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Lead Enterprise Systems Engineer in San Francisco

609 active opportunities · Updated October 2026

Explore current lead enterprise systems engineer jobs in San Francisco. Filter by work mode, employment type, experience, department, date posted and distance.

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📍 San Francisco, California, United States· Full-time
✓ High-confidence listing

From $840K/yr

Quick readStrong listing-quality and freshness signals

Overview: Guidepoint’s Client Service team connects leading investment firms, consultancies, and corporations with the subject-matter experts they need to make informed business and investment decisions. By understanding each client’s specific research needs and delivering targeted expert matches, often within hours, the team plays a critical role in providing a fast, high-quality client experience. As an Associate on the Client Service team, you will play a central role in delivering that experience. You will learn how to assess client needs, identify the types of experts best suited to address them, and recruit new experts into Guidepoint’s global network of more than 1,750,000 Advisors. The role offers exposure to a dynamic, results-oriented environment where strong judgment, responsiveness, and the ability to execute across multiple priorities are highly valued. Due to the collaborative nature of the Client Service team, the work schedule is hybrid with three days in the office required. Who We Are: High-performing team driven by execution, accountability, and consistent client impact Client-centric culture where responsiveness, resourcefulness, and attention to detail define how we operate Team committed to developing talent through hands-on mentorship, coaching, and leadership support Workplace that embeds continuous learning and career development as a core part of how we grow and excel Environment where strong performers take on increasing leadership, commercial responsibility, and client ownership Guidepoint is passionate about your career growth: Check out our Client Service Career Trajectory What You Will Own: Recruit new experts into Guidepoint’s network and engage them for client consultations Independently conduct targeted research across LinkedIn, press releases, company websites, case studies, and other public sources to identify relevant subject-matter experts Lead cold outreach, phone-based vetting, and screening conversations with experts to evalu

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📍 San Francisco, California, United States· Full-time
✓ High-confidence listing

From $840K/yr

Quick readStrong listing-quality and freshness signals

Overview: Guidepoint’s Client Service team connects leading investment firms, consultancies, and corporations with the subject-matter experts they need to make informed business and investment decisions. By understanding each client’s specific research needs and delivering targeted expert matches, often within hours, the team plays a critical role in providing a fast, high-quality client experience. As an Associate on the Client Service team, you will play a central role in delivering that experience. You will learn how to assess client needs, identify the types of experts best suited to address them, and recruit new experts into Guidepoint’s global network of more than 1,750,000 Advisors. The role offers exposure to a dynamic, results-oriented environment where strong judgment, responsiveness, and the ability to execute across multiple priorities are highly valued. Due to the collaborative nature of the Client Service team, the work schedule is hybrid with three days in the office required. Who We Are: High-performing team driven by execution, accountability, and consistent client impact Client-centric culture where responsiveness, resourcefulness, and attention to detail define how we operate Team committed to developing talent through hands-on mentorship, coaching, and leadership support Workplace that embeds continuous learning and career development as a core part of how we grow and excel Environment where strong performers take on increasing leadership, commercial responsibility, and client ownership Guidepoint is passionate about your career growth: Check out our Client Service Career Trajectory What You Will Own: Recruit new experts into Guidepoint’s network and engage them for client consultations Independently conduct targeted research across LinkedIn, press releases, company websites, case studies, and other public sources to identify relevant subject-matter experts Lead cold outreach, phone-based vetting, and screening conversations with experts t

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Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time
✓ High-confidence listingCompany trend -84.1%
Quick readStrong listing-quality and freshness signals

