Jobs in United States

Senior Lead Technical Program Manager Infrastructure in California

54 active opportunities · Updated October 2026

Explore current senior lead technical program manager infrastructure jobs in California. Filter by work mode, employment type, experience, department, date posted and distance.

Hiring demand

43/100

watch · 145 related jobs

Hiring trend

-64.5%

Job postings compared with the previous 30 days

Remote options

20.7%

Share of matching jobs listed as remote

G
📍 California, United States
✓ High-confidence listingCompany trend +190.5%

$157.6K – $203.9K/yr

Quick readStrong listing-quality and freshness signals

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description As a Senior Manager, Supplier Strategy and Management, Devices at Gilead you will own the business relationships with assigned suppliers of devices and device related components used with any Gilead branded product. This includes ownership of the strategy, selection, risk, and performance management of suppliers providing devices and device related components for development or commercial products. This role is responsible for both the strategic and tactical business management of these supplier relationships. You will have responsibility for indirectly leading and influencing others, bidding, selecting and managing multiple devices and device related components. This position is based at the

Project ManagementFinanceSupply ChainRecruitment
G
📍 California, United States
✓ High-confidence listingCompany trend +190.5%

$157.6K – $203.9K/yr

Quick readStrong listing-quality and freshness signals

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description This Data Platform Engineer will have the unique opportunity to apply cutting-edge data and analytics technologies to one of the most meaningful challenges in healthcare: ensuring the quality of medicines that improve and save lives. As a pivotal member of R&D Quality, this role will help transform how quality insights are generated, scaled, and acted upon across Gilead's drug development and clinical research programs. Through the development of robust data pipelines and advanced analytics platforms, the successful candidate will enable more proactive quality oversight, smarter decision-making, and continuous improvement, ultimately supporting Gilead's mission to deliver life-changing t

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P
📍 California, United States
✓ High-confidence listingCompany trend +671.4%

$68.6K – $114.3K/yr

Quick readStrong listing-quality and freshness signals

Position Summary Pfizer is seeking a motivated Senior Associate Scientist to join the In Vivo Pharmacology group within the Oncology Research Unit, with a focus on antibody-drug conjugate (ADC) programs, but including other large molecule and small molecule programs. This role supports the execution of in vivo oncology studies that enable ADC discovery and preclinical development, including efficacy, tolerability, pharmacodynamic, and sample collection workflows. The ideal candidate will demonstrate strong technical aptitude, careful attention to detail, and a commitment to animal welfare, compliance, and high-quality study execution. The Senior Associate Scientist is expected to contribute as a dependable technical team member while building scientific understanding of oncology pharmacology and ADC-specific study requirements. Position Responsibilities Execute in vivo oncology studies supporting discovery programs using a variety of in vivo models including human cell line- derived, patient-derived xenograft, syngeneic models as appropriate with minimum guidance from study leads. Perform routine and advanced in vivo procedures, including tumor measurements, body weight monitoring, test article administration (IV, PO, subQ, IP dosing), clinical observations, and sample collection. Perform routine in vitro tissue culture procedures Support pharmacology studies evaluating efficacy, tolerability, pharmacodynamic biomarkers, dosing schedules, and combination approaches. Prepare study materials, confirm dosing and sampling schedules, and ensure study activities are performed according to approved protocols and SOPs. Maintain accurate, timely, and compliant study records using approved electronic data capture and documentation systems. Communicate study observations, technical issues, animal welfare concerns, and timeline risks promptly to managers and study line leads. Collabo

AIRecruitment
I
📍 California, United States· Remote
✓ High-confidence listing

$98.4K – $147.6K/yr

Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Position Summary: The Senior Informatics Sales Specialist will use their strong genomics, healthcare and Informatics technical knowledge and expertise to identify and close Informatics opportunities. This involves selling to prospective customers and Illumina colleagues on Next Generation Sequencing and Genomic data analysis pipelines, applications and products primarily for use in clinical research or testing. They will act as an influencer and expert resource for customers and others to ensure success while enabling sales growth through strategic activities and creative problem solving. The Informatics Sales Specialist should be viewed as a “go to” subject matter expert for all things Informatics, with primary focus on Illumina’s clinical software products. As an Informatics Sales Specialist, you are impacting clinical data analysis and interpretation through effective engagement with C-level executives, Laboratory Directors, Healthcare practitioners, IT leaders, and data analysts. You are establishing Illumina as a prominent cloud-based enterprise platform provider to the Clinical, Pharma, and Healthcare se

