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Senior Applied Ai Engineer Startups Jobs

7,101 active opportunities · Updated for October 2026

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Explore current senior applied ai engineer startups jobs. Use filters to narrow by work mode, employment type, experience and date posted.

PE
Private Employer
📍 Remote• Full-time• Remote
1mo ago

At Curai, we believe that access to high-quality healthcare is a fundamental human right, not a privilege. Our mission is to radically transform healthcare delivery by harnessing the power of artificial intelligence and clinical expertise to make care more affordable, accessible, and effective for everyone. Patients interact with advanced AI systems at every step of their care and follow-up. Licensed physicians review each case with the patient for the clinical decision in our integrated virtual clinic. We ground our approach in rigorous research, continuous learning, and a deep commitment to clinical integrity. We focus on making a real impact: improving health outcomes, expanding access to care, and setting new standards for what trustworthy, patient-centered healthcare is. Read some of our latest publications.

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E
19 days ago

Everpure (NYSE: P) has evolved from storage pioneer to data platform, closing fiscal 2026 with $3.7 billion in revenue, its first billion-dollar quarter, and accelerating growth into FY27. Our strategic agenda spans the companies defining the next era of technology - hyperscalers, AI labs, the AI hardware supply chain, data platform providers, and the broader AI ecosystem. This type of work—work that changes the world—is what the tech industry was founded on. So, if you're ready to seize the endless opportunities and leave your mark, come join us. THE ROLE Our Senior Applied AI Engineer builds and operate production-grade AI systems that extract meaning from large-scale unstructured document collections, enabling enterprise data discovery classification, and governance. This role owns the full lifecycle of graph intelligence solutions — from problem definition and data modelling, to building and enriching knowledge graphs, and deploying ML- and LLM-assisted analytics in production. The focus is on semantic and contextual analysis of unstructured data to uncover relationships, patterns, and insights that support AI safety, security, and compliance requirements. WHAT YOU'LL DO Design, build, and deploy graph-based AI solutions, combining knowledge graphs , LLMs, and ML models applied to large-scale unstructured data Define and own data pipelines that extract, transform, and enrich entity relationships into production-grade knowledge graphs Integrate LLMs and ML models into text processing pipelines for classification, embedding generation, document similarity, and semantic analysis Design, deploy, and operate graph and vector databases to support retrieval, reasoning, and analytics Optimize models and inference pipelines for production constraints including latency, throughput, cost, and infrastructure Deploy, monitor, and iterate on ML systems in production environments ensuring reliability and continuous integration Drive architectural decisions and tech

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V
Vanta
📍 United States• Full-time
1mo ago

At Vanta, our mission is to help businesses earn and prove trust. We believe that security should be monitored and verified continuously, and we empower companies to practice better security and prove it with ease. Vanta has a kind and talented team, and while some have prior security experience, many have been successful at Vanta without it. As a Senior Applied AI Engineer at Vanta, you will play a crucial role in shaping Vanta’s AI offerings, setting technical strategy, and leading projects that leverage AI to deliver smarter, faster outcomes for our customers. You'll be part of a team integrating AI into the Vanta product, working alongside a multidisciplinary group of product engineers, machine learning engineers, product managers, designers, and security and compliance experts to implement, scale, and maintain AI-enabled product experiences. In this role, you’ll build products that enable Vanta’s customers to leverage AI to accelerate their journey towards compliance, managing risk, and earning trust. Visit our Vanta Engineering Blog to learn more about what our team is working on! What you’ll do as an engineer working on Applied AI at Vanta: Work cross-functionally to design and implement AI-powered features to deliver customer value and integrate LLMs with Vanta’s existing products and systems. You’ll work with other product engineers across Vanta to understand how AI systems can accelerate product adoption at Vanta Instrument evaluations, guardrails, and monitoring, and review customer usage to continually improve quality Collaborate with AI Platform engineers shaping foundational AI systems and tooling that accelerate product teams Make pragmatic tradeoffs that consider business priorities, user experience, and a sustainable technical foundation Mentor engineers, champion good technical and product instincts, and model a collaborative, high-ownership engineering culture How to be successful in this role: At least 7 years of industry experience as a software

