Jobs in United States
Principal Senior Machine Learning Scientist in United States
716 active opportunities · Updated October 2026
Showing
15 jobs
Explore current principal senior machine learning scientist jobs across United States. Filter by work mode, employment type, experience, department, date posted and distance.
Principal Financial Analyst — Minneapolis, Minnesota, United States of America. Apply via Workday.
Principal Software Engineer — San Francisco, CA, USA. Apply via Workday.
Principal Scientist, Diagnostics — United States - California - Foster City. Apply via Workday.
About Pinterest: Millions of people around the world come to our platform to find creative ideas, dream about new possibilities and plan for memories that will last a lifetime. At Pinterest, we’re on a mission to bring everyone the inspiration to create a life they love, and that starts with the people behind the product. Discover a career where you ignite innovation for millions, transform passion into growth opportunities, celebrate each other’s unique experiences and embrace the flexibility to do your best work. Creating a career you love? It’s Possible. At Pinterest, AI isn't just a feature, it's a powerful partner that augments our creativity and amplifies our impact, and we’re looking for candidates who are excited to be a part of that. To get a complete picture of your experience and abilities, we’ll explore your foundational skills and how you collaborate with AI. Through our interview process, what matters most is that you can always explain your approach, showing us not just what you know, but how you think. You can read more about our AI interview philosophy and how we use AI in our recruiting process here . About the role: We’re looking for a Principal Engineer to set the technical vision and lead foundational work across Homefeed, Search, and our emerging AI Assistant experiences at Pinterest. This role sits at the intersection of relevance, ranking, retrieval, and generative AI, and will shape how hundreds of millions of Pinners discover and act on inspiration every day. You will operate as a cross-cutting technical leader: defining long-term architecture, raising the bar on ML and systems excellence, and partnering closely with product and executive leadership to drive step‑function improvements in engagement, quality, and creator value. What you’ll do: Define the long-term technical strategy and architecture for Homefeed, Search, and AI Assistant, including retrieval, ranking, personalization, and generative experiences. Drive a multi‑year road
Principal Quality Engineer - CST - Memphis, TN (Onsite) — Memphis, Tennessee, United States of America. Apply via Workday.
Principal Automation Software Test Engineer: SDET — Lafayette, Colorado, United States of America. Apply via Workday.
Principal Materials Engineer (Combination Devices) — Mounds View, Minnesota, United States of America. Apply via Workday.
At ClickUp, we're building the future of work: the first truly converged AI workspace unifying tasks, docs, chat, calendar, and enterprise search, all supercharged by context-driven AI. We are an AI-native company. Every team member is expected to leverage AI daily, and we evaluate AI fluency as part of our hiring process. Join us and help redefine what's possible. 🚀 We’re hiring a highly influential product analytics leader who can turn ambiguous questions into sharp insight, scalable measurement, and recommendations that directly shape what we build. This person will partner closely with Product, Engineering, Design, and Growth to raise the bar on decision quality and establish a more AI-native analytics operating model. Mission Drive the product insight agenda by helping ClickUp make faster, smarter product decisions through rigorous analysis, strong product judgment, and AI-enabled analytics workflows. What You'll Do Own the product analytics agenda across product usage, activation, feature adoption, retention, and expansion, and translate open-ended business questions into structured analyses and clear recommendations Partner with Product, Engineering, and Design to define success metrics early, improve instrumentation quality, and ensure important product surfaces are measurable from launch Build reusable analysis frameworks, semantic layers, metric definitions, and self-serve resources that help product teams answer routine questions faster and more consistently Apply AI-first methods across the analytics workflow, using large language models, coding agents, and automation for tasks like query drafting, QA, validation, documentation, and first-pass synthesis while keeping human judgment at the center of final recommendations Design and interpret experiments, observational analyses, and trend investigations, including situations where data is incomplete or traditional experimentation is not feasible Surface meaningful patterns in behavioral, subscription, and
