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Senior Lead Python Jobs

10,000 active opportunities · Updated for October 2026

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Explore current senior lead python jobs. Use filters to narrow by work mode, employment type, experience and date posted.

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Nuro
📍 United States• Full-time• From $193.9K/yr
4mo ago

Who We Are Nuro believes self-driving vehicles are the most immediate and profound opportunity for AI to drive positive change in the physical world. Safer streets, more time for what matters, and easier access to the world around us, that’s why we’re building a universal autonomy platform: self-driving for all roads and all rides. Founded in 2016, Nuro is a physical AI company developing Level 4 autonomous driving technology for a wide range of vehicles, use cases, and markets. Powered by the Nuro Driver™, our universal autonomy platform enables the global mobility ecosystem to deploy autonomy at scale, from robotaxis and logistics fleets to personal vehicles. With years of real-world deployment experience and a flexible, partner-led business model, Nuro is working toward a future where millions of autonomous vehicles powered by our technology help make everyday life safer, easier, and more connected. Nuro has raised over $2B in capital from Uber, NVIDIA, Google, Softbank, Fidelity, T. Rowe Price, and other leading investors About the Role Nuro is seeking a Software Engineer with expertise in large-scale infrastructure, workload orchestration, and data processing to join our ML Infrastructure team . In this role, you will focus on building and evolving the core platform that provides researchers and engineers with seamless access to compute and data resources. You will be responsible for executing the technical strategy for automated resource provisioning, high-performance workload scheduling, and efficient feature management to accelerate the Nuro Driver™ development lifecycle. About the Work You will build the foundation that powers Nuro’s model development from experimentation to production. Key responsibilities include: Resource Provisioning & IaC: Scaling automated infrastructure-as-code (IaC) pipelines to manage thousands of GPU/CPU nodes across diverse environments. Intelligent Scheduling: Designing and optimizing workload orchestration to maximize

redisawsazure
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Nuro
📍 United States• Full-time• From $193.9K/yr
4mo ago

Who We Are Nuro believes self-driving vehicles are the most immediate and profound opportunity for AI to drive positive change in the physical world. Safer streets, more time for what matters, and easier access to the world around us, that’s why we’re building a universal autonomy platform: self-driving for all roads and all rides. Founded in 2016, Nuro is a physical AI company developing Level 4 autonomous driving technology for a wide range of vehicles, use cases, and markets. Powered by the Nuro Driver™, our universal autonomy platform enables the global mobility ecosystem to deploy autonomy at scale, from robotaxis and logistics fleets to personal vehicles. With years of real-world deployment experience and a flexible, partner-led business model, Nuro is working toward a future where millions of autonomous vehicles powered by our technology help make everyday life safer, easier, and more connected. Nuro has raised over $2B in capital from Uber, NVIDIA, Google, Softbank, Fidelity, T. Rowe Price, and other leading investors. About the Role The Autonomy ML Infrastructure team is responsible for building & improving the core infrastructure for autonomy teams at Nuro. In this role, you will work closely with teams across Nuro, to design, build and deploy core infrastructure components in machine learning model life cycle, to push the autonomous future forward. You will have an opportunity to work across the full stack of machine learning solutions - from designing robust and scalable model pipelines to building to deploying the optimized models on Nuro’s fleet of self-driving robots! About the Work Optimize Nuro’s autonomy stack with cutting-edge optimization techniques like quantization, distillation, and model compression. Work with autonomy engineers to optimize, validate, and deploy large language models. Develop and maintain a world-class model compiler framework, FTL . Write robust, high quality software to increase our confidence in our vehicle

