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Lead Enterprise Systems Engineer in San Francisco

607 active opportunities · Updated October 2026

Explore current lead enterprise systems engineer jobs in San Francisco. Filter by work mode, employment type, experience, department, date posted and distance.

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📍 San Francisco, California, United States· Full-time
✓ High-confidence listingCompany trend -79.2%

From £240K/yr

Quick readStrong listing-quality and freshness signals

Who are we? Cohere is the leading security-first enterprise AI company. We build cutting-edge foundation AI models and end-to-end products that are designed to solve real-world business problems. We’re training and deploying frontier models for enterprises who are building AI systems. We believe that our work is instrumental to the widespread adoption of AI and we are looking for folks that want to be part of that. We obsess over what we build. Each one of us is responsible for contributing to increasing the capabilities of our models and the value they drive for our customers. Cohere is a team of researchers, engineers, designers, and more, who are all passionate about their craft. We are a global technology company headquartered in Toronto with key offices in London, New York City, San Francisco, Montreal, Paris, Berlin and Seoul. Join us! Why this role? Cohere is building a Communications team worthy of a world-class technical organization, and Corporate Communications is at the center of that ambition. We're looking for a Director, Corporate Communications to own and evolve Cohere’s narrative globally as we grow to become the transatlantic leader in sovereign AI. This is a rare opportunity to build a comprehensive Corporate Communications function at a fast-growing company in the most dynamic space in technology. In this cross functional role, you will oversee critical functions including corporate, executive, policy, internal, crisis, and enterprise communications. You'll create the communications strategy that fuels our growth among governments and enterprises in the most highly-regulated industries. You’ll partner directly with C-Suite executives, nurture how we talk to customers, partners, and employees, and most importantly - build and lead a high-performing team that thrives off collaboration and scrapiness. This is a role for someone who likes to take big swings – and have fun doing it – where no job is too big or too small. As Director, Corporate Communi

GitRestAIGo
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Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -84.1%

About the Team OpenAI’s mission is to ensure that general-purpose artificial intelligence benefits all of humanity. The Payments team works across product, engineering, design, and finance to build the financial infrastructure that makes OpenAI’s products accessible to consumers and enterprises around the world. As AI introduces new ways for people and organizations to work, the team is defining how to support and monetize emerging forms of product usage, from usage-based pricing to agentic work. We’re building the foundational systems that help OpenAI products deliver clear, reliable, and scalable payment experiences while ensuring that this powerful technology is deployed responsibly. About the Role In this role, you’ll lead design for one of OpenAI’s most foundational product areas: the payments and monetization infrastructure that supports our consumer and enterprise products. You’ll partner closely with product, engineering, and cross-functional teams to shape how customers understand, manage, and pay for entirely new kinds of AI usage. Your work will extend beyond traditional checkout and billing. You’ll help define the systems, frameworks, and experiences behind durable pay-as-you-go models, Codex usage, and agentic workflows, translating complex business and technical requirements into intuitive experiences. As a product designer in a highly ambiguous and rapidly evolving space, you’ll influence both product strategy and the underlying infrastructure that OpenAI products depend on. This role is based in our San Francisco HQ. We offer relocation assistance to new employees. In this role, you will: Lead the design direction for foundational payments, billing, and monetization experiences across OpenAI’s consumer and enterprise products. Design and ship high-quality, end-to-end product experiences, from early systems and interaction concepts to high-fidelity prototypes and production-ready designs. Shape the infrastructure and product frameworks that support em

AWSRestAIGo
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📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -84.1%

