Jobs in United States

Senior Lead Technical Program Manager Infrastructure in United States

2,037 active opportunities · Updated October 2026

Explore current senior lead technical program manager infrastructure jobs across United States. Filter by work mode, employment type, experience, department, date posted and distance.

Hiring demand

44/100

watch · 156 related jobs

Hiring trend

-64.3%

Job postings compared with the previous 30 days

Remote options

21.2%

Share of matching jobs listed as remote

Typical salary

$145.7K – $145.7K/yr

Based on 9 salary observations

G
📍 California, United States
✓ Quality checkedCompany trend +117.9%

We’re here for one reason and one reason only – to cure cancer. Every moment is dedicated to developing treatments and every action moves us one step closer to our goal. We’ve made incredible scientific breakthroughs and our pioneering personalized CAR T-cell therapies have changed the paradigm. But we're not finished yet. Join Kite, as we make even bigger advances in cancer therapies, and help shape where our business and medical science goes next. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Kite and help create more tomorrows. Job Description The Senior Manager, Kite Safety and Pharmacovigilance provides scientific and strategic leadership for pharmacovigilance activities supporting Kite’s investigational and marketed products. This role serves as a senior pharmacovigilance science expert, leading complex safety analyses, regulatory deliverables, and cross-functional safety strategy execution. Key Responsibilities Aggregate Reporting and Medical Writing Serve as lead author for complex aggregate safety reports, including PSURs, PBRERs, and DSURs, synthesizing global safety data and clinical context Author and review high-impact safety documents supporting regulatory submissions and lifecycle management Safety Analysis and Signal Management <

Recruitment
B
📍 New York, New York, United States
✓ High-confidence listing

$147K – $187K/yr

Quick readStrong listing-quality and freshness signals

Why join us Brex is the intelligent finance platform that enables companies to spend smarter and move faster in more than 200 markets. By combining global corporate cards and banking with intuitive spend management, bill pay, and travel software, Brex enables founders and finance teams to accelerate operations, gain real-time visibility, and control spend effortlessly. Brex’s AI-native automation and world-class service eliminate manual expense and accounting tasks for customers so they can focus on what matters most. Tens of thousands of the world's best companies run on Brex, including DoorDash, Coinbase, Robinhood, Zoom, Plaid, Reddit, and SeatGeek. Working at Brex allows you to push your limits, challenge the status quo, and collaborate with some of the brightest minds in the industry. We’re committed to building a diverse team and inclusive culture and believe your potential should only be limited by how big you can dream. We make this a reality by empowering you with the tools, resources, and support you need to grow your career. Design at Brex Design at Brex creates the experiences that make complex systems feel effortless through thoughtful, scalable design. Whether crafting interfaces, shaping product strategy, or harnessing AI to empower our users, we obsess over quality and clarity. This is a team where creativity meets high craft — and where designers grow by building for ambitious customers. Our production and operations function is essential to making our designers succeed on this mission. What you’ll do We’re seeking an exceptional Senior Brand Producer to join as the first individual contributor on the Creative Operations team. You’ll set the high bar for this role and help define what great production looks like at Brex. This is a highly visible, hands-on role where you’ll lead the execution of complex creative projects from start to finish. You’ll bring both strategic oversight and tactical excellence — ensuring the right systems, vendors, and work

AIAccountingFinance
M
📍 Colorado, United States of America, United States
✓ Quality checkedDemand 44/100Company trend +420%

$145.7K – $148.8K/yr · Jobiba est.

We anticipate the application window for this opening will close on - 2 Oct 2026 Careers that change lives start here. Medtronic is a global leader in healthcare technology with a Mission to alleviate pain, restore health, and extend life. Our 95,000 employees work across more than 150 countries to put patients first — developing innovative medical technologies that improve the lives of 72&#43; million patients each year. Your unique talents will help shape the future of healthcare while building a career grounded in purpose, growth, and impact. A Day in the Life The Acute Care & Monitoring (ACM) Operating Unit develops technologies that help clinicians monitor, diagnose, and manage patients across care settings. Within ACM, the Product DNA organization is responsible for advancing product lifecycle processes, data governance, and digital capabilities that support efficient product development, commercialization, and ongoing lifecycle management. The team partners across research and development, quality, regulatory, operations, information technology, and business functions to drive standardized processes, enterprise system adoption, and operational excellence. This role may be based at the Medtronic campus in Lafayette, Colorado or the office in Mounds View, Minnesota. This is an onsite position that requires regular in-person collaboration with cross-functional stakeholders and project teams. Travel up to 25% is required to support program activities, stakeholder engagement, deployments, and collaboration across Medtronic locations. As Senior Program Manager, Business Transformation, you will lead strategic transformation initiatives like the PTC Windchill integration that improve how product information, business processes, and enterprise technologies support the product lifecycle. This role