About the Team OpenAI’s Hardware organization develops silicon and system-level solutions designed for the unique demands of advanced AI workloads. The team is responsible for building the next generation of AI-native silicon while working closely with software and research partners to co-design hardware tightly integrated with AI models. In addition to delivering production-grade silicon for OpenAI’s supercomputing infrastructure, the team also creates custom design tools and methodologies that accelerate innovation and enable hardware optimized specifically for AI. About the Role We are looking for an experienced Mechanical Engineer with 7+ years of experience in design of IT hardware from chip/package to system levels. You’ll work alongside experts in thermal, mechanical, electrical, software, and systems engineering to support the design, analysis, and validation of mechanical and thermal systems that ensure the reliability, efficiency, and longevity of mission-critical hardware. This position requires strong analytical skills, hands-on testing experience, and the ability to work in a fast-paced, cross-disciplinary environment. This role is based in San Francisco, CA. We use a hybrid work model of 3 days in the office per week and offer relocation assistance to new employees. In this role, you will: Lead mechanical design for AI supercomputer product in the data center application Collaborate with the cross functional team to design and optimize thermal solutions for data center hardware, including chips, power modules, and system-level cooling architectures Collaborate with cross-functional teams to integrate thermal management strategies into hardware design, from concept to mass production Design and validate mechanical systems, including chassis, enclosures, cooling systems, and high-power connections, ensuring alignment with performance and reliability standards. Perform 3D modeling, FEA, tolerance analysis, and prototyping, ensuring manufacturability and a

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📍 San Francisco, California, United States· Full-time
✓ High-confidence listingCompany trend -84.1%
Quick readStrong listing-quality and freshness signals

About the Team The Consumer Devices team at OpenAI builds end-to-end hardware and software systems that bring AI into the physical world. We work at the intersection of custom silicon, embedded systems, operating systems, cloud services, mechanical engineering, electrical engineering, and product design to deliver reliable, production-ready devices at scale. Within Consumer Devices, Hardware Engineering eXperience, or HEX, is a new bootstrapped team building the environments, applications, compute, product-data systems, and workflows that let hardware engineers do their work without needing to troubleshoot the machinery underneath. HEX owns virtual engineering environments, HPC/GPU compute, storage, networking, licensing, MCAD/ECAD/CAE applications, PLM, product data, automation, validation, and support as one connected system. About the Role As a Staff PLM & Engineering Applications Engineer, you will be one of the first technical builders of HEX and the primary counterpart to the HEX lead. You will own the engineering-application and product-data side of the hardware engineering experience, with an initial focus on NX, Teamcenter, licensing, parts import, integrations, packaging, validation, and user workflows. This is not a traditional Teamcenter administration role and not a Corporate IT application-support role. You will take complex, fragile workflows and turn them into reliable engineering systems. This role is highly hands-on and systems-oriented. You will not inherit a mature environment and support queue. You will help build a fresh one, replacing manual setup guides, tribal knowledge, repeated support issues, and team handoffs with tested automation and reliable workflows. In This Role, You Will Own the technical architecture, deployment, configuration, integration, validation, and long-term operation of NX and Teamcenter. Build reliable workflows for parts import, product-data migration, metadata quality, BOMs, revisions, lifecycle states, and releas

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Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time· Remote
✓ High-confidence listingCompany trend -84.1%
Quick readStrong listing-quality and freshness signals

About the Team OpenAI’s Hardware organization develops AI-native silicon and system-level solutions for the unique demands of advanced AI workloads. Building on efforts like Jalapeño, the team is developing future generations of AI-native silicon and tightly integrated systems to power the next generation of frontier models. By co-designing chips, systems, tools, and methodologies, the team helps deliver faster, more efficient, and production-ready hardware for OpenAI’s supercomputing platform. About the Role We’re looking for a product manufacturing & quality engineer, who will be responsible for driving technical initiatives related to the manufacturing, quality and reliability of our AI supercomputer hardware systems to ensure product success from concept to launch and through mass production. You’ll have the opportunity to coordinate with functional SMEs and work with a wide range of stakeholders, from design engineering and operations teams, TPMs, external industry vendors and partners to ensure that all products are developed and delivered on time and to the highest quality standards. This role is based in San Francisco, CA. We use a hybrid work model of 3 days in the office per week and offer relocation assistance to new employees In this role, you will: Own the integrated manufacturing and quality readiness for a product across L6, L10, and L11, with clear gates, milestones, deliverables, owners, and closure criteria. Lead readiness of process flows, tooling, fixtures, assembly operations, test interfaces, and production controls. Review and contribute to work instructions. Translate product requirements into qualification plans, process controls, test requirements and acceptance criteria with design engineering and Area SMEs Coordinate and drive execution of product and process qualification, reliability testing, and validation with the relevant SMEs. Maintain traceable evidence that assigned products and processes meet agreed performance, reliability,