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V
1mo ago

At Vanta, our mission is to help businesses earn and prove trust. We believe that security should be monitored and verified continuously, and we empower companies to practice better security and prove it with ease. Vanta has a kind and talented team, and while some have prior security experience, many have been successful at Vanta without it. As a Senior Applied AI Engineer at Vanta, you will play a crucial role in shaping Vanta’s AI offerings, setting technical strategy, and leading projects that leverage AI to deliver smarter, faster outcomes for our customers. You'll be part of a team integrating AI into the Vanta product, working alongside a multidisciplinary group of product engineers, machine learning engineers, product managers, designers, and security and compliance experts to implement, scale, and maintain AI-enabled product experiences. In this role, you’ll build products that enable Vanta’s customers to leverage AI to accelerate their journey towards compliance, managing risk, and earning trust. Visit our Vanta Engineering Blog to learn more about what our team is working on! What you’ll do as an engineer working on Applied AI at Vanta: Work cross-functionally to design and implement AI-powered features to deliver customer value and integrate LLMs with Vanta’s existing products and systems. You’ll work with other product engineers across Vanta to understand how AI systems can accelerate product adoption at Vanta Instrument evaluations, guardrails, and monitoring, and review customer usage to continually improve quality Collaborate with AI Platform engineers shaping foundational AI systems and tooling that accelerate product teams Make pragmatic tradeoffs that consider business priorities, user experience, and a sustainable technical foundation Mentor engineers, champion good technical and product instincts, and model a collaborative, high-ownership engineering culture How to be successful in this role: At least 7 years of industry experience as a software

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H
1mo ago

Become a part of our caring community Most AI engineering jobs are a thin wrapper around a model API. This role is different. We build the platform that transforms millions of clinical documents into trusted, actionable data. Our systems use large language models (LLMs) to read medical records, extract structured facts, answer complex questions with citations back to the source document, and route ambiguous cases to human experts for review. Our users make decisions that impact real healthcare outcomes, so “good enough” is not good enough. Building AI systems that are accurate, reliable, auditable, and scalable is at the core of this role. As a Senior AI Applied Engineer, you will design, build, deploy, and operate production AI systems used at scale within one of the largest health insurers in the United States. You will own solutions end-to-end, from user experience and APIs to model orchestration, evaluation frameworks, infrastructure, and production operations. Why Join Us Build production AI systems where LLMs are in the critical path, not just demos or proofs of concept. Work on extraction, retrieval, agentic workflows, and human-review systems that process real healthcare data at scale. Own projects end-to-end across frontend, backend, AI orchestration, infrastructure, deployment, and operations. Solve challenging problems around accuracy, explainability, traceability, and reliability in regulated environments. Ship quickly in a small, high-impact team that embraces AI-assisted development and rigorous quality standards. Build systems that continuously improve through expert feedback, evaluations, and human-in-the-loop workflows. Key Responsibilities Design, develop, and deploy full-stack AI-powered application

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NVIDIA has continuously reinvented itself over two decades. Our invention of the GPU in 1999 sparked the growth of the PC gaming market, redefined modern computer graphics, and revolutionized parallel computing. More recently, GPU deep learning ignited modern AI — the next era of computing. NVIDIA is a “learning machine” that constantly evolves by adapting to new opportunities that are hard to solve, that only we can address, and that matter to the world. This is our life’s work, to amplify human creativity and intelligence. Make the choice to join us today. Design-for-Test Engineering at NVIDIA works on groundbreaking innovations involving crafting creative solutions for DFT architecture, verification and post-silicon validation on some of the industry's most complex semiconductor chips. What you'll be doing: As a senior member in our team, you will work with pre-silicon and post-silicon data analytics - visualization, insights and modeling. Design and uphold sturdy data pipelines and ETL processes for the ingestion and processing of DFX Engineering data from various origins Lead engineering efforts by collaborating with cross-functional teams (execution, analytics, data science, product) to define data requirements and ensure data quality and consistency You will work on hard-to-solve problems in the Design For Test space which will involve application of algorithm design, using statistical tools to analyze and interpret complex datasets and explorations using Applied AI methods. In addition, you will help develop and deploy DFT methodologies for our next generation products using Gen AI solutions. You will also help mentor junior engineers on test designs and trade-offs including cost and quality. What we need to see: BSEE (or equivalent experience) with 5+, MSEE with 3+, or PhD wi

