Jobs in United States

Rare Disease in United States

88 active opportunities · Updated October 2026

Explore current rare disease jobs across United States. Filter by work mode, employment type, experience, department, date posted and distance.

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📍 San Mateo, CA, United States· Full-time
✓ High-confidence listingCompany trend -100%

From $276.3K/yr

Quick readStrong listing-quality and freshness signals

Every day, tens of millions of people come to Roblox to explore, create, play, learn, and connect with friends in 3D immersive digital experiences– all created by our global community of developers and creators. At Roblox, we’re building the tools and platform that empower our community to bring any experience that they can imagine to life. Our vision is to reimagine the way people come together, from anywhere in the world, and on any device. We’re on a mission to connect a billion people with optimism and civility, and looking for amazing talent to help us get there. A career at Roblox means you’ll be working to shape the future of human interaction, solving unique technical challenges at scale, and helping to create safer, more civil shared experiences for everyone. Roblox is currently at a critical inflection point in its financial evolution. We recently achieved a significant payout milestone to our Creator community in 2025. To successfully build upon this momentum year over year while controlling our costs, a world-class payments and wallets ecosystem is essential to ensure frictionless transactions across the platform for our Users and Creators. This role offers the rare opportunity to lead a 0-to-1 buildout of a new payments division. If successful, you will transition Roblox from standard payment processing to a strategic orchestration model, utilizing AI-driven approach to optimize significant transaction cost. Beyond cost savings, you will spearhead the transformation of our creator payouts, building a product designed to empower the livelihood of millions of developers through instant, transparent, and global financial access. You Will Own Global Partnership Negotiation & Account Management: Lead RFPs and high-stakes contractual negotiations with major global payment processors (e.g., Stripe, PayPal, etc) and financial institutions. Establish formal business relationships where none currently exist, securing advantageous commercial

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📍 San Mateo, CA, United States· Full-time
✓ High-confidence listingCompany trend -100%

From $153.1K/yr

Quick readStrong listing-quality and freshness signals

Every day, tens of millions of people come to Roblox to explore, create, play, learn, and connect with friends in 3D immersive digital experiences– all created by our global community of developers and creators. At Roblox, we’re building the tools and platform that empower our community to bring any experience that they can imagine to life. Our vision is to reimagine the way people come together, from anywhere in the world, and on any device. We’re on a mission to connect a billion people with optimism and civility, and looking for amazing talent to help us get there. A career at Roblox means you’ll be working to shape the future of human interaction, solving unique technical challenges at scale, and helping to create safer, more civil shared experiences for everyone. As a Software Engineer on the Account Authentication Team, you will help authenticate and authorize Roblox's user base, setting the foundation for every other feature on our platform. You will build the authentication and security controls that meet each user's needs, along with just-in-time friction that adapts to each user's unique risk profile, all while scaling to 1 billion active users. This is a rare opportunity to sit at the convergence of security, user experience, and scale. You'll join Roblox's Safety organization, whose mission is to become the leader in civil immersive online communities by detecting, removing, and preventing problematic accounts, content, and behavior, and by keeping accounts secure and free from compromise. The team draws on a broad tech spectrum, including machine learning, classifiers, experimentation, automation, and AI-powered filters, partnering with product teams to shape the roadmap, build safety products, and measure impact on our community of users and developers. You Will: Own the design, implementation and landing of features that make Roblox more secure and more accessible for users of all ages on all platforms. Collaborate cross-organizationally w

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📍 San Mateo, CA, United States· Full-time
✓ High-confidence listingCompany trend -100%

