Lead Senior Python Developer Jobs

Natera’s Research team is building tests that can detect many cancers from a single blood draw. We are looking for a Senior or Lead Bioinformatics Scientist to join the team building the technology at the heart of that effort. You will work with large-scale, multi-modal genomic datasets from clinical cohorts and partner closely with molecular biologists and clinical scientists. You will help advance the state-of-the-art and drive new methods from prototype, through scalable implementation, toward clinical validation and, ultimately, to patients. PRIMARY RESPONSIBILITIES: Develop and validate new algorithms to analyze large multimodal epigenomic datasets Drive research analyses through implementation, testing and performance evaluation, including developing new features within existing pipelines Work with sequencing and clinical data from large cohorts, ensuring data integrity and quality control Partner with molecular biologists and clinical scientists to solve challenging, open-ended problems Visualize results and present complex findings to both technical and non-technical audiences Contribute to the team’s standards for code quality and reproducibility QUALIFICATIONS: Ph.D. in Bioinformatics, Computer Science, Biology, or a related field; alternatively a Bachelor’s or Master’s degree with at least 4 years of professional experience Track record developing and validating analysis workflows for high-throughput sequencing data Experience applying and evaluating statistical and ML methods to large datasets Strong quantitative reasoning and data analysis skills, applied effectively to real scientific problems. Software development experience, including proficiency in Python and its scientific computing ecosystem Fluent using Linux command-line tools and cloud computing environments Strong verbal and written communication skills Preferred Experience Working knowledge of DNA methylation and other epigenomic data Experience with cell-free DNA and liquid biopsy samples Ba

Natera’s Research team is building tests that can detect many cancers from a single blood draw. We are looking for a Senior or Lead Bioinformatics Scientist to join the team building the technology at the heart of that effort. You will work with large-scale, multi-modal genomic datasets from clinical cohorts and partner closely with molecular biologists and clinical scientists. You will help advance the state-of-the-art and drive new methods from prototype, through scalable implementation, toward clinical validation and, ultimately, to patients. PRIMARY RESPONSIBILITIES: Develop and validate new algorithms to analyze large multimodal epigenomic datasets Drive research analyses through implementation, testing and performance evaluation, including developing new features within existing pipelines Work with sequencing and clinical data from large cohorts, ensuring data integrity and quality control Partner with molecular biologists and clinical scientists to solve challenging, open-ended problems Visualize results and present complex findings to both technical and non-technical audiences Contribute to the team’s standards for code quality and reproducibility QUALIFICATIONS: Ph.D. in Bioinformatics, Computer Science, Biology, or a related field; alternatively a Bachelor’s or Master’s degree with at least 4 years of professional experience Track record developing and validating analysis workflows for high-throughput sequencing data Experience applying and evaluating statistical and ML methods to large datasets Strong quantitative reasoning and data analysis skills, applied effectively to real scientific problems. Software development experience, including proficiency in Python and its scientific computing ecosystem Fluent using Linux command-line tools and cloud computing environments Strong verbal and written communication skills Preferred Experience Working knowledge of DNA methylation and other epigenomic data Experience with cell-free DNA and liquid biopsy samp

Work Flexibility: Remote As a Senior Lead, Data Engineering, you will serve as a technical leader who helps shape the future of enterprise data solutions. In this role, you will drive complex data initiatives, influence technical strategy, and partner with teams across the organization to build scalable, high-impact data products. This is an opportunity to solve challenging business problems while mentoring fellow engineers and elevating data engineering best practices. What You Will Do Lead the architecture, development, and modernization of scalable enterprise data platforms that support global procurement analytics and business transformation. Define and help execute a multi-year data engineering strategy focused on platform scalability, reliability, automation, technical debt reduction, and long-term maintainability. Design, build, and optimize Azure-based data solutions using technologies such as Databricks, Delta Lake, Azure Data Factory, Azure DevOps, CI/CD pipelines, and infrastructure automation. Integrate and harmonize data across multiple ERP systems by standardizing supplier, purchasing, and master data into common enterprise data models. Partner with procurement analysts, architects, engineers, and business stakeholders to translate complex business needs into reusable, scalable data products and engineering solutions. Establish engineering standards, conduct architecture reviews, improve documentation, and mentor engineers to raise the overall technical capability of the team. Identify and implement AI-enabled approaches that accelerate development, improve data quality, automate documentation, support testing, and enhance analyst productivity. Evaluate and recommend tools, frameworks, patterns, and platform investments that improve performance, reliability, security, governance, and operational ef

