Jobs in United States

Lead Systems Engineer in United States

2,598 active opportunities · Updated October 2026

Explore current lead systems engineer jobs across United States. Filter by work mode, employment type, experience, department, date posted and distance.

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Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 Massachusetts, Cambridge, United States
✓ Quality checkedCompany trend +107.7%

$162.9K – $271.5K/yr

ROLE SUMMARY: The key strategic focus within the Internal Medicine Research Unit (IMRU) is identifying novel therapies to prevent or treat metabolic diseases such as obesity and cardiovascular disease. Our goal is to build a world-class research team of dedicated scientists committed to developing a deep mechanistic understanding of the metabolic pathways underlying disease pathogenesis. As a senior scientific leader and member of the obesity discovery biology team, this individual will play a significant role in shaping the scientific direction for the obesity therapeutic area and influencing broader IMRU research strategy and portfolio priorities. The individual will help create and drive discovery research strategy across multiple programs, including target ideation, validation, translational biomarker strategy, hypothesis testing, and early clinical development within the IMRU obesity portfolio. The successful candidate will lead through both direct team leadership and influence across multidisciplinary partners, helping align scientific decisions across discovery biology, translational sciences, clinical, computational, and external collaborators. The individual will identify emerging therapeutic opportunities, advance portfolio programs with scientific rigor and urgency, and represent research strategies to internal leadership and the external scientific community. Knowledge and experience in the study of metabolic pathways are essential, and familiarity with the pathophysiology of dysmetabolic states would be advantageous. Strong self-motivation, excellent communication and interpersonal skills, and the ability to lead, mentor, and build scientific capability in a highly collaborative environment are essential. ROLE RESPONSIBILITIES: Shape and influence the scientific direction for discovery research programs aligned with IMRU therapeutic area and portfolio strategy. Ap

AIRecruitment
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📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -83.9%

About the team The Partnerships team supports OpenAI’s mission by building and managing external relationships that expand product reach, accelerate adoption, strengthen strategic capabilities, and help the company scale responsibly. We partner across the organization to develop ecosystem strategy, create shared value, and support relationships that are critical to OpenAI’s growth. About the role We’re looking for a Partnerships Manager to lead high-impact relationships across technology, product, go-to-market, and operations. You’ll manage a portfolio of strategic external partners—including technology platforms, distribution channels, service providers, and other ecosystem partners—and work closely with internal teams to turn business needs into effective partnership strategies. This role combines relationship management, commercial judgment, and hands-on execution. You’ll help evaluate new partners, negotiate agreements, improve existing programs, and create the operating mechanisms needed to manage partnerships at scale. This role is based in San Francisco or New York in office 3 days a week. In this role, you will Own and deepen relationships with key strategic and ecosystem partners. Develop partnership strategies aligned with OpenAI’s product, go-to-market, and operational priorities. Source, evaluate, and onboard new partners and service providers. Lead commercial negotiations in partnership with Legal, Business Operations, Procurement, Security, and other stakeholders. Translate complex business requirements into clear partner selection criteria and operating plans. Establish performance metrics, governance processes, and regular business reviews for strategic relationships. Identify opportunities to improve economics, service quality, resilience, and scalability across the partner portfolio. Coordinate cross-functional initiatives involving Sales, Product, Engineering, Legal, Security, Marketing, Business Operations, and other partner-facing teams. Monitor

AWSRestAIGo
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📍 United States· Full-time· Remote
✓ Quality checkedCompany trend -92.7%

