Jobs in United States

Senior Business Systems Lead in California

54 active opportunities · Updated October 2026

Explore current senior business systems lead jobs in California. Filter by work mode, employment type, experience, department, date posted and distance.

I
📍 California, United States
✓ High-confidence listing

$141.6K – $212.4K/yr

Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Summary The Staff Data Engineer is a seasoned, hands-on engineer who designs, builds, and scales data products on our cloud lakehouse, powering analytics, reporting, and AI/ML across Illumina. We are looking for someone with strong proficiency in Python, SQL, and data modeling, a solid understanding of distributed systems and system design who has built and scaled data products on modern cloud platforms such as Databricks and Snowflake. This is a hands-on, senior individual-contributor role with end-to-end ownership and leadership spanning multiple domains such as Supply Chain, Manufacturing and Quality, including mentoring engineers on our global (India-based) team. Responsibilities Partner across business, AI, and platform teams translating domain needs (e.g., SAP, Manufacturing, Quality) into well-modeled, governed and scalable data products. Design, build, and scale end-to-end data products on Databricks (and interoperating with Snowflake) — from ingestion through curated, analytics-ready datasets following a medallion (Bronze/Silver/Gold) architecture. Develop reusable frameworks, libraries, and

PythonSQLAWSGit
G
📍 California, United States
✓ High-confidence listingCompany trend +190.5%

$115.3K – $149.2K/yr

Quick readStrong listing-quality and freshness signals

We’re here for one reason and one reason only – to cure cancer. Every moment is dedicated to developing treatments and every action moves us one step closer to our goal. We’ve made incredible scientific breakthroughs and our pioneering personalized CAR T-cell therapies have changed the paradigm. But we're not finished yet. Join Kite, as we make even bigger advances in cancer therapies, and help shape where our business and medical science goes next. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Kite and help create more tomorrows. Job Description Position Summary The Senior IT Quality Engineering Specialist serves as the technical lead for the Kite Laboratory Information Management System (KLIMS) within North America West Coast (El Segundo). This role is responsible for the operational stability, compliance, maintenance, enhancement, and technical governance of the LabVantage platform and associated integrations. The position partners closely with Quality Control, Manufacturing, Validation, Infrastructure, and Kite Business stakeholders to ensure reliable and compliant laboratory operations. Key Responsibilities System Administration & Operational Support • Provide day-to-day administration and technical support for KLIMS and related

JavaSQLRecruitment
A
📍 California, USA - Remote, United States· Remote
✓ Quality checkedCompany trend +90.9%

Job Requisition ID # 26WD97363 Position Overview We are seeking a Principal Software Engineer – Backend to join Autodesk’s Enterprise Data Management (EDM) organization within the COO-GET Engineering group. This is a senior individual contributor role operating at the Principal (P4) level , expected to drive technology direction for large, complex, and business-critical backend and distributed systems . This role is anchored in backend software engineering excellence : designing, building, and evolving scalable services, APIs, and event-driven systems that operate at enterprise scale. As a Principal Engineer, you will work with high autonomy and ambiguity , shape long-term architecture, and influence multiple teams and domains. Familiarity with data engineering concepts is valuable, but backend systems, service design, and distributed systems are the core competencies. You will function as a technical authority and force multiplier—guiding design decisions, setting standards, and ensuring Autodesk’s core data services are reliable, resilient, and evolvable over time. Responsibilities Provide principal-level technical

PythonAWSAI
A
📍 California, USA - Remote, United States· Remote
✓ High-confidence listingCompany trend +90.9%
Quick readStrong listing-quality and freshness signals

Job Requisition ID # 26WD98292 Senior Art Director / Designer, Flow Studio &#64; Autodesk We are building an integrated marketing and creative team designed for how modern products grow—combining high standards, thoughtful experimentation, and a strong focus on impact. We work as One Autodesk, partnering across functions to create clear, engaging experiences that help customers understand and adopt what is next. If you are energized by creative technology, collaborative problem-solving, and the opportunity to shape how a product shows up in the world, we would love to hear from you. Autodesk builds the tools behind the world around us. From the buildings we live in to the products we use, our customers design and make what’s next, and we power that work. As we evolve into a Design and Make platform, we are creating more connected, intelligent experiences that help our customers move from idea to reality. That transformation is grounded in our One Orbit values: being Optimistic about what is possible, Relentless in pursuit of better outcomes, Brave enough to challenge convention, Ingenious in solving complex problems, Trusted in how we show up, and united as One Autodesk. Within Autodesk, Flow Studio is building a new category at the intersection of AI, creativity, and storytelling. This is an opportunity to shape how that vision comes to life through world-class design. Position Overview Flow Studio is a visual product and brand, and how it shows up matters. We need a Senior Art Director / Designer who can define and execute a modern, distinctive visual language across everything we create.<