Replit is the agentic software creation platform that enables anyone to build applications using natural language. With millions of users worldwide, Replit is democratizing software development by removing traditional barriers to application creation. About the Role: This is a Principal Product Engineering role focused on Money Infrastructure at Replit. You’ll work on the financial backbone that powers how Replit earns money, how builders earn money, and how Agents transact. This role sits at the intersection of engineering, product, and the business. The systems you build directly impact revenue, trust, and some of the most critical user journeys on the platform. Getting them right enables growth, experimentation, and global scale. Getting them wrong creates broken payments, confusing pricing, and lost trust. We’re looking for engineers who can design and scale reliable financial systems while translating complex monetary logic into intuitive, user-friendly experiences for both Replit customers and builders on the platform. We love folks who have a passion for monetizing innovation and being a part of the greater pricing story. You will: Lead the design, architecture, and implementation of Replit’s core money infrastructure, spanning pricing, billing, payments, and monetization. Own and scale the global order-to-cash foundation supporting credit-based subscriptions, usage-based billing, marketplaces, in-app payments, and commerce for Agents. Enable rapid pricing and packaging experimentation across the company by building flexible abstractions and APIs for new SKUs, plans, and monetization models. Build high-converting, localized payment experiences across geographies — thinking globally while enabling users to pay locally. Power builder monetization by creating payment rails for apps, Agents, subscriptions, and new monetization primitives. Partner closely on data specifications with finance, accounting, and data teams to produce accurate, auditable, and reliable f
What you’ll do Partner with medical image reconstruction scientists / engineers to build ML components that improve reconstruction quality, speed, robustness, or quantitative accuracy. Define training/evaluation pipelines, datasets, and metrics that map to user needs and design requirements. Productionize models: inference performance, reproducibility, monitoring for drift/regressions, and safe fallbacks. Collaborate on hybrid algorithms, incorporating physics and learned priors, denoisers, learned regularizers, and quality estimation. Help build tooling for rapid experimentation as well as rigorous verification of algorithm changes. What we’re looking for Strong applied ML experience plus comfort with signal processing / imaging or adjacent domains. Ability to move fluidly between research prototypes and production-quality systems. Strong evaluation discipline: metrics, ablations, data leakage avoidance, and reproducibility. A demonstrated track record of applying ML to physics-based or inverse problems (i.e., shipped projects, a portfolio, or publications.) Useful experience ML for imaging/inverse problems (or adjacent) with strong evaluation discipline and comfort with GPU performance constraints. Pragmatic production mindset: reproducible training/inference, regression testing, and safe deployment in high-stakes contexts. A background in computational physics or scientific computing. Leverage ML-based methods such as PiNNs and Neural Operators to solve partial differential equations arising in ultrasound simulation and imaging. Experience in Agentic-SciML is a plus. Hands-on experience with data curation for ML: building datasets from messy, real-world sources, defining ground truth, and managing labeling or simulation pipelines. Background in data assimilation: combining observations with physics-based models (Kalman filtering, variational methods, ensemble approaches, or learned variants).
What you’ll do Act as the technical lead for large parts of the scanner platform: system architecture, codebase structure, and long-term maintainability. Own core runtime foundations: distributed control, state management, fault handling, and reliability. Drive engineering rigor: testability, code quality, review standards, performance regression prevention, and release processes. Build robust observability: logs, metrics, traces, and replayable diagnostics (with privacy constraints). Collaborate with hardware and recon/ML teams to define interfaces, data contracts, timing/synchronization, and failure modes. Lead complex refactors (e.g., message passing / RPC boundaries, modularization, concurrency model) without halting forward progress. What we’re looking for Deep software architecture experience for real-world systems: robotics, instrumentation, medical devices, or other complex distributed products. Strong Python and concurrency background (asyncio, multiprocessing, profiling, performance engineering). Track record of shipping systems that are observable, debuggable, and resilient. Strong technical leadership: clarity, pragmatic trade-offs, and mentoring. Useful experience Building but rock-solid systems: clear interfaces (gRPC/protobuf or equivalent), strong state modeling, and failure handling. High-leverage engineering habits on a lean team: good tests, CI, reproducible dev environments, and fast code review. Practical performance + concurrency work in Python (asyncio, profiling, multiprocessing) and comfort debugging distributed behavior. Security-minded device software: safe defaults, encrypted data paths, and disciplined handling of PII/PHI. Operational thinking: remote updates/management, excellent logging, and diagnostics that make real hardware debuggable.