About the Team The Employee Technology & Experience (ETX) team is responsible for delivering a world-class internal technology experience that enables employees to do their best work. We support and operate the employee-facing systems that keep the company moving quickly and efficiently. ETX spans support, logistics, AV, identity, endpoints, SaaS administration, automation, enterprise tooling, and internal infrastructure operations. We partner closely with Security, Engineering, Workplace, Finance, People, and other teams to keep OpenAI’s internal technology reliable, scalable, and moving at the pace of the company. About the Role We are hiring a Program Manager to help scale how IT operates across OpenAI. This role will lead complex cross-functional programs that improve operational maturity, streamline how teams work together, and turn high-impact initiatives into durable operational capabilities. You will work across IT, Security, Engineering, Workplace, and other functions to drive alignment, remove friction, and help build the operational foundation needed to support OpenAI’s rapid growth. You’ll be responsible for: Lead cross-functional operational programs that improve scalability, consistency, and operational maturity. Drive operational excellence initiatives across IT Support, employee lifecycle operations, meeting room and calendaring services, onsite support, vending, and research support environments. Build operating models, readiness plans, escalation paths, governance cadences, and success metrics for complex operational programs. Partner with technical teams to ensure new deployments, infrastructure investments, and internal platforms are operationally ready and sustainably supported at scale. Drive high-priority operational programs supporting company growth, including infrastructure expansion, operational integrations, and other emerging initiatives. Improve operational visibility, stakeholder alignment, and coordination across long-running cros

AWSRestAIGo
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Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time
✓ High-confidence listingCompany trend -84.1%
Quick readStrong listing-quality and freshness signals

About the Team The Product & Platform teams at OpenAI are responsible for delivering the company’s most impactful offerings—such as ChatGPT, our API platform, and new enterprise capabilities—to a global and diverse customer base. These systems must perform at scale and deliver exceptional experiences to developers, consumers, and businesses alike. The ChatGPT Multimodal team works across voice, image generation, and other multimodal experiences to turn frontier research capabilities into reliable products. The team connects product usage and failure patterns with research, evaluation, data, inference, capacity, and external partnerships so that model and product improvements translate into better experiences for users. About the Role We are seeking a Technical Program Manager to build the flywheel that helps ChatGPT multimodal products learn from real-world usage and improve quickly. You will lead programs spanning production-signal mining, evaluation and data pipelines, research-to-production parity, multimodal capacity planning, and complex cross-functional dependencies for voice and image-generation launches. You will work closely with product engineering, research, Human Data, inference and capacity teams, safety partners, and external vendors or product partners. Success requires technical depth, strong systems thinking, comfort with ambiguity, and the ability to turn fragmented or manual work into durable mechanisms that teams adopt. This role is based in San Francisco, CA. We use a hybrid work model of 3 days in the office per week and offer relocation assistance to new employees. In this role, you will: Build a system for mining production conversations and product signals to identify representative multimodal workflows, user needs, and failure modes. Establish and maintain evaluations for the highest-priority multimodal behaviors and use cases, with clear coverage, quality standards, and ownership. Package production signals into decision-ready data and

AWSRestMachine LearningAI
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Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -84.1%

About the Team The Product & Platform teams at OpenAI are responsible for delivering the company’s most impactful offerings—such as ChatGPT, our API platform, and new enterprise capabilities—to a global and diverse customer base. These systems must perform at scale and deliver exceptional experiences to developers, consumers, and businesses alike. The ChatGPT engineering org builds and operates the systems that bring product improvements to users across backend services, web, mobile, and desktop platforms. The Developer Velocity team partners with product engineering, platform, infrastructure, reliability, engineering acceleration, and observability teams to make everyday development faster and releases safer, more predictable, and easier to operate. About the Role We are seeking a Technical Program Manager to improve developer velocity and deployment excellence across ChatGPT. You will lead durable improvements to local development, CI, testing, build systems, release trains, progressive rollout, and post-deployment validation. You will identify the highest-leverage sources of engineering friction, align teams around shared standards and metrics, and drive adoption of tooling and workflows that improve both speed and reliability. This role combines systems thinking, technical program leadership, and hands-on operating rigor across a broad engineering surface. This role is based in San Francisco, CA. We use a hybrid work model of 3 days in the office per week and offer relocation assistance to new employees. In this role, you will: Own the cross-functional roadmap for improving local development, CI, testing, build workflows, and release infrastructure. Create a durable intake and prioritization mechanism for developer friction, using evidence to focus teams on the highest-impact improvements. Lead programs that improve deployment speed and safety, including pre-merge confidence, progressive rollout, release guardrails, rollback readiness, and post-deploy valida