At Vanta, our mission is to help businesses earn and prove trust. We believe that security should be monitored and verified continuously, and we empower companies to practice better security and prove it with ease. Vanta has a kind and talented team, and while some have prior security experience, many have been successful at Vanta without it. As a Staff Software Engineer on the Automation - Foundations team, you will lead the re-platforming of the data layer underneath Vanta’s entire compliance product. This is a migration that spans multiple teams, has to preserve every public API contract along the way, and cannot lose a single customer’s evidence while it happens. Foundations is Vanta’s data platform team. We ingest security and compliance data from across our customer’s environments, currently tens of thousands of resources per second, with single-customer bursts running into the millions. We store the data, catalog it, make it queryable, and turn it into evidence that has to survive a real SOC 2 or FedRAMP audit. We are in the middle of moving our platform from a Mongo-centric architecture to a schema-aware, Postgres-backed architecture, on a Kafka and S3 pipeline that decouples data fetching from processing. Both pipelines run in parallel today, the hard problems here are correctness under migration, eventual consistency, and multi-tenancy, in a domain where “mostly right” is not an acceptable failure mode. Visit our Vanta Engineering Blog to learn more about what our team is working on. What you'll do as a Staff Software Engineer at Vanta: Lead the migration of Vanta’s resource data model from a Mongo-centric solution to a schema-aware Postgres-backed solution and running both generations in parallel without breaking a customer integration. Drive solutions across teams that you do not own but are dependent on the platform built by your team. Design for correctness under eventual consistency with idempotent session handling, conditional writes that survive out

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📍 United States· Full-time
✓ Quality checkedCompany trend -96%

Employee Applicant Privacy Notice Who we are: Shape a brighter financial future with us. Together with our members, we’re changing the way people think about and interact with personal finance. We’re a next-generation financial services company and national bank using innovative, mobile-first technology to help our millions of members reach their goals. The industry is going through an unprecedented transformation, and we’re at the forefront. We’re proud to come to work every day knowing that what we do has a direct impact on people’s lives, with our core values guiding us every step of the way. Join us to invest in yourself, your career, and the financial world. Role Summary: This role will lead the data engineering function supporting People Analytics, including AI-assisted workforce analytics on Snowflake. This is a player-coach role requiring hands-on technical leadership plus people leadership, with strong business partnership and the ability to balance speed, quality, governance, and innovation. What you’ll do: Manage and develop data engineers Manage, coach, and grow a team of data engineers. Set expectations for quality, collaboration, delivery, and technical ownership. Create a strong engineering culture where people solve hard problems, move quickly, and enjoy the work. Collaborate with cross-functional teams, such as other data engineers, people analysts, data scientists, and business stakeholders, to translate requirements into production-ready deliverables, and communicate technical trade-offs to non-technical partners. Stay hands on Write and review production code. Lead design reviews, code reviews, and technical problem solving. Step into critical pipelines, models, or AI workflows when needed. Build scalable People data foundations Design and maintain sustainable data models, pipelines, semantic layers, and testing frameworks. Establish team practices for documentation, lineage, data quality, and observability. Own engineering standards Set standard

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📍 United States· Full-time· Remote
✓ High-confidence listingCompany trend -100%

From $200K/yr

Quick readStrong listing-quality and freshness signals

About Stitch Fix, Inc. Stitch Fix (NASDAQ: SFIX) Stitch Fix is redefining retail by combining human creativity with advanced data science and Generative AI. As we build the future of personalized shopping, we’re equally committed to building yours. We believe in investing in our team as much as our technology. Join us to be a trendsetter in the industry and help us redefine what’s possible for our clients, while we help you reach your full potential. About the Role At Stitch Fix, we are at the forefront of innovation, creating cutting-edge solutions that blend fashion, technology, and data science. Our data science team combines machine learning with expert human judgment to generate innovative recommendations and insights that transform the way our clients discover what they love. We believe in a curiosity-driven data science culture where members are empowered to deliver impact through end-to-end model development. The diversity of the problems that we work on and the data-rich environment of our business make it possible, even essential, to bring the tools of multiple disciplines to bear on our hardest problems. We are looking for an experienced Styling Algorithms Team Manager to lead a group of talented machine learning engineers and data scientists. In this role, you will shape the future of fashion technology by driving the development and deployment of our styling algorithms, which empower our human stylists to delight clients by nailing their fit and style. This includes ML-, AI-, and product-driven feature curation and testing for our proprietary styling platform, as well as client-facing AI personalization experiences, such as Stitch Fix Vision, our virtual try-on. Responsibilities: Champion bold AI and ML interventions to improve our styling experiences, enabling our stylists to have a multiplicative impact on their client connection points. Likewise, actively shape the product roadmap for direct client-facing styling experiences, expand