At Snowflake, we are powering the era of the agentic enterprise. To usher in this new era, we seek AI-native thinkers across every function who are energized by the opportunity to reinvent how they work. You don’t just use tools; you possess an innate curiosity, treating AI as a high-trust collaborator that is core to how you solve problems and accelerate your impact. We look for low-ego individuals who thrive in dynamic and fast-moving environments and move with an experimental mindset — who rapidly test emerging capabilities to discover simpler, more powerful ways to deliver results. At Snowflake, your role isn't just to execute a function, but to help redefine the future of how work gets done. Data Engineering - Applied Field Engineer- CA- Menlo Park- Remote Snowflake is about empowering enterprises to achieve their full potential — and people too. With a culture that’s all in on impact, innovation, and collaboration, Snowflake is the sweet spot for building big, moving fast, and taking technology — and careers — to the next level. Our Solution Engineering organization is seeking a Data Engineering Specialist to join our Applied Field Engineering team who can provide technical leadership in working with both technical and business executives in the design and architecture of the Snowflake Cloud Data Platform as a critical component of their enterprise data architecture and overall ecosystem. In this role you will work directly with the sales team to understand the needs of our customers, strategize on how to navigate winning sales cycles, provide compelling value-based demonstrations, support enterprise Proof of Concepts, and ultimately close business. You will leverage your expertise, best practices and reference architectures highlighting Snowflake’s Data Platform capabilities across data ingestion, transformation, and lakehouse workloads. You are equally comfortable in both a business and technical context, interacting with executives and talking shop with tec
From $203.2K/yr
GitLab is the intelligent orchestration platform for DevSecOps. GitLab enables organizations to increase developer productivity, improve operational efficiency, reduce security and compliance risk, and accelerate digital transformation. More than 50 million registered users and more than 50% of the Fortune 100* trust GitLab to ship better, more secure software faster. The same principles built into our products are reflected in how our team works: we embrace AI as a core productivity multiplier, with all team members expected to incorporate AI into their daily workflows to drive efficiency, innovation, and impact. GitLab is where careers accelerate, innovation flourishes, and every voice is valued. Our high-performance culture is driven by our values and continuous knowledge exchange, enabling our team members to reach their full potential while collaborating with industry leaders to solve complex problems. Co-create the future with us as we build technology that transforms how the world develops software. * Fortune 500® is a registered trademark of Fortune Media IP Limited, used under license. Claim based on GitLab data. Fortune 100 refers to the top 20% ranked companies in the 2025 Fortune 500 list, published in June 2025. Fortune and Fortune Media IP Limited are not affiliated with, and do not endorse products or services of GitLab. GitLab is an open-core software company that develops the intelligent orchestration platform for DevSecOps, used by more than 100,000 organizations and 50 million people. Our mission is to unlock every team to ship trusted software at the speed of imagination. Software is increasingly built by machines and directed by people. When agentic coding tools accelerate without context, governance, and lifecycle control, teams get speed with chaos. GitLab enables speed with control: customers deploy agents across the software development lifecycle (SDLC) with the orchestration, context, security, and governance to ship trusted software a
GitLab is the intelligent orchestration platform for DevSecOps. GitLab enables organizations to increase developer productivity, improve operational efficiency, reduce security and compliance risk, and accelerate digital transformation. More than 50 million registered users and more than 50% of the Fortune 100* trust GitLab to ship better, more secure software faster. The same principles built into our products are reflected in how our team works: we embrace AI as a core productivity multiplier, with all team members expected to incorporate AI into their daily workflows to drive efficiency, innovation, and impact. GitLab is where careers accelerate, innovation flourishes, and every voice is valued. Our high-performance culture is driven by our values and continuous knowledge exchange, enabling our team members to reach their full potential while collaborating with industry leaders to solve complex problems. Co-create the future with us as we build technology that transforms how the world develops software. * Fortune 500® is a registered trademark of Fortune Media IP Limited, used under license. Claim based on GitLab data. Fortune 100 refers to the top 20% ranked companies in the 2025 Fortune 500 list, published in June 2025. Fortune and Fortune Media IP Limited are not affiliated with, and do not endorse products or services of GitLab. An overview of this role You will lead the product strategy for GitLab's next generation of engineering insight, helping software leaders, engineering managers, CTOs, and CPOs understand not just what their teams shipped, but why, and what to do next. As Principal Product Manager, Engineering Intelligence & Insights, you will shape how GitLab turns engineering data into decision-ready intelligence: the core data infrastructure and knowledge graph integrations that connect it, the out-of-the-box dashboards customers rely on today, and the conversational AI experiences that let leaders simply ask a question and get an answer in
Other cities to consider
More places hiring for this role
Get new principal senior machine learning scientist jobs in United States by email
Daily job updates · Unsubscribe anytime