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Senior Principal Program Manager Jobs

10,000 active opportunities · Updated for October 2026

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Explore current senior principal program manager jobs. Use filters to narrow by work mode, employment type, experience and date posted.

C
Coinbase
📍 United States• Full-time• Remote• $186.1K – $218.9K/yr
10mo ago

Ready to do the most impactful work of your career? At Coinbase , we are uncompromising on our mission to increase economic freedom. The bar is high, the environment is intense, and we like it that way. This isn't a place for complacency, it’s a place to be pushed past your perceived limits. If you're ready to build the future of finance alongside people who refuse to settle for "good enough," you belong here. Coinbase is a remote-first, but not remote-only company. Expect to get together quarterly for intense in-person working sessions called “surges.” learn more about working at Coinbase . Senior Software Engineer (EAA) The EAA Compliance CXAE team, part of Coinbase's Enterprise Applications and Architecture org, builds AI-first surfaces, tools, and applications that streamline compliance processes and improve the efficiency and effectiveness of Compliance agents. As a Senior Software Engineer, you'll build full-stack applications that enable Coinbase Compliance Agents to increase productivity, drive automation, and deliver impact at scale through custom development and third-party integrations. What you'll do: Build end-to-end user-facing features using Golang, React, and cloud technologies, delivering AI-first compliance tooling that improves agent productivity and KYC process accuracy. Lead assessment, selection, and implementation of third-party tools and vendor integrations into the compliance agent experience platform. Drive cross-functional delivery of complex technical solutions in collaboration with product, design, security, data, and peer engineering teams. Architect platform improvements that build upon existing development practices and technical domains, delivering reusable capabilities that benefit multiple teams across the organization. Own reliability for Tier-1 compliance systems by anticipating potential issues before they reach production and adapting your approach proactively to work within constraints. Mentor engineers in f

REMOTEreactsqlaws
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S
10mo ago

Synthesia is the world’s leading AI video platform for business, used by over 90% of the Fortune 100. Founded in 2017, the company is headquartered in London, with offices and teams across Europe and the US. As AI continues to shape the way we live and work, Synthesia develops products to enhance visual communication and enterprise skill development, helping people work better and stay at the center of successful organizations. Following our recent Series E funding round, where we raised $200 million, our valuation stands at $4 billion. Our total funding exceeds $530 million from premier investors including Accel, NVentures (Nvidia's VC arm), Kleiner Perkins, GV, and Evantic Capital, alongside the founders and operators of Stripe, Datadog, Miro, and Webflow. About the role As a Senior Research Engineer, you will join a team of 40+ Researchers and Engineers within the R&D Department working on cutting edge challenges in the Generative AI space, with a focus on avatar-centric interactive video diffusion models. Within the team you’ll have the opportunity to work on the applied side of our research efforts and directly impact our solutions that are used worldwide by over 60,000 businesses. This is a unique opportunity for experts in machine learning and diffusion models to shape the future of AI video agents that can think, act, and react like humans. As part of our Interactive Avatars Team, you’ll work on cutting-edge research with a clear focus on turning breakthrough ideas into real product capabilities. You’ll join a team that moves fast, iterates often, and builds models that ship and make a meaningful impact. Example tasks and responsibilities include: Adapt diffusion models to incorporate diverse conditioning signals (e.g., audio, motion, interaction cues). Develop methods for streaming infinitely long video sequences at real-time rates. Work on the perceptual layer of interactive agents, including understanding user audio and generating appropriate contextu

REMOTEpythonreactgit
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R
Roblox
📍 San Mateo• Full-time• From $242.1K/yr
10mo ago

