Jobs in United States

Senior Principal Model Optimization Engineer in United States

1,941 active opportunities · Updated October 2026

Explore current senior principal model optimization engineer jobs across United States. Filter by work mode, employment type, experience, department, date posted and distance.

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📍 Jersey City New Jersey United States, United States
✓ High-confidence listingCompany trend +800%
Quick readStrong listing-quality and freshness signals

Citi, the leading global bank, has approximately 200 million customer accounts and does business in more than 160 countries and jurisdictions. Citi provides consumers, corporations, governments, and institutions with a broad range of financial products and services, including consumer banking and credit, corporate and investment banking, securities brokerage, transaction services, and wealth management. As a bank with a brain and a soul, Citi creates economic value that is systemically responsible and in our clients’ best interests. As a financial institution that touches every region of the world and every sector that shapes your daily life, our Enterprise Operations & Technology teams are charged with a mission that rivals any large tech company. Our technology solutions are the foundations of everything we do from keeping the bank safe, managing global resources, and providing the technical tools our workers need to be successful to designing our digital architecture and ensuring our platforms provide a first-class customer experience. We reimagine client and partner experiences to deliver excellence through secure, reliable, and efficient services. Our commitment to diversity includes a workforce that represents the clients we serve from all walks of life, backgrounds, and origins. We foster an environment where the best people want to work. We value and demand respect for others, promote individuals based on merit, and ensure opportunities for personal development are widely available to all. Ideal candidates are innovators with well-rounded backgrounds who bring their authentic selves to work and complement our culture of delivering results with pride. If you are a problem solver who seeks passion in your work, come join us. We’ll enable growth and progress together. The Applications Development Senior Group Manager is a senior management level position responsible for accomplishing results through the management o

JavaArtificial IntelligenceAIProject Management
C
📍 Tampa Florida United States, United States
✓ High-confidence listingCompany trend +800%
Quick readStrong listing-quality and freshness signals

At Citi Services - Global Trade and Working Capital Solutions (TWCS) Technology Organization, we are on a mission to harness the power of data to drive innovation, create exceptional customer experiences, and solve complex business challenges. Our data team is at the heart of this mission, building the scalable and resilient infrastructure that turns data into our most asset. We are a passionate, collaborative group dedicated to pushing the boundaries of what's possible. The Opportunity We are seeking an Engineering Director to join our development team. The ideal candidate is a seasoned technologist with extensive experience in building and delivering data & AI solutions for business functions. This individual will be directly and fully accountable for solution delivery and should have a history of creating strategic technology architecture roadmaps aligned with business outcomes. The successful candidate will define and execute the technology roadmap for the Data & AI portfolio of TWCS, providing strategic direction and critical input into technology decisions to ensure a scalable buildout. This role involves building strong relationships with senior business and technology partners, driving agile execution, and leading a team of expert engineers to deliver with velocity and quality. Applicants should demonstrate exceptional technical acumen, a strong data engineering background, and a proven ability to lead and provide technical direction to high-performing engineering teams. A proven expertise in Data Engineering, Data Analytics, and AI Engineering delivery at scale is essential. Responsibilities: Manage/develop multiple teams of professionals to accomplish established goals and conduct personnel duties for team (e.g. performance evaluations, hiring and disciplinary actions) as well as ensure team adheres to best practices and processes Develop vision for team aroun

PythonJavaAWSAzure
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📍 Kentucky, United States· Remote
✓ High-confidence listingCompany trend +671.4%

$108.6K – $250.7K/yr

Quick readStrong listing-quality and freshness signals

Pfizer US/PR Commercial Sales Founded in 1849, Pfizer Inc. began as a small chemistry enterprise built on the belief that scientific ingenuity can improve—and protect—human life. Today, as one of the world’s leading biopharmaceutical companies, Pfizer’s purpose is Breakthroughs that change patients’ lives : discovering, developing, and delivering medicines and vaccines that address unmet need, earn trust through quality and integrity, and reach patients through strong partnerships across the healthcare system. In a complex and rapidly evolving pharmaceutical landscape, our work is measured by one outcome - helping patients live longer, healthier lives . Rare Disease Sales Organization Mission & Impact Pfizer’s Rare Disease – Rare Cardiac Sales organization exists to help improve the lives of people living with serious rare cardiac conditions by connecting scientific innovation to the clinicians and systems that deliver care. We lead with integrity and patient need— advancing disease and product education grounded in robust clinical evidence , promoting Pfizer Rare Cardiac therapies compliantly, and supporting healthcare professionals’ understanding of appropriate patient identification and use based on approved indications. Through evidence‑based scientific exchange, we help reduce access, diagnostic, and workflow barriers so more patients can start and stay on the right therapy. Our impact is more informed clinical decision ‑ making, improved consistency of care, and better outcomes for patients , contributing to a higher standard of care across the rare cardiac community. Role Summary The Rare Disease – Rare Cardiac, Senior Health & Science Specialist is a field-based specialty sales role responsible for driving the growth of Rare Cardiac products through compliant, strategic relationships within assigned accounts. This role par

