Jobs in United States

Lead Sr Staff Technical Program Manager in United States

2,434 active opportunities · Updated October 2026

Explore current lead sr staff technical program manager jobs across United States. Filter by work mode, employment type, experience, department, date posted and distance.

Hiring demand

43/100

watch · 145 related jobs

Hiring trend

-60.6%

Job postings compared with the previous 30 days

Remote options

20.7%

Share of matching jobs listed as remote

Typical salary

$145.7K – $145.7K/yr

Based on 9 salary observations

P
📍 New York, United States
✓ High-confidence listingCompany trend +671.4%

$230.9K – $384.8K/yr

Quick readStrong listing-quality and freshness signals

ROLE SUMMARY Pfizer Commercial Oncology is introducing the world to the next era of cancer care. With a growing portfolio of novel therapies, industry-leading R&D, and a goal of delivering eight breakthroughs by 2030 across major cancer types, we're translating cutting-edge science into market-shaping impact. Here, you'll partner with exceptional colleagues across scientific, medical, and manufacturing teams, backed by advanced digital and AI-enabled infrastructure and the authority to accelerate medicines from discovery to delivery. Guided by our values of courage, excellence, equity, and joy, you'll have the opportunity to stretch your skills and build a career that evolves with you—across teams, roles, and the Pfizer enterprise. Join us to make history — for patients, for their families, for the future. The US Precision Medicine Thoracic Franchise is entering its most consequential — and most complex — growth chapter. Our in-line thoracic portfolio spans two biomarker-defined populations: LORBRENA (lorlatinib) for adults with ALK-positive metastatic non-small cell lung cancer (NSCLC), and the BRAFTOVI + MEKTOVI (encorafenib + binimetinib) regimen for BRAF V600E-mutant metastatic NSCLC. Both sit inside a molecularly driven treatment landscape where the right patient is identified by a biomarker signature. Winning here means mastering precision targeting: reaching narrow, high-value, genomically defined patient populations through the exact clinicians who test for and treat them. This is a people-management leadership role that demands a strong enterprise leader — one fluent in both commercial strategy and AI-enabled execution, and able to think and operate at the enterprise level. The colleague who leads this team will set a multi-year strategic vision, make thoughtful trade-off and resource-prioritization decisions across two brands, and influence senior leadership across the wider organizati

Machine LearningAIExcelRecruitment
C
📍 Irving Texas United States, United States
✓ High-confidence listingCompany trend +800%
Quick readStrong listing-quality and freshness signals

The Applications Development Technology Lead Analyst is a senior level position responsible for building robust, high-performance, large-scale applications. The overall objective of this role is to lead applications systems analysis and programming activities. Responsibilities: * Partner with multiple management teams to ensure appropriate integration of functions to meet goals as well as identify and define necessary system enhancements to deploy new products and process improvements * Resolve variety of high impact problems/projects through in-depth evaluation of complex business processes, system processes, and industry standards * Provide expertise in area and advanced knowledge of applications programming and ensure application design adheres to the overall architecture blueprint * Utilize advanced knowledge of system flow and develop standards for coding, testing, debugging, and implementation * Develop comprehensive knowledge of how areas of business, such as architecture and infrastructure, integrate to accomplish business goals * Provide in-depth analysis with interpretive thinking to define issues and develop innovative solutions * Serve as advisor or coach to mid-level developers and analysts, allocating work as necessary * Appropriately assess risk when business decisions are made, demonstrating particular consideration for the firm's reputation and safeguarding Citigroup, its clients and assets, by driving compliance with applicable laws, rules and regulations, adhering to Policy, applying sound ethical judgment regarding personal behavior, conduct and business practices, and escalating, managing and reporting control issues with transparency. Qualifications: * 5 to 8 years of relevant experience in Apps Development or systems analysis role * Extensive experience system analysis and in programming of software applications * Hands-on experience in