Machine LearningArtificial IntelligenceAICustomer Service
Z
📍 California, United States· Full-time· Remote
✓ High-confidence listing

From $224K/yr

Quick readStrong listing-quality and freshness signals

Zscaler (NASDAQ: ZS) accelerates digital transformation so customers can be more agile, efficient, resilient, and secure. The Zscaler Zero Trust Exchange™️ platform protects thousands of customers from cyberattacks and data loss by securely connecting users, devices, and applications in any location. Distributed across 160+ public exchanges globally and thousands of private exchanges at the edge, the SASE-based Zero Trust Exchange is the world’s largest in-line cloud security platform. We believe the future of work is Human + AI and are building an AI-native enterprise where human potential is amplified by machine intelligence to solve the world’s hardest security challenges. Driven by deep customer obsession, we are committed to the mission, outcome, and to each other. We bring these commitments to life through three core behaviors: ownership and collaboration, trust through outcomes and impact, and a challenge culture with ongoing feedback. Ready to make an impact at the company pioneering security transformation in the AI era? Join us at Zscaler. The Zscaler Sales and Go-to-Market team is a global group of professionals who are passionate about delighting our customers, nurturing trusted partnerships, and sharing their expertise to drive a secure, cloud-enabled digital future and further cement our position as the world leader in cloud security. Sales, Customer Success, Sales Enablement, Solution Architects, Business Development, Transformation, and Technology Partnerships all work together to demonstrate the power and agility of Zscaler cloud transformation to the world. We're looking for an experienced Healthcare Provider CISO/CTO to join our team sitting in the West region. Reporting to our Healthcare Strategic Leader, you'll manage the following: You will be Zscaler's technical executive sponsor with the largest healthcare providers and make technology decisions on behalf of the organization You will provide technical leadership and serve a necessary r

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H
📍 California, United States of America, United States
✓ High-confidence listingCompany trend +103.7%

$162K – $225K/yr

Quick readStrong listing-quality and freshness signals

Senior Software Engineer, Cloud Services Description - Who We Are HP IQ is HP’s new AI innovation lab. Combining startup agility with HP’s global scale, we’re building intelligent technologies that redefine how the world works, creates, and collaborates. We’re assembling a diverse, world-class team—engineers, designers, researchers, and product minds—focused on creating an intelligent ecosystem across HP’s portfolio. Together, we’re developing intuitive, adaptive solutions that spark creativity, boost productivity, and make collaboration seamless. We create breakthrough solutions that make complex tasks feel effortless, teamwork more natural, and ideas more impactful—always with a human-centric mindset. By embedding AI advancements into every HP product and service, we’re expanding what’s possible for individuals, organisations, and the future of work. Join us as we reinvent work, so people everywhere can do their best work. About The Role As a Senior Software Engineer, Cloud Services, you will create scalable, reliable backend systems that support HP IQ's mission to transform the way people work. We value how we work as much as what we deliver. Our journey of continuous learning and evolution requires a flexible and resilient services platform that fosters innovation, experimentation, and adaptation. To enable this, we focus on designs and tools rooted in strong engineering principles like abstraction, composition, virtualization, automation, and iterative development cycles. What You Might Do Design, develop, and maintain backend services and RESTful APIs using Java and Spring Boot. Write clean, efficient, and well-tested code following established best practices. Collaborate with frontend developers, product managers, and other engineers to deliver end-to-end features. Integ

JavaPostgreSQLMySQLAWS
G
📍 California, United States
✓ High-confidence listingCompany trend +190.5%

$117.9K – $152.6K/yr

Quick readStrong listing-quality and freshness signals

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description Senior Associate, Global External Manufacturing, (Oral Solid Dosage) works to ensure uninterrupted supply of Gilead’s clinical and commercial products through execution of manufacturing campaigns within our global external contract manufacturing network, while ensuring compliance with cGMP, regulatory requirements, and environmental, health, and safety legislations. This position is part of the Manufacturing Operations group within the larger Pharmaceutical Development and Manufacturing organization (PDM). This role requires collaboration with the Development, Quality, Regulatory, Analytical, Supply Chain, and Product & Portfolio Strategy organizations within PDM to ensure su

Supply ChainRecruitment
A
📍 California, United States
✓ Quality checkedCompany trend +365.2%