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📍 San Francisco, United States· Full-time
✓ High-confidence listingCompany trend -60%

From $130K/yr

Quick readStrong listing-quality and freshness signals

About Mixpanel Mixpanel is the leading product intelligence and analytics platform, trusted by more than 29,000 companies to help understand how people use the products they build. By combining powerful analytics with AI that knows your business, Mixpanel helps teams see what’s working, diagnose what’s not, and decide what to build next. Learn more at mixpanel.com . About the Team The Revenue Marketing team at Mixpanel is responsible for pipeline generation across paid, website, and product-led channels. This role sits within that team as its dedicated engineering owner — accountable for the technical systems that power how people discover, evaluate, and request Mixpanel. You are the only engineer dedicated to this surface, which means you set its technical direction rather than execute against someone else's. You work directly with our marketing teams and partner with Growth Engineering on shared systems. Website design and content are handled by our web design team; your focus is the technical infrastructure, integrations, and systems that sit underneath. About the Role As our Marketing Systems Engineer, you own the technical layer of our marketing engine: the integrations and infrastructure that power our marketing website. The website is our primary lead capture system that turns traffic into pipeline. You own the systems that connect our marketing surface to Salesforce, Customer.io/Hubspot, and our broader GTM stack. You set the technical roadmap for this surface, move fast, measure impact, and treat reliability as a first-class concern rather than a cleanup task.You will also collaborate with Growth Engineering on shared infrastructure including handraiser routing and tracking. Responsibilities Own the technical health of the Mixpanel marketing website: page speed, WCAG compliance, Google Tag Manager, technical SEO, and third-party integrations including Qualified, Optimizely, and TrustArc. Own the integrations between the marketing website and our GTM stack t

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📍 San Francisco, United States· Full-time
✓ High-confidence listingCompany trend -99%

From $204K/yr

Quick readStrong listing-quality and freshness signals

Airbnb was born in 2007 when two hosts welcomed three guests to their San Francisco home, and has since grown to over 5 million hosts who have welcomed over 2 billion guest arrivals in almost every country across the globe. Every day, hosts offer unique stays and experiences that make it possible for guests to connect with communities in a more authentic way. The Community You Will Join: The Total Rewards Compensation team serves as a strategic advisor to business leaders, managers, and employees across Airbnb. We are compensation experts with a deep understanding of our stakeholders, problem solvers who use data and insights to drive value, and partners who build the tools, models, and frameworks that support sound compensation decision-making across the company. This role sits within the Compensation function and will work closely with the Technology organization and cross-functional partners including Talent Directors, Recruiting, People Analytics, Finance, and Legal. The Difference You Will Make: We are looking for a Senior Compensation Partner to own Airbnb's compensation strategy for the Technology organization, covering functions such as Engineering, Infrastructure, ML/AI and Data Science. You will be the primary Total Rewards advisor to Technology leadership and the compensation point of contact for Talent Directors and Recruiting, defining how Airbnb competes for AI, ML, and frontier engineering talent. Working alongside our regional Total Rewards Partners, you will hold a global view of how we pay technical talent across all markets. Beyond your client group, you will contribute to the design and strategy of complex global programs, lead core Total Rewards priorities, and build the models and tools the broader Compensation team relies on. You are equally credible advising our most senior technical leaders and in the data behind the recommendation. A Typical Day: Serve as the senior compensation advisor to Technology leadership across func

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📍 San Francisco, California, United States· Full-time· Remote
✓ High-confidence listingCompany trend -84.1%
Quick readStrong listing-quality and freshness signals