pythonsqlaws
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O
1mo ago

About the Team The Applied AI Engineer - Digital Natives team is responsible for ensuring the safe and effective deployment of Generative AI applications for developers and enterprises. We act as a trusted advisor and thought partner for our customers, working to build an effective backlog of frontier AI use cases for their industry and drive them to production through strong technical guidance. As an Applied AI Engineer in the Digital Native segment, you’ll help large and highly sophisticated companies transform their business through custom AI solutions applications such as customer service, automated content generation, contextual search, personalization, and other novel use cases leveraging OpenAI’s newest, most exciting models and latest capabilities. About the Role We are looking for a driven solutions leader with a product mindset to partner with our customers and ensure they achieve tangible business value with frontier AI. You will pair with senior customer leaders to establish AI strategic roadmaps and identify the highest value applications. You’ll then partner with their engineering and product teams to move from prototype through production. You’ll take a holistic view of their needs and design an enterprise architecture using OpenAI APIs and other services to maximize customer value. You will collaborate closely with Sales, Solutions Engineering, Applied Research, and Product. This role is based in our São Paulo, Brazil office. We use a hybrid work model of 3 days in the office per week and offer relocation assistance to new employees. In this role, you will: Deeply embedd with our most sophisticated and technical platform customers, serving as their technical thought partner in ideating and building novel applications on our APIs. Proactively provide guidance to our customers on how to maximize business impact from their applications, accelerating their time to value. Experiment and prototype solutions with and for your customers. Forge and manage rel

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O
1mo ago

About the team The Applied AI Engineer, Digital Natives team is responsible for ensuring the safe and effective deployment of Generative AI applications for developers and enterprises. We act as a trusted advisor and thought partner for our customers, working to build an effective backlog of frontier AI use cases for their industry and drive them to production through strong technical guidance. As an Applied AI Engineer in the Digital Native segment, you’ll help large and highly sophisticated companies transform their business through custom AI solutions applications such as customer service, automated content generation, contextual search, personalization, and other novel use cases leveraging OpenAI’s newest, most exciting models and latest capabilities. About the role We are looking for a driven solutions leader with a product mindset to partner with our customers and ensure they achieve tangible business value with frontier AI. You will pair with senior customer leaders to establish AI strategic roadmaps and identify the highest value applications. You’ll then partner with their engineering and product teams to move from prototype through production. You’ll take a holistic view of their needs and design an enterprise architecture using OpenAI APIs and other services to maximize customer value. You will collaborate closely with Sales, Solutions Engineering, Applied Research, and Product. This role is based in our NYC office. We use a hybrid work model of 3 days in the office per week and offer relocation assistance to new employees. In this role, you will: Deeply embedded with our most sophisticated and technical platform customers, serving as their technical thought partner in ideating and building novel applications on our APIs. Proactively provide guidance to our customers on how to maximize business impact from their applications, accelerating their time to value. Experiment and prototype solutions with and for your customers. Forge and manage relationships wi

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O
OpenAI
📍 San Francisco• Full-time
1mo ago

About the team The Applied AI Engineer - Digital Natives team is responsible for ensuring the safe and effective deployment of Generative AI applications for developers and enterprises. We act as a trusted advisor and thought partner for our customers, working to build an effective backlog of frontier AI use cases for their industry and drive them to production through strong technical guidance. As an Applied AI Engineer in the Digital Native segment, you’ll help large and highly sophisticated companies transform their business through custom AI solutions applications such as customer service, automated content generation, contextual search, personalization, and other novel use cases leveraging OpenAI’s newest, most exciting models and latest capabilities. About the role We are looking for a driven solutions leader with a product mindset to partner with our customers and ensure they achieve tangible business value with frontier AI. You will pair with senior customer leaders to establish AI strategic roadmaps and identify the highest value applications. You’ll then partner with their engineering and product teams to move from prototype through production. You’ll take a holistic view of their needs and design an enterprise architecture using OpenAI APIs and other services to maximize customer value. You will collaborate closely with Sales, Solutions Engineering, Applied Research, and Product. This role is based in our SF or Seattle office. We use a hybrid work model of 3 days in the office per week and offer relocation assistance to new employees. In this role, you will: Deeply embedded with our most sophisticated and technical platform customers, serving as their technical thought partner in ideating and building novel applications on our APIs. Proactively provide guidance to our customers on how to maximize business impact from their applications, accelerating their time to value. Experiment and prototype solutions with and for your customers. Forge and manage relat

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O
OpenAI
📍 Washington• Full-time• Remote
29 days ago