SapRecruitmentHR
S
📍 New York City, New York, United States· Full-time· Remote
✓ High-confidence listingCompany trend -81%
Quick readStrong listing-quality and freshness signals

Synthesia is the world’s leading AI video platform for business, used by over 90% of the Fortune 100. Founded in 2017, the company is headquartered in London, with offices and teams across Europe and the US. As AI continues to shape the way we live and work, Synthesia develops products to enhance visual communication and enterprise skill development, helping people work better and stay at the center of successful organizations. Following our recent Series E funding round, where we raised $200 million, our valuation stands at $4 billion. Our total funding exceeds $530 million from premier investors including Accel, NVentures (Nvidia's VC arm), Kleiner Perkins, GV, and Evantic Capital, alongside the founders and operators of Stripe, Datadog, Miro, and Webflow. About the Role Synthesia is looking for a Senior Sales Operations Analyst to help our sales organization run efficiently, scale smoothly, and make faster, better-informed decisions. You'll own the systems, data, and processes that power our go-to-market motion partnering closely with Sales, Finance, and RevOps to keep the engine running and to surface the insights leadership needs to forecast and plan. This is a hands-on role for someone who's equally comfortable deep in Salesforce configuration as they are building a forecast model or presenting a pipeline analysis to sales leadership. What You'll Do Drive reporting & analytics — Build and maintain dashboards for pipeline, forecast, quota attainment, and funnel conversion; deliver regular reporting to sales leadership Support forecasting — Prepare and validate the data behind weekly/monthly/quarterly forecast calls Design sales processes — Improve territory planning, lead routing, deal desk operations, and quote-to-cash workflows Support compensation & quota planning — Model commission plans, calculate payouts, and assist with quota-setting analysis alongside Finance Partner cross-functionally — Work with Marketing, Customer Success/RevOps, and Finance

SQLAISalesforceExcel
G
📍 California, United States
✓ High-confidence listingCompany trend +117.9%

$169.3K – $219.1K/yr

Quick readStrong listing-quality and freshness signals

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description At Gilead our pursuit of a healthier world for all people has yielded a cure for hepatitis C, revolutionary improvements in HIV treatment and prevention as well as advancements in therapies for viral and inflammatory diseases and certain cancers. We set and achieve bold ambitions in our fight against the world’s most devastating diseases, united in our commitment to confronting the largest public health challenges of our day and improving the lives of patients for generations to come. The Protein Therapeutics department is seeking a highly motivated laboratory-based scientist to lead the Molecular Biology function within the Mammalian Expression team. In this capacity

PythonExcelRecruitment
SX
📍 Chicago, United States
✓ High-confidence listing

$100K – $120K/yr

Quick readStrong listing-quality and freshness signals

ROLE: SENIOR STRATEGIST TEAM: THE KITCHEN NORTH AMERICA LOCATION: CHICAGO COMPANY OVERVIEW: The Kitchen brings together a range of disciplines and capabilities. It’s a team of creatives, producers, data analysts and social experts working together to deliver remarkable ideas that live in a variety of mediums, from everything from social to TV. This team moves at the speed of culture. It is built to respond to trends and events as they happen, coming up with the ideas that transcend social media to capture the spirit of the moment, earn media impressions, and get the country talking. Are you ready to join an award-ambitious team that's making waves in the advertising industry? Our incredible team has been recognized internationally by industry giants like Cannes, One Show and was named Campaign's Global ‘In-House Agency of The Year’, further solidifying our position as a leader in the industry. Join us and be a part of something truly special - a team that's dedicated to creating ground-breaking work and pushing limits. At The Kitchen, we're not just looking for individuals who want to be a part of the advertising industry - we're looking for trailblazers who are ready to lead the way to the next big thing! We want individuals who are passionate about producing award-winning work and have an innate drive to their craft and are eager to generate innovative ideas both within and outside of the brief. ROLE OVERVIEW: The Senior Strategist at The Kitchen is responsible for serving as the day-to-day strategic lead across multiple brands. We seek someone who thrives in a fast-paced, creative environment. This role demands a unique blend of strategic thinking, cultural curiosity, and, above all, a passion for social media. Day-to-day responsibilities include developing strategies for brand activations an