JavaReactDockerKubernetes
C
📍 Irving Texas United States, United States
✓ High-confidence listingCompany trend +800%
Quick readStrong listing-quality and freshness signals

The Applications Development Technology Lead Analyst is a senior level position responsible for building robust, high-performance, large-scale applications. The overall objective of this role is to lead applications systems analysis and programming activities. Responsibilities: * Partner with multiple management teams to ensure appropriate integration of functions to meet goals as well as identify and define necessary system enhancements to deploy new products and process improvements * Resolve variety of high impact problems/projects through in-depth evaluation of complex business processes, system processes, and industry standards * Provide expertise in area and advanced knowledge of applications programming and ensure application design adheres to the overall architecture blueprint * Utilize advanced knowledge of system flow and develop standards for coding, testing, debugging, and implementation * Develop comprehensive knowledge of how areas of business, such as architecture and infrastructure, integrate to accomplish business goals * Provide in-depth analysis with interpretive thinking to define issues and develop innovative solutions * Serve as advisor or coach to mid-level developers and analysts, allocating work as necessary * Appropriately assess risk when business decisions are made, demonstrating particular consideration for the firm's reputation and safeguarding Citigroup, its clients and assets, by driving compliance with applicable laws, rules and regulations, adhering to Policy, applying sound ethical judgment regarding personal behavior, conduct and business practices, and escalating, managing and reporting control issues with transparency. Qualifications: * 6 to 9 years of relevant experience in Apps Development or systems analysis role * Extensive experience system analysis and in programming of software applications * Hands-on experience in

JavaReactDockerKubernetes
C
📍 Irving Texas United States, United States
✓ High-confidence listingCompany trend +800%
Quick readStrong listing-quality and freshness signals

The Applications Development Technology Lead Analyst is a senior level position responsible for building robust, high-performance, large-scale applications. The overall objective of this role is to lead applications systems analysis and programming activities. Responsibilities: * Partner with multiple management teams to ensure appropriate integration of functions to meet goals as well as identify and define necessary system enhancements to deploy new products and process improvements * Resolve variety of high impact problems/projects through in-depth evaluation of complex business processes, system processes, and industry standards * Provide expertise in area and advanced knowledge of applications programming and ensure application design adheres to the overall architecture blueprint * Utilize advanced knowledge of system flow and develop standards for coding, testing, debugging, and implementation * Develop comprehensive knowledge of how areas of business, such as architecture and infrastructure, integrate to accomplish business goals * Provide in-depth analysis with interpretive thinking to define issues and develop innovative solutions * Serve as advisor or coach to mid-level developers and analysts, allocating work as necessary * Appropriately assess risk when business decisions are made, demonstrating particular consideration for the firm's reputation and safeguarding Citigroup, its clients and assets, by driving compliance with applicable laws, rules and regulations, adhering to Policy, applying sound ethical judgment regarding personal behavior, conduct and business practices, and escalating, managing and reporting control issues with transparency. Qualifications: * 5-8 years of relevant experience in Apps Development or systems analysis role * Extensive experience system analysis and in programming of software applications * Hands-on experience in We

JavaReactDockerKubernetes
G
📍 521 Fifth Avenue, New York, United States
✓ High-confidence listingCompany trend -50%
Quick readStrong listing-quality and freshness signals

Sr. Project Manager Ready to turn bold ideas into real-world impact? At Genpact, we don’t just adapt to change, we lead it. AI and digital innovation are transforming the way businesses work, and we’re at the forefront of it. Genpact’s AI Gigafactory , our industry-first accelerator, exemplifies how we scale advanced technology solutions to help global enterprises work smarter, grow faster, and transform at scale. Whether tackling complex challenges through large-scale models or agentic AI , our breakthrough solutions tackle companies’ most complex challenges. If you thrive in a fast-moving, innovation-driven environment, love building and deploying cutting-edge AI solutions, and want to push the boundaries of what’s possible, this is your moment. Genpact (NYSE: G) is an agentic and advanced technology solutions company. We leverage process intelligence and artificial intelligence to deliver measurable outcomes. With a strong partner ecosystem and decades of client trust, we provide innovative solutions that transform how businesses run. Powered by a team with an active learning mindset and client centricity at its core, we deliver lasting value for the world’s leading enterprises. Get to know us at genpact.com and on LinkedIn , YouTube , X , and Facebook . Job Description • Problem solving on different client situations taking a data driven approach to shape best of breed solution