About the Team OpenAI’s Legal team helps advance our mission by tackling novel legal issues in AI. Our team brings together professionals across technology, privacy, intellectual property, corporate, employment, tax, regulatory, and litigation. Our regulatory compliance work turns legal requirements into practical programs that support responsible AI development and deployment. About the Role As a Legal Program Manager focused on regulatory compliance, you will build and manage cross-functional programs that translate counsel’s guidance into practical, sustainable operations. Your initial focus may include content moderation and/or frontier AI governance, with the mix shaped by team priorities and your strengths. You will partner with internal and external counsel, other legal program managers, and technical and business teams to coordinate implementation, evidence collection, reporting, and ongoing compliance. You’ll build repeatable systems that scale across regulations, products, and jurisdictions, helping teams navigate emerging requirements with clarity and sound judgment. This full-time role is based in San Francisco, CA, or New York, NY. In this role, you will: Lead regulatory compliance programs end to end: define scope, owners, milestones, dependencies, risks, and escalation paths, and drive execution with counsel and cross-functional partners. Translate counsel’s regulatory guidance into repeatable workflows, controls, and documentation. Depending on your portfolio, this may include content moderation disclosures, transparency reporting, reporting and appeals workflows, or frontier AI model launch readiness, evaluation and risk-management evidence, and incident reporting. Build strong partnerships across Product, Engineering, User Operations, Governance, Risk and Compliance (GRC), Global Affairs, Communications, and Go-to-Market to align program priorities and deliverables. Support regulatory inquiries, audits and investigations with counsel, organizing ev

SQLAWSRestAI
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📍 San Francisco, California, United States· Full-time· Remote
✓ High-confidence listingCompany trend -84.1%
Quick readStrong listing-quality and freshness signals

About the Team The Cooperative AI team is scaling OpenAI with OpenAI. We are building a model-powered scaled automated workforce and knowledge system that evolves and learns alongside a human workforce. By leveraging OpenAI’s state-of-the-art models and technologies, some already in production, others still in the lab, we develop systems that reason and work autonomously for a wide variety of operational work. We leverage real workloads for critical systems across finance, sales, customer support, integrity, product insights, internal operations, and more in order to drive insights into product and industry. We partner closely with internal teams and external customers globally, operating in a hyper-fast feedback loop where many of our users are just a few steps away. This proximity allows us to iterate quickly, validate impact in real time, and accelerate industry impacting learnings and systems builds. We are a highly multidisciplinary, self-contained team focused on transforming the workplace via smart systems, knowledge, scalable and reliable primitives that apply world-class AI capabilities across domains. Our mission is to learn fast and transform how humans collaborate with AI at scale. About the Role We are looking for a hands-on Engineering Manager to lead a small, fast-moving team building AI-powered automation systems that redefine how work gets done across OpenAI. This role sits at the intersection of applied AI, research, and product engineering. You’ll lead a team that builds systems that know how to learn from humans, and carry real workloads across, sales, support, finance, IT, and more, while staying deeply involved in the technical work. You will operate in a highly iterative environment, deploying systems directly to internal users, gathering rapid feedback, and evolving solutions in real time. This is a high-ownership role for someone excited about building 0→1 systems, working closely with customers, and shaping how AI transforms operational wor

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📍 San Francisco, California, United States· Full-time· Remote
✓ High-confidence listingCompany trend -73.5%
Quick readStrong listing-quality and freshness signals

We believe that the way people interact with their finances will drastically improve in the next few years. We’re dedicated to empowering this transformation by building the tools and experiences that thousands of developers use to create their own products. Plaid powers the tools millions of people rely on to live a healthier financial life. We work with thousands of companies like Venmo, SoFi, several of the Fortune 500, and many of the largest banks to make it easy for people to connect their financial accounts to the apps and services they want to use. Plaid’s network covers 12,000 financial institutions across the US, Canada, UK and Europe. Founded in 2013, the company is headquartered in San Francisco with offices in New York, Seattle, Washington D.C., Raleigh, London, and Amsterdam. The Fraud Data team at Plaid builds the machine learning systems that power Plaid’s fraud detection products, leveraging insights from across Plaid’s network to help identify and stop fraud before it happens. Our team works across the full data science and machine learning lifecycle—from discovering new signals and experimenting with models to deploying and optimizing them in production. We continuously learn from real-world model performance and customer feedback to improve our systems and develop new ways to protect customers and consumers from evolving fraud threats. As a Senior Machine Learning Engineer on Plaid's Fraud Data team, you will develop models that improve fraud detection for our customers. You will identify predictive patterns in Plaid's network data and lead projects from initial experiments through model deployment and ongoing improvement. Investigate fraud patterns and model errors to identify new signals, improve detection, and expand coverage across customers and use cases. Develop training datasets and predictive features, addressing challenges such as incomplete labels, class imbalance, data leakage, and changing fraud behavior. Design, train, and tune model