AWSCI/CDRestAI
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Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -84.1%

About the Team OpenAI’s mission is to ensure that artificial general intelligence benefits all of humanity. Safely delivering increasingly capable AI systems requires scalable technical safeguards, clear ownership of emerging risks, rigorous deployment readiness, and close coordination across research, engineering, product, operations, legal, policy, and external partners. Our Technical Program Managers lead complex, high-stakes initiatives that turn safety commitments into deployed systems and measurable outcomes. We work across model development, infrastructure, product, and operational response to help ensure our technology is deployed responsibly and cannot be used to cause serious real-world harm. About the Role We’re seeking Technical Program Managers to drive complex product, platform, and safety initiatives across ChatGPT, API, enterprise, and related deployment environments. These roles operate at the intersection of technical strategy and execution: you will turn safety and product priorities into actionable plans, influence architectural and operational decisions, and deliver durable capabilities across model, infrastructure, application, and platform layers. Depending on the role, you may enable sensitive or high-impact model deployments, integrate safeguards into cloud and API platforms, prevent violent misuse and other serious harms, improve detection and enforcement systems, create platform solutions for safety or establish new programs as risks evolve. You will partner deeply with engineers, researchers, product managers, and operational teams while communicating technical tradeoffs and program decisions to senior leadership. You bring technical fluency, product judgment, and a strong execution record. You’re comfortable navigating ambiguity, advocating for users and developers, balancing safety with model usefulness, and leading cross-functional work with urgency, rigor, and empathy. Specific focus areas and scope will vary by opening and level. Thi

AWSRestMachine LearningAI
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Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -84.1%

About the Team The Product & Platform teams at OpenAI are responsible for delivering the company’s most impactful offerings—such as ChatGPT, our API platform, and new enterprise capabilities—to a global and diverse customer base. These systems must perform at scale and deliver exceptional experiences to developers, consumers, and businesses alike. Technical Program Managers at OpenAI play a key leadership role in scaling these efforts, partnering deeply with product, engineering, design, and go-to-market teams to bring ambitious ideas to life and ensure clarity and discipline in execution. About the Role We are hiring a Technical Program Manager to support OpenAI's critical AI deployments across strategic cloud partners. This role is designed for a candidate who can operate as an end-to-end owner across internal engineering teams and external partner organizations. This role will drive the technical strategy and execution required to bring OpenAI models and platform capabilities into partner environments responsibly and at scale. The work spans engineering deliverables, shared roadmaps, model launch pipelines, technical integration, launch readiness, and post-launch follow-through. You will work closely with senior leaders across OpenAI engineering, infrastructure, product, safety, security, legal, finance, and go-to-market, as well as technical counterparts at our partners. The job is to turn broad partnership commitments into concrete execution plans, align both sides on what must land, and build repeatable mechanisms for launching OpenAI capabilities on third-party platforms. This role is based in San Francisco, CA. We use a hybrid work model of 3 days in the office per week and offer relocation assistance to new employees. In this role, you will: Lead end-to-end execution for major cloud partner programs spanning model deployment, product integration, operational readiness, launch follow-through, and partner-platform adoption. Own integrated technical roadma

AWSRestAIGo
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Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -84.1%