AWSArtificial IntelligenceAIProject Management
G
📍 Wauwatosa, WI, United States
✓ Quality checkedCompany trend -50%

Sr. Engineer - Testing & Quality Assurance S Ready to turn bold ideas into real-world impact? At Genpact, we don’t just adapt to change, we lead it. AI and digital innovation are transforming the way businesses work, and we’re at the forefront of it. Genpact’s AI Gigafactory , our industry-first accelerator, exemplifies how we scale advanced technology solutions to help global enterprises work smarter, grow faster, and transform at scale. Whether tackling complex challenges through large-scale models or agentic AI , our breakthrough solutions tackle companies’ most complex challenges. If you thrive in a fast-moving, innovation-driven environment, love building and deploying cutting-edge AI solutions, and want to push the boundaries of what’s possible, this is your moment. Genpact (NYSE: G) is an agentic and advanced technology solutions company. We leverage process intelligence and artificial intelligence to deliver measurable outcomes. With a strong partner ecosystem and decades of client trust, we provide innovative solutions that transform how businesses run. Powered by a team with an active learning mindset and client centricity at its core, we deliver lasting value for the world’s leading enterprises. Get to know us at genpact.com and on LinkedIn , YouTube , X , and Facebook . Job Description • Develop and execute test cases to identify software defects; • Collaborate w

PythonLinuxArtificial IntelligenceAI
G
📍 3409 Gllc 1155 Perimeter Center West, Atlanta, United States
✓ Quality checkedCompany trend -50%

Sr. Architect - Enterprise Application - Oracle S Ready to turn bold ideas into real-world impact? At Genpact, we don’t just adapt to change, we lead it. AI and digital innovation are transforming the way businesses work, and we’re at the forefront of it. Genpact’s AI Gigafactory , our industry-first accelerator, exemplifies how we scale advanced technology solutions to help global enterprises work smarter, grow faster, and transform at scale. Whether tackling complex challenges through large-scale models or agentic AI , our breakthrough solutions tackle companies’ most complex challenges. If you thrive in a fast-moving, innovation-driven environment, love building and deploying cutting-edge AI solutions, and want to push the boundaries of what’s possible, this is your moment. Genpact (NYSE: G) is an agentic and advanced technology solutions company. We leverage process intelligence and artificial intelligence to deliver measurable outcomes. With a strong partner ecosystem and decades of client trust, we provide innovative solutions that transform how businesses run. Powered by a team with an active learning mindset and client centricity at its core, we deliver lasting value for the world’s leading enterprises. Get to know us at genpact.com and on LinkedIn , YouTube , X , and Facebook . Job Description Inviting applications for the role of Sr. Architect - Cloud Delivery / Adviso

AWSArtificial IntelligenceAICRM
R
📍 Salt Lake City, Utah, United States· Full-time
✓ Quality checkedCompany trend -85.9%