AIRecruitment
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📍 New York, United States
✓ High-confidence listingCompany trend +671.4%

$230.9K – $384.8K/yr

Quick readStrong listing-quality and freshness signals

ROLE SUMMARY Pfizer Commercial Oncology is introducing the world to the next era of cancer care. With a growing portfolio of novel therapies, industry-leading R&D, and a goal of delivering eight breakthroughs by 2030 across major cancer types, we're translating cutting-edge science into market-shaping impact. Here, you'll partner with exceptional colleagues across scientific, medical, and manufacturing teams, backed by advanced digital and AI-enabled infrastructure and the authority to accelerate medicines from discovery to delivery. Guided by our values of courage, excellence, equity, and joy, you'll have the opportunity to stretch your skills and build a career that evolves with you—across teams, roles, and the Pfizer enterprise. Join us to make history — for patients, for their families, for the future. The US Precision Medicine Thoracic Franchise is entering its most consequential — and most complex — growth chapter. Our in-line thoracic portfolio spans two biomarker-defined populations: LORBRENA (lorlatinib) for adults with ALK-positive metastatic non-small cell lung cancer (NSCLC), and the BRAFTOVI + MEKTOVI (encorafenib + binimetinib) regimen for BRAF V600E-mutant metastatic NSCLC. Both sit inside a molecularly driven treatment landscape where the right patient is identified by a biomarker signature. Winning here means mastering precision targeting: reaching narrow, high-value, genomically defined patient populations through the exact clinicians who test for and treat them. This is a people-management leadership role that demands a strong enterprise leader — one fluent in both commercial strategy and AI-enabled execution, and able to think and operate at the enterprise level. The colleague who leads this team will set a multi-year strategic vision, make thoughtful trade-off and resource-prioritization decisions across two brands, and influence senior leadership across the wider organizati

Machine LearningAIExcelRecruitment
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📍 Santa Clara, United States
✓ High-confidence listingCompany trend -8%
Quick readStrong listing-quality and freshness signals

NVIDIA is looking for a hands-on Solutions Architect Manager to lead a team of GPU, networking & software solution architects and engineers. Do you want to build and lead a group that designs, debugs, and deploys new AI hardware and software technologies into production in customer data centers? As part of the NVIDIA SA organization, you will drive people and technical leadership for end-to-end solutions deployments at some of NVIDIA's most strategic technology customers, while directly contributing to designs and deep-dive debugging and shaping our product roadmap with customer feedback. What you will be doing: Recruit & manage a team of solutions architects, system/network and software engineers focused on large-scale GPU and AI networking deployments. Set priorities, allocate resources, mentor, and ensure high-quality customer delivery across multiple concurrent projects - while remaining directly involved in key technical reviews, design decisions, and critical debug efforts. Provide deep subject-matter expertise in advanced GPU and network systems and serve as the senior technical point of contact for strategic customers. Personally lead and guide complex compute/network configuration and performance debugging, working side-by-side with your team to deliver performant, reliable clusters. Guide your team as they lead network / compute / software architecture discussions, and support server, network, and cluster bring-up, including on-site data center work where needed. Systematically collect and synthesize customer-specific requirements across your portfolio. Partner with GPU/Network Systems Engineering, Product Management, and Sales to influence roadmap priorities and packaging of reference designs and solutions. Demonstrate SME in advanced GPU & network systems and be a trusted technical advisor to NVIDIA's strategic customers. Bring customer-sp

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📍 California, USA - Remote, United States· Remote
✓ High-confidence listingCompany trend +90.9%
Quick readStrong listing-quality and freshness signals

Job Requisition ID # 26WD100708 Director, Expansion & Strategic Accounts D&M We are seeking a strategic Director Expansion & Strategic Accounts to lead a regional sales organization focused on the Design and Manufacturing industry. This leader will drive revenue growth, develop high-performing teams, strengthen customer and partner relationships, and execute sales strategies aligned with Autodesk’s business objectives. What You’ll Do Lead, coach, and develop a high-performing sales team focused on revenue growth and customer expansion. Develop and execute territory and industry sales strategies aligned to Autodesk priorities. Drive quota attainment through pipeline discipline, forecasting, deal inspection, and accountability. Build strong customer, partner, and internal relationships to identify growth opportunities and deliver outcomes. Partner across sales, technical sales, customer success, partner management, marketing, finance, and product teams to improve execution. Create a culture of ownership, collaboration, inclusion, and continuous improvement. What You Bring Experience leading sales teams in enterprise software, SaaS, technology, or a related B2B environment. Track record of achieving revenue targets and building predictable sales performance. Strong understanding of territory planning, pipeline generation, forecasting, account planning, and customer expansion. Experience with direct and indirect sales channels, including partner ecosystems. Ability to lead through influence across matrixed teams and senior stakeho