Work Experience Required: 8 - 12 Years Experience in programing (Python, R, SQL, NoSQL,Spark) with ML tools & Cloud Technology (AWS, Azure, GCP) Experience in Python libraries such as numpy, pandas, scikit-learn, tensor-flow, scapy, scrapy, BERT etc. Good understanding in statistics, and ability to design statistical hypothesis testing to aid formal decision making. Develops predictive models using Machine Learning algorithms (SVM, Random Forest, Neural Network, Decision Tree, Logistic Regression, K-mean Clustering, linear regression, PCA etc.) Engaging with clients, understanding complex problem statements, and offering solutions in the domains of Retail, Pharma, Banking, Insurance, etc. Contribute to internal product development initiatives related to data science. Develop data science roadmap, and guide data scientist to meet their deliverables. Handling end-to-end client AI & analytics programs. Your role will be a combination of hands-on contribution, technical team management, and client interaction. Proven ability to discover solutions hidden in large datasets and to drive business results with their data-based insights Drive excellent project management required to deliver complex projects, including effort/time estimation. Be proactive, with full ownership of the engagement. Build scalable client engagement level processes for faster turnaround & higher accuracy Define Technology/ Strategy and Roadmap for client accounts, and guides implementation of that strategy within projects Run regular project reviews and audits to ensure that projects are being executed within the guardrails agreed by all stakeholders Manage the team-members, to ensure that the project plan is being adhered to over the course of the project Manage the client stakeholders, and their expectations, with a regular cadence of weekly meetings and status updates. Build a trusted advisor relationship with the IT management at clients and internal accounts leadership. Build

Data Engineering – Technical Lead About Us: Paytm is India’s leading digital payments and financial services company, which is focused on driving consumers and merchants to its platform by offering them a variety of payment use cases. To merchants, Paytm offers acquiring devices like Soundbox, EDC, QR and Payment Gateway where payment aggregation is done through PPI and also other banks’ financial instruments. To further enhance merchants’ business, Paytm offers merchants commerce services through advertising and Paytm Mini app store. Operating on this platform leverage, the company then offers credit services such as merchant loans, personal loans and BNPL, sourced by its financial partners. About the Role: This position requires someone to work on complex technical projects and closely work with peers in an innovative and fast-paced environment. For this role, we require someone with a strong product design sense & specialized in Hadoop and Spark technologies. Requirements: 4 to 8 years of experience in Big Data technologies. The position Grow our analytics capabilities with faster, more reliable tools, handling petabytes of data every day. Brainstorm and create new platforms that can help in our quest to make available to cluster users in all shapes and forms, with low latency and horizontal scalability. Make changes to our diagnosing any problems across the entire technical stack. Design and develop a real-time events pipeline for Data ingestion for real-time dash- boarding.Develop complex and efficient functions to transform raw data sources into powerful, reliable components of our data lake. Design & implement new components and various emerging technologies in Hadoop Eco- System, and successful execution of various projects. Be a brand ambassador for Paytm – Stay Hungry, Stay Humble, Stay Relevant! Skills that will help you succeed in this role: Fluent with Strong hands-on experience with Hadoop, MapReduce, Hive, Spark, PySpark etc.Excellent progr

About Us: Sauce Labs is the leading provider of continuous test and error reporting solutions that give companies the confidence to develop, deliver and update high quality software at speed. The Sauce Labs Continuous Testing Cloud identifies quality signals in development and production, accelerating the ability to release and update web and mobile applications that look, function and perform exactly as they should on every browser, operating system and device, every single time. Sauce Labs is a privately held company funded by TPG and Riverwood Capital. The Role: Sauce Labs seeks a Senior Software Engineer to join the Virtual Device Cloud team, which builds and operates the infrastructure that hosts remote iOS, macOS, Windows, and Linux devices at scale for automated app and browser testing. This is not a narrow specialist role. We need someone who can move across the whole stack of a distributed system: understand how the pieces fit together, make the system observable enough that we know what's working and can diagnose what isn't, write and structure code with clear boundaries and the right things encapsulated, and be just as comfortable SSHing into a fleet machine to dig into a live problem as designing the system on a whiteboard. You'll join the Virtual Device Cloud team, which has deep, concentrated strength in macOS, CoreSimulator and APFS internals, and work closely with the Product Manager and with the Test Orchestration and Cloud teams. Your job is to improve testing discipline and cross-platform observability, and to raise delivery cadence, correctness, and visibility across the fleet. Responsibilities: Lead by example - set the team’s standard for testing, observability and delivery through code review and pairing, and bring others along. Own the device lifecycle - design and build the services this team owns across the whole device lifecycle, from the image a device boots to its teardown. That covers readiness, session lifecycle and the fle