PythonRestMachine LearningAI
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📍 Huntington Beach, CA 92646-4808, United States
✓ Quality checkedCompany trend +89.4%

From $21/hr

Starting Hourly Rate / Salario por Hora Inicial: $21.00 USD per hour ALL ABOUT TARGET Working at Target means helping all families discover the joy of everyday life. We bring that vision to life through our values and culture. Learn more about Target here. ALL ABOUT ASSETS PROTECTION Assets Protection ( AP ) teams function to keep our guests, team and brand secure and lead through crisis events. They protect profitable sales by mitigating shortage risks, preventing, and resolving theft and fraud to ensure product is available for our guest . They also build relationships inside and outside of Target , including store leaders and public safety officials, inclusive of law enforcement. At Target , we believe in our team members having meaningful experiences that help them build and develop skills for a career. The role of a Target Security Specialist can provide you with the skills and experience of : <sp

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📍 Oswego, IL 60543-8333, United States
✓ Quality checkedCompany trend +89.4%

From $19/hr

The Starting Hourly Rate / Salario por Hora Inicial is $19.25 USD per hour. The Pay Range / Rango salarial is $19.25 USD - $28.90 USD per hour. ALL ABOUT TARGET Working at Target means helping all families discover the joy of everyday life. We bring that vision to life through our values and culture. Learn more about Target here. ALL ABOUT ASSETS PROTECTION Assets Protection ( AP ) teams function to keep our guests, team and brand secure and lead through crisis events. They protect profitable sales by mitigating shortage risks, preventing, and resolving theft and fraud to ensure product is available for our guest . They also build relationships inside and outside of Target , including store leaders and public safety officials, inclusive of law enforcement. At Target , we believe in our team members having meaningful experiences that help them build and develop skills for a career. The role of a Target Security Specialist can provide you with the skills and experience o

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📍 Midland, TX 79707-3534, United States
✓ Quality checkedCompany trend +89.4%

From $19/hr

Starting Hourly Rate / Salario por Hora Inicial: $19.00 USD per hour ALL ABOUT TARGET Working at Target means helping all families discover the joy of everyday life. We bring that vision to life through our values and culture. Learn more about Target here. ALL ABOUT ASSETS PROTECTION Assets Protection ( AP ) teams function to keep our guests, team and brand secure and lead through crisis events. They protect profitable sales by mitigating shortage risks, preventing, and resolving theft and fraud to ensure product is available for our guest . They also build relationships inside and outside of Target , including store leaders and public safety officials, inclusive of law enforcement. At Target , we believe in our team members having meaningful experiences that help them build and develop skills for a career. The role of a Target Security Specialist can provide you with the skills and experience of : <sp

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📍 Santa Monica, CA 90401-2314, United States
✓ Quality checkedCompany trend +89.4%

From $23/hr

Starting Hourly Rate / Salario por Hora Inicial: $23.25 USD per hour ALL ABOUT TARGET Working at Target means helping all families discover the joy of everyday life. We bring that vision to life through our values and culture. Learn more about Target here. ALL ABOUT ASSETS PROTECTION Assets Protection ( AP ) teams function to keep our guests, team and brand secure and lead through crisis events. They protect profitable sales by mitigating shortage risks, preventing, and resolving theft and fraud to ensure product is available for our guest . They also build relationships inside and outside of Target , including store leaders and public safety officials, inclusive of law enforcement. At Target , we believe in our team members having meaningful experiences that help them build and develop skills for a career. The role of a Target Security Specialist can provide you with the skills and experience of : <sp