From $280.5K/yr

Quick readStrong listing-quality and freshness signals

Every day, tens of millions of people come to Roblox to explore, create, play, learn, and connect with friends in 3D immersive digital experiences– all created by our global community of developers and creators. At Roblox, we’re building the tools and platform that empower our community to bring any experience that they can imagine to life. Our vision is to reimagine the way people come together, from anywhere in the world, and on any device. We’re on a mission to connect a billion people with optimism and civility, and looking for amazing talent to help us get there. A career at Roblox means you’ll be working to shape the future of human interaction, solving unique technical challenges at scale, and helping to create safer, more civil shared experiences for everyone. As a Senior Product Manager in Engineering Acceleration , you will define the vision and strategy for how software engineers work at Roblox. Your mission is to ensure that Roblox engineers spend more time building the metaverse and less time managing infrastructure complexity in your areas of responsibility. The Engineering Acceleration portfolio includes Source Control, Testing, Secure Software Supply Chain Management, Continuous Deployment, and Observability among many others. In this role, you will primarily own the developer experience for Continuous Deployment, Testing , and Observability , while remaining adaptable as organizational priorities evolve. AI has been transforming how we approach these systems. We’re already leveraging AI to test our software and to identify and diagnose production incidents. The successful candidate here will bring deep expertise not only in the software development lifecycle, but crucially also on the rapidly evolving landscape of AI tooling. This is a rare opportunity for an infrastructure product leader to drive meaningful impact at scale across a very large engineering organization. You Will: Define and drive the long-term visi

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📍 San Mateo, CA, United States· Full-time
✓ High-confidence listingCompany trend -100%

From $226.4K/yr

Quick readStrong listing-quality and freshness signals

Every day, tens of millions of people come to Roblox to explore, create, play, learn, and connect with friends in 3D immersive digital experiences– all created by our global community of developers and creators. At Roblox, we’re building the tools and platform that empower our community to bring any experience that they can imagine to life. Our vision is to reimagine the way people come together, from anywhere in the world, and on any device. We’re on a mission to connect a billion people with optimism and civility, and looking for amazing talent to help us get there. A career at Roblox means you’ll be working to shape the future of human interaction, solving unique technical challenges at scale, and helping to create safer, more civil shared experiences for everyone. As Senior Technical Program Manager for the Human-in-the-Loop (HITL) Operations , you will own the end-to-end lifecycle of Roblox's AI data labeling and model evaluation ecosystem. This is a high-leverage, high-ownership role at the intersection of Research, Engineering, and Operations. You will scale our data operations that is handling million of items evaluated annually today with projection of 4x the current volume by 2030, managing a multi-million annual budget and a distributed workforce of 100+ remote contractors — all while driving the platform evolution from manual workflows to AI-assisted, LLM-accelerated operations. This is a rare opportunity to build the data infrastructure that directly determines the quality of Roblox's AI models across creator tools, content discovery, in-experience AI, and 3D generative content — at the exact moment when human judgment is the critical ingredient for getting these models right. You Will Lead data programs end-to-end. Own the full lifecycle of labeling and model evaluation workflows across Roblox's AI teams — from translating ambiguous ML requirements into structured annotation tasks, to overseeing contractor execution, quality review, a

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📍 Massachusetts, California, United States· Full-time
✓ High-confidence listingCompany trend -83.5%

From $224K/yr

Quick readStrong listing-quality and freshness signals

Datadog's Technical Solutions (TS) organization is one of the largest organizations in the company — spanning Sales Engineers, Technical Account Managers, Enterprise Customer Success Managers, Technical Support Engineers, and Solutions Architects who work with prospects and customers across every stage of their journey with Datadog. Technical Solutions Operations (TSO) exists to make that organization faster, smarter, and more scalable. We build the systems, analytics & programs that give TS teams more leverage — and we measure our success by the business outcomes we drive, not the projects we complete. The programs this team runs touch every function in TS, and the operating model you build will define how that scales. We're looking for a Director of Technical Program Management to lead the TSO Program Management team. This role sits at the intersection of strategy and execution: you'll own the programs that shape how TS operates at scale, lead a team of technical program managers, and serve as a peer to the Directors and VPs who run the teams you support. Your counterparts are leaders overseeing hundreds of customer-facing technical professionals, and your role is to successfully interface with each organization with proactive solutions on how your team can help them be more effective. This is a rare opportunity to lead a function where the output isn't a deliverable, it's organizational capability. If you want to build something that compounds across an entire organization, this is the role. At Datadog, we place value in our office culture - the relationships and collaboration it builds and the creativity it brings to the table. We operate as a hybrid workplace to ensure our Datadogs can create a work-life harmony that best fits them. What You’ll Do Run the PMO as a business impact function. Own the PMO operating model end-to-end, including intake, prioritization, scoping, execution, and impact measurement — with every program directly linked to measurable bu

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📍 United States· Full-time· Remote
✓ High-confidence listingCompany trend -84.3%