Every day, tens of millions of people come to Roblox to explore, create, play, learn, and connect with friends in 3D immersive digital experiences– all created by our global community of developers and creators. At Roblox, we’re building the tools and platform that empower our community to bring any experience that they can imagine to life. Our vision is to reimagine the way people come together, from anywhere in the world, and on any device. We’re on a mission to connect a billion people with optimism and civility, and looking for amazing talent to help us get there. A career at Roblox means you’ll be working to shape the future of human interaction, solving unique technical challenges at scale, and helping to create safer, more civil shared experiences for everyone. What You’ll Do: In this Senior Frontend Engineering role, you will be a key contributor in shaping the future of Roblox’s application surfaces. You will develop the architecture and technical direction of our frontend stack for consumer-facing surfaces, working across teams and technology platforms to ensure our solutions are universal and scalable​. This role would require defining how all our frontend pieces fit together, how data flows through the client, and how we can build features faster and more reliably. You will have the opportunity to work with modern frameworks and also dive into our custom Luau-based tech, bridging the best ideas from the web ecosystem into Roblox’s unique environment. If you are excited by the idea of creating the foundation on which dozens of engineers will build new features – and doing it in a way that delights our end-users with speed and stability – then this role will be perfect for you. Join us and help build the frontend platform that underpins the metaverse! Together, we’ll enable incredible new experiences for our users and a productive, joyful development experience for our engineers. You Have: Bachelor’s degree in Computer Science or a relate

javascripttypescriptjava
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R
Roblox
📍 San Mateo• $263.7K – $322.8K/yr
10mo ago

Every day, tens of millions of people come to Roblox to explore, create, play, learn, and connect with friends in 3D immersive digital experiences– all created by our global community of developers and creators. At Roblox, we’re building the tools and platform that empower our community to bring any experience that they can imagine to life. Our vision is to reimagine the way people come together, from anywhere in the world, and on any device. We’re on a mission to connect a billion people with optimism and civility, and looking for amazing talent to help us get there. A career at Roblox means you’ll be working to shape the future of human interaction, solving unique technical challenges at scale, and helping to create safer, more civil shared experiences for everyone. WHY DATA SCIENCE & ANALYTICS? The Data Science & Analytics organization's mission is to increase our speed, frequency and acumen of making decisions at scale by instilling a data-influenced approach to building products. We cover a wide area of the data spectrum including analytical data engineering, product analytics, experimentation, causal inference, statistical modeling and machine learning. Aligned and partnering with product verticals, we use this extensive tool belt to discover new opportunities and unmet use cases, influence and shape the product roadmap and prioritization, build data products and measure impact on our community of players and developers. WHY GROWTH MEASUREMENT? In this role, you will leverage your expertise in data science, statistics, and causal inference to develop measurement framework and product to deepen our quantitative understanding of growth efforts, which includes but not limited to performance marketing efficacy, attribution modeling and incrementality measurement. You will collaborate with cross-functional teams to develop and implement data-driven products and strategies that maximize the impact of our growth initiatives. You will also report t

pythonsqlmachine learning
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C
10mo ago

About Us At Cloudflare, we are on a mission to help build a better Internet. Today the company runs one of the world’s largest networks that powers millions of websites and other Internet properties for customers ranging from individual bloggers to SMBs to Fortune 500 companies. Cloudflare protects and accelerates any Internet application online without adding hardware, installing software, or changing a line of code. Internet properties powered by Cloudflare all have web traffic routed through its intelligent global network, which gets smarter with every request. As a result, they see significant improvement in performance and a decrease in spam and other attacks. Cloudflare was named to Entrepreneur Magazine’s Top Company Cultures list and ranked among the World’s Most Innovative Companies by Fast Company. At Cloudflare, we’re not looking for people who wait for a polished roadmap; we’re looking for the builders who see the cracks in the Internet that everyone else has simply learned to live with. We value candidates who have the instinct to spot a "normalized" problem and the AI-native curiosity to create a solution using the latest tools. Our culture is built on iteration, leveraging AI to ship faster today to make it better tomorrow, while ensuring that every improvement, no matter how small, is shared across the team to lift everyone up. If you’re the type of person who values curiosity over bureaucracy, and that AI is a partner in solving tough problems to keep the Internet moving forward, you’ll fit right in. Available Locations Ontario, Canada Toronto, Canada About the Role Account Executives, Channel Account Managers, Business Development Representatives, Solution Engineers, Customer Success, and Sales Operations - all working together help our customers adopt Cloudflare and create great Internet-enabled experiences. The sales team at Cloudflare helps customers solve real-world problems by delivering business solutions powered by Cloudflare’s global AI-pow