About the Team The mission of the Applied AI Engineering team is to enable the secure and impactful implementation of GenAI solutions. We serve as technical thought partners and trusted advisors to our clients, ideating high-value use cases and providing the hands-on guidance necessary to drive projects into production. In this role within the Government team, you will empower agencies to evolve their operations through automated content synthesis, advanced search capabilities, and bespoke applications leveraging our latest foundational technologies and models. About the Role We are looking for a driven solutions leader with a product mindset to partner with our public sector customers and ensure they achieve tangible value with GenAI. You will pair with government agencies (federal, state, and local), policymakers, and other public institutions to establish a GenAI strategy and identify the highest value applications. You’ll then partner with their technical teams, subject matter experts, systems integrators, and implementation partners to move from prototype through production. You’ll take a holistic view of their needs and design an architecture using the OpenAI API and other services to maximize customer value. You will collaborate closely with Sales, Solutions Engineering, Global Affairs, Applied Research, and Product teams. This role is based in Washington, DC. We offer relocation support to new employees. In this role, you will: Deeply embed with our most sophisticated public sector customers as the technical lead, serving as their technical thought partner to ideate and build novel applications on our API and other OpenAI foundational technologies like Codex. Work with senior customer stakeholders to identify the best applications of GenAI in their industry and to build/qualify a comprehensive backlog to support their AI roadmap. Intervene directly to accelerate customer time to value through building hands-on prototypes and/or by delivering impactful strate

REMOTEtypescriptpythonaws
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For over 20 years, Smartsheet has empowered teams to manage work seamlessly and scale solutions smarter. Now, in our most ambitious chapter yet, we are uniting human teams with AI agents. By orchestrating the work agents do best, automating manual tasks and uncovering insights at scale, we create the space for people to focus on what truly matters: judgment, creativity, and big thinking. That is magic at work, and it’s what we show up for every day. You independently lead the most complex AI deployments Smartsheet undertakes. You own the full engagement lifecycle from technical discovery through production deployment through solutions org handoff. You architect multi-agent solutions, design client-personalized MCP resource packs, and build the Deployment Kits that transform how 200+ solutions consultants and partners operate. You mentor junior FDEs, drive the intelligence loop, and present field findings at weekly Applied AI strategy sessions. You are building a function, not filling a role. What You Will Do Lead complex, multi-system AI deployments end-to-end scope, architect, build, validate, and manage the customer relationship throughout. Own the AI workshop program for your pod, customize modules per customer, lead technical sessions, translate outputs into production requirements, evolve content from field learning. Architect multi-agent solutions selecting the right coordination pattern for each customer’s workflow characteristics and compliance requirements. Design client-specific and industry-specific MCP resource packs that serve personalized intelligence from the server so every connected AI surface gets smarter for that customer automatically. Own Deployment Kit quality for your pod. If a kit is not documented well enough for a solutions consultant with no engineering background to follow, it isn’t done. Lead Solutions Enablement Sprints: transfer AI deployment patterns to solutions consultants and partners with training materials and certification crite

REMOTEjavascripttypescriptpython
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F
1mo ago

About Flexport: At Flexport, we believe global trade can move the human race forward. That’s why it’s our mission to make global commerce so easy there will be more of it. We’re shaping the future of a $10T industry with solutions powered by innovative technology and exceptional people. Today, companies of all sizes—from emerging brands to Fortune 500s—use Flexport technology to move more than $19B of merchandise across 112 countries a year. The recent global supply chain crisis has put Flexport center stage as we continue to play a pivotal role in how goods move around the world. We are proud to have the support of the best investors in the game who believe in our mission, solutions and people. Ready to tackle global challenges that impact business, society, and the environment? Come join us. Senior Software Engineer: Applied AI Every day, thousands of shipments cross borders, change hands, and hit unexpected problems. For decades, fixing those problems meant phone calls, emails, and humans heroically firefighting. We think that's about to change completely. We've been building AI agents that spot trouble before it happens, reroute shipments, and keep goods moving—with our team of experts in the loop where it counts. The early results have been jaw-dropping. We're now going all in on a future where supply chains run themselves, and we're looking for the people who want to build that future with us. This isn't a role where you join a team and pick up tickets. You'll find the highest-leverage problems, design the solutions, and ship them to operators moving freight across 112 countries. If that sounds like your idea of a good time, read on. What You'll Do You'll build th