From $158.8K/yr

Quick readStrong listing-quality and freshness signals

About Pinterest: Millions of people around the world come to our platform to find creative ideas, dream about new possibilities and plan for memories that will last a lifetime. At Pinterest, we’re on a mission to bring everyone the inspiration to create a life they love, and that starts with the people behind the product. Discover a career where you ignite innovation for millions, transform passion into growth opportunities, celebrate each other’s unique experiences and embrace the flexibility to do your best work. Creating a career you love? It’s Possible. At Pinterest, AI isn't just a feature, it's a powerful partner that augments our creativity and amplifies our impact, and we’re looking for candidates who are excited to be a part of that. To get a complete picture of your experience and abilities, we’ll explore your foundational skills and how you collaborate with AI. Through our interview process, what matters most is that you can always explain your approach, showing us not just what you know, but how you think. You can read more about our AI interview philosophy and how we use AI in our recruiting process here . Pinterest is looking for a thoughtful, highly skilled Staff Motion Designer to join the Design Innovation team. You will define and evolve the motion design language that brings clarity, coherence, and delight to Pinterest across surfaces and flagship features. This is a hands-on, horizontal role for a rare blend of motion craft leader, systems thinker, and design technologist. You will establish reusable motion principles, patterns, tokens, and implementation guidance within the design system; partner directly with product and engineering teams to solve challenging interaction problems; and build tools and prototypes that make it easier to explore and ship exceptional motion at scale. Your impact will extend from the details of a single interaction to the cohesive experience of Pinterest as a whole. Join us to define the motion language that ma

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📍 United States· Full-time
✓ High-confidence listingCompany trend -98.8%

From $200K/yr

Quick readStrong listing-quality and freshness signals

Airbnb was born in 2007 when two hosts welcomed three guests to their San Francisco home, and has since grown to over 5 million hosts who have welcomed over 2 billion guest arrivals in almost every country across the globe. Every day, hosts offer unique stays and experiences that make it possible for guests to connect with communities in a more authentic way. The Community You Will Join: At Airbnb, we're driven by our mission to create a world where anyone can belong anywhere. The Community Support (CS) Platform & Engineering team is at the forefront of this mission - building the AI systems that power world-class support experiences for millions of guests and hosts globally. We are building to a bold vision, where our AI doesn't just answer questions, but truly understands each person's unique context, mirrors the judgment and empathy of our highest-performing human agents, and delivers 10-Star support at scale. The AI Personalization team is the intelligence layer that makes this possible. We own the full-stack systems that enable the AI to give every guest and host a response that feels written just for them. The Difference You Will Make: We are looking for a visionary Staff Platform Manager to lead the product strategy and execution for AI Personalization across Airbnb's customer support ecosystem. This is one of the most consequential roles in CS Platform Product: you will own the full stack of personalization, from the underlying retrieval systems to the consumer-facing AI experience, and scale it across multiple Airbnb surfaces. The north star: enable AIA to emulate the judgment, empathy, and accuracy of Airbnb's highest-performing human agents. To achieve this, you'll build a platform that continuously enriches the AI's understanding of each user, and surfaces that understanding at the right moment, in the right form, across every channel. This role demands a rare combination: customer experience chops to build meaningful and delightful perso

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📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -79.2%

About the Team OpenAI’s Applied AI Engineering team helps organizations turn frontier AI capabilities into safe, reliable, and high-impact production systems. We work with customer executives, product and engineeriIng teams, security leaders, and transformation teams to identify valuable opportunities, accelerate technical implementation, and scale what works. Enterprise deployments are defined by complexity rather than any one industry: existing architectures, diverse data environments, security and governance requirements, multiple stakeholder groups, and organization-wide change. We turn lessons from these deployments into better products and reusable patterns for customers everywhere. About the Role As an Enterprise Applied AI Engineer you will partner directly with leading organizations to design, build, and deploy AI systems that deliver measurable business outcomes. You will combine deep technical judgment, hands-on engineering, and customer leadership to take ambitious ideas from use-case selection and architecture through prototyping, evaluation, production launch, and scale. You will write and debug code, build evaluation systems, resolve complex integrations, and guide decisions involving model behavior, reliability, latency, cost, safety, security, governance, and operational readiness. Success is measured by production systems, sustained adoption, and meaningful customer impact—not simply activity or successful demonstrations. This is a rare opportunity to work on consequential real-world deployments at the frontier of AI while directly influencing how OpenAI’s products evolve. This role is based in our SF or NYC office. We use a hybrid work model of 3 days in the office per week and offer relocation assistance to new employees. In this role, you will: Partner directly with enterprise customers to identify high-value opportunities and translate them into technical architectures, implementation plans, evaluation strategies, and measurable success criteri