About Citi: Citi, the leading global bank, has approximately 200 million customer accounts and does business in more than 160 countries and jurisdictions. Citi provides consumers, corporations, governments, and institutions with a broad range of financial products and services, including consumer banking and credit, corporate and investment banking, securities brokerage, transaction services, and wealth management. As a bank with a brain and a soul, Citi creates economic value that is systemically responsible and in our clients' best interests. As a financial institution that touches every region of the world and every sector that shapes your daily life, our Enterprise Operations & Technology teams are charged with a mission that rivals any large tech company. Our technology solutions are the foundations of everything we do from keeping the bank safe, managing global resources, and providing the technical tools our workers need to be successful to designing our digital architecture and ensuring our platforms provide a first-class customer experience. We reimagine client and partner experiences to deliver excellence through secure, reliable, and efficient services. Our commitment to diversity includes a workforce that represents the clients we serve from all walks of life, backgrounds, and origins. We foster an environment where the best people want to work. We value and demand respect for others, promote individuals based on merit, and ensure opportunities for personal development are widely available to all. Ideal candidates are innovators with well-rounded backgrounds who bring their authentic selves to work and complement our culture of delivering results with pride. If you are a problem solver who seeks passion in your work, come join us. We'll enable growth and progress together. About the Team: The <span style="font-size:inherit"

Location Details: Remote, India At GoDaddy the future of work looks different for each team. Some teams work in the office full-time; others have a hybrid arrangement (they work remotely some days and in the office some days) and some work entirely remotely.​ This is a remote position, so you’ll be working remotely from your home. You may occasionally visit a GoDaddy office to meet with your team for events or meetings. Join Our Team... We are looking for an experienced engineer to join the Infrastructure Management and Automation team. In this role, you’ll help shape and build the tools, platforms, and automation that power and manage GoDaddy’s growing infrastructure footprint while leading the design of scalable solutions to complex operational challenges. Our infrastructure platform empowers GoDaddy engineers to help small business customers start, grow, and run their ventures. GoDaddy teams rely on our infrastructure solutions every day, whether for development workflows or hosting production workloads at global scale. If you enjoy solving complex technical problems, designing scalable systems, influencing technical direction, and improving how infrastructure is managed and automated, we’d love to hear from you! What you'll get to do... Lead the design and evolution of GoDaddy’s next generation of infrastructure management platforms and automation systems, taking ownership of complex technical areas from design through delivery and operation Leverage modern engineering practices and AI-assisted development workflows to rapidly design, build, and deliver scalable internal tooling and automation Design and build reliable services and integrations across infrastructure platforms and operational systems, including provisioning, networking, IPAM, DNS, CMDB, and asset management workflows Partner with engineering and operations teams to identify opportunities, shape technical solutions, and improve infrastructure reliability, scalability, utilization, and opera

Lead AI Engineer (Senior/Principal Consultant) Location: London (Hybrid) | Practice Area : Technology & Engineering | Type: Permanent Empower the next frontier of AI with Capco. Shape, build, and deliver future-ready generative systems. The Role We’re looking for a Lead AI Engineer (Senior/Principal Consultant) to join our Technology Delivery Team. You’ll combine your expertise in AI/ML engineering and software development to build and deploy cutting-edge generative AI and agentic systems across the financial services sector. As a hands-on leader, you’ll architect AI solutions, embed them within enterprise environments, and drive impactful outcomes through advanced engineering, scalable pipelines, and deep cross-functional collaboration. What You’ll Do Architect and develop autonomous AI systems integrating multi-modal LLMs (text, image, audio, video) Design agentic workflows enabling AI agents to interact with data sources and APIs using prompt engineering and RAG Fine-tune, optimize, and deploy large language and multi-modal models with a focus on performance and latency Build scalable MLOps pipelines and full-stack applications to support robust, production-grade AI deployments Guide multidisciplinary teams and clients through strategic decisions in AI engineering and GenAI adoption What We’re Looking For Bachelor’s degree or higher in Computer Science, AI, or related STEM fields Hands-on experience deploying LLMs and multi-modal models at scale Strong engineering background in Python with proven backend and API development skills Solid understanding of scalable MLOps, observability, and cloud-native AI deployment Excellent communication, problem-solving, and project management skills in agile environments Bonus Points For Experience with agentic frameworks (e.g., LangChain, LlamaIndex) Experience in deep learning frameworks and front-end development Familiarity with Langfuse, Langsmith, or other LLM observability tools Understanding of Model Context Protocol