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Who We Are At Justworks, you’ll enjoy a welcoming and casual environment, great benefits, wellness program offerings, company retreats, and the ability to interact with and learn from leaders in the startup community. We work hard and care about our most prized asset - our people. We’re helping businesses get off the ground by enabling them to focus on running their business. We solve HR issues. We’re data-driven and never stop iterating. If you’d like to work in a supportive, entrepreneurial environment, are interested in building something meaningful and having fun while doing it, we’d love to hear from you. We're united by shared goals and shared motivations at Justworks. These are best summed up in our company values, which are reflected in our product and in our team. Our Values If this sounds like you, you’ll fit right in. About the Role We’re seeking a Business Development Manager, Strategic Alliances responsible for creating and scaling transformative partnerships that go far beyond transactional sales. These alliances will unlock multi-year revenue streams , new distribution channels , and mutual enterprise value between Justworks and our partners. This is not a traditional Account

awsrestai
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Vanta
📍 United States• Full-time
4mo ago

At Vanta, our mission is to help businesses earn and prove trust. We believe that security should be monitored and verified continuously, and we empower companies to practice better security and prove it with ease. Vanta has a kind and talented team, and while some have prior security experience, many have been successful at Vanta without it. We’re looking for a detail-oriented Senior General Ledger Accountant to join our growing Accounting team. This role will be involved in a broad range of general ledger accounting activities, including, but not limited to, Cash, Prepaids, Fixed Assets, Accounts Payable, Leases, Investments, Allocations, Intercompany transactions, and Payroll accounting. The position requires strong analytical skills, a keen sense of accuracy, exceptional attention to detail, and the ability to independently research and resolve discrepancies. The ideal candidate thrives in a fast-paced environment and enjoys partnering cross-functionally with teams such as FP&A, Payroll, PeopleOPs, PayablesOps, and other business stakeholders to ensure accurate and timely financial reporting. SaaS industry experience is a plus, particularly in high-growth environments. What you’ll do as a Senior GL Accountant at Vanta: Prepare and review monthly journal entries, account reconciliations, and supporting schedules across a variety of general ledger accounts, including Cash, Prepaids, Fixed Assets, Accounts Payable, Leases, Investments, Payroll, and other balance sheet and income statement accounts. Partner cross-functionally with FP&A, Payroll, PeopleOps, Legal, and other business stakeholders to ensure the accuracy, completeness, and timeliness of financial information. Support the monthly, quarterly, and annual close processes by analyzing financial results, investigating variances and discrepancies, and ensuring accurate financial reporting. Perform flux and variance analyses across key accounts, leveraging data analytics and AI-enabled tools to identify

restairust
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Fin
📍 England• Full-time
4mo ago

Fin is the AI Customer Agent company on a mission to help businesses provide perfect customer experiences. Our AI Agent Fin is the highest-performing AI Customer Agent on the market today, enabling businesses to deliver impeccable, always-on customer support across the customer journey – from service, to sales, to ecommerce. Powered by our own AI models, Fin resolves complex customer issues end-to-end across every channel, with minimal set-up and integration. Fin can also be combined with our natively integrated Intercom help desk for one single system that is designed to meet the needs of modern day support teams. Founded in 2011, Fin became one of the fastest growing companies and remains one of the largest private software companies in the world with nearly 30,000 global businesses using our products to transform their customer support. Driven by our core values, we push boundaries, build with speed and intensity, and relentlessly deliver incredible value to our customers. What’s The Opportunity? Fin is an AI-first company revolutionizing how customer service is delivered today. Our entire platform is driven by an advanced AI Agent who we call Fin, who blends automation with empathy, setting a new standard in customer support. At Fin, you’ll help shape the future of AI-first customer service, showing our customers the transformative power of artificial intelligence. By inspiring a bold vision and delivering impactful solutions, you’ll make AI-powered support not just possible, but a reality for our customers. About the Role: Fin is looking for an exceptional Solutions Architect to join our vibrant Customer Solutions Team. In this role, you’ll engage directly with our customers as their trusted advisor, playing a pivotal part in defining and demonstrating value across the entire sales cycle. With a natural curiosity, independent thinking, and strong problem-solving skills, you’ll partner closely with Product, R&D, and Engineering to ensure our customers’ needs

aigorust
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Zoox
📍 Foster City• Full-time• Hybrid• $254K – $350K/yr
4mo ago