Replit is the agentic software creation platform that enables anyone to build applications using natural language. With millions of users worldwide, Replit is democratizing software development by removing traditional barriers to application creation. Replit is seeking a Senior Business Development Manager to lead and scale our outbound sales development team as we expand our go-to-market efforts. This role will oversee a team of BDRs (Business Development Representatives) proactively targeting and engaging high-potential accounts to build a robust pipeline for our Account Executives. The ideal candidate will have hands-on outbound prospecting experience and proven leadership skills, a strong understanding of the modern GTM technology, previous experience in creating systems and orchestrating technology to support an efficient & scalable 0->1 outbound workflow, and previous experience collaborating tightly with marketing and sales ops to build highly-targeted account lists and multi-channel outreach sequences. Experience & interest in vibe coding and/or technical experience is highly valued. This position is critical to our go-to-market strategy, responsible for defining our outbound playbook, identifying key target personas , hiring top-tier talent, coaching team members, and ensuring persistent, high-quality outreach & pipeline generation across all segments from SMB to Enterprise. You'll establish the foundation for scalable revenue growth while architecting a personalized first-touch experience that sets the tone for their Replit journey. We believe this role offers a distinctive opportunity for proven sales development professionals who excel in both strategic account targeting and team leadership, with a passion for technology and AI. You'll leverage your expertise to build a world-class BDR organization that effectively cuts through the noise to communicate Replit's value proposition: a world where anyone can create software using natural langu

RestMachine LearningAIGo
T
📍 Boston, Massachusetts, United States· Full-time
✓ High-confidence listing

$100K – $500K/yr

Quick readStrong listing-quality and freshness signals

Tenstorrent is leading the industry on cutting-edge AI technology, revolutionizing performance expectations, ease of use, and cost efficiency. With AI redefining the computing paradigm, solutions must evolve to unify innovations in software models, compilers, platforms, networking, and semiconductors. Our diverse team of technologists have developed a high performance RISC-V CPU from scratch, and share a passion for AI and a deep desire to build the best AI platform possible. We value collaboration, curiosity, and a commitment to solving hard problems. We are growing our team and looking for contributors of all seniorities. Tenstorrent is seeking a SoC Design Verification Engineer to lead pre-silicon verification of the Beowulf SoC, with focus on the Compute Subsystem (CSS), DDR memory subsystem, and Fabric NoC. This role will drive coverage, coherency, memory traffic, connectivity, error handling, and bring-up features critical to silicon success. This role is hybrid, based out of Boston, MA; Toronto, ON; or Santa Clara, CA. We welcome candidates at various experience levels for this role. During the interview process, candidates will be assessed for the appropriate level, and offers will align with that level, which may differ from the one in this posting. Who You Are Deeply curious about SoC architecture, compute systems, DDR behavior, and Fabric NoC/interconnect verification. Expert in UVM, SystemVerilog, coverage-driven verification, assertions, and subsystem-level debug. Experienced in verifying compute subsystems, DDR controllers and PHY-facing logic, NoC/interconnect protocols, coherency, ordering, and data movement. Comfortable with reset, power management, error handling, performance, and high-concurrency system scenarios. Proactive, detail-oriented, and effective in cross-functional technical discussions. Familiar with Python, C/C++, Tcl, CocoTB, or similar verification automation tools. What We Need Develop and own scalable verification environmen

PythonAWSAIC++
S
📍 Chicago, Illinois, United States· Full-time
✓ High-confidence listingCompany trend -91.7%
Quick readStrong listing-quality and freshness signals

At Snowflake, we are powering the era of the agentic enterprise. To usher in this new era, we seek AI-native thinkers across every function who are energized by the opportunity to reinvent how they work. You don’t just use tools; you possess an innate curiosity, treating AI as a high-trust collaborator that is core to how you solve problems and accelerate your impact. We look for low-ego individuals who thrive in dynamic and fast-moving environments and move with an experimental mindset — who rapidly test emerging capabilities to discover simpler, more powerful ways to deliver results. At Snowflake, your role isn't just to execute a function, but to help redefine the future of how work gets done. Snowflake is transforming the future of data and we are looking for a dynamic Sr. Manager, Technical Delivery to lead our Snowflake Professional Services team. As strategic experts in implementing the Snowflake platform, we engage with customers to optimize, accelerate, and drive meaningful business outcomes through cutting-edge technology solutions including Artificial Intelligence (AI) and Generative AI (GenAI). As a Delivery Manager, you will lead teams executing complex migrations from legacy systems to the Snowflake platform. Your role will involve close collaboration with customers and system integrators to understand requirements, design robust migration strategies, oversee seamless transitions, and act as a strategic advisor to your customers. Your leadership will ensure that Snowflake is positioned as the premier solution in data warehousing and analytics, influencing both technical and executive stakeholders. AS A DELIVERY MANAGER AT SNOWFLAKE, YOU WILL: Lead, develop, and mentor a team of Solutions Architects and Consultants, who serve as our Snowflake implementation, optimization, development and delivery experts Play an active role in sourcing and screening potential candidates and managing the interview process Be a technical expert on all aspects of Snowflake