About the Team OpenAI’s mission is to ensure that general-purpose artificial intelligence benefits all of humanity. The Identity team builds the foundational systems that enable people, organizations, devices, and agents to securely access OpenAI products. The team works across consumer and enterprise experiences, including account structures, sign-in, authentication, recovery, privacy, permissions, administration, and agent identity. As AI systems become increasingly capable of acting on behalf of people and organizations, we are defining new models for authorization and trust across human-to-agent and agent-to-agent interactions. About the Role In this role, you’ll lead design for foundational identity experiences across OpenAI’s products. You’ll make permissions, access, risk, and administration feel clear, safe, and genuinely usable—whether someone is securing a personal account, administering access across an enterprise, signing in to another product with ChatGPT, or authorizing an agent to perform sensitive work. Your work will span established identity challenges and emerging interaction models without established design conventions. You’ll help define how users understand what an agent can access, who or what it is acting on behalf of, and when confirmation or stronger authentication should appear. Working closely with product, engineering, security, privacy, and design, you’ll translate complex policies and technical systems into coherent, trustworthy experiences. This role is based in our San Francisco HQ. We offer relocation assistance to new employees. In this role, you will: Lead the design direction for identity, account security, permissions, and administrative experiences across OpenAI’s consumer and enterprise products. Design and ship high-quality experiences spanning sign-in, authentication, account recovery, device accounts, privacy, access controls, governance, and remediation. Define mental models and interaction patterns for human-to-agent and

AWSRestAIGo
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📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -84.1%

Technical Program Manager – Applied Product & Platform About the Team The Product & Platform teams at OpenAI are responsible for delivering the company’s most impactful offerings—such as ChatGPT, our API platform, and new enterprise capabilities—to a global and diverse customer base. These systems must perform at scale and deliver exceptional experiences to developers, consumers, and businesses alike. Technical Program Managers at OpenAI play a key leadership role in scaling these efforts, partnering deeply with product, engineering, design, and go-to-market teams to bring ambitious ideas to life and ensure clarity and discipline in execution. About the Role We’re seeking a Technical Program Manager to drive complex, large-scale product and platform initiatives across ChatGPT, API, and related surfaces. This role sits at the intersection of technical strategy and execution. You’ll be responsible for translating product vision into actionable plans, shaping interfaces and experiences from both consumer and developer perspectives, and ensuring successful delivery across web, mobile, and platform layers. You’ll bring deep technical fluency, product sense, and a strong execution track record. You’re comfortable managing ambiguity, influencing architectural direction, advocating for developers, and leading cross-functional delivery with discipline and empathy. Location: San Francisco, CA (Hybrid – 3 days/week in-office) In this role, you will: Collaborate with product, engineering, and design to shape roadmaps, technical strategies, and long-term platform direction. Translate product vision into clear, scalable technical execution plans, balancing short-term delivery with long-term platform evolution. Lead end-to-end execution of cross-functional product and platform programs—from planning through launch and iteration. Own timelines, milestones, dependency management, risk mitigation, and accountability across teams. Partner with engineering teams to influence ar

AWSRestAIGo
O
Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -84.1%

About the Team The Corporate Development team sits at the intersection of OpenAI’s strategy and the global AI ecosystem. Partnering closely with research, engineering, product, GTM and business leaders, we analyze markets, technologies, and companies to identify opportunities that accelerate OpenAI’s mission and long-term strategy. Bringing together expertise in strategy, M&A, and integration, the team leads the end-to-end process of sourcing, evaluating, negotiating, and integrating acquisitions and other strategic transactions. About the Role This is a high-visibility, strategically critical, cross-functional role at the intersection of M&A execution, enterprise go-to-market, and operational excellence. You will lead the critical phase from diligence through integration planning and post-close follow-through, define repeatable integration playbooks, and partner directly with senior stakeholders to ensure each transaction delivers intended value. The ideal candidate brings structured, hands-on integration experience, with particular expertise in enterprise / B2B transactions and a passion for AI, including building an AI-native corp dev platform. This role is based in our San Francisco HQ. We use a hybrid work model of 3 days in the office per week and offer relocation assistance to new employees. In this role, you will: Lead integration planning and strategic execution for acquisitions from diligence through post-close follow-through, with clear owners, milestones, risks, and decision points. Translate deal rationale into practical integration goals and plans across product, engineering, sales, partnerships, customer success, people, finance, legal, security, systems, and communications. Partner with deal leads during evaluation and diligence to assess integration considerations, including tech stack, talent assessment, GTM alignment, transaction structure, operational readiness, and execution risk. Advise sponsors on how best to bring onboard acquisitions