MT
📍 Folsom, United States
✓ Quality checkedCompany trend +1250%

Our vision is to transform how the world uses information to enrich life for all . Micron Technology is a world leader in innovating memory and storage solutions that accelerate the transformation of information into intelligence, inspiring the world to learn, communicate and advance faster than ever. The Senior Manager, Industrial Segment & Distribution Operations leads global Segment Operations and Industrial Distribution Operations for Micron’s Industrial & Multi-Market (IMM) business. This role manages business planning, TAM, LRMSR, supply prioritization, analytics, distributor performance, MDF, QBRs, and SCA governance. You’ll direct global teams, strengthen decision-making, and create scalable processes that convert business and market insights into action. Why Join Us? This is an opportunity to build and lead a global operations organization supporting a complex and strategically important business. You’ll develop how IMM plans, prioritizes, and completes tasks while advancing analytics, automation, and operational scale. Join us and be part of a team that is committed to delivering outstanding results and setting world-class standards! Key Responsibilities: Lead global Segment and Distribution Operations teams across the Americas, Europe, and Asia. Manage TAM, LRMSR, business planning, forecasting, supply prioritization, and critical issue management. Establish operating m

AIFinanceSupply ChainRecruitment
M
📍 Indiana, United States of America, United States
✓ Quality checkedCompany trend +420%

We anticipate the application window for this opening will close on - 5 Oct 2026 Careers that change lives start here. Medtronic is a global leader in healthcare technology with a Mission to alleviate pain, restore health, and extend life. Our 95,000 employees work across more than 150 countries to put patients first — developing innovative medical technologies that improve the lives of 72&#43; million patients each year. Your unique talents will help shape the future of healthcare while building a career grounded in purpose, growth, and impact. A Day in the Life Are you passionate about driving innovation and improving manufacturing processes? Medtronic is seeking a Senior Manufacturing Engineer to join our team at our Warsaw, Indiana manufacturing site. In this role, you’ll play a critical part in optimizing production, ensuring quality, and advancing our mission to improve lives. As a Senior Manufacturing Engineer, you’ll lead key initiatives to enhance manufacturing efficiency, implement Lean principles, and collaborate with cross-functional teams to solve complex challenges. You’ll also have the opportunity to work on cutting-edge technologies and processes while contributing to the production of life-saving medical devices. At Medtronic, we bring bold ideas forward with speed and decisiveness to put patients first in everything we do. In-person exchanges are invaluable to our work. We’re working a minimum of 5 days a week onsite as part of our commitment to fostering a culture of professional growth and cross-functional collaboration as we work together to engineer the extraordinary. Responsibilities may include the following and other duties may be assigned. Responsible for the development of machining, metal finishing, and assembly methods for assigned product lines. <l

Project ManagementRecruitmentHR
M
📍 Minnesota, United States of America, United States
✓ Quality checkedCompany trend +420%

We anticipate the application window for this opening will close on - 30 Sep 2026 Careers that change lives start here. Medtronic is a global leader in healthcare technology with a Mission to alleviate pain, restore health, and extend life. Our 95,000 employees work across more than 150 countries to put patients first — developing innovative medical technologies that improve the lives of 72&#43; million patients each year. Your unique talents will help shape the future of healthcare while building a career grounded in purpose, growth, and impact. A Day in the Life The Surgical Operating Unit Program Management Office (PMO) Process Excellence team is responsible for enabling effective project planning, execution, and portfolio management through standardized processes, systems, and tools. This team partners with program leaders, project teams, and functional stakeholders to drive consistency, visibility, and operational excellence across product development and business initiatives. The Senior Project Management Specialist/ System Administrator supports the administration, optimization, and deployment of project management tools and systems while advancing project management best practices throughout the organization. This role combines project leadership, systems administration, process improvement, and stakeholder engagement to support successful project execution within a highly regulated medical device environment. This is an onsite position that may be located in North Haven, Connecticut; Lafayette, Colorado; or Mounds View, Minnesota. The Senior Project Management Specialist/ Systems Administrator partners with project and functional teams to support project management systems, lead tool-related initiatives, and drive adoption of project management processes. This role serves as a key resource f

Project ManagementPmpRecruitmentHR
D
📍 New York, New York, United States
✓ High-confidence listingCompany trend -86.8%
Quick readStrong listing-quality and freshness signals