S
10mo ago

For over 20 years, Smartsheet has empowered teams to manage work seamlessly and scale solutions smarter. Now, in our most ambitious chapter yet, we are uniting human teams with AI agents. By orchestrating the work agents do best, automating manual tasks and uncovering insights at scale, we create the space for people to focus on what truly matters: judgment, creativity, and big thinking. That is magic at work, and it’s what we show up for every day. Smartsheet’s Enterprise Systems team manages the development, use, and support of the Enterprise Applications including the internal use of Smartsheet. Our team is looking to hire a Senior NetSuite Administrator who is an active listener with great technical skills. As we continue to scale, we are looking for a NetSuite Administrator who understands how to implement and scale enterprise systems. Smartsheet is looking to hire a Senior NetSuite Administrator who will proactively improve and support the development, implementation, and maintenance of Smartsheet’s NetSuite system and other related SAAS enterprise systems. This role reports to the Manager, Enterprise Systems within Corporate IT and is based in India. This NetSuite Administrator will need to demonstrate strong influence and communications skills to collaborate internally with the Finance, Engineering, Sales and IT departments and act as an advisor to the organization on system efficiency and effectiveness. The position will be the primary internal support contact for NetSuite, all related points of integration. You Will: Maintain the NetSuite application and other related 3rd party business applications for internal users Develop, test and deploy customizations, custom objects, 3rd party tools / applications and new NetSuite modules based on evolving business needs Support end user requests for new saved searches, reports, KPI’s, and dashboards, and maintain proper system access for user roles Act as NetSuite SME providing training, communication and upd

aiproject managementfinance
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C
10mo ago

Responsibilities: Annotate Case Report Form (acrf.pdf) following FDA/CDISC or sponsor guidelines. Develop SDTM specifications and generate SDTM datasets using SAS. Develop ADaM specifications and generate ADaM datasets using SAS based on Statistical Analysis Plan. Develop Tables, Listings, Graphs, Patient Profile in support of the Clinical Study Report, Posters, Manuscripts. Develop ADaM data, Tables, Listings, Figures for Integrated Summary of Safety (ISS) and Integrated Summary of Efficacy (ISE). Create electronic submission package to FDA, e.g., define.xml or define.pdf following FDA guidelines with minimum supervision. Proficient in analyze information and develop innovative solutions to programming and data analysis challenges; Support the point of contact (POC) of programming with statisticians for statistical input and analysis interpretation Follow and reinforce regulatory agency requirements during daily job. Serve as a programming team lead and contribute to department initiative. Provide guidance, mentoring, training for team members and help solve issues from cross-functional teams. Review draft and final production deliverables for project to ensure quality and consistency. Skills and Qualifications: Bachelor’s/Master’s degree in Statistics, Mathematics, Computer Science, Electrical Engineering, Biotechnology or related scientific disciplines. Minimum of 4+ years of clinical programming experience, along with 1+ year of project management and 1+ year of people management experience. Proven knowledge and training in high level computing languages such as. SAS, C/C++, Java, R, Python, MATLAB and SQL. Database programming experience is a plus. Proficient in decoding programming logic and assembling programming code based on logic provided and be able to explain to team members. Proficient in applying concepts in Artificial Intelligence and Machine Learning in the real world. In-depth knowledge of ICH, Good Clinical Practices, Clinical research, Clini

