API-development work: design and review benchmark tasks and their mock API environments, extend the evaluation harness and task-generation pipeline in Python, and help maintain the public multi-model leaderboard with statistical confidence intervals. Help build a new action-level AI safety benchmark: instead of grading what a model says, it scores what an agent actually does inside a simulated enterprise API environment. You’ll work on scenari

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A
📍 California, United States
✓ High-confidence listingCompany trend +365.2%
Quick readStrong listing-quality and freshness signals

Abbott is a global healthcare leader that helps people live more fully at all stages of life. Our portfolio of life-changing technologies spans the spectrum of healthcare, with leading businesses and products in diagnostics, medical devices, nutritionals and branded generic medicines. Our 122,000 colleagues serve people in more than 160 countries. JOB DESCRIPTION: At Lingo, we’re building a groundbreaking health platform that combines continuous biosensor data, real-time analytics, and personalized insights to help people live fuller, longer, and healthier lives. Our systems ingest millions of sensor readings daily, powering experiences for consumers and partners worldwide, with the reliability and scalability of cloud-native, enterprise-grade platforms. At Abbott, you can do work that matters, grow, and learn, care for yourself and family, be your true self and live a full life. You’ll also have access to: Career development with an international company where you can grow the career you dream of. Employees can qualify for free medical coverage in our Health Investment Plan (HIP) PPO medical plan in the next calendar year An excellent retirement savings plan with high employer contribution Tuition reimbursement, the Freedom 2 Save student debt program and FreeU education benefit - an affordable and convenient path to getting a bachelor’s degree. A company recognized as a great place to work in dozens of countries around the world and named one of the most admired companies in the world by Fortune. A company that is recognized as one of the best big companies to wor

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DA
📍 California, United States· Full-time· Remote
✓ High-confidence listing
Quick readStrong listing-quality and freshness signals

About Dawn Aerospace Dawn Aerospace is redefining space transportation through reusable, sustainable, and high-cadence flight systems. Our Aurora Spaceplane enables rapid access to suborbital space and speeds over Mach 3, serving a growing need for near-space testing, high-speed flight, and microgravity research. Together with our in-space propulsion business, Dawn is building the infrastructure for sustainable access to and operation in space. Role Overview Aurora is the first vehicle capable of flying missions to the edge of space multiple times a day. Your job is to transform this vehicle capability into mission success for our customers working from anywhere in the US - although Huntsville , USA is preferred (with domestic and international travel) . As a Mission Manager, your core role is to translate customer objectives into executable flight plans. You will be the customer’s interface to Dawn's flight operations, engineering, regulatory, and commercial teams. Throughout any project, you will coordinate the specialists required to solve individual problems while retaining responsibility for the mission. This is not a passive account-management role. You will be expected to assess mission feasibility, challenge customer assumptions, defend engineering realities, and drive clarity across complex, first-of-a-kind mission concepts. You will be the customer’s technical advocate inside Dawn, and Dawn’s operational interface to the customer. You will succeed here if you can lead through ambiguity, communicate with precision, and have the technical depth to engage meaningfully with aerospace engineers and flight operators, while keeping customers aligned, informed, and confident. Key Responsibilities Mission Ownershi

AIGoSEOProject Management
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📍 California, United States of America, United States
✓ High-confidence listingCompany trend +103.7%

$180K – $270K/yr

Quick readStrong listing-quality and freshness signals

Lead RF Systems and Defense Engineer- HP IQ Description - Who We Are HP IQ is HP’s new AI innovation lab. Combining startup agility with HP’s global scale, we’re building intelligent technologies that redefine how the world works, creates, and collaborates. We’re assembling a diverse, world-class team—engineers, designers, researchers, and product minds—focused on creating an intelligent ecosystem across HP’s portfolio. Together, we’re developing intuitive, adaptive solutions that spark creativity, boost productivity, and make collaboration seamless. We create breakthrough solutions that make complex tasks feel effortless, teamwork more natural, and ideas more impactful—always with a human-centric mindset. By embedding AI advancements into every HP product and service, we’re expanding what’s possible for individuals, organisations, and the future of work. Join us as we reinvent work, so people everywhere can do their best work. About The Role HP IQ's Wireless Technology Team works cross-functionally with Electrical Engineering, Software, Mechanical Engineering, Product Design, Industrial Design, Program Management, and Operations to develop next-generation wearable and AI-connected products. As a Lead RF Systems & Desense Engineer, you will own the RF system architecture from concept through mass production. You will lead RF integration across Wi-Fi, Bluetooth, UWB, NFC and emerging wireless technologies while driving RF desense, coexistence, and wireless performance for highly integrated products. <span style=