Opportunity Overview: As a Lead Applied Scientist, you’ll join our growing team of world-class applied scientists and clinical experts to deploy machine learning models that help automate burdensome administrative clinical practices. Our AS team’s work is focused on designing, prototyping, and partnering with AI Engineering to deploy and monitor production models which extract or predict relevant clinical findings from structured and unstructured data sources. What you’ll do: Design and develop advanced machine learning algorithms for retrieval, classification and generative use cases. Write and maintain reusable codebases to perform data preprocessing, model training, and model evaluation Provide scientific and machine learning best practice guidance to junior engineers Work cross-functionally with diverse stakeholders, including product managers, clinicians, and technical leadership to align ML solutions with Cohere’s core objectives. What you’ll need: Must-haves Minimum 7+ years of experience in applied ML with a masters degree or 5+ years with a PhD, ideally in a senior or lead role in a large technology or healthcare company Clear understanding of model building, model maintenance and the measures that optimize models for production use Understand experimental design and can independently perform collection, measurement, and interpretation of results Expert in Python with experience in deep learning frameworks (e.g., PyTorch) Hands on experience building deep learning models (e.g., transformers) for NLP tasks MS or PhD required Nice-to-haves Experience with generative AI or Retrieval Augmented Generation (RAG) Experience working with unstructured healthcare data (e.g., clinical notes) Experience with OCR or image-based document understanding techniques Hands on experience using AWS tools such as SageMaker Studio ISMS roles and responsibilities Good knowledge of Information practices. Assist the manager in all the information security activitie

About us Graphcore is one of the world’s leading innovators in Artificial Intelligence compute. It is developing hardware, software and systems infrastructure that will unlock the next generation of AI breakthroughs and power the widespread adoption of AI solutions across every industry. As part of the SoftBank Group, Graphcore is a member of a best-in-class family of companies responsible for some of the world’s most transformative technologies. Together, they share a bold vision: to enable Artificial Super Intelligence and ensure its benefits are accessible to everyone. Graphcore’s teams are drawn from a diverse group of backgrounds and bring a broad range of skills and perspectives. A melting pot of AI research specialists, silicon designers, software engineers and systems architects, Graphcore enjoys a culture of continuous learning and constant innovation. Job Summary We are seeking a senior validation lead engineer to lead at-scale rack validation efforts for next-generation AI hyperscale systems. This role focuses on post-silicon system validation across the full lifecycle, ensuring functional, electrical, and thermal performance meets product objectives. You will own end-to-end blade and rack validation including planning, development, execution, and debug while collaborating across firmware, systems, and hardware teams. The Team The Rack Validation team is responsible for ensuring system readiness and quality at scale. The team works cross-functionally with firmware, silicon, and system engineering teams to validate complex AI compute platforms. Responsibilities and Duties Lead post-silicon validation of AI compute blades and racks including test planning, development, and automation. Drive provisioning and integration of system components (SoC FW, BMC, RMC, OS) for rack-level readiness. Own execution against program achievements and report validation progress and risks. Triage test failures, collect debug data, and collaborate on root cause analysis. Track

Senior Data Engineer Insurance underwriting runs on human judgment, manual workflows, and knowledge locked in someone's head. It breaks when that person leaves and doesn't scale when the book doubles. Sixfold is building AI agents that understand risk the way a 20-year veteran underwriter does. Not summaries or flags, but systems that make real decisions on billions in premium for some of the world's largest carriers. AI is the product and the workflow. The Senior Data Engineer makes sure the data powering those decisions is trusted, governed, and built to scale. If you live and breathe Data and AI tools, understand how models work under the hood, and can translate that into business outcomes for a room full of skeptical underwriters, this role was written for you. Who We Are 🏔 Product: Sixfold is the AI brain for underwriting. Our platform handles submissions at scale, assessing risk against appetite, surfacing cited insights, and deploying AI agents to handle triage, research, and referrals so underwriters can focus on building profitable portfolios. 💪 Team: A focused team of insurance operators, AI researchers, and engineers who love hard problems. We're pushing the boundaries of AI adoption across every function, from how we build, to how we sell and to how we support customers. We ship fast and stay close. 📈 Traction: Processing billions in premium for some of the world's largest carriers. We know AI. We know underwriting. We're building what comes next. About the Role In this role, you will: Lead data platform strategy and execution. Partner with the CDAO to shape overall data strategy and translate it into engineering roadmaps with clear owners, timelines, and outcomes. You're not inheriting a finished system — you're making consequential architectural decisions that compound over time. Own the Snowflake data lake end to end. Develop, maintain, and evolve the platform and its associated services — from ingestion to serving. This includes architecting data

