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Senior Infrastructure Architect Jobs

7,101 active opportunities · Updated for October 2026

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Explore current senior infrastructure architect jobs. Use filters to narrow by work mode, employment type, experience and date posted.

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Pfizer
📍 Connecticut• $93.6K – $156K/yr
1mo ago

ROLE SUMMARY We are seeking a highly motivated individual to join our high content imaging lab within the Discovery Biology and Pharmacology (DBP) group at the vibrant Groton campus in Connecticut. DBP is responsible for hit-identification, lead optimization, and molecular characterization of our small molecules and has teams focused on high-throughput screening, DNA-encoded libraries, pharmacology, protein homeostasis platforms, cellular models, functional genomics, and high-content imaging. The group is highly integrated with other groups in Medicine Design including Chemists, Structural Biologists, and Computational Scientists, and supports the small molecule portfolio across multiple therapeutic areas. The individual in this role will bring in rich experience in high content imaging and high throughput flow cytometry, and apply them to support our diverse small molecule portfolio spanning various therapeutic areas. ROLE RESPONSIBILITIES High-content imaging assay design, development, and optimization: Apply a broad range of imaging and flow cytometry assay technologies to address project needs. Independently develop, optimize, and troubleshoot high-content imaging and flow cytometry assays. Imaging data analysis and interpretation: Design and implement advanced image-analysis workflows, build complex analysis algorithms, and streamline data processing to support medium- to high-throughput screening. Translate imaging data into clear, actionable biological insights. Imaging infrastructure management and continuous improvement: Partner with team experts to support high-content imaging and flow cytometry instrumentation, implement software solutions that enable advanced imaging applications and data analysis, and continuously improve ima

airecruitment
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H
1mo ago

Become a part of our caring community Most AI engineering jobs are a thin wrapper around a model API. This role is different. We build the platform that transforms millions of clinical documents into trusted, actionable data. Our systems use large language models (LLMs) to read medical records, extract structured facts, answer complex questions with citations back to the source document, and route ambiguous cases to human experts for review. Our users make decisions that impact real healthcare outcomes, so “good enough” is not good enough. Building AI systems that are accurate, reliable, auditable, and scalable is at the core of this role. As a Senior AI Applied Engineer, you will design, build, deploy, and operate production AI systems used at scale within one of the largest health insurers in the United States. You will own solutions end-to-end, from user experience and APIs to model orchestration, evaluation frameworks, infrastructure, and production operations. Why Join Us Build production AI systems where LLMs are in the critical path, not just demos or proofs of concept. Work on extraction, retrieval, agentic workflows, and human-review systems that process real healthcare data at scale. Own projects end-to-end across frontend, backend, AI orchestration, infrastructure, deployment, and operations. Solve challenging problems around accuracy, explainability, traceability, and reliability in regulated environments. Ship quickly in a small, high-impact team that embraces AI-assisted development and rigorous quality standards. Build systems that continuously improve through expert feedback, evaluations, and human-in-the-loop workflows. Key Responsibilities Design, develop, and deploy full-stack AI-powered application

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Our Purpose Mastercard powers economies and empowers people in 200+ countries and territories worldwide. Together with our customers, we’re helping build a sustainable economy where everyone can prosper. We support a wide range of digital payments choices, making transactions secure, simple, smart and accessible. Our technology and innovation, partnerships and networks combine to deliver a unique set of products and services that help people, businesses and governments realize their greatest potential. Title and Summary Senior AI Platform Engineer (DevOps) Who is Mastercard? Mastercard powers economies and empowers people in 200+ countries and territories worldwide. Together with our customers, we're helping build a sustainable economy where everyone can prosper. We support a wide range of digital payment choices, making transactions secure, simple, smart, and accessible. Our technology and innovation, partnerships, and networks combined to deliver a unique set of products and services that help people, businesses, and governments realize their greatest potential. Our decency quotient (DQ) drives our culture and everything we do inside and outside our company. We cultivate an environment where individuals can thrive, collaborate, and contribute to innovations that power the global economy. Overview: The AI Platform Engineering team is responsible for building, operating, and evolving Mastercard's enterprise AI platforms and capabilities. Our mission is to provide scalable, secure, and reliable AI infrastructure that enables teams across Mastercard to accelerate the development and deployment of AI-powered solutions. As a Senior AI Engineer, you will help design, implement, and operate the foundational platforms that support AI and machine learning workloads across the enterprise. You will work at the intersect

pythondockerkubernetes
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M
1mo ago

