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Early Career Mechanical Design Engineer in California

20 active opportunities · Updated October 2026

Explore current early career mechanical design engineer jobs in California. Filter by work mode, employment type, experience, department, date posted and distance.

I
📍 California, United States· Hybrid
✓ High-confidence listing

$82.5K – $123.7K/yr

Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Position Title: Senior Financial Analyst, R&D Finance Location: San Diego, CA (Hybrid) Reports To: Associate Director, Finance – R&D FLSA Status: Exempt Position Summary: The R&D Finance Business Partner provides finance support for a complex portfolio of R&D functions, programs, strategic initiatives, and R&D leadership team members. The role works with R&D and Finance leadership to translate technical and operational activity into clear financial insight, improve forecast accuracy, evaluate investment trade-offs, and support resource decisions across operating expense, headcount, and capital investment. This position operates as an individual contributor in a matrixed environment with limited day-to-day direction. Success requires strong financial rigor, sound business judgment, clear communication, and the ability to build trusted partnerships while maintaining appropriate financial challenge and discipline. *This is a full-time role, Monday through Friday, with an expectation of 2–3 in-office days per week and additional on-site presence as

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I
📍 California, United States
✓ High-confidence listing

$62.9K – $94.3K/yr

Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Illumina is seeking a talented individual to fulfill a Scientist 1 role in next-generation sequencing (NGS) assay research and development. This is a unique opportunity to join a talented team of scientists at the frontier of innovation in spatial transcriptomics. At Illumina you will work in a dynamic, team-oriented environment and help create novel molecular biology assays that support expansion of Illumina’s spatial transcriptomics portfolio Responsibilities Design and execute lab-based experiments using biochemistry and molecular biology skills Troubleshoot and optimize workflows and assays to improve performance Innovate new spatial transcriptomics methods and devise solutions to technical issues Work independently and as part of an interdisciplinary team Effectively communicate experimental results and next steps to team members at regular meetings Maintain detailed records of experimental work and analysis Complete goals within defined timelines Listed responsibilities are an essential, but not exhaustive list, of the usual duties associated with th

Artificial IntelligenceAI
I
📍 California, United States
✓ High-confidence listing

$155.6K – $233.4K/yr

Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Why Us We are a multi-disciplinary and multinational team focused in using next-generation sequencing technology to transform human health and save patient’s lives. Our team works at the interface of research and clinical practice developing and improving innovative algorithms to biomarkers and variants that fill gaps in clinical practice, focusing primarily on oncology. We collaborate deeply with internal and external teams, to augment DRAGEN, Illumina’s software platform to analyze high-throughput sequencing data, remove barriers for its use in clinical settings, and develop new biomarkers in areas such as MRD and methylation. Why You We know the importance of your role and offer you a collaborative and supportive environment in which you are actively encouraged to develop your skills and knowledge. Illumina's mission is to improve human health by unlocking the power of the genome - if that inspires you, let's talk. If you are excited as we are about using genomics to transform the practice of medicine, have a proven track record of algorithm development, data analysis, and strong coding ability, this is the ro

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I
📍 California, United States
✓ High-confidence listing

$155.6K – $233.4K/yr

Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Our team specializes in developing a fast and accurate platform called DRAGEN for the secondary analysis of NGS genomic data. The platform covers a wide range of pipelines spanning germline and somatic analysis (WGS and targeted; tumor/normal and tumor-only), DNA and RNA workflows, and variant classes including small variants, CNVs, and structural variants. We are looking for a highly driven and talented Staff Bioinformatics Scientist to join our methods development team to work on secondary analysis algorithms. The ideal candidate will have a strong background in computer science, algorithms, statistics, or digital signal processing in addition to expertise in genomics and next generation sequencing. The candidate should be a proven team player and will contribute to the production software codebase. This role will focus on software development for structural variant detection, pangenome references, graph-based algorithms, and NGS assembly methods. Responsibilities: Design, prototype, and implement innovative computational or statistical algorithms to extract meaningful biological signal from sequencing assays. Im

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I
📍 California, United States
✓ High-confidence listing
Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. This position maintains and repairs the facility's structure, equipment and ground, including plumbing, electrical and HVAC. Key Responsibilities: Responsible for mechanical service calls and in-house repairs throughout facility and grounds. Performs skilled trade work, such as carpentry or painting in the construction, repair or alteration of structures such as walls, roofs or office fixtures. Monitor, maintain document and perform preventative maintenance on HVAC system including central plant. May provide guidance and oversee other personnel. May work from sketches, blueprints, and drawings. Act as liaison and supervise work of contractors. Be on call and able to respond 7/24/365. Listed responsibilities are an essential, but not exhaustive list, of the usual duties associated with the position. Changes to individual responsibilities may occur due to business needs. Requirements: Requires 2-5 years of related experience Ability to continually learn through on-t

Artificial IntelligenceAI
I
📍 California, United States
✓ High-confidence listing