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📍 San Francisco, California, United States
✓ High-confidence listingCompany trend +212.5%
Quick readStrong listing-quality and freshness signals

Our Purpose Mastercard powers economies and empowers people in 200+ countries and territories worldwide. Together with our customers, we’re helping build a sustainable economy where everyone can prosper. We support a wide range of digital payments choices, making transactions secure, simple, smart and accessible. Our technology and innovation, partnerships and networks combine to deliver a unique set of products and services that help people, businesses and governments realize their greatest potential. Title and Summary Vice President, Software Engineering Overview Decision Stream is Mastercard's next-generation AI-native decisioning platform, designed to power intelligent, real-time decisions across fraud, authentication, payments, and risk. Built with a startup mindset and enterprise-scale ambition, the platform combines innovation, speed, and engineering excellence to redefine decisioning across Mastercard's global ecosystem. We are seeking a visionary and hands-on VP of Software Engineering to help build and scale the platform. This leader will partner closely with Product, Architecture, AI, and Platform Engineering teams to drive technology strategy, architecture, engineering execution, and organizational growth. What You'll Do Lead Through Technical Excellence • Serve as a senior technology leader and role model for engineering teams. • Drive architecture, design, and technology decisions across distributed systems, streaming, AI, and cloud-native platforms. • Engage deeply with engineers, architects, and product leaders to solve complex technical challenges. • Influence engineering standards, software quality, and operational excellence. Build and Scale the Platform • Help shape and deliver a highly scalable, resilient, and secure decisioning platform operating at Mastercard scale. • Balan

KubernetesAIRecruitment
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📍 California, United States
✓ High-confidence listingCompany trend +190.5%

$195.7K – $253.2K/yr

Quick readStrong listing-quality and freshness signals

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description As an Associate Director, Global Commercial Project Management at Gilead you will report to the Senior Director, Global Commercial Project Management and will serve as the project manager of early Commercialization and Commercialization Teams (eCTs / CTs). This role will lead strategic execution and support governance while coordinating cross-functional teams and initiatives to ensure successful delivery and operational execution of their teams’ priorities. This role will primarily support Gilead’s programs in Liver and Inflammation with the opportunity to support other therapeutic areas as needed. The successful candidate will be dynamic, with excellent project management capabi

AIProject ManagementPmpRecruitment
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📍 California, United States
✓ High-confidence listingCompany trend +190.5%

$109.7K – $141.9K/yr

Quick readStrong listing-quality and freshness signals

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description The Oncology department at Gilead Sciences is seeking an experienced and motivated Associate Scientist/ Senior associate Scientist with exceptional technical skills to support research programs focused on the discovery and development of novel therapies that mobilize the immune response against cancer. The successful candidate will be instrumental in conducting experiments and help develop novel assays to test therapeutic hypotheses and advance immune engager therapeutic candidates to selectively target tumors. Our highly diverse, collaborative, and interdisciplinary research teams utilize state-of-the-art technologies and innovative methodologies to advance novel immuno-oncology therapies in

Recruitment
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📍 San Francisco, California, United States
✓ High-confidence listingCompany trend +100%

$285K – $305K/yr

Quick readStrong listing-quality and freshness signals

Fin , now part of Salesforce, is on a mission to help businesses provide perfect customer experiences. Our AI Agent Fin is the highest-performing AI Customer Agent on the market today, enabling businesses to deliver impeccable, always-on customer support across the customer journey, from service, to sales, to ecommerce. Powered by our own AI models, Fin resolves complex customer issues end-to-end across every channel, with minimal set-up and integration. Fin can also be combined with our natively integrated Intercom help desk, giving modern support teams one single system. Together with Salesforce, the #1 AI CRM, where humans with agents drive customer success, we're building the future of customer experience. Here, ambition meets action. Tech meets trust. And innovation isn't a buzzword, it's a way of life. The world of work as we know it is changing, and we're looking for Trailblazers who are passionate about bettering business and the world through AI. Ready to level up your career at the company leading workforce transformation in the agentic era? You're in the right place. Agentforce is the future of AI, and you are the future of Salesforce. What's the opportunity? The Solutions Marketing team positions Fin to win in the market through compelling messaging, content, audience understanding, and field activation. The Director of Solutions will manage a team of solution marketers that will fundamentally help our revenue teams to be more effective and grow Fin ARR. This is a strategic role in the company, working directly with the senior leadership team. The Role The Solutions Marketing team can be thought of as the solutions or outbound equivalent of a traditional product marketing team. Fin already has a product marketing team that works closely with product managers to understand our product, create messaging, and build assets for product launches, the Website and our field. The Solutions Marketing team on the other hand, will focus on our prod