At Playlist, life's richest moments happen when people step away from screens to move, connect, explore, and play. We're building the definitive platform for intentional living, connecting people with inspiring experiences in fitness, wellness, and beyond. With popular brands like Mindbody and ClassPass, Playlist empowers businesses and individuals, making it effortless for aspirations to become actions. Join us in reshaping technology's role to foster meaningful, real-world connections. Mindbody equips wellness entrepreneurs with technology to support thriving businesses and create exceptional experiences. Innovation and curiosity drive our culture, connecting businesses and individuals through cutting-edge solutions. Join us if you're passionate about enhancing wellness through technology. The Team Mindbody has a complex suite of products and features that customers rely on to run and grow their businesses. As the platform has grown in size and complexity, so has the opportunity to more consistently embed data into how we build and prioritize. Product Analytics exists to unlock that opportunity. We are a dedicated analytics function embedded within the Product organization, focused on surfacing timely, actionable insights that help our teams build better products and drive real business outcomes. We partner closely with Product, Design, and Engineering to understand how customers interact with our platform, identify friction and opportunity, and measure the impact of what we ship. We are a distinct team from Business Intelligence, though we partner closely with BI, who own centralized reporting infrastructure, while we focus on fast-paced, exploratory analysis tied directly to product decisions. The Role and Responsibilities We're looking for a Senior Product Analyst to join our growing Product Analytics team. This is a high-impact, high-visibility role focused on Mindbody software. You'll act as a strategic analytics partner to product

pythonsqlai
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M
1mo ago

At Playlist, life's richest moments happen when people step away from screens to move, connect, explore, and play. We're building the definitive platform for intentional living, connecting people with inspiring experiences in fitness, wellness, and beyond. With popular brands like Mindbody and ClassPass, Playlist empowers businesses and individuals, making it effortless for aspirations to become actions. Join us in reshaping technology's role to foster meaningful, real-world connections. Mindbody equips wellness entrepreneurs with technology to support thriving businesses and create exceptional experiences. Innovation and curiosity drive our culture, connecting businesses and individuals through cutting-edge solutions. Join us if you're passionate about enhancing wellness through technology. The Team Mindbody has a complex suite of products and features that customers rely on to run and grow their businesses. As the platform has grown in size and complexity, so has the opportunity to more consistently embed data into how we build and prioritize. Product Analytics exists to unlock that opportunity. We are a dedicated analytics function embedded within the Product organization, focused on surfacing timely, actionable insights that help our teams build better products and drive real business outcomes. We partner closely with Product, Design, and Engineering to understand how customers interact with our platform, identify friction and opportunity, and measure the impact of what we ship. We are a distinct team from Business Intelligence, though we partner closely with BI, who own centralized reporting infrastructure, while we focus on fast-paced, exploratory analysis tied directly to product decisions. The Role and Responsibilities We're looking for a Senior Product Analyst to join our growing Product Analytics team. This is a high-impact, high-visibility role focused on Mindbody software. You'll act as a strategic analytics partner to product

