Staff Biostatistician (Clinical Validation)

Natera’s Research team is building tests that can detect many cancers from a single blood draw. We are looking for a Staff Machine Learning and Bioinformatics Scientist to help design the models at the heart of that effort. You’ll work with large-scale, multi-modal genomic datasets from clinical cohorts and partner closely with molecular biologists and clinical scientists. Your research will advance the state-of-the-art and you will drive new methods from prototype, through scalable implementation, toward clinical validation and, ultimately, to patients. PRIMARY RESPONSIBILITIES: Lead the development of novel statistical and machine learning methods for cancer signal detection on multi-modal genomic data Build interpretable, well-calibrated models, setting the standard for uncertainty estimation and reproducibility across the group Prototype, test and productionize ML models using scalable infrastructure Own key technical deliverables within larger projects and help shape the team’s research roadmap Collaborate closely with molecular biologists and clinical experts on design and analysis of experiments and validation studies Keep raising the bar through code and design reviews across projects Translate complex results into clear stories for technical and non-technical audiences Mentor junior scientists and champion a culture of curiosity, collaboration, and scientific excellence QUALIFICATIONS: PhD in Computer Science, Mathematics, Bioinformatics, or a related quantitative field with 6-12 years of experience post-PhD Hands-on experience developing novel statistical / ML analysis methods applied to complex biological data Proven track record of innovation and technical leadership in complex method development projects Expertise in deep learning and multimodal foundation models Proficient in Python and its scientific computing ecosystem Scientific rigor throughout the R&D process, with eagerness to teach and learn new computational methods and biology Excellent co

Natera is seeking a Staff Scientist to join our Early Research Team. The primary focus of this role is to independently lead the research and development of novel next-generation sequencing (NGS) technologies. In this role, you will lead projects from ideation to prototype, specifically designing and optimizing high-complexity NGS methods to advance our oncology diagnostic portfolio. Success in this role requires a deep technical foundation in molecular biology and NGS plus a proven track record of industrial R&D leadership. Primary Responsibilities: Lead and manage the development of innovative NGS-based diagnostic assays from feasibility through optimization. Define project goals and plans with input from stakeholders and manage multiple project streams in parallel. Independently design and execute complex laboratory experiments; analyze and interpret results to guide research direction. Coordinate cross-functional efforts to meet milestones and collaborate closely with bioinformatics, statistics, and data science teams to ensure robust experimental design and data analysis. Mentor and guide junior scientists while promoting scientific rigor and best practices. Author high-quality protocols, technical reports, and study documentation. Communicate progress regularly to stakeholders, including departmental meetings and senior leadership. Contribute to risk management, strategy development, and continuous improvement of scientific workflows. Qualifications: Ph.D. in molecular biology, genomics, or a closely related field. Minimum 8 years of relevant industry experience, or 2+ years postdoctoral research with 6+ years in industry. Proven experience in designing and advancing NGS-based diagnostics, preferably in the field of oncology. Required Expertise: A strong technical foundation in molecular biology or chemistry. Deep mechanistic knowledge of NGS library preparation chemistry. Demonstrated ability to independently design and execute complex experiments (solid

POSITION SUMMARY The Clinical Lab Supervisor is a leader in Natera’s lab operations whose role is to oversee employees' performance and serve as a liaison between employees and senior management to meet company goals and quality objectives. The supervisor is responsible for daily supervision of lab staff performing duties such as laboratory testing and data review. Duties include but are not limited to coaching, motivating, staffing, evaluating, and training staff. The supervisor works closely with the manager to ensure company and team goals are met while adhering to good manufacturing practices and CLIA/CAP guidelines. The shift timings are from Monday- Friday , 1.00 PM- 9.30 PM PRIMARY RESPONSIBILITIES Responsible for day-to-day staffing/scheduling/setting up sample run schedules. Ensures production work is consistently completed according to department goals. Ensures all case samples are processed and accounted for. Monitors team members to ensure adherence to SOPs and safety procedures Oversees training for new hires: works in conjunction with lead to train new hires. Document nonconformance reports and all corrective actions taken when test systems deviate from the established performance specifications as needed. Escalates protocol deviation to lead/supervisor. Assists manager in initiating and completing CAPAs. Handles employee issues. Collaborates with Manager and/or Human Resources to resolve issues. Ensures alignment with team for reasoning behind instructions/processes and changes Meets regularly with individual team members to discuss goals and progress. Responsible for staff performance reviews. Plans and leads shift meetings Maintains team morale and professionalism of team members, including by acting as role model. Adheres to Departmental Expectations Ensures compliance with all regulatory agency requirements through documentation, audits, and corrective action. Go-to person when manager is not present. May assist lab team in day to day