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📍 San Francisco, California, United States· Full-time· Remote
✓ High-confidence listingCompany trend -73.5%
Quick readStrong listing-quality and freshness signals

We believe that the way people interact with their finances will drastically improve in the next few years. We’re dedicated to empowering this transformation by building the tools and experiences that thousands of developers use to create their own products. Plaid powers the tools millions of people rely on to live a healthier financial life. We work with thousands of companies like Venmo, SoFi, several of the Fortune 500, and many of the largest banks to make it easy for people to connect their financial accounts to the apps and services they want to use. Plaid’s network covers 12,000 financial institutions across the US, Canada, UK and Europe. Founded in 2013, the company is headquartered in San Francisco with offices in New York, Seattle, Washington D.C., Raleigh, London, and Amsterdam. About the Team The Fraud Partnerships Pod is responsible for overseeing all traditional business development and partnerships for the Anti-Fraud Product Area (PA) at Plaid, focusing primarily on our product partnerships and data acquisition (supply side) efforts. The team supports all products under the Fraud Product Area's purview: IDV, Monitor, Layer, and Protect. About the Role You will have an opportunity to lead the strategy and execution of our supply side and "data in" efforts for our Fraud product area across four products (Plaid IDV, Monitor, Layer, and Protect). You will own all critical data partner relationship management with key stakeholders and be expected to grow them over time. You will be the internal quarterback driving alignment with key major internal stakeholders at Plaid, including Finance, BizOps, Commercial, Legal, and Risk. What You'll Do Spend the majority of your time working hand in hand with product leadership as well as other cross-functional leaders to operationalize our data partners for all fraud products at Plaid. Help our data science and research teams define the source data ecosystem for IDV and Protect according to our 3-year strategy. Help e

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📍 San Francisco, California, United States· Full-time· Remote
✓ High-confidence listingCompany trend -73.5%
Quick readStrong listing-quality and freshness signals

We believe that the way people interact with their finances will drastically improve in the next few years. We’re dedicated to empowering this transformation by building the tools and experiences that thousands of developers use to create their own products. Plaid powers the tools millions of people rely on to live a healthier financial life. We work with thousands of companies like Venmo, SoFi, several of the Fortune 500, and many of the largest banks to make it easy for people to connect their financial accounts to the apps and services they want to use. Plaid’s network covers 12,000 financial institutions across the US, Canada, UK and Europe. Founded in 2013, the company is headquartered in San Francisco with offices in New York, Seattle, Washington D.C., Raleigh, London, and Amsterdam. About the Team The Workplace Experience (WPE) team is responsible for shaping the employee experience at Plaid, ensuring that our workspaces, events, and cultural touchpoints drive connection, collaboration, productivity, and engagement. Within WPE, the Events & Experiences team brings Plaid's culture to life by designing and executing programs that foster belonging and engagement across both in-office and distributed environments. The team curates a wide range of experiences—from flagship company-wide gatherings to in-office celebrations, DEIB initiatives, virtual events, and milestone moments. They also lead Plaid's in-person onboarding, ensuring every new hire has a meaningful, high-impact introduction to our culture, values, and ways of working. About the Role We're looking for an Onboarding Coordinator to join our Employee Experience team in San Francisco. You'll help create a warm and seamless welcome for new Plaids by coordinating onboarding logistics, supporting new-hire travel, answering questions, and assisting with in-person sessions. You'll also support employee events and programs that help Plaids feel connected, valued, and engaged. What You'll Do Onboarding Help

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📍 San Francisco, California, United States· Full-time· Remote
✓ High-confidence listingCompany trend -84.1%
Quick readStrong listing-quality and freshness signals