The Senior Manager, Sponsorship Sales will own the strategy, sales, and execution of the sponsorship program for DASH, Datadog’s flagship annual conference, while also supporting sponsorship strategy and sales for global Datadog Summits. You will manage the full sponsorship sales cycle, from developing packages and prospecting through negotiation, closing, renewal, and partner experience. This role carries a sponsorship revenue target and partners closely with Events, Partner Marketing, Community, Sales, Finance, and leadership to build a scalable sponsorship program. You will have the opportunity to shape how Datadog packages, positions, and grows sponsorship offerings across its global conference portfolio. At Datadog, we place value in our office culture - the relationships and collaboration it builds and the creativity it brings to the table. We operate as a hybrid workplace to ensure our Datadogs can create a work-life harmony that best fits them. What You’ll Do: Build and manage the sponsorship revenue plan, pipeline, and forecast for DASH, reporting progress against targets to Events and Marketing leadership while supporting sponsorship strategy and sales for global Datadog Summits. Develop and evolve tiered sponsorship packages across branding, speaking opportunities, booth space, digital assets, lead generation, and other offerings based on sponsor needs and event capacity. Manage the full consultative sales cycle, including prospecting, qualification, pitching, negotiation, closing, renewals, and expansion with new and existing sponsors, while maintaining accurate CRM and sales activity reporting. Serve as the primary commercial relationship owner for sponsors from contract through onsite delivery, orchestrating the end-to-end partner journey while Event Marketing and agency partners manage fulfillment. Collaborate with Events, Marketing, Sales, Partner Marketing, Community, and Finance on event inventory and logistics, sponsorship positioning, account str

AIFinanceLogisticsCRM
H
📍 Austin, Texas, United States
✓ High-confidence listing
Quick readStrong listing-quality and freshness signals

Hyliion is committed to creating innovative solutions that enable clean, flexible and affordable electricity production. The Company’s primary focus is to develop distributed power generators that can operate on various fuel sources to future-proof against an ever-changing energy economy. Job Purpose The Senior Manager, Additive Fleet is responsible for the day-to-day performance of Hyliion's laser powder bed fusion (LPBF) printer fleet in Austin, which produces the complex, high-density metal heat exchanger hardware in the KARNO Core. This hardware can only be produced through metal additive manufacturing, so Hyliion's ability to build KARNO at scale depends directly on the health, uptime, and throughput of the fleet. The role leads the technicians and operators who run and maintain the machines, and owns preventive maintenance strategy, machine health monitoring, and decisions on hardware and software upgrades. The fleet runs the full range of Colibrium Additive LPBF platforms, including new machine technology being adopted in real time, and a primary focus is reducing machine-to-machine variation and building repeatable processes across machine models. This is a hands-on leadership role with regular time on the shop floor, and its scope will grow as Hyliion's print capacity scales. AI at Hyliion At Hyliion, AI is core to how we work. We equip every team member with leading AI tools and count on you to use them — to move faster, solve harder problems, and help us realize the full potential of KARNO technology for the world. Duties and Responsibilities Own fleet uptime and drive continuous improvement in machine-to-machine consistency across Hyliion's LPBF printer fleet. Build and maintain a preventive maintenance program across all machines to identify failure modes before they cause downtime. Lead, schedule, and develop the team of technicians and operators who run and maintain the fleet. Develop machine health monitoring us

AIHuman ResourcesHR
SA
📍 Seattle, Washington, United States
✓ High-confidence listing

$180K – $190K/yr

Quick readStrong listing-quality and freshness signals

Sapience AI is the collective intelligence platform for professional communities. We sit above the CRMs, AMS platforms, and knowledge bases that organizations already run, and we turn the expertise scattered across them into something every member can search, act on, and share. The intelligence a community needs is already inside it. Most organizations just cannot reach it. Knowledge lives in silos, in legacy systems, in the heads of a few experts, and in fragmented records no one can connect. We change that. Our work is grounded in four commitments: technology elevates people and never replaces them, the best expertise is already inside the community, everything is built on trust, and every deployment is purpose-driven for the organization it serves. Let’s achieve more, together. Where this role sits This role owns a product area end to end. Where the product marketer is the market lens, you are the person accountable for what we build, how it works, and whether it ships and succeeds. You lead a cross-functional team of engineers, designers, and applied AI specialists to turn strategy into a product members rely on. You own the roadmap for your area, the decisions inside it, and the outcomes it produces. You work at the center of the product organization, translating a clear point of view into shipped work that moves MINERVA and the COGENT architecture forward through each GR/GA milestone. Why this role exists In an AI market where capabilities can be copied in weeks, the advantage goes to teams that decide well and ship fast. Someone has to hold the point of view, make the calls, and keep a team building the right thing. Collective intelligence is hard product work: reasoning over messy knowledge, earning member trust, and fitting into how communities already operate. It needs an owner who can hold both the ambition and the details. The Senior Product Manager is that owner. You set direction for your area, make the hard prioritization calls, and are accountable fo