PythonSQLAIRuby
M
📍 Boise, ID - Main Site, United States
✓ Quality checkedCompany trend -75%

Our vision is to transform how the world uses information to enrich life for all . Micron Technology is a world leader in innovating memory and storage solutions that accelerate the transformation of information into intelligence, inspiring the world to learn, communicate and advance faster than ever. The Sr. Process Manager II - Construction Procurement role at Micron is an outstanding chance to lead and improve top-tier processes that promote operational excellence and compliance in construction. This role includes defining, optimizing, standardizing, and managing construction procurement methods to guarantee detailed performance, strict adherence to standards, and strong partner alignment. We will analyze current workflows, find gaps, develop future-state solutions, and guide cross-functional teams to efficiently implement procurement enhancements. Key Responsibilities Take responsibility for and consistently enhance the entire construction procurement cycle, covering sourcing readiness, requisitioning, purchase order management, supplier onboarding, buyout tracking, contract administration, invoicing, payment coordination, change order handling, and closeout procedures. Design, document, and maintain standard operating procedures, work instructions, workflow diagrams, RACI models, decision matrices, approval paths, and governance controls for construction procurement activities. Partner with Construction Procurement, contract management, logistics, Finance, Legal, project controls, and construction collaborators to gather requirements and translate business needs into scalable process solutions. Identify process gaps, inefficiencies, regulatory risks, unclear handoffs, duplicated work, and automation opportunities across procurement and contract administration wo

Artificial IntelligenceAISapProject Management
S
📍 New York, New York, United States· Full-time
✓ Quality checkedCompany trend -91.7%

At Snowflake, we are powering the era of the agentic enterprise. To usher in this new era, we seek AI-native thinkers across every function who are energized by the opportunity to reinvent how they work. You don’t just use tools; you possess an innate curiosity, treating AI as a high-trust collaborator that is core to how you solve problems and accelerate your impact. We look for low-ego individuals who thrive in dynamic and fast-moving environments and move with an experimental mindset — who rapidly test emerging capabilities to discover simpler, more powerful ways to deliver results. At Snowflake, your role isn't just to execute a function, but to help redefine the future of how work gets done. LEAD. STRATEGIZE. TRANSFORM. We are seeking an advanced professional handling complex enterprise AI/ML deployments, deconstructing system dependencies, and ensuring production robustness. WHY THIS ROLE? This role marks a shift from managing tactical tasks to managing strategic outcomes. You are a seasoned professional with a full understanding of your specialization, resolving a wide range of issues in creative ways. WHAT YOU'LL DO: Design robust, scalable AI/ML solutions utilizing the full Snowflake native stack and partner ecosystem. Perform deep-dive Root Cause Analysis (RCA) for complex system dependencies in AI/ML solutions. Collaborate cross-functionally with Sales and Product teams to align technical roadmaps with customer ROI. Mentor Level 3 architects on best practices for MLOps and architectural design. TECHNICAL DEPTH & RISK MANAGEMENT: Distributed Systems: Deconstruct failures in complex pipelines involving external cloud services (AWS/Azure/GCP). Predictive Failure Analysis: Critically think about potential failure modes like model drift and data skew early in the lifecycle. Governance: Architect data security and access controls specifically for sensitive AI/ML training data. SNOWFLAKE-NATIVE TECH STACK: Snowflake Model Registry, Cortex Functions, Python,