POSITION SUMMARY: Join Natera’s Oncology Research Use Only (RUO) team as a Supervisor for the Signatera Plasma Team. You will direct laboratory staff executing cell-free DNA (cfDNA) extraction, library preparation, and Next-Generation Sequencing (NGS) workflows to advance our personalized Minimal Residual Disease (MRD) assays. Every sample represents a real person, and you will ensure that all lab processes operate with the pace and precision required to support our clinical pipeline. PRIMARY RESPONSIBILITIES: Oversee the daily scheduling of employees executing DNA extractions, library preparation, Nucleic Acid Quality Control (QC), and NGS workflows Conduct regular 1:1 meetings to deliver unvarnished, data-backed performance evaluations and guide career development Take ownership of daily lab operations by directly executing sample processing alongside the team to maintain throughput Serve as the primary technical point of contact, using data to guide team members on data interpretation, next steps, and troubleshooting Execute process development and method/instrument testing to increase operational precision and scale Use data to identify lab process deviations, root-cause the underlying issues, and document findings via nonconformance reports to drive corrective action Draft, generate, and rigorously review Standard Operating Procedures (SOPs) and work instructions Maintain precise records of lab work using Google Sheets, Microsoft Excel, and internal Laboratory Information Management Systems (LIMS) Ensure accurate, ethical, and appropriate management of samples in strict compliance with all applicable federal regulations Think team by partnering directly with Oncology RUO peer groups to eliminate bottlenecks and optimize sample processing without needing translation layers Present data-backed summaries on team activities, project milestones, and timeline adherence Adapt to evolving science and operational needs, taking ownership of tasks that move th

POSITION SUMMARY: The role of a Laboratory Assistant I has the ability to receive specimens with an ability to exercise independent judgement in the performance of assigned laboratory tasks. This role ensures all workflow stations within the laboratory are given specimens in a timely manner, with turnaround time in consideration. PRIMARY RESPONSIBILITIES: •Assist licensed/certified staff in preparing specimen (i.e. blood tubes, tissue) to be processed for testing •Receive and deliver specimens to the appropriate workflows and/or labs •Maintain organization of samples through physical and electronic sample storage and/or disposal. •Accurately enter patient data into the Laboratory Inventory Management System (LIMS). •Prepares samples for shipment •Maintains organization of inventory, materials, and supplies within the lab •Assists in cleaning lab equipment and benches •Responsible for maintaining an updated understanding and knowledge of methods pertaining to the role •Completes training and other deadlines on time. •Recognizes and escalates issues to the lead/supervisor •Participate in Continuous Improvement Projects (TAG, 5S) •Conducts himself/herself in a professional manner •Adheres to Departmental Expectations •This role works with PHI on a regular basis both in paper and electronic form and has access to various technologies to access PHI (paper and electronic) in order to perform the job •Must maintain a current status on Natera training requirements. •Performs other duties as assigned. QUALIFICATIONS: Provide a list of qualifications that are truly required (e.g. Education and Experience, Equivalent job experience substituted for degree, preferred level to perform principal responsibilities, required certifications to successfully perform principal responsibilities, etc.) • High School Diploma required • Science - related degree preferred • Less than 1 year industry related experience preferred • Employee must complete training relating to HIPAA/PHI pri

POSITION SUMMARY: Performs histological preparations for Signatera Whole Exome/Genome Sequencing PRIMARY RESPONSIBILITIES: • Perform histological preparations for the tissue whole exome sequencing laboratory with little to no errors • Duties may include but not limited to: preparation of tissues, stained slides, microdissection, and supporting workflow tasks • May independently perform testing, reagent and equipment preparation after completion of training and competency. • Participates in validations • Performs qualifications of reagents • Monitors and performs case management; ensures all cases are processed within department TAT goals and investigates sample processing issues • Actively participate in EH&S initiatives such as safety audits • Participates in updating and creating Standard Operating Procedures • May serve as a general supervisor (Depending on education and years of experience) and perform competencies • Trains staff on department procedures • Participates in Projects and initiatives initiated by the department/external departments • May serve as a general supervisor (Depending on education and years of experience) and perform competencies • Extensive knowledge in equipment and process troubleshooting • Document all corrective actions taken when test systems deviate from the established performance specifications as needed. Escalates protocol deviation to lead/supervisor. • Provides general oversight of personnel and the daily operations in the lab. Provides guidance to new team members • Engages with external departments such as Engineering, Biodev, Stats to resolve issues • May work with leaders of the department to streamline processes. QUALIFICATIONS: • A bachelor's, or higher, degree in a histotechnician program OR A bachelor's, or higher, degree in one of the chemical, or biological sciences, including a combination of thirty (30) hours in biology and chemistry; and, either one of the following conditions:-one year of experien