typescriptagileai
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For over 20 years, Smartsheet has empowered teams to manage work seamlessly and scale solutions smarter. Now, in our most ambitious chapter yet, we are uniting human teams with AI agents. By orchestrating the work agents do best, automating manual tasks and uncovering insights at scale, we create the space for people to focus on what truly matters: judgment, creativity, and big thinking. That is magic at work, and it’s what we show up for every day. About the Role The AI Platform Engineering team is looking for a highly motivated and talented engineer who are passionate about continuous learning and excited to grow in a fast-paced, innovative environment. We are an agile team that operates iteratively, focused on building high-quality software and adhering to rigorous operational best practices across complex, cross-functional distributed systems. This full-time position reports to a Software Engineering Manager and can be located in our Bellevue, WA office, or you may work remotely from anywhere in the US where Smartsheet is a registered employer. What You'll Do Build the AI Platform Foundation : Lead the design and ownership of the core infrastructure that serves as the backbone for all Smartsheet AI experiences. Focus on building a robust, multi-tenant environment that reduces friction for internal teams, allowing them to deploy reliable and scalable AI features with ease. Standardize the AI Developer Path : Architect high-level abstractions and "Golden Path" APIs that democratize AI development across Smartsheet. By insulating product teams from infrastructure complexity, you will enable them to ship intelligent features with high velocity while guaranteeing safety and consistency at scale. Engineer AI Trust & Safety Systems : Establish the mission-critical monitoring and quality assurance layers that protect Smartsheet customers. By creating rigorous evaluation pipelines, you will ensure every AI-driven feature meets the high bar for safety, data privacy, a

REMOTEpythonvueaws
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S
1mo ago

At Snowflake, we are powering the era of the agentic enterprise. To usher in this new era, we seek AI-native thinkers across every function who are energized by the opportunity to reinvent how they work. You don’t just use tools; you possess an innate curiosity, treating AI as a high-trust collaborator that is core to how you solve problems and accelerate your impact. We look for low-ego individuals who thrive in dynamic and fast-moving environments and move with an experimental mindset — who rapidly test emerging capabilities to discover simpler, more powerful ways to deliver results. At Snowflake, your role isn't just to execute a function, but to help redefine the future of how work gets done. At Snowflake, we are building a high-impact team to help the world's most innovative companies unlock the power of AI. As a Senior Forward Deployed Engineer, Applied AI on our Cortex AI team, you will be a hands-on technical leader and trusted partner to our most strategic customers. You will own the end-to-end delivery of enterprise AI programs, leading a team of 2–4 engineers while staying deeply technical yourself. You will set the technical direction for your customer engagements, mentor your team, and serve as the senior technical voice at the intersection of product, engineering, and customer success. IN THIS ROLE AT SNOWFLAKE, YOU WILL: Lead Customer Programs : Own the full lifecycle of complex, multi-engineer AI engagements – from scoping and architecture through deployment, monitoring, and handoff. Be accountable for delivery quality and customer outcomes for the projects you lead. Own AI Quality : Define what "good" means for each engagement. Translate ambiguous customer goals into measurable quality metrics, evaluation frameworks, and golden datasets – then run systematic eval loops to hill-climb on agent quality, catch regressions before customers do, and continuously raise the bar on accuracy, faithfulness, and safety. Set the standard for how the team measures

awsazuregcp
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F
1mo ago

About Flexport: At Flexport, we believe global trade can move the human race forward. That’s why it’s our mission to make global commerce so easy there will be more of it. We’re shaping the future of a $10T industry with solutions powered by innovative technology and exceptional people. Today, companies of all sizes—from emerging brands to Fortune 500s—use Flexport technology to move more than $19B of merchandise across 112 countries a year. The recent global supply chain crisis has put Flexport center stage as we continue to play a pivotal role in how goods move around the world. We are proud to have the support of the best investors in the game who believe in our mission, solutions and people. Ready to tackle global challenges that impact business, society, and the environment? Come join us. Senior Software Engineer: Applied AI Every day, thousands of shipments cross borders, change hands, and hit unexpected problems. For decades, fixing those problems meant phone calls, emails, and humans heroically firefighting. We think that's about to change completely. We've been building AI agents that spot trouble before it happens, reroute shipments, and keep goods moving—with our team of experts in the loop where it counts. The early results have been jaw-dropping. We're now going all in on a future where supply chains run themselves, and we're looking for the people who want to build that future with us. This isn't a role where you join a team and pick up tickets. You'll find the highest-leverage problems, design the solutions, and ship them to operators moving freight across 112 countries. If that sounds like your idea of a good time, read on. What You'll Do You'll build the cutting-edge agents and AI-powered applications that make Flexport's operations smarter, faster, and increasingly autonomous. That means: Designing and shipping end-to-end AI agents that handle real logistics work—customs compliance, document processing, exception management, and more. C

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