G
📍 California, United States
✓ High-confidence listingCompany trend +190.5%

$157.6K – $203.9K/yr

Quick readStrong listing-quality and freshness signals

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description Gilead Sciences is seeking a collaborative, hands-on leader to shape and deliver the ERP capabilities for a new, next-generation bulk drug substance manufacturing facility at our Foster City site. As the site’s SAP business lead, you will translate operational needs into integrated processes across production, procurement, quality, and warehousing. Working closely with site stakeholders and the IT implementation team, you will define requirements, guide implementation, and connect SAP with other digital platforms to help create a compliant, paperless manufacturing environment. R

SapLogisticsProcurementWarehouse
I
📍 California, United States· Hybrid
✓ High-confidence listing

$82.5K – $123.7K/yr

Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Position Title: Senior Financial Analyst, R&D Finance Location: San Diego, CA (Hybrid) Reports To: Associate Director, Finance – R&D FLSA Status: Exempt Position Summary: The R&D Finance Business Partner provides finance support for a complex portfolio of R&D functions, programs, strategic initiatives, and R&D leadership team members. The role works with R&D and Finance leadership to translate technical and operational activity into clear financial insight, improve forecast accuracy, evaluate investment trade-offs, and support resource decisions across operating expense, headcount, and capital investment. This position operates as an individual contributor in a matrixed environment with limited day-to-day direction. Success requires strong financial rigor, sound business judgment, clear communication, and the ability to build trusted partnerships while maintaining appropriate financial challenge and discipline. *This is a full-time role, Monday through Friday, with an expectation of 2–3 in-office days per week and additional on-site presence as

Artificial IntelligenceAISapExcel
G
📍 California, United States
✓ High-confidence listingCompany trend +190.5%
Quick readStrong listing-quality and freshness signals

We’re here for one reason and one reason only – to cure cancer. Every moment is dedicated to developing treatments and every action moves us one step closer to our goal. We’ve made incredible scientific breakthroughs and our pioneering personalized CAR T-cell therapies have changed the paradigm. But we're not finished yet. Join Kite, as we make even bigger advances in cancer therapies, and help shape where our business and medical science goes next. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Kite and help create more tomorrows. Job Description The Senior Manager, Kite Safety and Pharmacovigilance provides scientific and strategic leadership for pharmacovigilance activities supporting Kite’s investigational and marketed products. This role serves as a senior pharmacovigilance science expert, leading complex safety analyses, regulatory deliverables, and cross-functional safety strategy execution. Key Responsibilities Aggregate Reporting and Medical Writing Serve as lead author for complex aggregate safety reports, including PSURs, PBRERs, and DSURs, synthesizing global safety data and clinical context Author and review high-impact safety documents supporting regulatory submissions and lifecycle management Safety Analysis and Signal Management <

Recruitment
H
📍 California, United States of America, United States
✓ High-confidence listingCompany trend +103.7%
Quick readStrong listing-quality and freshness signals

Business Strategy Principal – HP Solutions Strategy – SW Description - The Opportunity Join HP’s high-impact, high-visibility HP Solutions Strategy team and help shape the future of HP Solutions across software, services, AI-enabled solutions, and emerging growth areas. This team partners closely with senior HPS leaders to define long-term direction, medium-term strategic priorities, and near-term business choices that influence portfolio strategy, planning, investment priorities, and growth opportunities. This is an exciting opportunity for a highly analytical, results-oriented strategy leader who thrives in ambiguity, enjoys solving complex business problems, and wants to make a visible impact at scale. In this role, you will help translate market, customer, technology, competitive, and financial insights into clear strategic choices—especially across software, services, vertical solutions, AI-enabled offerings, and go-to-market models. You will work across executive leaders, GBU teams, product, sales, marketing, finance, category, and cross-functional partners to develop insight-driven recommendations grounded in rigorous analysis and compelling strategic narratives. The role combines strategic problem solving with portfolio and GTM rigor, business case development, pricing and packaging support, and executive-ready deliverables for high-priority leadership discussions. If you are energized by strategic problem solving, cross-functional collaboration, and building what is next for HP Solutions, we would love to hear from you. Responsibilities Develop strategic analyses and insights that inform HP’s software, services, and solutions portfolio strategy, including market trends, customer needs, competitive dynamics, portfolio maturity, and growth op