$74.9K – $112.3K/yr

Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. We are looking for a talented and motivated scientist to join the Assay Research and Development group. You will play an important role in developing new and novel sequencing library preparation assays that meet the high performance and robustness characteristics that our customers require. You will be responsible to design and execute experiments, collect data, perform analysis, draw conclusions and participate on product development teams. A background in molecular biology and biochemistry lab techniques is desired. Position Responsibilities: Designs and performs experiments of varying complexity and across a broad array of techniques, foresees issues and works to overcome obstacles to completing tasks or assignments, conceives of new ways to analyze the data and present it. Makes detailed technical observations and documents them in laboratory notebooks and confluence pages, etc. Plans, conducts, summarizes, reports consistent conclusions, and generates recommendations for follow up experiments and may suggest alternate strategies. <

Artificial IntelligenceAI
I
📍 California, United States
✓ High-confidence listing

$82.5K – $123.7K/yr

Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Position Summary: The Sr. Materials Planner is responsible for ensuring optimal material availability for Illumina's instrument and spare parts portfolio by balancing supply, demand, inventory, and lead-times to support manufacturing, service, and customer needs. Responsibilities: Develop and execute material plans to support instrument manufacturing, service, repair, and refurbishment operations. Monitor material availability and proactively communicate shortages or surplus to prevent supply disruptions in the network. Manage inventory levels to balance customer service, operational readiness, and inventory investment. Review and recommend updates to planning parameters, lead times, and master data. Analyze demand and supply changes, communicate risks and mitigation plans. Partner with Procurement to resolve delivery issues and improve material availability. Support product lifecycle transitions from a material readiness perspective. Collaborate cross-functionally with Manufacturing, Service, Quality, Logistics, and Supply Plan

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I
📍 California, United States
✓ High-confidence listing

$98.4K – $147.6K/yr

Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. We are seeking a Senior Mechanical Engineer to support new product development in genomics instrumentation. This is a highly technical mechanical design role focused on the development of custom mechanisms, precision motion systems, and electromechanical assemblies used in advanced instrumentation. The ideal candidate will be an engineer with experience designing motorized mechanisms and precision motion systems, including a strong understanding of system requirements, motion architecture, controls integration, structural design, and performance validation. The ideal candidate also has experience developing motion solutions from requirements through implementation and understands the engineering principles behind achieving precise, reliable motion in complex systems. Responsibilities Design and develop custom mechanical mechanisms for use in genomics instruments, including motion systems, precision assemblies, and fluidic or sample‑handling components. Integrate mechanical designs with electrical, firmware, and control systems Create and maintain 3D CAD models, engineering drawings, and support

Artificial IntelligenceAI
I
📍 California, United States
✓ High-confidence listing

$141.6K – $212.4K/yr

Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Summary The Staff Data Engineer is a seasoned, hands-on engineer who designs, builds, and scales data products on our cloud lakehouse, powering analytics, reporting, and AI/ML across Illumina. We are looking for someone with strong proficiency in Python, SQL, and data modeling, a solid understanding of distributed systems and system design who has built and scaled data products on modern cloud platforms such as Databricks and Snowflake. This is a hands-on, senior individual-contributor role with end-to-end ownership and leadership spanning multiple domains such as Supply Chain, Manufacturing and Quality, including mentoring engineers on our global (India-based) team. Responsibilities Partner across business, AI, and platform teams translating domain needs (e.g., SAP, Manufacturing, Quality) into well-modeled, governed and scalable data products. Design, build, and scale end-to-end data products on Databricks (and interoperating with Snowflake) — from ingestion through curated, analytics-ready datasets following a medallion (Bronze/Silver/Gold) architecture. Develop reusable frameworks, libraries, and

PythonSQLAWSGit
I
📍 California, United States
✓ High-confidence listing

$82.5K – $123.7K/yr

Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. *Candidate must be able to work out of our San Diego, Hayward, or Foster City locations* Position Summary This position will support the Regional Project Planning function within Global Facilities and provide facility planning and construction design management to facilitate execution at multiple project scales and delivery methods in an energetic and fast-paced environment. The role is responsible for construction project and renovation space planning, estimation, scheduling, and resourcing. This person will work closely with consultants and internal stakeholders to create functional area program, layout, and to coordinate facility infrastructure support needs. The ideal candidate for this role has proven ability to identify and resolve issues resourcefully and independently, and will work to understand key business drivers, applying this knowledge to decision making. We are looking for your talent, experience and initiative to join our growing team! Specific Responsibilities: Leading feasibility analysis and site master planning studies Tracking 3 year horizon of planned efforts to info

Artificial IntelligenceAIExcelProcurement
I
📍 California, United States
✓ High-confidence listing

$155.6K – $233.4K/yr

Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Responsibilities: Drive staff results by communicating job expectations, planning, monitoring and appraising job results, coaching and counseling employees, recognizing performance issues and driving improvement, developing, coordinating and enforcing systems, policies, procedures and productivity standards Establish strategic goals by gathering pertinent business, financial, service and operations information, choosing a course of action, defining objectives, and evaluating outcomes Maintain staff by recruiting, selecting, orienting and training employees; maintaining a safe, secure and legal work environment; developing personal growth opportunities Ensure validation program meets requirements of FDA (21 CFR Part 11 and Part 820), ISO 9001/13485, IEC 62304 and MDSAP Identify differences between ISO and FDA requirements and their applicability to products targeting different markets Report broadly through the organization on validation activities and instrument manufacturing audit readiness Estimate timelines and budgeting for validation engineering development efforts Formaliz