Abbott is a global healthcare leader that helps people live more fully at all stages of life. Our portfolio of life-changing technologies spans the spectrum of healthcare, with leading businesses and products in diagnostics, medical devices, nutritionals and branded generic medicines. Our 115,000 colleagues serve people in more than 160 countries. JOB DESCRIPTION: Working at Abbott At Abbott, you can do work that matters, grow, and learn, care for yourself and your family, be your true self, and live a full life. You’ll also have access to: Career development with an international company where you can grow the career you dream of. Employees can qualify for free medical coverage in our Health Investment Plan (HIP) PPO medical plan in the next calendar year. An excellent retirement savings plan with a high employer contribution Tuition reimbursement, th e Freedom 2 Save student debt program, an d FreeU education benefit - an affordable and convenient path to getting a bachelor’s degree. A company recognized as a great place to work in dozens of countries worldwide and named one of the most admired companies in the world by Fortune. A company that is recognized as one of the best big companies to work for as well as the best place to work for diversity, working mothers, female e

P
📍 California, United States· Remote
✓ High-confidence listingCompany trend +671.4%

$108.6K – $250.7K/yr

Quick readStrong listing-quality and freshness signals

Role Summary Pfizer Commercial Oncology is introducing the world to the next era of cancer care. With a growing portfolio of novel therapies, industry-leading R&D, and a goal of delivering eight breakthroughs by 2030 across major cancer types, we're translating cutting-edge science into market-shaping impact. Here, you'll partner with exceptional colleagues across scientific, medical, and manufacturing teams, backed by advanced digital and AI-enabled infrastructure and the authority to accelerate medicines from discovery to delivery. Guided by our values of courage, excellence, equity, and joy, you'll have the opportunity to stretch your skills and build a career that evolves with you—across teams, roles, and the Pfizer enterprise. Join us to make history — for patients, for their families, for the future. The Senior Oncology Account Specialist (SOAS) will have a variety of responsibilities, ranging from promoting Pfizer’s product portfolio to health care providers and specialists, to educating members of the healthcare community regarding the appropriate use of Pfizer products, to calling on accounts and organized customers to help improve patients’ experience with Pfizer products, as well as the overall quality of patient care delivered. The SOAS plays a critical role in increasing Pfizer’s brand with high-value target customers by linking an insightful assessment of the account and/or business landscape with a strong understanding of Pfizer’s products and resources. BASIC QUALIFICATIONS BA/BS Degree from an accredited institution BA/BS Degree from an accredited institution OR an associate’s degree with 8+ years of experience; OR a high school diploma (or equivalent) with 10+ years of relevant experience. Ability to travel domestically and stay overnight as necessary Valid US driver’s license and drivin

AIRecruitment
I
📍 California, Santa Clara, United States
✓ High-confidence listingCompany trend +315.4%
Quick readStrong listing-quality and freshness signals

Job Details: Job Description: As a Senior Power and Performance (PnP) Engineer, you will be responsible for PnP product execution focused on measurements, analysis, and projections/estimates of Intel's unlaunched notebook and desktop products. Based on your technical knowledge of both Intel and the competition, you will help influence OEM customers, internal marketing teams, internal engineering teams, debug Intel silicon/platform on PnP issues, and be an integral part for Intel product launches. Core responsibilities to include following: Measure, analyze, and debug workloads to call out any power and/or performance gaps and close with internal engineering teams/architects Measure and analyze SoC/CPU and platform power on a rail by rail basis and debug any issues/gaps Align with other internal engineering teams and architects to ensure there is consensus on power and performance projections/estimates/measurements for both internal and external communication Guide, educate, and influence internal engineering teams, field account teams, and marketing teams on power and performance positioning of Intel products Create power and performance estimates on upcoming Intel products based on workloads to aid marketing decisions and help set internal KPI targets Own the publication of the Power Performance Guide (PPG) collateral to help guide OEM customers Bring up full test platform to enable both power and performance measurements including setup, calibration, and measurements. Qualifications: You mus

Recruitment
H
📍 California, United States of America, United States
✓ High-confidence listingCompany trend +103.7%
Quick readStrong listing-quality and freshness signals