pythonjavasql
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D
10mo ago

Datadog is seeking a Senior People Business Partner (PBP) to work closely with business leadership and our People team to help support our growing cross-functional team in our Tokyo office. This position will work closely to support the needs of our go-to-market (GTM) team members in Japan while working strategically on all People programs and initiatives. Datadog has had exponential growth year-over-year and has no plans to stop - so there is a lot to learn from and contribute to our rapidly scaling team. At Datadog, we place value in our office culture - the relationships and collaboration it builds and the creativity it brings to the table. We operate as a hybrid workplace to ensure our Datadogs can create a work-life harmony that best fits them. What You’ll Do: Act as regional PBP for all employees in Japan across a variety of pre-sales, post-sales and related GTM support teams; represent our global PBP team to partner on the front line with all employees and leadership in Datadog’s Tokyo office Advise, coach, and influence management on all things people-related, including: performance management, coaching, career pathing, employee relations, compensation, organizational development & scaling, training, culture, inclusion, employee engagement Maintain close partnership with departmental PBPs to collaborate on critical needs and change management Consult with the appropriate People Center of Excellence (COE) team to gather their expertise to provide input on program design to enhance the employee experience Build, advise and consult on People policies, guidelines, and programs with employee base, in collaboration with COE colleagues Provide analysis and consulting to leadership to drive data-driven people decisions and implementation of best practices Assess employee development needs, make recommendations, and implement appropriate solutions aligned with the organization’s broader strategy Handle complex global employee relations issues, w

aigorust
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C
10mo ago

Responsibilities: Annotate Case Report Form (acrf.pdf) following FDA/CDISC or sponsor guidelines. Develop SDTM specifications and generate SDTM datasets using SAS; Develop ADaM,specifications and generate ADaM datasets using SAS based on Statistical Analysis Plan; Develop Tables, Listings, Graphs, Patient Profile in support of the Clinical Study Report, Posters, Manuscripts; Develop ADaM data, Tables, Listings, Figures for Integrated Summary of Safety (ISS) and Integrated Summary of Efficacy (ISE) Create electronic submission packages to FDA, e.g., define.xml or define.pdf following FDA guidelines with no supervision. Expert-level in analyze information and develop innovative solutions to programming and data analysis challenges; Serve as point of contact (POC) of programming with statisticians for statistical input and analysis interpretation; Follow and reinforce regulatory agency requirements during daily job. Serve as a programming team lead and contribute to department initiatives. Provide guidance, mentoring, training for team members and help solve issues from cross-functional teams; Review draft and final production deliverables for project to ensure quality and consistency. Work with global team or sponsors to coordinate project deliverables, timelines and resources. Skills and Responsibilities: Bachelor’s/Master’s degree in Statistics, Mathematics, Computer Science, Electrical Engineering, Biotechnology or related scientific disciplines with 5+years of clinical programming experience. Proven knowledge and training in high level computing languages such as. SAS, C/C++, Java, R, Python, MATLAB and SQL. Database programming experience is a plus. Expert-level in decoding programming logic and assembling programming code based on logic provided and be able to explain to team members. Expert level in applying concept in Artificial Intelligence and Machine Learning in real world. In-depth knowledge of ICH, Good Clinical Practices, Clinical research, Clinical tria

pythonjavasql
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B
Brex
📍 Vancouver• Full-time• From C$192K/yr
10mo ago

Why join us Brex is the intelligent finance platform that enables companies to spend smarter and move faster in more than 200 markets. By combining global corporate cards and banking with intuitive spend management, bill pay, and travel software, Brex enables founders and finance teams to accelerate operations, gain real-time visibility, and control spend effortlessly. Brex’s AI-native automation and world-class service eliminate manual expense and accounting tasks for customers so they can focus on what matters most. Tens of thousands of the world's best companies run on Brex, including DoorDash, Coinbase, Robinhood, Zoom, Plaid, Reddit, and SeatGeek. Working at Brex allows you to push your limits, challenge the status quo, and collaborate with some of the brightest minds in the industry. We’re committed to building a diverse team and inclusive culture and believe your potential should only be limited by how big you can dream. We make this a reality by empowering you with the tools, resources, and support you need to grow your career. Engineering at Brex Engineering at Brex is about building systems that scale with speed and intention. Our teams span Software, Data, Security, and IT, and operate with high autonomy and deep collaboration. We tackle hard technical problems, own our outcomes, and push for excellence at every level — from architecture to deployment. It’s an environment where engineering is a craft, and builders become leaders. What you’ll do As a Security Operations Engineer at Brex, you will focus on preventing, detecting and responding to security threats across Brex's corporate and cloud environments. You will use existing systems and develop tools to improve our security capabilities. Our team is responsible for functions across corporate security, detection & response and infrastructure security domains; and we perform systems engineering and automation to support those functions. Security Operations is part of our wider Trust & IT o