AWSRestAIGo
O
Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -84.1%

About the team OpenAI’s mission is to build safe artificial general intelligence (AGI) which benefits all of humanity. This long-term undertaking brings the world’s best scientists, engineers, and business professionals into one lab together to accomplish this. In pursuit of this mission, our Go To Market (GTM) team is responsible for helping customers learn how to leverage and deploy our highly capable AI products across their business. The team is made of Sales, Solutions, Support, Marketing, and Partnership professionals that work together to create valuable solutions that will help bring AI to as many users as possible. About the role As an Account Director focused on Healthcare, you will own executive-level relationships with leading healthcare organizations, including integrated delivery networks (IDNs), health systems, academic medical centers, health insurers, digital health companies, and healthcare technology providers. You’ll help these organizations safely and effectively deploy OpenAI’s technology to improve clinical and administrative workflows, enhance patient and provider experiences, automate operational processes, and accelerate enterprise-wide AI adoption. This role blends enterprise sales expertise, technical depth, business acumen, and relationship-driven selling. You will collaborate closely with researchers, engineers, and healthcare-focused solution strategists to design secure, compliant, and high-impact AI deployments. This role is based in San Francisco. We use a hybrid work model of three days in the office per week and offer relocation assistance to new employees. In this role, you’ll: Manage a focused portfolio of large healthcare provider, payer, and healthcare technology accounts, developing long-term strategic account plans. Lead complex, multi-stakeholder sales cycles spanning clinical, operational, IT, digital transformation, and executive leadership teams. Partner with Solutions and Research Engineering to design pilots that demon

AWSGitRestAI
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📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -84.1%

About the Team OpenAI’s mission is to ensure the responsible and widespread adoption of artificial intelligence. In support of that mission, the Marketing team helps deeply understand customer audiences and market dynamics, influence the development of the right products, build sustainable and customer-aligned monetization models, and drive awareness, adoption, and usage across OpenAI’s products and platform. We take a data-driven approach to understand markets, develop monetization strategies, and uncover customer needs that shape product strategy and messaging. We partner closely with Sales, Partnerships, Product, Engineering, Research, Comms, and Design to deliver a cohesive end-to-end customer experience and lead go-to-market efforts for new product launches across channels. About the Role As a Product Marketing Manager, Research & Safety , you will shape how the world understands OpenAI’s frontier research and our approach to developing AI responsibly. You will establish the strategic narrative for some of the company’s most important research themes—including frontier capabilities, safety, preparedness, reasoning, and compute—and translate complex technical work into clear, credible stories for researchers, policymakers, and the broader public, working with cross-functional teams to translate that messaging and reach developers and enterprise. Working closely with Research, Safety Systems, Policy, Communications, and Product teams, you’ll lead the go-to-market strategy and messaging for major research and safety initiatives. You’ll develop narratives that build trust, translating technical concepts into tangible artifacts and messaging, drive industry understanding of emerging evaluation frameworks, and help communicate OpenAI’s unique perspective on responsible frontier AI development. You’ll also identify creative and non-traditional ways to bring these stories to the audiences that matter most. In this role, you will: Establish the strategic narrative f

AWSRestAIGo
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📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -83%

ABOUT BASETEN Baseten powers mission-critical inference for the world's most dynamic AI companies, like Cursor, Notion, OpenEvidence, Abridge, Clay, Gamma and Writer. By uniting applied AI research, flexible infrastructure, and seamless developer tooling, we enable companies operating at the frontier of AI to bring cutting-edge models into production. We're growing quickly and recently raised our $1.5B Series F , led by Altimeter Capital, Conviction Partners, and Spark Capital. Join us and help build the platform engineers turn to to ship AI products. THE ROLE As the Head of IT at Baseten, you will build, scale, and secure our internal technology function to support our rapid growth. Reporting to our Chief Information Security Officer, you will lead and mentor a team of 5+ IT engineers, leading the charge to transition Baseten from startup-era IT to a highly automated, enterprise-ready IT organization. You will take full ownership of corporate IT infrastructure, Helpdesk operations, corporate identity management, device lifecycles, and vendor procurement. As we scale to support the world’s most dynamic AI companies, you will ensure our internal systems scale seamlessly with our headcount, providing a secure, frictionless, and world-class technology experience for all Baseten employees. RESPONSIBILITIES Team Leadership: Manage, mentor, and grow a team of IT engineers, fostering a high-performance culture focused on technical excellence and end-user satisfaction. Helpdesk Operational Excellence: Build a fast-response support function by establishing clear response SLAs, tracking employee satisfaction metrics, and formalizing on-call and incident response processes. Zero-Touch Automation: Architect and implement automated employee onboarding, offboarding, and role-based access changes through deep integrations across HRIS, MDM, and IAM systems. SaaS Management & Procurement: Establish comprehensive SaaS management processes to eliminate shadow IT, automate access w