Zoox is looking for an experienced software engineer to work on large-scale simulation pipelines used to validate the behavior of the Zoox self-driving vehicle. These are data and GPU intensive workloads built on Ray.io and Kubernetes. Given the massive scale and criticality of these pipelines, ensuring their reliability and efficiency has a significant impact on the company's ability to safely and quickly iterate on autonomy development. We are a small, scrappy team within the larger Autonomy organization. Although this role primarily involves off-vehicle pipelines, you will work closely with engineers developing the on-vehicle algorithms and models in our autonomy stack. We stay close to the end users - autonomy engineers - and think about the end to end use case for these validation pipelines. This is a hands-on role with a high degree of independence and ownership. You will be expected to contribute towards the framework’s architecture, reliability, efficiency, and grow its capabilities to support new use cases. You should have a track record of keeping production systems running with high availability. Experience with robotics or autonomous systems is not required but an understanding of the robotic data lifecycle is preferred. In this role, you will: Improve the cost efficiency, reliability, and performance of our validation and simulation pipelines Create production-grade APIs, SDKs, and tools to enable a varied set of validations of autonomous behaviors Improve the ML training pipelines supporting the autonomous behavior org Qualifications Bachelor’s degree in Computer Science or related field and 8+ years of industry experience Experience optimizing large-scale distributed systems for cost and efficiency Experience with AWS or similar providers Proficiency with Python and familiarity with C++ Bonus Qu

pythonawskubernetes
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Noctrix Health
📍 Pittsburgh• $120K – $140K/yr
4mo ago

Noctrix Health is redefining the treatment of chronic neurological disorders with clinically validated therapeutic wearables. Our team of medical device specialists, neuroscientists, and consumer electronics engineers is dedicated to delivering prescription-grade therapy with an outstanding user experience. We have pioneered the world’s first drug-free wearable therapy, clinically proven to alleviate symptoms in adults with drug-resistant Restless Legs Syndrome (RLS). Be part of our mission to transform healthcare, improve lives, and drive meaningful change with Noctrix Health. We are seeking an experienced Senior Full Stack Software Engineer to design, develop, and maintain software systems that support Noctrix's patient-facing and customer support applications. This role will own complex backend data processing, API services, and front-end integrations across Noctrix's software ecosystem, including Galen Data, Nidra Sync API, Nidra Sync, Nidra Virtual, and Nidra Care. The ideal candidate combines strong backend engineering expertise with modern web application development skills and a passion for building secure, scalable, and maintainable software solutions in a regulated medical device environment. This individual will play a key role in shaping technical architecture, mentoring engineers, and advancing software engineering best practices across the organization. This position reports to the Director of Software Engineering . ***This is a full-time, hybrid position located in our Pittsburgh office.*** Responsibilities: Design, develop, and maintain full stack software solutions across backend services, web applications, and mobile application integrations Own complex backend data processing and service workflows within Galen Data and Nidra Sync API, including data parsing, API integrations, and data storage architectures Build and maintain secure, scalable RESTful APIs supporting Nidra Sync, Nidra Care, Nidra Virtual, a

javascripttypescriptpython
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Instacart
📍 BC, Canada• Full-time• Remote• From C$185K/yr
4mo ago

We're transforming the grocery industry At Instacart, we invite the world to share love through food because we believe everyone should have access to the food they love and more time to enjoy it together. Where others see a simple need for grocery delivery, we see exciting complexity and endless opportunity to serve the varied needs of our community. We work to deliver an essential service that customers rely on to get their groceries and household goods, while also offering safe and flexible earnings opportunities to Instacart Personal Shoppers. Instacart has become a lifeline for millions of people, and we’re building the team to help push our shopping cart forward. If you’re ready to do the best work of your life, come join our table. Instacart is a Flex First team There’s no one-size fits all approach to how we do our best work. Our employees have the flexibility to choose where they do their best work—whether it’s from home, an office, or your favorite coffee shop—while staying connected and building community through regular in-person events. Learn more about our flexible approach to where we work. Overview Instacart’s Enterprise Solutions – Connected Stores team is building the next generation of in-store experiences, bridging physical retail with digital capabilities through cutting-edge hardware, software, and AI. We partner with enterprise retailers to deliver seamless, high-scale integrations that power magical shopping experiences for millions of customers and thousands of stores. As a Senior Solution Architect, you will own end-to-end technical design and solutioning for our enterprise retail partners, serving as the primary technical liaison across Instacart Product and Engineering while collaborating closely with partner technology and business stakeholders. You’ll work on first-of-a-kind challenges in the in-store physical AI space, translating business needs into scalable architectures that launch successfully and stand the test of time. This role