I
📍 California, United States
✓ High-confidence listing

$98.4K – $147.6K/yr

Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. We are seeking a Senior Mechanical Engineer to support new product development in genomics instrumentation. This is a highly technical mechanical design role focused on the development of custom mechanisms, precision motion systems, and electromechanical assemblies used in advanced instrumentation. The ideal candidate will be an engineer with experience designing motorized mechanisms and precision motion systems, including a strong understanding of system requirements, motion architecture, controls integration, structural design, and performance validation. The ideal candidate also has experience developing motion solutions from requirements through implementation and understands the engineering principles behind achieving precise, reliable motion in complex systems. Responsibilities Design and develop custom mechanical mechanisms for use in genomics instruments, including motion systems, precision assemblies, and fluidic or sample‑handling components. Integrate mechanical designs with electrical, firmware, and control systems Create and maintain 3D CAD models, engineering drawings, and support

Artificial IntelligenceAI
I
📍 California, United States
✓ High-confidence listing

$141.6K – $212.4K/yr

Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Summary The Staff Data Engineer is a seasoned, hands-on engineer who designs, builds, and scales data products on our cloud lakehouse, powering analytics, reporting, and AI/ML across Illumina. We are looking for someone with strong proficiency in Python, SQL, and data modeling, a solid understanding of distributed systems and system design who has built and scaled data products on modern cloud platforms such as Databricks and Snowflake. This is a hands-on, senior individual-contributor role with end-to-end ownership and leadership spanning multiple domains such as Supply Chain, Manufacturing and Quality, including mentoring engineers on our global (India-based) team. Responsibilities Partner across business, AI, and platform teams translating domain needs (e.g., SAP, Manufacturing, Quality) into well-modeled, governed and scalable data products. Design, build, and scale end-to-end data products on Databricks (and interoperating with Snowflake) — from ingestion through curated, analytics-ready datasets following a medallion (Bronze/Silver/Gold) architecture. Develop reusable frameworks, libraries, and

PythonSQLAWSGit
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📍 California, Santa Clara, United States
✓ High-confidence listingCompany trend +315.4%
Quick readStrong listing-quality and freshness signals

Job Details: Job Description: The Role and Impact As a GPU Platform Hardware Design Engineer, you will play a pivotal role in designing and developing high-quality GPU hardware platforms that drive innovation in high-performance computing, graphics, and visualization technologies. You will lead the design process from initial feasibility studies through board layout, tapeout, and platform power-on, ensuring robust functionality and compatibility with industry standards. Your expertise in platform-level requirements, electrical engineering applications, and system bring-up will directly contribute to delivering cutting-edge GPU systems that accelerate Intel's leadership in computing. Business group The Data Center Group (DCG) is dedicated to advancing Intel's role in powering the digital world with leading-edge technologies. Focused on delivering innovative solutions for data center and cloud environments, DCG supports high-performance computing and graphics to enable capabilities such as AI, machine learning, and advanced visualizations. As part of the GPU IP Engineering team within DCG, you'll contribute to developing GPU systems that meet the evolving demands of the industry while supporting Intel's broader mission to create world-changing technology. Key Responsibilities - Design, develop, and evaluate electronic components, PCBs, and integrated circuits for GPU hardware platforms. - Translate platform-level requirements into detailed specifications and ensure adherence throughout the design process. - Define component placement and trace routing rules to optimize board layouts for performance, power, and signal integrity. - Conduct feasibility studies, board layout, tapeout, and platform power-on activities. - Perform functionality tests and utilize tools to verify platform configurations and compatibility. - Research, develop, and validate firmware, hardwa

Machine LearningAIRecruitment
A
📍 California, USA - Remote, United States· Remote
✓ Quality checkedCompany trend +90.9%

Job Requisition ID # 26WD97363 Position Overview We are seeking a Principal Software Engineer – Backend to join Autodesk’s Enterprise Data Management (EDM) organization within the COO-GET Engineering group. This is a senior individual contributor role operating at the Principal (P4) level , expected to drive technology direction for large, complex, and business-critical backend and distributed systems . This role is anchored in backend software engineering excellence : designing, building, and evolving scalable services, APIs, and event-driven systems that operate at enterprise scale. As a Principal Engineer, you will work with high autonomy and ambiguity , shape long-term architecture, and influence multiple teams and domains. Familiarity with data engineering concepts is valuable, but backend systems, service design, and distributed systems are the core competencies. You will function as a technical authority and force multiplier—guiding design decisions, setting standards, and ensuring Autodesk’s core data services are reliable, resilient, and evolvable over time. Responsibilities Provide principal-level technical