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📍 New York, New York, United States· Full-time
✓ Quality checkedCompany trend -91.7%

At Snowflake, we are powering the era of the agentic enterprise. To usher in this new era, we seek AI-native thinkers across every function who are energized by the opportunity to reinvent how they work. You don’t just use tools; you possess an innate curiosity, treating AI as a high-trust collaborator that is core to how you solve problems and accelerate your impact. We look for low-ego individuals who thrive in dynamic and fast-moving environments and move with an experimental mindset — who rapidly test emerging capabilities to discover simpler, more powerful ways to deliver results. At Snowflake, your role isn't just to execute a function, but to help redefine the future of how work gets done. Role Overview At Snowflake, we are powering the era of the agentic enterprise. We are looking for AI-native builders and operators who use AI as a core part of how they think, learn, and execute. The Startup Business Development Lead will be a key member of the Snowflake for Startups team, responsible for identifying, engaging, and growing relationships with the most strategic AI-native startups. This person will work across Sales, Product, Marketing, AI Partnerships, Ventures, and Solutions Engineering to help high-potential startups build with Snowflake and accelerate adoption of Snowflake AI. This role requires a rare combination of startup ecosystem credibility, business development judgment, and practical understanding of modern AI application architectures. The ideal candidate can engage founders on both business value and technical direction, and can translate Snowflake’s AI platform into compelling growth opportunities for startup partners. This is an individual contributor role and will be accountable for building a high-quality pipeline of AI-native startup opportunities, increasing activation and adoption of Snowflake AI products, and driving long-term consumption growth from strategic startup partners. Key Responsibilities Build and grow relationships with high-

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📍 Bellevue, Washington, United States· Full-time
✓ Quality checkedCompany trend -91.7%

At Snowflake, we are powering the era of the agentic enterprise. To usher in this new era, we seek AI-native thinkers across every function who are energized by the opportunity to reinvent how they work. You don’t just use tools; you possess an innate curiosity, treating AI as a high-trust collaborator that is core to how you solve problems and accelerate your impact. We look for low-ego individuals who thrive in dynamic and fast-moving environments and move with an experimental mindset — who rapidly test emerging capabilities to discover simpler, more powerful ways to deliver results. At Snowflake, your role isn't just to execute a function, but to help redefine the future of how work gets done. Streamlit in Snowflake (SiS) is our flagship app development platform, enabling data engineers, analysts, and developers to build and deploy interactive, data-driven applications directly within Snowflake. As Principal Engineer for the Streamlit in Snowflake team, you will be the top technical voice shaping how millions of users build and deploy apps on Snowflake's data platform. This role requires a rare combination: deep hands-on engineering expertise in Python/container runtimes, a systems architect's instinct for platform design, and the organizational influence to drive cross-team programs. You will define how SiS evolves from its container-native SPCS runtime and embedding/iframe SDK, to its developer experience, performance at scale, and integration with Snowflake's broader AI and data ecosystem. AS THE PRINCIPAL ENGINEER FOR STREAMLIT IN SNOWFLAKE YOU WILL: Define and own the architectural vision for the SiS platform spanning the SPCS container runtime, the warehouse runtime, the embedding SDK, developer tooling, and the Snowsight integration layer. Drive the platform's evolution toward its next-generation capabilities building on publicly shipping features like chromeless viewer URLs and IdP integration, and shaping the architectural direction for areas still in de

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📍 Menlo Park, California, United States· Full-time
✓ Quality checkedCompany trend -91.7%