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About Us At Cloudflare, we are on a mission to help build a better Internet. Today the company runs one of the world’s largest networks that powers millions of websites and other Internet properties for customers ranging from individual bloggers to SMBs to Fortune 500 companies. Cloudflare protects and accelerates any Internet application online without adding hardware, installing software, or changing a line of code. Internet properties powered by Cloudflare all have web traffic routed through its intelligent global network, which gets smarter with every request. As a result, they see significant improvement in performance and a decrease in spam and other attacks. Cloudflare was named to Entrepreneur Magazine’s Top Company Cultures list and ranked among the World’s Most Innovative Companies by Fast Company. At Cloudflare, we’re not looking for people who wait for a polished roadmap; we’re looking for the builders who see the cracks in the Internet that everyone else has simply learned to live with. We value candidates who have the instinct to spot a "normalized" problem and the AI-native curiosity to create a solution using the latest tools. Our culture is built on iteration, leveraging AI to ship faster today to make it better tomorrow, while ensuring that every improvement, no matter how small, is shared across the team to lift everyone up. If you’re the type of person who values curiosity over bureaucracy, and that AI is a partner in solving tough problems to keep the Internet moving forward, you’ll fit right in. Available Locations Austin, US About the Role Ad Fraud is a pervasive threat on the Internet, and has been since programmatic advertising first started. However, the ways that Users and Consumers interact with the internet is changing, and the systems of the past to protect against fraud may no longer be optimal. At Cloudflare, we believe that it is time for the industry to rethink their approach to solving this problem. And with our v

sqlawsai
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Coinbase
📍 - USA• Full-time• Remote• From $180.4K/yr
4mo ago

Ready to do the most impactful work of your career? At Coinbase , we are uncompromising on our mission to increase economic freedom. The bar is high, the environment is intense, and we like it that way. This isn't a place for complacency, it’s a place to be pushed past your perceived limits. If you're ready to build the future of finance alongside people who refuse to settle for "good enough," you belong here. Coinbase is a remote-first, but not remote-only company. Expect to get together quarterly for intense in-person working sessions called “surges.” learn more about working at Coinbase . As a Senior Data Scientist on the CX Consumer Analytics team, you will serve as the foundational link between CX operations and top-line financial impact, owning the revenue calibration models, experimentation frameworks, and behavioral intelligence that connect every customer support interaction to Coinbase's asset accumulation flywheel. You will partner closely with CX Analytics Engineers, Program Managers, and Product teams to translate complex operational and behavioral data into defensible, executive-ready insights that drive measurable improvements in retention, product adoption, and automation quality. What you'll do: Own and evolve CX's Downstream Impact of Support (DSI) revenue calibration models, translating support interaction data into quantified revenue signals. Design and execute causal inference frameworks and experiments to measure the incremental impact of CX programs (Concierge, Proactive Outreach, automation interventions) on customer retention and product engagement. Build and maintain LLM-powered classification pipelines for CX contact taxonomy, customer friction detection, and issue attribution, partnering with Analytics Engineers to productionize models into CX's governed Source of Truth infrastructure. Partner with CX Program Managers and Product teams to define segmentation models and behavioral signals that enable personalized experiences an

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Forma.ai
📍 Toronto• Full-time• From C$190K/yr
4mo ago