Artificial IntelligenceAIProject ManagementPmp
I
📍 California, United States
✓ High-confidence listing

$98.4K – $147.6K/yr

Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Core Job Summary Position Summary: Manages the design, planning, construction and maintenance of equipment, machinery, buildings, and other facilities. Plans, budgets, and schedules facility modifications, including estimates on equipment, labor, materials and other related costs. Designs and develops organizational policies relevant to the facilities department. Oversees the coordination of building space allocation and layout, communication services and facilities expansion. May have responsibility for establishing and overseeing health and safety standards. Changes to individual responsibilities may occur due to business needs and other related duties may be assigned. Scope of Responsibilities: Receives predetermined work assignments with incremental objectives and defined processes, subject to a moderate level of control and review. Directs subordinates to complete assignments using established guidelines and procedures. Administers company policies that directly affect subordinate employees and recommends changes to unit, sub-unit, or discipline policies. Works on assignment

Artificial IntelligenceAI
I
📍 California, United States· Remote
✓ High-confidence listing

$98.4K – $147.6K/yr

Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Position Summary: The Senior Informatics Sales Specialist will use their strong genomics, healthcare and Informatics technical knowledge and expertise to identify and close Informatics opportunities. This involves selling to prospective customers and Illumina colleagues on Next Generation Sequencing and Genomic data analysis pipelines, applications and products primarily for use in clinical research or testing. They will act as an influencer and expert resource for customers and others to ensure success while enabling sales growth through strategic activities and creative problem solving. The Informatics Sales Specialist should be viewed as a “go to” subject matter expert for all things Informatics, with primary focus on Illumina’s clinical software products. As an Informatics Sales Specialist, you are impacting clinical data analysis and interpretation through effective engagement with C-level executives, Laboratory Directors, Healthcare practitioners, IT leaders, and data analysts. You are establishing Illumina as a prominent cloud-based enterprise platform provider to the Clinical, Pharma, and Healthcare se

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H
📍 California, United States of America, United States
✓ Quality checkedCompany trend +103.7%

$107.4K – $155.7K/yr

Interactive Design Engineer - HPIQ Description - About The Role As a Product Design Engineer at HP IQ, you’ll work at the intersection of creativity, engineering, and design to develop groundbreaking devices that redefine how people interact with technology. You’ll collaborate closely with industrial designers, hardware engineers, and interaction designers to transform ideas into functional prototypes and production-ready designs. From 3D CAD modeling and hands-on prototyping to engineering analysis and design validation, you’ll help solve complex mechanical challenges and drive designs from early concepts toward production. You’ll have the opportunity to take ownership of meaningful engineering work while learning from an experienced, multidisciplinary team and contributing to products that push the boundaries of what’s possible. What You Might Do Design mechanical parts, components, and assemblies for new consumer devices using 3D CAD (NX) Create detailed 2D engineering drawings, define specifications and tolerances, and work closely with overseas vendor partners to ensure accuracy and quality Design and run experiments, applying engineering analysis and test results to guide design decisions Evaluate materials, manufacturing processes, and design tradeoffs to develop robust and scalable solutions Work cross-functionally with hardware, software, industrial design, and other engineering teams to bring concepts from ideation through development Conceptualize, design, and build prototypes that quickly validate ideas Participate in design reviews, clearly communicating design decisions, technical analysis, and tradeoffs to both technical and non-technical audiences Build, test, troubleshoot, and iterate prototypes to identify issues and improve product performance, reliability, a

H
📍 California, United States of America, United States
✓ Quality checkedCompany trend +103.7%

$107.4K – $155.7K/yr

Product Design Engineer - HPIQ Description - About The Role As a Product Design Engineer at HP IQ, you’ll work at the intersection of creativity, engineering, and design to develop groundbreaking devices that redefine how people interact with technology. You’ll collaborate closely with industrial designers, hardware engineers, and interaction designers to transform ideas into functional prototypes and production-ready designs. From 3D CAD modeling and hands-on prototyping to engineering analysis and design validation, you’ll help solve complex mechanical challenges and drive designs from early concepts toward production. You’ll have the opportunity to take ownership of meaningful engineering work while learning from an experienced, multidisciplinary team and contributing to products that push the boundaries of what’s possible. What You Might Do Design mechanical parts, components, and assemblies for new consumer devices using 3D CAD (NX) Create detailed 2D engineering drawings, define specifications and tolerances, and work closely with overseas vendor partners to ensure accuracy and quality Design and run experiments, applying engineering analysis and test results to guide design decisions Evaluate materials, manufacturing processes, and design tradeoffs to develop robust and scalable solutions Work cross-functionally with hardware, software, industrial design, and other engineering teams to bring concepts from ideation through development Conceptualize, design, and build prototypes that quickly validate ideas Participate in design reviews, clearly communicating design decisions, technical analysis, and tradeoffs to both technical and

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