Machine LearningAIGoRust
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Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -84.1%

About the Team The Support team is central to ensuring that our customers' experience with our products is nothing short of exceptional. We resolve complex issues, provide technical guidance, and support customers in maximizing value and adoption from deploying our products. We work closely with Sales, Technical Success, Product, Engineering and others to deliver the best possible experience to our customers at scale. OpenAI's customers represent a range of diverse backgrounds and maturity, from individual customers to early-stage startups and established global enterprises. Given OpenAI’s breakneck shipping cadence and growth – and the expectation that it will only accelerate – our ability to architect automation systems and agentic workflows for scale is central to our ability to maintain exceptional support quality in the face of AGI. About the Role We are seeking a Support Operations Lead who combines operational leadership, systems thinking, vendor management, and hands-on execution. You’ll own service health, automation programs, partner and vendor management. In addition to delivering high-quality service, you’ll identify opportunities to reduce manual work, experiment with tools and help operationalize AI across support at scale. This is not a traditional support operations lead role. We’re looking for someone to help us define the future of support, who thrive at the intersection of team/project management, systems building, data science/engineering, and with deep craft experience in the support operations space. This role is based in San Francisco, CA. We use a hybrid work model of 3 days in the office per week and offer relocation assistance to new employees. In this role, you will: Lead and evolve organizational design for our frontline operations across partner and vendor management, coaching teams to expand automation and deliver measurable capacity gains. Lead multi-site partner management, including commercial ownership, capacity planning and workfor

AWSRestAIGo
O
📍 San Francisco, California, United States
✓ High-confidence listing
Quick readStrong listing-quality and freshness signals

Strength in Trust OneTrust’s mission is to enable innovation through the responsible use of data and AI. We believe that ensuring data is trusted shouldn’t slow teams down—it should accelerate what’s possible. This led us to develop the first technology platform for responsible data use in 2016. Today, with AI representing the latest and most impactful expansion of data yet, OneTrust is once again redefining what responsible innovation looks like. OneTrust, the AI‑Ready Governance Platform™, unifies regulatory intelligence, automation, and connected governance workflows so businesses can continue to move at the speed of AI while ensuring good governance to prevent data misuse at scale. Trusted by thousands of organizations worldwide, OneTrust is shaping the future where trusted data becomes a transformative force for business and society. The Challenge As a Senior Staff Software Engineer, you will serve as a technical leader for OneTrust’s AI Governance (AIG) platform, driving the design, scalability, and reliability of systems that enable enterprises to deploy and govern AI and LLM-powered applications responsibly. You will deeply understand how customers build, deploy, and operate AI systems, and translate those needs into secure, compliant, and observable platform capabilities. Your Mission Development Lead the design and development of Java/Python microservices and shared libraries integrating with AI platforms for OneTrust’s AI Governance product. Design, build, and test cloud-native applications deployed on Microsoft Azure using Core Java, REST, and the Spring ecosystem. Lead the architecture and development of reusable AIG reporting and dashboard capabilities that integrate governance data from SQL databases and analytical platforms with runtime observability signals. Design reusable semantic-layer and metric-abstraction capabilities, including dataset contracts, metric defini

PythonJavaSQLAWS
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