PythonAWSAzureGCP
V
📍 United States· Full-time
✓ Quality checkedCompany trend -85.7%

At Vanta, our mission is to help businesses earn and prove trust. We believe that security should be monitored and verified continuously, and we empower companies to practice better security and prove it with ease. Vanta has a kind and talented team, and while some have prior security experience, many have been successful at Vanta without it. At Vanta, our mission is to help businesses earn and prove trust. We believe that security should be monitored and verified continuously, and we empower companies to practice better security and prove it with ease. Vanta has a kind and talented team, and while some have prior security experience, many have been successful at Vanta without it. As the Sr. Manager, Commercial Customer Success, East Region you will lead a team of commercial Customer Success Managers to deliver successful onboarding, healthy adoption, advocacy and retention for our commercial customers in Vanta’s rapidly expanding customer base. You will develop a high performing team of CSMs who are customer value focused and results driven. You will be responsible for influencing the design of our upmarket CS strategy, developing a repeatable methodology to guide our customers in using Vanta as the foundation of their modern GRC program. Partnering closely with Sales, Product and Account Management leaders to represent your team and customers will be key to success in this role. You will be at the forefront of delivering Vanta’s GRC value and a key leader in executing our upmarket strategy. What you’ll do as a Sr. Manager, Commercial Customer Success at Vanta: Hire, mentor and develop a team of expert CSMs and a culture of customer centricity, high performance and accountability Influence strategy and design of the customer success methodology including implementation, adoption, customer value and risk management Define strategies and coach your team to achieve KPIs including revenue retention and customer health Through coaching your team, drive adoption of effec

RestAIGoRust
MT
📍 Boise, ID - ID1, United States
✓ High-confidence listingCompany trend +1266.7%
Quick readStrong listing-quality and freshness signals

Our vision is to transform how the world uses information to enrich life for all . Micron Technology is a world leader in innovating memory and storage solutions that accelerate the transformation of information into intelligence, inspiring the world to learn, communicate and advance faster than ever. The US Expansion Construction team is driving some of the most significant semiconductor manufacturing projects in the United States, including two high-volume manufacturing facilities in Boise, Idaho (ID1 and ID2) and a greenfield manufacturing facility in Clay, New York. Our team partners across engineering, construction, commissioning, and operations to deliver world-class facilities that support the future of technology and innovation. As the ID Quality Assurance Lead, you will be a key member of the US Expansion Strategic Programs team, reporting to the ID Sr. Commissioning Manager. In this highly visible role, you will lead quality governance across major capital projects, ensuring compliance, commissioning readiness, documentation integrity, and operational turnover excellence. You will serve as the primary owner-side quality leader, collaborating with contractors, vendors, inspection agencies, operations teams, and regulatory stakeholders to deliver successful project outcomes. Responsibilities: Lead quality governance, performance metrics, audit programs, reporting, and continuous improvement initiatives across Idaho capital projects Oversee contractor and vendor quality execution, including quality plans, inspections, testing, material verification, hold points, and compliance with project requirements Manage special inspection programs, testing agency coordination, regulatory interfaces, and turnover-ready quality documentation Align construction quality activities with co

AIRecruitment
G
📍 California, United States
✓ High-confidence listingCompany trend +190.5%

$169.3K – $219.1K/yr

Quick readStrong listing-quality and freshness signals

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description The Senior Scientist, Purification Process Development (Pivotal & Commercial) role will be responsible for leading aspects of purification development including commercial process development and process characterization for multiple biologics programs during pivotal phases (phases II/III and post-launch). In addition, this role is also expected to lead/support technology transfer, participate in purification and cross-functional initiatives, and support purification regulatory documentation. Key Responsibilities: Design experiments and demonstrate hands-on technical leadership of all aspects of purification process development including chromatography, TFF, virus f

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