PythonAWSAI
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📍 California, United States of America, United States
✓ High-confidence listingCompany trend +103.7%

$162K – $225K/yr

Quick readStrong listing-quality and freshness signals

Senior Software Engineer, Cloud Services Description - Who We Are HP IQ is HP’s new AI innovation lab. Combining startup agility with HP’s global scale, we’re building intelligent technologies that redefine how the world works, creates, and collaborates. We’re assembling a diverse, world-class team—engineers, designers, researchers, and product minds—focused on creating an intelligent ecosystem across HP’s portfolio. Together, we’re developing intuitive, adaptive solutions that spark creativity, boost productivity, and make collaboration seamless. We create breakthrough solutions that make complex tasks feel effortless, teamwork more natural, and ideas more impactful—always with a human-centric mindset. By embedding AI advancements into every HP product and service, we’re expanding what’s possible for individuals, organisations, and the future of work. Join us as we reinvent work, so people everywhere can do their best work. About The Role As a Senior Software Engineer, Cloud Services, you will create scalable, reliable backend systems that support HP IQ's mission to transform the way people work. We value how we work as much as what we deliver. Our journey of continuous learning and evolution requires a flexible and resilient services platform that fosters innovation, experimentation, and adaptation. To enable this, we focus on designs and tools rooted in strong engineering principles like abstraction, composition, virtualization, automation, and iterative development cycles. What You Might Do Design, develop, and maintain backend services and RESTful APIs using Java and Spring Boot. Write clean, efficient, and well-tested code following established best practices. Collaborate with frontend developers, product managers, and other engineers to deliver end-to-end features. Integ

JavaPostgreSQLMySQLAWS
I
📍 California, United States
✓ High-confidence listing

$155.6K – $233.4K/yr

Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Responsibilities: Drive staff results by communicating job expectations, planning, monitoring and appraising job results, coaching and counseling employees, recognizing performance issues and driving improvement, developing, coordinating and enforcing systems, policies, procedures and productivity standards Establish strategic goals by gathering pertinent business, financial, service and operations information, choosing a course of action, defining objectives, and evaluating outcomes Maintain staff by recruiting, selecting, orienting and training employees; maintaining a safe, secure and legal work environment; developing personal growth opportunities Ensure validation program meets requirements of FDA (21 CFR Part 11 and Part 820), ISO 9001/13485, IEC 62304 and MDSAP Identify differences between ISO and FDA requirements and their applicability to products targeting different markets Report broadly through the organization on validation activities and instrument manufacturing audit readiness Estimate timelines and budgeting for validation engineering development efforts Formaliz

Artificial IntelligenceAIProject ManagementPmp
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📍 California, United States of America, United States
✓ High-confidence listingCompany trend +103.7%

$162K – $252K/yr

Quick readStrong listing-quality and freshness signals

Lead Firmware Engineer Description - Who We Are HP IQ is HP’s new AI innovation lab. Combining startup agility with HP’s global scale, we’re building intelligent technologies that redefine how the world works, creates, and collaborates. We’re assembling a diverse, world-class team—engineers, designers, researchers, and product minds—focused on creating an intelligent ecosystem across HP’s portfolio. Together, we’re developing intuitive, adaptive solutions that spark creativity, boost productivity, and make collaboration seamless. We create breakthrough solutions that make complex tasks feel effortless, teamwork more natural, and ideas more impactful—always with a human-centric mindset. By embedding AI advancements into every HP product and service, we’re expanding what’s possible for individuals, organisations, and the future of work. Join us as we reinvent work, so people everywhere can do their best work. About The Role The System Software team is responsible for firmware, operating system software, hardware-accelerated algorithms, and core developer frameworks supporting our products. We serve as the glue between our hardware teams and our higher-level software teams, and delight in finding creative solutions to complex, interdisciplinary problems as we bring our product visions to life. As a firmware engineer on our team, you will develop firmware for low-power embedded microcontrollers to coordinate sensors, ensure securi