AIProject ManagementFinance
G
📍 California, United States
✓ High-confidence listingCompany trend +190.5%

$243.1K – $314.6K/yr

Quick readStrong listing-quality and freshness signals

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description The Senior Director, Applied AI Solutions, leads the applied AI function within the AI Research Center (ARC), part of Gilead’s Clinical Data Science (CDS) organization in Drug Development. As CDS’s center of excellence for applied AI, this leader is accountable for the technical and product path from a prioritized AI use case defined by CDS functional organizations to a trusted, reusable capability in production — spanning discovery, experimentation, technical validation, first production release, adoption support, and measured value. The ownership model is deliberate. Business ownership of priorities, requirements, funding, process change, and workflow outcomes remains with the CDS and Develo

Machine LearningAIRecruitment
G
📍 California, United States
✓ High-confidence listingCompany trend +190.5%

$157.6K – $203.9K/yr

Quick readStrong listing-quality and freshness signals

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description As a Senior Manager, Supplier Strategy and Management, Parenteral Packaging, at Gilead you will own business relationships with assigned suppliers of Parenteral Packaging components used with any Gilead branded product. This includes ownership of the strategy, selection, risk, and performance management of suppliers providing Parenteral Packaging components for development or commercial products. This role is responsible for both the strategic and tactical business management of these supplier relationships. You will have responsibility for indirectly leading and influencing others, bidding, selecting and managing multiple components. This position is based at the Gilead site in Foster City, C

Project ManagementFinanceSupply ChainRecruitment
G
📍 California, United States
✓ High-confidence listingCompany trend +190.5%

$157.6K – $203.9K/yr

Quick readStrong listing-quality and freshness signals

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description As a Senior Manager, Supplier Strategy and Management, Devices at Gilead you will own the business relationships with assigned suppliers of devices and device related components used with any Gilead branded product. This includes ownership of the strategy, selection, risk, and performance management of suppliers providing devices and device related components for development or commercial products. This role is responsible for both the strategic and tactical business management of these supplier relationships. You will have responsibility for indirectly leading and influencing others, bidding, selecting and managing multiple devices and device related components. This position is based at the

Project ManagementFinanceSupply ChainRecruitment
Z
📍 California, United States· Full-time· Remote
✓ High-confidence listing

From $224K/yr

Quick readStrong listing-quality and freshness signals

Zscaler (NASDAQ: ZS) accelerates digital transformation so customers can be more agile, efficient, resilient, and secure. The Zscaler Zero Trust Exchange™️ platform protects thousands of customers from cyberattacks and data loss by securely connecting users, devices, and applications in any location. Distributed across 160+ public exchanges globally and thousands of private exchanges at the edge, the SASE-based Zero Trust Exchange is the world’s largest in-line cloud security platform. We believe the future of work is Human + AI and are building an AI-native enterprise where human potential is amplified by machine intelligence to solve the world’s hardest security challenges. Driven by deep customer obsession, we are committed to the mission, outcome, and to each other. We bring these commitments to life through three core behaviors: ownership and collaboration, trust through outcomes and impact, and a challenge culture with ongoing feedback. Ready to make an impact at the company pioneering security transformation in the AI era? Join us at Zscaler. The Zscaler Sales and Go-to-Market team is a global group of professionals who are passionate about delighting our customers, nurturing trusted partnerships, and sharing their expertise to drive a secure, cloud-enabled digital future and further cement our position as the world leader in cloud security. Sales, Customer Success, Sales Enablement, Solution Architects, Business Development, Transformation, and Technology Partnerships all work together to demonstrate the power and agility of Zscaler cloud transformation to the world. We're looking for an experienced Healthcare Provider CISO/CTO to join our team sitting in the West region. Reporting to our Healthcare Strategic Leader, you'll manage the following: You will be Zscaler's technical executive sponsor with the largest healthcare providers and make technology decisions on behalf of the organization You will provide technical leadership and serve a necessary r

AWSGitAgileAI
Z
📍 California, United States· Full-time· Remote
✓ High-confidence listing