About Forma.ai: Forma.ai is a Series B startup that's revolutionizing how sales compensation is designed, managed and optimized. We handle billions in annual managed commissions for market leaders like Edmentum, Stryker, and Autodesk. Our growth has been fuelled by our passion for fundamentally changing and shaping how companies use sales intelligence to drive business strategy. We’re welcoming equally driven individuals who are excited about creating something big! About the Team Engineers on this team build our rules-based calculation engine for processing sales commissions. This might sound simple if you have never been exposed to sales compensation plans, it is not. We are low on meetings and high on accountability. Most of the team is in the EST time zone, with a few located in PST and Central as well. We are still evolving many areas of the platform, which means there is meaningful room to improve the design, reliability, and scalability of the systems we build. What you’ll be doing Reporting to the Manager of Data Platform, you will play an important role in the evolution of our Spark-based data platform. You’ll design and build data-rich platform capabilities, contribute to system design discussions, and help ensure our data systems remain reliable, maintainable, and scalable as Forma grows. As a Senior Engineer, Data Platform, you are expected to operate with strong ownership and sound technical judgment. This includes identifying risks in the work you own, surfacing edge cases, asking thoughtful questions, and proposing improvements that strengthen the quality and reliability of the platform. You will: Design, build, and improve Spark-based data pipelines and platform services. Work with complex data models representing sales compensation plans, hierarchies, relationships, and enterprise datasets. Build reliable, deterministic data systems that customers and internal teams can trust. Improve testing, observability, data quality,

javascripttypescriptpython
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Forma.ai
📍 Toronto• Full-time• From C$190K/yr
4mo ago

About Forma.ai: Forma.ai is a Series B startup that's revolutionizing how sales compensation is designed, managed and optimized. We handle billions in annual managed commissions for market leaders like Edmentum, Stryker, and Autodesk. Our growth has been fuelled by our passion for fundamentally changing and shaping how companies use sales intelligence to drive business strategy. We’re welcoming equally driven individuals who are excited about creating something big! About the Team We build enterprise software that helps organizations optimize sales performance and improve go-to-market agility. Our engineering organization includes multiple product application teams responsible for delivering core customer-facing capabilities. We are seeking Senior Backend Engineers to join our application teams. You’ll work alongside staff, senior, and early-career engineers to design, build, and scale backend systems that power enterprise-grade product workflows. This is an opportunity to work on complex product and data problems while contributing meaningfully to technical decisions, system quality, and team delivery. We are low on meetings and high on accountability. Most of the team is in the EST time zone, with a few located in AST, PST, and Central as well. What you’ll be doing You will play an important role in the continued evolution of our application stack. You will design and build backend capabilities for complex product workflows, contribute to system design discussions, and help ensure our systems remain maintainable, reliable, and scalable as we grow. As a Senior Backend Engineer, you are expected to operate with strong ownership and sound technical judgment. This includes identifying risks in the work you own, surfacing edge cases, asking thoughtful questions, and proposing improvements that strengthen the quality and reliability of the system. You will: Design and build backend services that power complex product workflows. Contribute to d

javascripttypescriptpython
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Twilio
📍 - US• Full-time• Remote• $141.5K – $213.9K/yr
4mo ago

Who we are At Twilio, we’re shaping the future of communications, all from the comfort of our homes. We deliver innovative solutions to hundreds of thousands of businesses and empower millions of developers worldwide to craft personalized customer experiences. Our dedication to remote-first work , and strong culture of connection and global inclusion means that no matter your location, you’re part of a vibrant team with diverse experiences making a global impact each day. As we continue to revolutionize how the world interacts, we’re acquiring new skills and experiences that make work feel truly rewarding. Your career at Twilio is in your hands. . Hiring and how we work We use Artificial Intelligence (AI) to help make our hiring process efficient. That said, every hiring decision is made by real Twilions! Also, while we are a remote-first company, you may be asked to report in person on an ad-hoc basis for team gatherings, functional off-sites or customer meetings. . See yourself at Twilio Join the team as Twilio's next Senior or Staff Applied Software Research Engineer for Emerging Technologies. We are hiring for multiple positions at either a Senior or Staff level. Who we are At Twilio, we're shaping the future of communications, all from the comfort of our homes. We deliver innovative solutions to hundreds of thousands of businesses and empower millions of developers worldwide to craft personalized customer experiences. Our dedication to remote-first work, and strong culture of connection and global inclusion means that no matter your location, you're part of a vibrant team with diverse experiences making a global impact each day. As we continue to revolutionize how the world interacts, we're acquiring new skills and experiences that make work feel truly rewarding. Your career at Twilio is in your hands. Welcome to Twilio Forward, the incubation lab where we push boundaries, unlock next-era growth, and turn the once-unimagined