pythonsqlai
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N
1mo ago

NVIDIA is leading the way in groundbreaking developments in Artificial Intelligence, High Performance Computing and Visualization. The GPU, our invention, serves as the visual cortex of modern computers and is at the heart of our products and services. Our work opens up new universes to explore, enables amazing creativity and discovery, and powers what were once science fiction inventions from artificial intelligence to autonomous cars. We are the GPU Communications Libraries and Networking team at NVIDIA. We deliver libraries like NCCL, NVSHMEM, UCX for Deep Learning and HPC. We are looking for a motivated Performance engineer to influence the roadmap of our communication libraries. The DL and HPC applications of today have a huge compute demand and run on scales which go up to tens of thousands of GPUs. The GPUs are connected with high-speed interconnects (eg. NVLink, PCIe) within a node and with high-speed networking (eg. Infiniband, Ethernet) across the nodes. Communication performance between the GPUs has a direct impact on the end-to-end application performance; and the stakes are even higher at huge scales! This is an outstanding opportunity for someone with HPC and performance background to advance the state of the art in this space. Are you ready for to contribute to the development of innovative technologies and help realize NVIDIA's vision? What you will be doing: Conduct in-depth performance characterization and analysis on large multi-GPU and multi-node clusters. Study the interaction of our libraries with all HW (GPU, CPU, Networking) and SW components in the stack Evaluate proof-of-concepts, conduct trade-off analysis when multiple solutions are available Triage and root-cause performance issues reported by our customers Collect a lot of performance data; build tools and infrastructure to visualize and analyze the information <li

pythondockerkubernetes
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Snowflake
📍 Bellevue• Full-time• Remote
1mo ago

At Snowflake, we are powering the era of the agentic enterprise. To usher in this new era, we seek AI-native thinkers across every function who are energized by the opportunity to reinvent how they work. You don’t just use tools; you possess an innate curiosity, treating AI as a high-trust collaborator that is core to how you solve problems and accelerate your impact. We look for low-ego individuals who thrive in dynamic and fast-moving environments and move with an experimental mindset — who rapidly test emerging capabilities to discover simpler, more powerful ways to deliver results. At Snowflake, your role isn't just to execute a function, but to help redefine the future of how work gets done. Senior Software Engineer, Capacity Engineering At Snowflake, we are powering the era of the agentic enterprise. To usher in this new era, we seek AI-native thinkers across every function who are energized by the opportunity to reinvent how they work. You don’t just use tools; you possess an innate curiosity, treating AI as a high-trust collaborator that is core to how you solve problems and accelerate your impact. We look for low-ego individuals who thrive in dynamic, fast-moving environments and approach challenges with an experimental mindset, rapidly testing emerging capabilities to discover simpler, more powerful ways to deliver results. At Snowflake, your role isn't just to execute a function, but to help redefine the future of how work gets done. Snowflake’s infrastructure is expanding rapidly across AWS, Azure, and GCP. The Capacity team plays a pivotal role in provisioning the cloud resources essential for Snowflake's operations and ongoing growth. Capacity Engineering accurately models demand, forecasts requirements, and delivers optimal CPU and GPU capacity on schedule. We drive hardware cost-efficiency and price/performance while continually maximizing fleet utilization. To achieve this across all major cloud providers, the team is building a centralized, self-se

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Gitlab
📍 United States• Full-time• Remote• From $126.4K/yr
1mo ago

GitLab is the intelligent orchestration platform for DevSecOps. GitLab enables organizations to increase developer productivity, improve operational efficiency, reduce security and compliance risk, and accelerate digital transformation. More than 50 million registered users and more than 50% of the Fortune 100* trust GitLab to ship better, more secure software faster. The same principles built into our products are reflected in how our team works: we embrace AI as a core productivity multiplier, with all team members expected to incorporate AI into their daily workflows to drive efficiency, innovation, and impact. GitLab is where careers accelerate, innovation flourishes, and every voice is valued. Our high-performance culture is driven by our values and continuous knowledge exchange, enabling our team members to reach their full potential while collaborating with industry leaders to solve complex problems. Co-create the future with us as we build technology that transforms how the world develops software. * Fortune 500® is a registered trademark of Fortune Media IP Limited, used under license. Claim based on GitLab data. Fortune 100 refers to the top 20% ranked companies in the 2025 Fortune 500 list, published in June 2025. Fortune and Fortune Media IP Limited are not affiliated with, and do not endorse products or services of GitLab. An overview of this role As an Assigned Support Engineer, you’ll be a trusted technical advisor to GitLab’s largest Self-managed, GitLab Dedicated, and GitLab.com customers, helping them avoid operational disruption and get the most from GitLab. You’ll combine deep Linux systems expertise, GitLab and CI/CD knowledge, and a proactive support mindset to understand each customer’s environment, anticipate and prevent issues, and solve complex technical and business challenges. In a typical week, you might be prioritizing strategic blockers with customer stakeholders, partnering with Product, Development, Infrastructure, Customer Succ