AISalesforceCRM
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📍 San Francisco, California, United States· Full-time· Remote
✓ High-confidence listingCompany trend -93.7%

$165K – $270K/yr

Quick readStrong listing-quality and freshness signals

Drata is building the trust layer between great companies - automating compliance, managing risk, and helping organizations prove trust continuously as they scale. We're Dratanauts: a global crew of 600+ professionals united by a culture that rewards integrity, ownership, and raising the bar, no matter where in the world we're working from. Why Join the Drata Team? At Drata, you're not maintaining legacy compliance software - you're building the agentic AI platform defining what trust looks like for the next generation of companies. Here's what makes the work itself worth showing up for: Problems without a playbook: You'll work at the edge of AI and security, building agentic governance, continuous compliance, and real-time trust verification to solve problems that don't have an established answer yet. You're writing it as you go. Real ownership, not just process: Our values center on owning outcomes and raising the bar, not checking boxes. You're expected to have opinions and back them. A seat at the table: Your perspective is unique and valued. Open debate and diverse viewpoints are built into how decisions actually get made here, at every level. Growth at rocketship speed: Drata is scaling fast, which means scope grows fast too. High performers get more ownership, visibility, and experience. A crew, not just coworkers: Dratanauts consistently describe a "come as you are" culture with sharp, curious people—the kind of team that makes hard problems genuinely fun to solve. See what they say here and follow us on LinkedIn for company news, employee stories, and career updates. Job Summary: Drata is looking for a Staff Data Engineer! This person will be a key member of the growing data team, supporting one of the fastest growing B2B SaaS startups to achieve unicorn status. At Drata, we’re on a mission to help build trust across the internet! Data accuracy is an essential cornerstone of our mission. We are looking for a senior data engineer that can help us strategize

PythonSQLAI
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📍 New York, NY, United States
✓ High-confidence listingCompany trend +33.3%
Quick readStrong listing-quality and freshness signals

At Lyft, our purpose is to serve and connect. We aim to achieve this by cultivating a work environment where all team members belong and have the opportunity to thrive. Safety is fundamental to the Lyft experience and to the trust riders, drivers, and our broader communities place in our platform. Lyft’s Safety and Customer Care team works through product, technology, data, policy, and operations to prevent harm before it happens, respond compassionately when it does, and continuously learn from every incident in efforts to make Lyft the safest way to get around. We are looking for an experienced safety leader with deep Trust & Safety experience to help turn Lyft’s Trust & Safety strategy into impact at scale, with the final shape of this role informed by the strengths of the leader we bring on. This is a highly visible leadership role within Lyft’s Safety & Customer Care organization. You will report to the Senior Director and General Manager of Trust & Safety and sit on the Trust & Safety leadership team. You will additionally partner deeply with Product, Engineering, Data Science, Research & Design, Legal, Compliance, Risk, Communications, Finance, and other teams across Lyft. The ideal candidate is an exceptional operator and people leader with Trust & Safety expertise, strong strategic judgment, and a track record of leading complex, high-stakes Trust & Safety organizations at scale. You can move fluidly between setting strategy with senior executives, developing leaders, overseeing large global operations and budgets, and diving into an emerging safety issue when the situation demands it. Responsibilities Lead Global Safety Compliance & Risk Oversee Lyft’s global safety compliance, transparency, and risk functions, supporting strong functional leaders and individual contributors on your team and strengthening capabilities as Lyft scales globally. Set direction across compliance readiness, safety transparency repo

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📍 Atlanta, Georgia, United States· Full-time· Remote
✓ High-confidence listingCompany trend -92.9%
Quick readStrong listing-quality and freshness signals