P
📍 California, United States
✓ High-confidence listingCompany trend +671.4%

$68.6K – $114.3K/yr

Quick readStrong listing-quality and freshness signals

Position Summary Pfizer is seeking a motivated Senior Associate Scientist to join the In Vivo Pharmacology group within the Oncology Research Unit, with a focus on antibody-drug conjugate (ADC) programs, but including other large molecule and small molecule programs. This role supports the execution of in vivo oncology studies that enable ADC discovery and preclinical development, including efficacy, tolerability, pharmacodynamic, and sample collection workflows. The ideal candidate will demonstrate strong technical aptitude, careful attention to detail, and a commitment to animal welfare, compliance, and high-quality study execution. The Senior Associate Scientist is expected to contribute as a dependable technical team member while building scientific understanding of oncology pharmacology and ADC-specific study requirements. Position Responsibilities Execute in vivo oncology studies supporting discovery programs using a variety of in vivo models including human cell line- derived, patient-derived xenograft, syngeneic models as appropriate with minimum guidance from study leads. Perform routine and advanced in vivo procedures, including tumor measurements, body weight monitoring, test article administration (IV, PO, subQ, IP dosing), clinical observations, and sample collection. Perform routine in vitro tissue culture procedures Support pharmacology studies evaluating efficacy, tolerability, pharmacodynamic biomarkers, dosing schedules, and combination approaches. Prepare study materials, confirm dosing and sampling schedules, and ensure study activities are performed according to approved protocols and SOPs. Maintain accurate, timely, and compliant study records using approved electronic data capture and documentation systems. Communicate study observations, technical issues, animal welfare concerns, and timeline risks promptly to managers and study line leads. Collabo

AIRecruitment
P
📍 California, United States
✓ High-confidence listingCompany trend +671.4%

$79.4K – $132.4K/yr

Quick readStrong listing-quality and freshness signals

Position Summary Pfizer is seeking a highly motivated Scientist to join the In Vivo Pharmacology group within the Oncology Research Unit, with a focus on antibody-drug conjugate (ADC) programs. This role supports the execution of high-quality in vivo efficacy, pharmacodynamic, tolerability, and mechanistic studies that enable preclinical ADC discovery and development. The ideal candidate will demonstrate strong technical capability in oncology animal models, careful attention to study details, and a commitment to animal welfare, compliance, and scientific rigor. The Scientist is expected to contribute as a reliable technical and scientific team member while developing increasing independence in study execution, data interpretation, and cross-functional collaboration. Position Responsibilities Execute in vivo oncology studies supporting ADC discovery programs using a variety of in vivo models including syngeneic, cell line-derived, and patient-derived xenograft models as appropriate. Perform routine and advanced in vivo procedures, including tumor measurements, body weight monitoring, test article administration, clinical observations, and sample collection. Support ADC pharmacology studies assessing efficacy, tolerability, pharmacodynamic biomarkers, dose-response relationships, schedule optimization, and combination strategies. Prepare, review, and follow study protocols, dosing schedules, randomization plans, and sample collection timelines in alignment with project goals and internal standards. Maintain accurate, timely, and compliant study records using electronic data capture systems and approved documentation practices. Coordinate with project line leads, vivarium operations, pathology, toxicology translational scientists, bioanalytical, pharmacodynamic and pharmacokinetic teams, and external partners to enable efficient study execution. Assist with data quality revie

AIRecruitment
I
📍 California, United States
✓ High-confidence listing

$155.6K – $233.4K/yr

Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Position Summary: Designs, models, and develops data management systems that integrate laboratory, operation and research data. Designs, builds, improves and maintains high performance and highly scalable data pipelines. Oversees transition of data pipelines to production and commercial settings; develops technology choices and practices that support pipeline maturation. Researches and assesses the viability of new data management and processing technologies. Scope of Responsibilities: Applies subject matter expertise and extensive knowledge of theories, practices, and design matters to lead the application of existing principles and guide the development of new ideas. Provides, guides, and uses professional concepts to resolve critical issues. Works on highly complex assignments that address future concepts where problem solving requires conceptual thinking and an evaluation of enigmatic components. Accountable for results which may impact multiple functions. Enhances formal networks with key decision makers and recognized as a thought le

Artificial IntelligenceAI
I
📍 California, United States
✓ High-confidence listing
Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. This position maintains and repairs the facility's structure, equipment and ground, including plumbing, electrical and HVAC. Key Responsibilities: Responsible for mechanical service calls and in-house repairs throughout facility and grounds. Performs skilled trade work, such as carpentry or painting in the construction, repair or alteration of structures such as walls, roofs or office fixtures. Monitor, maintain document and perform preventative maintenance on HVAC system including central plant. May provide guidance and oversee other personnel. May work from sketches, blueprints, and drawings. Act as liaison and supervise work of contractors. Be on call and able to respond 7/24/365. Listed responsibilities are an essential, but not exhaustive list, of the usual duties associated with the position. Changes to individual responsibilities may occur due to business needs. Requirements: Requires 2-5 years of related experience Ability to continually learn through on-t

Artificial IntelligenceAI
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