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Gitlab
📍 United Kingdom• Full-time• Remote
1mo ago

GitLab is the intelligent orchestration platform for DevSecOps. GitLab enables organizations to increase developer productivity, improve operational efficiency, reduce security and compliance risk, and accelerate digital transformation. More than 50 million registered users and more than 50% of the Fortune 100* trust GitLab to ship better, more secure software faster. The same principles built into our products are reflected in how our team works: we embrace AI as a core productivity multiplier, with all team members expected to incorporate AI into their daily workflows to drive efficiency, innovation, and impact. GitLab is where careers accelerate, innovation flourishes, and every voice is valued. Our high-performance culture is driven by our values and continuous knowledge exchange, enabling our team members to reach their full potential while collaborating with industry leaders to solve complex problems. Co-create the future with us as we build technology that transforms how the world develops software. * Fortune 500® is a registered trademark of Fortune Media IP Limited, used under license. Claim based on GitLab data. Fortune 100 refers to the top 20% ranked companies in the 2025 Fortune 500 list, published in June 2025. Fortune and Fortune Media IP Limited are not affiliated with, and do not endorse products or services of GitLab. An overview of this role As an Assigned Support Engineer, you’ll be a trusted technical advisor to GitLab’s largest Self-managed, GitLab Dedicated, and GitLab.com customers, helping them avoid operational disruption and get the most from GitLab. You’ll combine deep Linux systems expertise, GitLab and CI/CD knowledge, and a proactive support mindset to understand each customer’s environment, anticipate and prevent issues, and solve complex technical and business challenges. In a typical week, you might be prioritizing strategic blockers with customer stakeholders, partnering with Product, Development, Infrastructure, Customer Succ

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Instacart
📍 BC, Canada• Full-time• Remote• From C$165K/yr
1mo ago

We're transforming the grocery industry At Instacart, we invite the world to share love through food because we believe everyone should have access to the food they love and more time to enjoy it together. Where others see a simple need for grocery delivery, we see exciting complexity and endless opportunity to serve the varied needs of our community. We work to deliver an essential service that customers rely on to get their groceries and household goods, while also offering safe and flexible earnings opportunities to Instacart Personal Shoppers. Instacart has become a lifeline for millions of people, and we’re building the team to help push our shopping cart forward. If you’re ready to do the best work of your life, come join our table. Instacart is a Flex First team There’s no one-size fits all approach to how we do our best work. Our employees have the flexibility to choose where they do their best work—whether it’s from home, an office, or your favorite coffee shop—while staying connected and building community through regular in-person events. Learn more about our flexible approach to where we work. Overview The Instacart Catalog team is the product data infrastructure powering everything customers see, find, and trust across the marketplace. We ingest data from retailers and third-party sources and use AI/ML and human operations to validate, enrich, and publish product information at scale. At the heart of this infrastructure are product attributes — the structured descriptors that power search filters, item card badges, dietary safety signals, health personalization, brand advertising, and agentic commerce. They touch every major surface and every major stakeholder. We're looking for a Senior Product Manager to own the product data layer that determines how customers find what they need, how brands show up on shelf, and how Instacart earns trust as the definitive source of grocery product data. In this role, you'll set the end-to-end strategy for catalog att