From $175.9K/yr

Quick readStrong listing-quality and freshness signals

Zscaler (NASDAQ: ZS) accelerates digital transformation so customers can be more agile, efficient, resilient, and secure. The Zscaler Zero Trust Exchange™️ platform protects thousands of customers from cyberattacks and data loss by securely connecting users, devices, and applications in any location. Distributed across 160+ public exchanges globally and thousands of private exchanges at the edge, the SASE-based Zero Trust Exchange is the world’s largest in-line cloud security platform. We believe the future of work is Human + AI and are building an AI-native enterprise where human potential is amplified by machine intelligence to solve the world’s hardest security challenges. Driven by deep customer obsession, we are committed to the mission, outcome, and to each other. We bring these commitments to life through three core behaviors: ownership and collaboration, trust through outcomes and impact, and a challenge culture with ongoing feedback. Ready to make an impact at the company pioneering security transformation in the AI era? Join us at Zscaler. We are looking for a Senior Manager, Sales Engineering, Majors West based in the United States, reporting to our Director, Sales Engineering. You will lead and grow the sales engineering organization for the core portfolio, including the Gen AI market, across the region in the US. You will align closely with GTM Sales Leaders, Product Management, and Engineering to execute strategic solutions and close deals for customers and partners. What you’ll do (Role Expectations) Recruit, mentor, and develop the sales engineering team Refine and scale core sales engineering processes including discovery, technical qualification, and proof-of-concept Partner with sales leadership and clients to design and present business solutions that drive revenue growth Work within a matrixed environment to promote and support the Zscaler portfolio through value-based selling Who You Are (Success Profile) You thrive in ambiguity. You're c

AWSGitAgileAI
P
📍 California, United States· Remote
✓ High-confidence listingCompany trend +671.4%

$108.6K – $250.7K/yr

Quick readStrong listing-quality and freshness signals

Role Summary Pfizer Commercial Oncology is introducing the world to the next era of cancer care. With a growing portfolio of novel therapies, industry-leading R&D, and a goal of delivering eight breakthroughs by 2030 across major cancer types, we're translating cutting-edge science into market-shaping impact. Here, you'll partner with exceptional colleagues across scientific, medical, and manufacturing teams, backed by advanced digital and AI-enabled infrastructure and the authority to accelerate medicines from discovery to delivery. Guided by our values of courage, excellence, equity, and joy, you'll have the opportunity to stretch your skills and build a career that evolves with you—across teams, roles, and the Pfizer enterprise. Join us to make history — for patients, for their families, for the future. The Senior Oncology Account Specialist (SOAS) will have a variety of responsibilities, ranging from promoting Pfizer’s product portfolio to health care providers and specialists, to educating members of the healthcare community regarding the appropriate use of Pfizer products, to calling on accounts and organized customers to help improve patients’ experience with Pfizer products, as well as the overall quality of patient care delivered. The SOAS plays a critical role in increasing Pfizer’s brand with high-value target customers by linking an insightful assessment of the account and/or business landscape with a strong understanding of Pfizer’s products and resources. BASIC QUALIFICATIONS BA/BS Degree from an accredited institution BA/BS Degree from an accredited institution OR an associate’s degree with 8&#43; years of experience; OR a high school diploma (or equivalent) with 10&#43; years of relevant experience. Ability to travel domestically and stay overnight as necessary Valid US driver’s license and drivin

AIRecruitment
A
📍 California, United States· Full-time
✓ High-confidence listingCompany trend -98.8%

From $210K/yr

Quick readStrong listing-quality and freshness signals

Airbnb was born in 2007 when two hosts welcomed three guests to their San Francisco home, and has since grown to over 5 million hosts who have welcomed over 2 billion guest arrivals in almost every country across the globe. Every day, hosts offer unique stays and experiences that make it possible for guests to connect with communities in a more authentic way. Airbnb’s Legal Department is a global team that will require working with diverse international colleagues around the world. The successful candidate will be someone who is adaptable, collaborative and embodies Airbnb’s Core Values. Candidates will be required to approach complex legal issues with a balance for local and global perspectives, while being adaptable to cultural differences and nuances. A genuine and demonstrated interest in Airbnb and a commitment to ethics, integrity and fostering a workplace that emphasizes diversity and belonging is a must. The Community You Will Join: Airbnb’s Legal team embodies the company’s innovative, forward-thinking spirit. At the frontier of the new sharing economy, Airbnb is breaking new ground in matters of policy, law, and government relations. Where some see obstacles, we see the opportunity to find creative, practical solutions, right at the cutting edge. Our adventurous, fast-moving legal team is committed to building a team of talented, collaborative and self-motivated legal professionals across the globe who believe in Airbnb’s mission and leading as a 21st century company. The Difference You Will Make: Airbnb is looking for an experienced litigator to join our Risk and Regulatory group. Reporting to Airbnb's Lead Counsel, Litigation, Risk and Regulatory, the Senior Counsel, Litigation will own high-stakes disputes, investigations, and strategic counseling from first assessment through resolution, directing outside counsel and shaping our approach at every stage. This role is for you if you work well with business partners, bring a steady and positive presence,

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