About the Team OpenAI's Environmental, Health & Safety (EHS) team partners across the company to enable safe, responsible growth. This role will be a senior EHS partner to our robotics operations as our operating footprint expands. You will work closely with Robotics, Engineering, Operations, Facilities, Workplace, Construction, Security, People, Legal, and external partners to integrate safety into how our facilities are designed, built, staffed, and operated. About the Role We are seeking a Senior Manager, EHS - Robotics to provide senior, hands-on safety leadership across multiple sites. This role is for an experienced EHS leader who can operate independently in a fast-moving technical environment, anticipate risk before it becomes an incident, and build practical safety systems that scale with the business. Our robotics operations are scaling quickly, with a growing mix of construction, commissioning, workforce expansion, and around-the-clock operations. This creates a complex and evolving risk environment and requires strong preventive planning, consistent field presence, and sustained incident-management oversight. This leader will own site-level EHS strategy and execution for the robotics portfolio while partnering with the broader EHS team on company-wide standards and programs. The successful candidate will look around corners: planning for future ramps, identifying requirements early, influencing design and operating decisions, and creating durable systems that enable teams to move quickly without compromising safety. In this role you will: Serve as a senior EHS partner across robotics R&D operations, owning site-level safety strategy, priorities, and execution as the footprint scales. Anticipate EHS requirements for new operations, equipment, processes, construction phases, staffing ramps, and 24/7 operations, and translate them into practical plans before work begins. Lead proactive risk identification and control across robotics activities, incl

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Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time· Remote
✓ High-confidence listingCompany trend -84.1%
Quick readStrong listing-quality and freshness signals

About the Team OpenAI’s mission is to ensure that general-purpose artificial intelligence benefits all of humanity. The Youth team is focused on making AI safe, useful, and empowering for young people. Our work spans foundational protections—including age assurance and always-on safety—as well as new learning and education experiences. We’re also exploring how OpenAI’s technology can support K–12 schools, educators, classrooms, and collaborative learning. About the Role We’re looking for a staff-level product designer to shape how young people safely engage with AI and help define OpenAI’s emerging education experiences. You’ll work across immediate product needs and ambitious zero-to-one opportunities, from age-appropriate safety systems to tools for learning and group work. A high craft bar is imperative. You’ll be expected to pair exceptional interaction and visual design with deep product thinking—turning complex questions around safety, learning, and institutional needs into experiences that feel clear, trustworthy, and engaging. This is a highly generative role for someone who can move from early exploration to concrete, high-fidelity product direction. You’ll partner closely with product, engineering, research, safety, policy, and design to establish durable patterns for a space that is still being defined. This role is based in our San Francisco HQ. We offer relocation assistance to new employees. In this role you will: Establish an exceptionally high standard for craft across OpenAI’s youth and education experiences. Lead end-to-end design for products that help young people use AI safely, confidently, and productively. Design clear, age-appropriate experiences for safety, age assurance, and other sensitive or high-trust interactions. Shape zero-to-one K–12 experiences spanning school districts, educators, classrooms, collaborative work, and builder-style workflows. Turn emerging ideas into compelling concepts, prototypes, and high-fidelity product experien

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📍 San Francisco, California, United States· Full-time
✓ High-confidence listingCompany trend -84.1%
Quick readStrong listing-quality and freshness signals

About the Team OpenAI, in partnership with our capital and technology partners, is building a global network of advanced datacenters to support the most demanding AI workloads. The Industrial Compute team ensures that all datacenter systems are manufactured, delivered, and commissioned to the highest standards of quality, reliability, and performance. We work closely with manufacturing partners, engineering teams, and operations staff to ensure that every component is delivered ready for installation, startup, and long-term service. About the Role We are seeking an experienced Quality Engineer (QE) to drive Product and Site Quality initiatives across OpenAI’s infrastructure ecosystem. In this role, you will establish, implement, and manage a comprehensive, quality-focused program across our global supply chain network, ensuring excellence from design through deployment. You will be responsible for end-to-end quality of finished products, as well as maintaining and elevating manufacturing site quality standards. Working cross-functionally with Design (NPI) and Engineering teams, you will help achieve First Pass Yield (FPY), quality, and reliability targets. This includes leading site and fixture validation efforts, driving yield improvement initiatives (Yield Bridge, CPI), and implementing robust corrective and preventive actions (CAPA) to resolve issues at their root cause. In addition, you will play a key role in supplier quality management, assessing and qualifying new vendors, overseeing ongoing supplier performance, and ensuring readiness for future business awards. You will lead vendor audits, monitor key performance metrics, and coordinate corrective actions to ensure predictable delivery schedules, reduced operational risk, and high system reliability. By partnering closely with external suppliers and internal Engineering and Operations stakeholders, you will help ensure OpenAI’s datacenter infrastructure is delivered on time, meets the highest quality standa

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