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Instacart
📍 United States• Full-time• Remote• From $189K/yr
1mo ago

We're transforming the grocery industry At Instacart, we invite the world to share love through food because we believe everyone should have access to the food they love and more time to enjoy it together. Where others see a simple need for grocery delivery, we see exciting complexity and endless opportunity to serve the varied needs of our community. We work to deliver an essential service that customers rely on to get their groceries and household goods, while also offering safe and flexible earnings opportunities to Instacart Personal Shoppers. Instacart has become a lifeline for millions of people, and we’re building the team to help push our shopping cart forward. If you’re ready to do the best work of your life, come join our table. Instacart is a Flex First team There’s no one-size fits all approach to how we do our best work. Our employees have the flexibility to choose where they do their best work—whether it’s from home, an office, or your favorite coffee shop—while staying connected and building community through regular in-person events. Learn more about our flexible approach to where we work. Overview The Instacart Catalog team is the product data infrastructure powering everything customers see, find, and trust across the marketplace. We ingest data from retailers and third-party sources and use AI/ML and human operations to validate, enrich, and publish product information at scale. At the heart of this infrastructure are product attributes — the structured descriptors that power search filters, item card badges, dietary safety signals, health personalization, brand advertising, and agentic commerce. They touch every major surface and every major stakeholder. We're looking for a Senior Product Manager to own the product data layer that determines how customers find what they need, how brands show up on shelf, and how Instacart earns trust as the definitive source of grocery product data. In this role, you'll set the end-to-end strategy for catalog att

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Join us in building the future of finance. Our mission is to democratize finance for all. An estimated $124 trillion of assets will be inherited by younger generations in the next two decades. The largest transfer of wealth in human history. If you’re ready to be at the epicenter of this historic cultural and financial shift, keep reading. About the team + role We are building an elite team, applying frontier technologies to the world's biggest financial problems. We're looking for bold thinkers. Sharp problem-solvers. Builders who are wired to make an impact. Robinhood isn't a place for complacency, it's where ambitious people do the best work of their careers. We're a high-performing, fast-moving team with ethics at the center of everything we do. Expectations are high, and so are the rewards. The Load and Fault team sits within Robinhood's Developer Infrastructure organization, with a mission to give every engineering team the tools they need to test their services under real-world conditions before those conditions test them in production. We build the platforms and frameworks that enable load testing, fault injection, and resilience validation at scale — treating reliability as a developer productivity problem, not just an operations one. Our work directly raises the quality bar for every service Robinhood ships, and we partner closely with engineering teams across the organization to make resilience testing a seamless part of the development workflow. As a Senior Software Engineer on the Load and Fault Environments team, you will design and build the infrastructure that lets Robinhood's engineers simulate load, inject faults, and validate system behavior under stress — at the scale of a fast-growing financial platform. You'll own meaningful components of the load testing and fault injection platform, write production-quality code, and collaborate with engineers across infrastructure and product teams to ensure the tooling you build gets adopted and drives real

pythonvueaws
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Roblox
📍 San Mateo• Full-time• From $243.3K/yr
1mo ago