B
📍 Daytona Beach, FL, United States
✓ Quality checkedCompany trend +274.2%

Senior Software Engineer Mission Systems Software Developer Company: The Boeing Company The Boeing Company has an exciting opportunity for a Senior Software Engineer Mission Systems Software Developer (Level 5) to join Boeing Defense, Space & Security (BDS) in Daytona Beach, Florida . BDS is a global leader in the development, production, maintenance and enhancement of fixed-wing and rotary wing aircraft, commercial and government satellites, human spaceflight programs and weapons. Key markets include aeronautics, space and weapons. Core capabilities are in development, production and mission enabling upgrades of integrated solutions. BDS delivers the most digitally advanced, simply and efficiently produced and intelligently supported solutions to its customers. Daytona Beach is the company's newest state-of-the-art facility focused on engineering excellence. Florida offers no state income tax and a variety of other desirable personal and financial benefits. This position will include developing software and software tests throughout all phases of the software development life cycle (requirements, architecture, implementation, and verification). The software engineer will develop software in a Continuous Integration / Continuous Deployment (CI/CD) DevSecOps software build pipeline using an agile methodology focused on code quality, security and automation. Position Responsibilities: Develop Participates in use case development of software requirements Ability to lead activities to develop, document and maintain software architecture, requirements, algorithms, interfaces and designs for mission systems software Leads development of code and integration of complex Mission Systems softwar

PythonJavaGitLinux
H
📍 Louisville, United States
✓ Quality checkedCompany trend +310%

Become a part of our caring community Job Description Summary The Lead Solutions Architect provides architecture leadership for CenterWell Home Health programs and platforms, shaping conceptual and reference architectures, governing solution designs, and aligning delivery teams to cloud and data strategies. The scope includes high-priority initiatives as well as interoperability and provider-data integrations that span CenterWell and Humana Insurance. As Lead Solution Architect, you'll be the senior individual contributor on a team with broad accountability across CenterWell's dispensing pharmacy portfolio — mail order, specialty, retail, and associated platforms. You'll own the architectural vision for complex, multi-system initiatives, shape how technology decisions get made, and act as a connective force between business strategy, engineering execution, and enterprise standards. You will operate within CenterWell IT – Cross-CenterWell Architecture. You will collaborate with product, engineering, EA Activation, security, data, and operations. You will engage governance forums to enable Integrated Health across CenterWell and Humana Insurance. Key Activities Quickly conduct structured knowledge transfer with existing architects and relevant stakeholders to capture critical in-flight designs and decisions. Review current initiatives and establish an architectural roadmap aligned with organizational priorities. Develop or refine reference architectures and design patterns for core platforms and solutions. Collaborate with governance and compliance teams to validate designs against enterprise standards and regulatory requirements. Define integration strategies and solution blueprints for key systems and data flows. Establish architecture review processes and decision forums to support de

AWSAzureAIRecruitment
M
📍 State Of Illinois, United States of America, United States
✓ Quality checkedCompany trend +420%

We anticipate the application window for this opening will close on - 28 Sep 2026 Careers that change lives start here. Medtronic is a global leader in healthcare technology with a Mission to alleviate pain, restore health, and extend life. Our 95,000 employees work across more than 150 countries to put patients first — developing innovative medical technologies that improve the lives of 72&#43; million patients each year. Your unique talents will help shape the future of healthcare while building a career grounded in purpose, growth, and impact. A Day in the Life We are seeking a committed professional to join our team. While this is a remote position not located at a physical Medtronic site, the candidate hired will be required to reside within the territory and drive to multiple accounts throughout the region. A valid driver's license is essential for this role. Bring your leadership talents to a leader in medical technology and healthcare solutions. Rooted in our long history of mission-driven innovation, our medical technologies open doors. We support your growth with the training, mentorship, and guidance you need to own your future success. Join us for a career in sales that changes lives. CAREERS THAT CHANGE LIVES - POSITION DESCRIPTION: To lead and drive achievement of revenue and market share goals for the Coronary portfolio across an assigned district by developing and executing strategic business plans, building high-performing sales teams, and fostering key customer relationships. This role partners closely with region leadership to deliver against broader cardiovascular sales and marketing objectives, ensuring alignment to organizational priorities. The Coronary Sales District Manager is accountable for cultivating a culture of excellence—championing product

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