Business Strategy Principal – HP Solutions Strategy – SW Description - The Opportunity Join HP’s high-impact, high-visibility HP Solutions Strategy team and help shape the future of HP Solutions across software, services, AI-enabled solutions, and emerging growth areas. This team partners closely with senior HPS leaders to define long-term direction, medium-term strategic priorities, and near-term business choices that influence portfolio strategy, planning, investment priorities, and growth opportunities. This is an exciting opportunity for a highly analytical, results-oriented strategy leader who thrives in ambiguity, enjoys solving complex business problems, and wants to make a visible impact at scale. In this role, you will help translate market, customer, technology, competitive, and financial insights into clear strategic choices—especially across software, services, vertical solutions, AI-enabled offerings, and go-to-market models. You will work across executive leaders, GBU teams, product, sales, marketing, finance, category, and cross-functional partners to develop insight-driven recommendations grounded in rigorous analysis and compelling strategic narratives. The role combines strategic problem solving with portfolio and GTM rigor, business case development, pricing and packaging support, and executive-ready deliverables for high-priority leadership discussions. If you are energized by strategic problem solving, cross-functional collaboration, and building what is next for HP Solutions, we would love to hear from you. Responsibilities Develop strategic analyses and insights that inform HP’s software, services, and solutions portfolio strategy, including market trends, customer needs, competitive dynamics, portfolio maturity, and growth op

AIProject ManagementFinance
I
📍 California, United States
✓ High-confidence listing

$98.4K – $147.6K/yr

Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. We are seeking a Senior Mechanical Engineer to support new product development in genomics instrumentation. This is a highly technical mechanical design role focused on the development of custom mechanisms, precision motion systems, and electromechanical assemblies used in advanced instrumentation. The ideal candidate will be an engineer with experience designing motorized mechanisms and precision motion systems, including a strong understanding of system requirements, motion architecture, controls integration, structural design, and performance validation. The ideal candidate also has experience developing motion solutions from requirements through implementation and understands the engineering principles behind achieving precise, reliable motion in complex systems. Responsibilities Design and develop custom mechanical mechanisms for use in genomics instruments, including motion systems, precision assemblies, and fluidic or sample‑handling components. Integrate mechanical designs with electrical, firmware, and control systems Create and maintain 3D CAD models, engineering drawings, and support

Artificial IntelligenceAI
A
📍 California, USA - Remote, United States· Remote
✓ Quality checkedCompany trend +90.9%

Job Requisition ID # 26WD97363 Position Overview We are seeking a Principal Software Engineer – Backend to join Autodesk’s Enterprise Data Management (EDM) organization within the COO-GET Engineering group. This is a senior individual contributor role operating at the Principal (P4) level , expected to drive technology direction for large, complex, and business-critical backend and distributed systems . This role is anchored in backend software engineering excellence : designing, building, and evolving scalable services, APIs, and event-driven systems that operate at enterprise scale. As a Principal Engineer, you will work with high autonomy and ambiguity , shape long-term architecture, and influence multiple teams and domains. Familiarity with data engineering concepts is valuable, but backend systems, service design, and distributed systems are the core competencies. You will function as a technical authority and force multiplier—guiding design decisions, setting standards, and ensuring Autodesk’s core data services are reliable, resilient, and evolvable over time. Responsibilities Provide principal-level technical

PythonAWSAI
G
📍 California, United States
✓ High-confidence listingCompany trend +190.5%

$210.4K – $272.3K/yr

Quick readStrong listing-quality and freshness signals

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description At Gilead our pursuit of a healthier world for all people has yielded a cure for hepatitis C, revolutionary improvements in HIV treatment and prevention as well as advancements in therapies for viral and inflammatory diseases and certain cancers. We set and achieve bold ambitions in our fight against the world’s most devastating diseases, united in our commitment to confronting the largest public health challenges of our day and improving the lives of patients for generations to come. The Director, Quality Assurance – GMP Operations provides senior Quality leadership and direct quality oversight of Manufacturing and

Supply ChainWarehouseRecruitment
I
📍 California, United States
✓ High-confidence listing

$141.6K – $212.4K/yr

Quick readStrong listing-quality and freshness signals

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Summary The Staff Data Engineer is a seasoned, hands-on engineer who designs, builds, and scales data products on our cloud lakehouse, powering analytics, reporting, and AI/ML across Illumina. We are looking for someone with strong proficiency in Python, SQL, and data modeling, a solid understanding of distributed systems and system design who has built and scaled data products on modern cloud platforms such as Databricks and Snowflake. This is a hands-on, senior individual-contributor role with end-to-end ownership and leadership spanning multiple domains such as Supply Chain, Manufacturing and Quality, including mentoring engineers on our global (India-based) team. Responsibilities Partner across business, AI, and platform teams translating domain needs (e.g., SAP, Manufacturing, Quality) into well-modeled, governed and scalable data products. Design, build, and scale end-to-end data products on Databricks (and interoperating with Snowflake) — from ingestion through curated, analytics-ready datasets following a medallion (Bronze/Silver/Gold) architecture. Develop reusable frameworks, libraries, and

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