At Snowflake, we are powering the era of the agentic enterprise. To usher in this new era, we seek AI-native thinkers across every function who are energized by the opportunity to reinvent how they work. You don’t just use tools; you possess an innate curiosity, treating AI as a high-trust collaborator that is core to how you solve problems and accelerate your impact. We look for low-ego individuals who thrive in dynamic and fast-moving environments and move with an experimental mindset — who rapidly test emerging capabilities to discover simpler, more powerful ways to deliver results. At Snowflake, your role isn't just to execute a function, but to help redefine the future of how work gets done. Role Overview At Snowflake, we are powering the era of the agentic enterprise. We are looking for AI-native builders and operators who use AI as a core part of how they think, learn, and execute. The Startup Business Development Lead will be a key member of the Snowflake for Startups team, responsible for identifying, engaging, and growing relationships with the most strategic AI-native startups. This person will work across Sales, Product, Marketing, AI Partnerships, Ventures, and Solutions Engineering to help high-potential startups build with Snowflake and accelerate adoption of Snowflake AI. This role requires a rare combination of startup ecosystem credibility, business development judgment, and practical understanding of modern AI application architectures. The ideal candidate can engage founders on both business value and technical direction, and can translate Snowflake’s AI platform into compelling growth opportunities for startup partners. This is an individual contributor role and will be accountable for building a high-quality pipeline of AI-native startup opportunities, increasing activation and adoption of Snowflake AI products, and driving long-term consumption growth from strategic startup partners. Key Responsibilities Build and grow relationships with high-

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📍 Bellevue, Washington, United States· Full-time· Hybrid
✓ Quality checkedCompany trend -91.7%

At Snowflake, we are powering the era of the agentic enterprise. To usher in this new era, we seek AI-native thinkers across every function who are energized by the opportunity to reinvent how they work. You don’t just use tools; you possess an innate curiosity, treating AI as a high-trust collaborator that is core to how you solve problems and accelerate your impact. We look for low-ego individuals who thrive in dynamic and fast-moving environments and move with an experimental mindset — who rapidly test emerging capabilities to discover simpler, more powerful ways to deliver results. At Snowflake, your role isn't just to execute a function, but to help redefine the future of how work gets done. Unistore (Hybrid Tables) is Snowflake's strategic convergence investment—seamlessly combining OLTP and analytical workloads in a single unified database, and one of the company's most strategically differentiated bets. Operating like a startup within Snowflake, you will own revenue goals, define product strategy for the next phase of growth following our recent General Availability (GA) milestones, and coordinate go-to-market as the primary product authority for the area. OLTP-HTAP convergence is a fast-moving, high-stakes space with strong customer demand—making this one of the highest-visibility product leadership roles in the company and a rare opportunity to define the future of transactional and analytical convergence at scale. AS A STAFF PRODUCT MANAGER AT SNOWFLAKE, YOU WILL: Drive the Unistore product area end-to-end—including product strategy, roadmap prioritization, and go-to-market execution. Rally engineering and product leadership around a compelling 2-3 year vision for Unistore, identifying untapped market opportunities for the next frontier of hybrid data. Define and drive clear requirements for data movement, storage lifecycle, reliability, cost, and quality of service. Champion AI-driven workflows by defining how Unistore serves as the low-latency transacti

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📍 Menlo Park, California, United States· Full-time
✓ Quality checkedCompany trend -91.7%

At Snowflake, we are powering the era of the agentic enterprise. To usher in this new era, we seek AI-native thinkers across every function who are energized by the opportunity to reinvent how they work. You don’t just use tools; you possess an innate curiosity, treating AI as a high-trust collaborator that is core to how you solve problems and accelerate your impact. We look for low-ego individuals who thrive in dynamic and fast-moving environments and move with an experimental mindset — who rapidly test emerging capabilities to discover simpler, more powerful ways to deliver results. At Snowflake, your role isn't just to execute a function, but to help redefine the future of how work gets done. At the center of the data cloud is the Snowflake Database Engineering team. We are responsible for building the core query engine used to process the massive amounts of diverse data managed by our customers. A core part of the Database Engineering group is the Query Language team which is responsible for designing, developing, and maintaining core SQL features, including advanced analytics, scripting, and the developer experience. We are seeking a Senior Engineering Manager to own and drive the effort to build core database capabilities to serve agentic workloads. You'll set the technical direction, build and grow the team behind it, and shape how the core engine and the SQL language evolve to serve this new class of workload. It's a rare chance to lead a foundational bet at the exact moment the industry is racing to solve it, with the scale, customer base, and platform to make your work matter to millions of queries a day. If you want your fingerprints on how the world's data platforms adapt to the age of AI agents, this is one of the best seats in the industry. AS A SENIOR ENGINEERING MANAGER AT SNOWFLAKE, YOU WILL BE EXPECTED TO: Drive the evolution of core database and SQL capabilities to serve emerging AI and agentic workloads alongside traditional analytics Lead and g

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