REMOTEjavascriptpythonjava
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Datadog
📍 United States• Full-time• $192K – $240K/yr
4mo ago

Senior Software Engineer - Streaming Platform Client Data streams are mission-critical at Datadog, powering near real-time communication across the vast majority of our services. Our Streaming Platform group builds the core infrastructure and abstractions that ensure Datadog remains a trusted partner for engineers worldwide. See our blog post . The Streaming Platform Client team sits at the heart of this ecosystem. We own the Rust client library (producers and consumers) with language bindings for Java, Go, and Python. We focus on building intuitive APIs and abstractions that make a powerful distributed system easy to adopt and operate for the hundreds of internal users of our library. Our library runs on critical data paths that handle hundreds of millions of messages per second making performance, observability, and reliability paramount. We also develop and operate the service that bridges the clients fleet with the platform's control plane, handling complex balancing, scaling, and static stability challenges. We are seeking a Senior Software Engineer to help us evolve these features. You will collaborate directly with our users, tackle performance-critical code, and solve complex distributed systems challenges across the control plane, client libraries, and data plane. At Datadog, we place value in our office culture - the relationships and collaboration it builds and the creativity it brings to the table. We operate as a hybrid workplace to ensure our Datadogs can create a work-life harmony that best fits them. What You’ll Do: Work within a distributed, high-impact team spanning Europe and the US, building critical technologies that power data pipelines for dozens of internal teams and hundreds of services. Architect and implement resilient interactions between our client libraries and the control plane. Optimize our high-throughput, low-level streaming library to push the boundaries of performance and efficiency. Champion the developer experience by pro

pythonjavaai
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4mo ago

Who we are At Twilio, we’re shaping the future of communications, all from the comfort of our homes. We deliver innovative solutions to hundreds of thousands of businesses and empower millions of developers worldwide to craft personalized customer experiences. Our dedication to remote-first work , and strong culture of connection and global inclusion means that no matter your location, you’re part of a vibrant team with diverse experiences making a global impact each day. As we continue to revolutionize how the world interacts, we’re acquiring new skills and experiences that make work feel truly rewarding. Your career at Twilio is in your hands. . Hiring and how we work We use Artificial Intelligence (AI) to help make our hiring process efficient. That said, every hiring decision is made by real Twilions! Also, while we are a remote-first company, you may be asked to report in person on an ad-hoc basis for team gatherings, functional off-sites or customer meetings. . See yourself at Twilio Join the team as Twilio's next Senior/Staff Applied Software Research Engineer for Emerging Technologies. We are hiring for multiple positions at a Senior and Staff level. About the job This full stack engineer position is needed to contribute hands-on technical expertise, collaborate on rapid prototyping, and develop innovative solutions as part of Twilio’s incubation team. As a Senior Applied Software Research Engineer, you’ll build hands-on skills with new technologies, collaborate with passionate engineers, and contribute to delivering solutions that help shape Twilio’s future offerings. This is a growth role, ideal for someone eager to learn and make a measurable difference in a fast-paced, entrepreneurial environment. As a Staff Applied Software Research Engineer, you’ll work closely with cross-functional partners to design and build new product ideas, leveraging modern technologies and your problem-solving abilities. This is a high-impact

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