Every day, tens of millions of people come to Roblox to explore, create, play, learn, and connect with friends in 3D immersive digital experiences– all created by our global community of developers and creators. At Roblox, we’re building the tools and platform that empower our community to bring any experience that they can imagine to life. Our vision is to reimagine the way people come together, from anywhere in the world, and on any device. We’re on a mission to connect a billion people with optimism and civility, and looking for amazing talent to help us get there. A career at Roblox means you’ll be working to shape the future of human interaction, solving unique technical challenges at scale, and helping to create safer, more civil shared experiences for everyone. Who We Are: Roblox is reimagining the way people come together to connect, create, and express themselves. To support our massive scale, we are powered by thousands of microservices. The Application Networking team connects and secures these services, building ingress gateways, managing the service mesh, and enabling seamless communication across Roblox’s hybrid on-prem and cloud infrastructure. We are executing on Cloud Bursting, a strategic initiative to enable Roblox’s core services to transparently burst from on-prem data centers to the cloud, allowing us to handle historical peak concurrent players and survive regional failures. You will join our Service Mesh team to build the networking fabric that makes this possible. You Will: Design and build the service mesh infrastructure that enables communication across Roblox’s hybrid Kubernetes and Nomad environments, supporting billions of daily requests. Drive the integration of service mesh with Kubernetes, ensuring reliable sidecar injection, mTLS, traffic policies, and observability for production workloads. Build the networking foundation for Cloud Bursting, enabling Roblox’s top services to transparently burst from on-prem data

awskubernetesgit
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R
1mo ago

Every day, tens of millions of people come to Roblox to explore, create, play, learn, and connect with friends in 3D immersive digital experiences– all created by our global community of developers and creators. At Roblox, we’re building the tools and platform that empower our community to bring any experience that they can imagine to life. Our vision is to reimagine the way people come together, from anywhere in the world, and on any device. We’re on a mission to connect a billion people with optimism and civility, and looking for amazing talent to help us get there. A career at Roblox means you’ll be working to shape the future of human interaction, solving unique technical challenges at scale, and helping to create safer, more civil shared experiences for everyone. We are seeking a highly motivated Senior Analyst to own and evolve a best-in-class tooling ecosystem that powers Roblox's Safety, Privacy, Trust & Safety, and Support Operations teams. In this role, you will sit at the intersection of operations and technology — driving systematic improvements, scaling tooling infrastructure, and ensuring agents across global vendor sites have the tools they need to operate efficiently and safely at Roblox's scale. You will join a growing team of administrators, incident managers, and product support specialists in India, providing comprehensive tooling and admin support to our global operations teams. You will help build a premier suite of agent tooling by managing systematic changes, identifying improvements, and delivering exceptional service to our internal customers. You will Administer and configure applications — including Zendesk, Absorb, JIRA, and other third-party and internally developed tools — to support 24/7 operations across multiple vendor sites. Design and implement queue and routing systems that reduce agent decision fatigue, enable quality support interactions, and support seamless multi-site operations. Analyze and translate b

awsgitagile
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S
1mo ago

At Snowflake, we are powering the era of the agentic enterprise. To usher in this new era, we seek AI-native thinkers across every function who are energized by the opportunity to reinvent how they work. You don’t just use tools; you possess an innate curiosity, treating AI as a high-trust collaborator that is core to how you solve problems and accelerate your impact. We look for low-ego individuals who thrive in dynamic and fast-moving environments and move with an experimental mindset — who rapidly test emerging capabilities to discover simpler, more powerful ways to deliver results. At Snowflake, your role isn't just to execute a function, but to help redefine the future of how work gets done. About the team The Apps & Experiences Platform team powers the systems and services behind all of our user-facing applications, including Snowsight, Snowflake Intelligence, and new mobile experiences. Our mission is to build innovative backend services, developer tooling, platform infrastructure, and AI-powered capabilities that enable exceptional product experiences at scale. As part of our team, you’ll work across feature development, platform engineering, infrastructure, and internal tooling to support both end users and developers. We care deeply about building systems that are reliable, scalable, maintainable, and performant. Snowflake is a high-growth AI Data Cloud company, and we’re looking for exceptional engineers to help us scale the next generation of our platform. A key part of this is our work on our internal AI developer agent, which is designed to fundamentally democratize end-to-end web app development across all engineering teams by translating product specs and designs into a fully functional, production-ready features. AS A SENIOR SOFTWARE ENGINEER FOR THE APPS & EXPERIENCES PLATFORM TEAM, YOU WILL: Design, build, and operate scalable backend services and platform infrastructure that power Snowflake’s user-facing applications. Contribute across th

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