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📍 Austin, TX 78758-7121, United States
✓ Quality checkedCompany trend +89.4%

From $20/hr

Starting Hourly Rate / Salario por Hora Inicial: $19.50 USD per hour ALL ABOUT TARGET Working at Target means helping all families discover the joy of everyday life. We bring that vision to life through our values and culture. Learn more about Target here. ALL ABOUT ASSETS PROTECTION Assets Protection ( AP ) teams function to keep our guests, team and brand secure and lead through crisis events. They protect profitable sales by mitigating shortage risks, preventing, and resolving theft and fraud to ensure product is available for our guest . They also build relationships inside and outside of Target , including store leaders and public safety officials, inclusive of law enforcement. At Target , we believe in our team members having meaningful experiences that help them build and develop skills for a career. The role of a Target Security Specialist can provide you with the skills and experience of : <sp

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📍 Riverhead, NY 11901-2073, United States
✓ Quality checkedCompany trend +89.4%

From $21/hr

Starting Hourly Rate / Salario por Hora Inicial: $21.00 USD per hour ALL ABOUT TARGET Working at Target means helping all families discover the joy of everyday life. We bring that vision to life through our values and culture. Learn more about Target here. ALL ABOUT ASSETS PROTECTION Assets Protection ( AP ) teams function to keep our guests, team and brand secure and lead through crisis events. They protect profitable sales by mitigating shortage risks, preventing, and resolving theft and fraud to ensure product is available for our guest . They also build relationships inside and outside of Target , including store leaders and public safety officials, inclusive of law enforcement. At Target , we believe in our team members having meaningful experiences that help them build and develop skills for a career. The role of a Target Security Specialist can provide you with the skills and experience of : <sp

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📍 Vancouver, WA 98665-8145, United States
✓ Quality checkedCompany trend +89.4%

From $21/hr

The Starting Hourly Rate / Salario por Hora Inicial is $20.75 USD per hour. The Pay Range / Rango salarial is $20.75 USD - $31.15 USD per hour. ALL ABOUT TARGET Working at Target means helping all families discover the joy of everyday life. We bring that vision to life through our values and culture. Learn more about Target here. ALL ABOUT ASSETS PROTECTION Assets Protection ( AP ) teams function to keep our guests, team and brand secure and lead through crisis events. They protect profitable sales by mitigating shortage risks, preventing, and resolving theft and fraud to ensure product is available for our guest . They also build relationships inside and outside of Target , including store leaders and public safety officials, inclusive of law enforcement. At Target , we believe in our team members having meaningful experiences that help them build and develop skills for a career. The role of a Target Security Specialist can provide you with the skills and experience o

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📍 San Francisco, CA, United States
✓ Quality checkedCompany trend -96%

Employee Applicant Privacy Notice Who we are: Shape a brighter financial future with us. Together with our members, we’re changing the way people think about and interact with personal finance. We’re a next-generation financial services company and national bank using innovative, mobile-first technology to help our millions of members reach their goals. The industry is going through an unprecedented transformation, and we’re at the forefront. We’re proud to come to work every day knowing that what we do has a direct impact on people’s lives, with our core values guiding us every step of the way. Join us to invest in yourself, your career, and the financial world. The Role: Positioned in the first line of defense (1LOD) and reporting to the Head of Business Controls, this experienced executive will act as the Business Controls Lead for SoFi’s Technology and Cybersecurity organizations. This includes comprehensive coverage of Engineering, Information Security, Infrastructure, and Data across the full SoFi Legal structure: SoFi Inc., SoFi Bank, Galileo, Technisys, and SoFi Hong Kong. The Business Controls Lead will act as the direct advisor to the Chief Technology Officer (CTO), Chief Information Security Officer (CISO), and their senior leadership teams. You will lead a team of experienced IT risk & controls team charged with promoting risk awareness and ensure the overall effectiveness of risk and compliance management program implementation and execution across the 1LOD. This role provides support, advisory services, and enables strategic alignment directly to department heads to accelerate and ensure quality execution. You will be responsible for supporting and driving consistent 1LOD adherence to critical programs, such as building and maintaining risk and control self-assessments (RCSAs); identification and evaluation of control effectiveness through control testing; 1LOD risk reporting; and supporting audits and regulatory exams. You will monitor the first l