At Snowflake, we are powering the era of the agentic enterprise. To usher in this new era, we seek AI-native thinkers across every function who are energized by the opportunity to reinvent how they work. You don’t just use tools; you possess an innate curiosity, treating AI as a high-trust collaborator that is core to how you solve problems and accelerate your impact. We look for low-ego individuals who thrive in dynamic and fast-moving environments and move with an experimental mindset — who rapidly test emerging capabilities to discover simpler, more powerful ways to deliver results. At Snowflake, your role isn't just to execute a function, but to help redefine the future of how work gets done. Build the future of data. Join the Snowflake team. We are looking for an experienced attorney to join Snowflake's Legal team as Director, Assistant General Counsel - Litigation. In this role, you will manage a diverse portfolio of litigation matters, serve as a trusted partner and advisor to the business, leverage artificial intelligence to enhance the way we get work done, and supervise one in-house litigation counsel. This role will report to Snowflake’s Senior Director, Associate General Counsel - Employment & Litigation. This is an in-person role based in Menlo Park, CA or Atlanta, GA. This is not a remote position. Responsibilities Litigation Management and Advising Working collaboratively with our Legal team, outside counsel, and cross-functional stakeholders, manage disputes and litigation matters across their full lifecycle — from initial case assessment through resolution. Lead and manage internal investigations on matters involving legal risks to Snowflake, including coordinating with the People team, Security organization, and other relevant functions. Manage and coordinate responses to subpoenas, garnishment orders, domestic relations orders, statutory requests for information, and requests from government and law enforcement agencies. Review and advise on l

Artificial IntelligenceAI
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📍 Aliso Viejo, United States· Remote
✓ High-confidence listing

$193.4K – $276.3K/yr

Quick readStrong listing-quality and freshness signals

Real people. Real service. At SupplyHouse.com , we value every individual team member and cultivate a community where people come first. Led by our core values of G enerosity, R espect, I nnovation, T eamwork, and GRIT, we’re dedicated to maintaining a supportive work environment that celebrates diversity and empowers everyone to reach their full potential. As an industry-leading e-commerce company specializing in HVAC, plumbing, heating, and electrical supplies since 2004, we strive to foster growth while providing the best possible experience for our customers. We are looking for a Director of Product to own our product operating model end to end: the practice of product management, the delivery engine that gets work shipped, and the annual roadmap that connects both to company strategy. Reporting into our COO, this individual will lead a team of Product Managers embedded in cross-functional pods and hold those pods accountable for measurable customer and business outcomes. The Director of Product will work in close partnership with the VP of IT, Senior Manager of UX, Director of Enterprise AI Adoption, and business leaders to connect customer needs, business priorities, technical strategy, and execution. If you’re passionate about building high-performing product organizations, enjoy turning strategy into action, and are excited to lead cross-functional teams in delivering product experiences that are strategically sound, technically feasible, thoughtfully designed, and impactful for customers and the business, we want to hear from you! This remote position is open to individuals who live in, or are open to relocating to, the following states: Arizona, Delaware, Florida, Georgia, Kentucky, Nevada, New Jersey, New York, North Carolina, Ohio, Rhode Island, South Carolina, Tennessee, Texas, Virginia, and Washington. This position requires travel to our headquarters in Melville, NY 6 times per year for internal meetings and team building activities.

AIProject ManagementCustomer Service
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📍 New York, NY, United States
✓ High-confidence listing
Quick readStrong listing-quality and freshness signals

WHAT IS BOX? Box (NYSE:BOX) is the leader in Intelligent Content Management. Our platform enables organizations to fuel collaboration, manage the entire content lifecycle, secure critical content, and transform business workflows with enterprise AI. We help companies thrive in the new AI-first era of business. Founded in 2005, Box simplifies work for leading global organizations, including JLL, Morgan Stanley, and Nationwide. Box is headquartered in Redwood City, CA, with offices across the United States, Europe, and Asia. By joining Box, you will have the unique opportunity to continue driving our platform forward. Content powers how we work. It’s the billions of files and information flowing across teams, departments, and key business processes every single day: contracts, invoices, employee records, financials, product specs, marketing assets, and more. Our mission is to bring intelligence to the world of content management and empower our customers to completely transform workflows across their organizations. With the combination of AI and enterprise content, the opportunity has never been greater to transform how the world works together and at Box you will be on the front lines of this massive shift. WHY BOX NEEDS YOU As a SMB Sales Director, you will lead a team of Account Executives that focus on closing pivotal deals in accounts experiencing high growth. You will join a team of highly motivated sales professionals that take pride in landing new customers, running strategic sales cycles and delivering the Box message to a wide base of accounts across various industries. WHAT YOU'LL DO Hire, train, and manage a team of SMB Account Executives Develop Account Executives for career growth within the Box Sales organization Support team in customer on-sites, calls, and meetings Report on sales metrics and forecast to Senior Sales Management Motivate team to exceed objectives through coaching and mentorship Utilize Salesforce to manage sa

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