pythonawsazure
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B
Brex
📍 Seattle• Full-time• $192K – $240K/yr
10mo ago

Why join us Brex is the intelligent finance platform that enables companies to spend smarter and move faster in more than 200 markets. By combining global corporate cards and banking with intuitive spend management, bill pay, and travel software, Brex enables founders and finance teams to accelerate operations, gain real-time visibility, and control spend effortlessly. Brex’s AI-native automation and world-class service eliminate manual expense and accounting tasks for customers so they can focus on what matters most. Tens of thousands of the world's best companies run on Brex, including DoorDash, Coinbase, Robinhood, Zoom, Plaid, Reddit, and SeatGeek. Working at Brex allows you to push your limits, challenge the status quo, and collaborate with some of the brightest minds in the industry. We’re committed to building a diverse team and inclusive culture and believe your potential should only be limited by how big you can dream. We make this a reality by empowering you with the tools, resources, and support you need to grow your career. Engineering at Brex Engineering at Brex is about building systems that scale with speed and intention. Our teams span Software, Data, Security, and IT, and operate with high autonomy and deep collaboration. We tackle hard technical problems, own our outcomes, and push for excellence at every level — from architecture to deployment. It’s an environment where engineering is a craft, and builders become leaders. What you’ll do As a Security Operations Engineer at Brex, you will focus on preventing, detecting and responding to security threats across Brex's corporate and cloud environments. You will use existing systems and develop tools to improve our security capabilities. Our team is responsible for functions across corporate security, detection & response and infrastructure security domains; and we perform systems engineering and automation to support those functions. Security Operations is part of our wider Trust & IT o

pythonawsazure
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B
Brex
📍 New York• Full-time• $192K – $240K/yr
10mo ago

Why join us Brex is the intelligent finance platform that enables companies to spend smarter and move faster in more than 200 markets. By combining global corporate cards and banking with intuitive spend management, bill pay, and travel software, Brex enables founders and finance teams to accelerate operations, gain real-time visibility, and control spend effortlessly. Brex’s AI-native automation and world-class service eliminate manual expense and accounting tasks for customers so they can focus on what matters most. Tens of thousands of the world's best companies run on Brex, including DoorDash, Coinbase, Robinhood, Zoom, Plaid, Reddit, and SeatGeek. Working at Brex allows you to push your limits, challenge the status quo, and collaborate with some of the brightest minds in the industry. We’re committed to building a diverse team and inclusive culture and believe your potential should only be limited by how big you can dream. We make this a reality by empowering you with the tools, resources, and support you need to grow your career. Engineering at Brex Engineering at Brex is about building systems that scale with speed and intention. Our teams span Software, Data, Security, and IT, and operate with high autonomy and deep collaboration. We tackle hard technical problems, own our outcomes, and push for excellence at every level — from architecture to deployment. It’s an environment where engineering is a craft, and builders become leaders. What you’ll do As a Security Operations Engineer at Brex, you will focus on preventing, detecting and responding to security threats across Brex's corporate and cloud environments. You will use existing systems and develop tools to improve our security capabilities. Our team is responsible for functions across corporate security, detection & response and infrastructure security domains; and we perform systems engineering and automation to support those functions. Security Operations is part of our wider Trust & IT o

pythonawsazure
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