AIFinanceSupply Chain
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📍 Bellevue, WA, United States· Full-time· Remote
✓ High-confidence listingCompany trend -92%
Quick readStrong listing-quality and freshness signals

For over 20 years, Smartsheet has empowered teams to manage work seamlessly and scale solutions smarter. Now, in our most ambitious chapter yet, we are uniting human teams with AI agents. By orchestrating the work agents do best, automating manual tasks and uncovering insights at scale, we create the space for people to focus on what truly matters: judgment, creativity, and big thinking. That is magic at work, and it’s what we show up for every day. We are looking for a VP of Product Management to lead AI product strategy at Smartsheet. You will lead a product team responsible for defining our comprehensive AI vision and roadmap, ensuring we build a cohesive, coordinated approach to how AI transforms our product. Your team will establish the strategic direction for specialized AI agents, evaluation infrastructure, and AI-powered capabilities, from platform foundations through to customer-facing features. You will report to our Chief Product and Technology Officer located in our Bellevue, WA office, or you may work remotely from anywhere in the US where Smartsheet is a registered employer. You Will: Lead a high-performing product team focused on defining and executing Smartsheet's comprehensive Applied AI product strategy. Define the strategic roadmap for AI product initiatives — from conversational experiences, MCP, automations, specialized agents, and evaluation infrastructure through to AI-powered features in customer-facing products — ensuring a cohesive, coordinated vision. Own the business outcomes of the AI portfolio — define the success metrics (adoption, retention, expansion, and revenue impact), set the targets, and hold the team accountable to them. Instrument, measure, and iterate: build the data and evaluation foundation that tells us whether AI features are actually working, and use it to make hard prioritization calls — including what to sunset. Move fast in a fast-moving space — ship, learn, and adjust in short cycles rather than waiting for per

VueAWSAIGo
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📍 California, United States· Full-time· Remote
✓ Quality checkedCompany trend -93.3%

At Snowflake, we are powering the era of the agentic enterprise. To usher in this new era, we seek AI-native thinkers across every function who are energized by the opportunity to reinvent how they work. You don’t just use tools; you possess an innate curiosity, treating AI as a high-trust collaborator that is core to how you solve problems and accelerate your impact. We look for low-ego individuals who thrive in dynamic and fast-moving environments and move with an experimental mindset — who rapidly test emerging capabilities to discover simpler, more powerful ways to deliver results. At Snowflake, your role isn't just to execute a function, but to help redefine the future of how work gets done. LEAD. STRATEGIZE. TRANSFORM. JOIN US AS A PROFESSIONAL SERVICES PRACTICE MANAGER! Are you ready to own your impact at the forefront of the data revolution ? As a Services Practice Manager , you’ll be a key driver in transforming businesses through cutting-edge cloud data solutions . You’ll collaborate with top-tier clients, strategize with elite sales teams, and lead groundbreaking professional service engagements —all while working with the best minds in the industry! This role is completely remote and can be based anywhere in the Pacific or Mountain Timezone. WHY THIS ROLE? Be a Market Leader: Own and execute a strategic vision for Professional Services. Drive Meaningful Change: Work with clients to unlock the power of data and fuel digital transformations. Lead from the Front: Manage high-impact projects, ensure seamless delivery, and drive revenue growth. Collaborate with the Best: Work cross-functionally with top industry experts to shape the future of cloud data solutions. Crush Your Goals: Meet and exceed bookings, utilization, and consumption targets while delivering exceptional customer experiences . WHAT YOU’LL DO: Spearhead services sales execution and project delivery success for key accounts. Engage C-level executives to create and execute services roadmaps tha

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