Location Details: USA Remote At GoDaddy the future of work looks different for each team. Some teams work in the office full-time, others have a hybrid arrangement (they work remotely some days and in the office some days) and some work entirely remotely. This position may be a hybrid or fully remote position, as decided by your manager. If designated as hybrid, you’ll divide your time between working remotely from your home and an office location, so you should live within commuting distance. If designated as remote, you’ll be working remotely from your home and may occasionally visit a GoDaddy office to meet with your team for events or meetings. Your hiring manager can share more about this role’s hybrid or remote designation. This position is not eligible to be performed in Alaska, Mississippi, North Dakota, or the Virgin Islands. GoDaddy is not currently considering candidates for this role in California, Seattle, or NYC. Join our Team GoDaddy's Identity Platform powers authentication, authorization, and core identity infrastructure, which sits at the heart of how millions of small businesses securely access, manage, and grow their online presence, across our products. We’re looking for a Director of Engineering to lead this critical platform into its next chapter — driving company-wide adoption of OAuth/OpenID Connect (OIDC) and OpenFGA, strengthening the reliability and security of core identity services, and crafting customer experiences that are flawless, scalable, and trusted. In this role, you’ll set the technical vision and the execution rhythm for a 50+ person engineering organization. This organization spans the US and India. You will lead through multiple Senior Managers while staying close to the technology. This is a hands-on leadership role — we expect you to code, prototype, run technical experiments, and to lead by example in using AI-assisted development tools. What you’ll get to do Own and set the engin

We’re building a world of health around every individual — shaping a more connected, convenient and compassionate health experience. At CVS Health®, you’ll be surrounded by passionate colleagues who care deeply, innovate with purpose, hold ourselves accountable and prioritize safety and quality in everything we do. Join us and be part of something bigger – helping to simplify health care one person, one family and one community at a time. Position Summary The Senior Software Engineer / Technical Lead (AI & Automation) will provide technical leadership for the design, development, modernization, and support of critical applications supporting Prior Authorization Operations (PAOps) under PBM line of business. This role will be responsible for building and maintaining scalable, cloud-native solutions that enable intelligent workflow automation, AI-driven decisioning, document processing, and business process optimization. The ideal candidate is a hands-on technical leader with strong software engineering and cloud architecture expertise, coupled with practical experience implementing Generative AI, Agentic AI, and Large Language Model (LLM) solutions in production environments. This individual will collaborate closely with Data Engineering, Data Science, Product, and Business teams to deliver highly available, secure, and scalable applications while driving innovation through AI-powered solutions. Key areas of focus include: Application architecture, development, and production support Cloud-native engineering and platform modernization Microservices and distributed systems AI/GenAI, Agentic AI, and LLM-based solutions Event-driven and streaming architectures Engineering best practices, mentoring, and technical leadership R

We’re building a world of health around every individual — shaping a more connected, convenient and compassionate health experience. At CVS Health®, you’ll be surrounded by passionate colleagues who care deeply, innovate with purpose, hold ourselves accountable and prioritize safety and quality in everything we do. Join us and be part of something bigger – helping to simplify health care one person, one family and one community at a time. Position Summary We are seeking a highly experienced Senior Technology Manager to lead the Finance Technology AI Enablement engineering team, responsible for architecting and building best-in-class AI solutions while enabling business and IT partners in their AI adoption journey. In this role, you will provide strategic direction to the engineering team, champion engineering best practices, and drive the end-to-end delivery and enablement of AI solutions across the enterprise. The Finance Technology AI Enablement team helps the business strategize, evaluate, define, and prioritize complex enterprise initiatives — designing and building them into AI-enabled, transformative solutions. This role requires building strong relationships with business stakeholders and domain-specific IT application development teams, working collaboratively to advance AI-driven transformation and deliver measurable results. You will oversee and execute multiple concurrent AI initiatives, delivering value across various business domains in a fast-paced, dynamic environment. Key Responsibilities Lead, mentor, and grow a high-performing engineering team focused on AI/ML and GenAI solution delivery. Set strategic technical direction for the AI Enablement team, advocating for engineering best practices, scalable architecture, and responsible AI development. Partner with