Jobs in United States

Senior System Architect in United States

1,941 active opportunities · Updated October 2026

Explore current senior system architect jobs across United States. Filter by work mode, employment type, experience, department, date posted and distance.

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📍 Kentucky, United States· Remote
✓ High-confidence listingCompany trend +671.4%

$108.6K – $250.7K/yr

Quick readStrong listing-quality and freshness signals

Pfizer US/PR Commercial Sales Founded in 1849, Pfizer Inc. began as a small chemistry enterprise built on the belief that scientific ingenuity can improve—and protect—human life. Today, as one of the world’s leading biopharmaceutical companies, Pfizer’s purpose is Breakthroughs that change patients’ lives : discovering, developing, and delivering medicines and vaccines that address unmet need, earn trust through quality and integrity, and reach patients through strong partnerships across the healthcare system. In a complex and rapidly evolving pharmaceutical landscape, our work is measured by one outcome - helping patients live longer, healthier lives . Rare Disease Sales Organization Mission & Impact Pfizer’s Rare Disease – Rare Cardiac Sales organization exists to help improve the lives of people living with serious rare cardiac conditions by connecting scientific innovation to the clinicians and systems that deliver care. We lead with integrity and patient need— advancing disease and product education grounded in robust clinical evidence , promoting Pfizer Rare Cardiac therapies compliantly, and supporting healthcare professionals’ understanding of appropriate patient identification and use based on approved indications. Through evidence‑based scientific exchange, we help reduce access, diagnostic, and workflow barriers so more patients can start and stay on the right therapy. Our impact is more informed clinical decision ‑ making, improved consistency of care, and better outcomes for patients , contributing to a higher standard of care across the rare cardiac community. Role Summary The Rare Disease – Rare Cardiac, Senior Health & Science Specialist is a field-based specialty sales role responsible for driving the growth of Rare Cardiac products through compliant, strategic relationships within assigned accounts. This role par

AIRecruitment
F
📍 San Francisco, California, United States
✓ High-confidence listingCompany trend +100%

$285K – $305K/yr

Quick readStrong listing-quality and freshness signals

Fin , now part of Salesforce, is on a mission to help businesses provide perfect customer experiences. Our AI Agent Fin is the highest-performing AI Customer Agent on the market today, enabling businesses to deliver impeccable, always-on customer support across the customer journey, from service, to sales, to ecommerce. Powered by our own AI models, Fin resolves complex customer issues end-to-end across every channel, with minimal set-up and integration. Fin can also be combined with our natively integrated Intercom help desk, giving modern support teams one single system. Together with Salesforce, the #1 AI CRM, where humans with agents drive customer success, we're building the future of customer experience. Here, ambition meets action. Tech meets trust. And innovation isn't a buzzword, it's a way of life. The world of work as we know it is changing, and we're looking for Trailblazers who are passionate about bettering business and the world through AI. Ready to level up your career at the company leading workforce transformation in the agentic era? You're in the right place. Agentforce is the future of AI, and you are the future of Salesforce. What's the opportunity? The Solutions Marketing team positions Fin to win in the market through compelling messaging, content, audience understanding, and field activation. The Director of Solutions will manage a team of solution marketers that will fundamentally help our revenue teams to be more effective and grow Fin ARR. This is a strategic role in the company, working directly with the senior leadership team. The Role The Solutions Marketing team can be thought of as the solutions or outbound equivalent of a traditional product marketing team. Fin already has a product marketing team that works closely with product managers to understand our product, create messaging, and build assets for product launches, the Website and our field. The Solutions Marketing team on the other hand, will focus on our prod

AISalesforceCRM
O
📍 Atlanta, Georgia, United States· Full-time
✓ High-confidence listing

From $116.5K/yr

Quick readStrong listing-quality and freshness signals

Strength in Trust OneTrust’s mission is to enable innovation through the responsible use of data and AI. We believe that ensuring data is trusted shouldn’t slow teams down—it should accelerate what’s possible. This led us to develop the first technology platform for responsible data use in 2016. Today, with AI representing the latest and most impactful expansion of data yet, OneTrust is once again redefining what responsible innovation looks like. OneTrust, the AI‑Ready Governance Platform™, unifies regulatory intelligence, automation, and connected governance workflows so businesses can continue to move at the speed of AI while ensuring good governance to prevent data misuse at scale. Trusted by thousands of organizations worldwide, OneTrust is shaping the future where trusted data becomes a transformative force for business and society. The Challenge We're looking for a Senior Software Engineer that will report to the Development Manager / R&D Head. In this role, you will part of the R&D Team that works on mission-critical applications. Your Mission Engage and partner with various Engineering, Operations, and Product teams to design, deliver, and maintain a highly available and performant application platform. Build and implement application observability and platform monitoring tools to continuously improve the customer experience Eliminate toil by automating processes, tuning alerts, and improving code where it is most needed Frequently evaluate new ideas and trends to identify potentially useful tools and techniques Collaborate with different functional groups to identify gaps, prioritize, and resolve issues Defining, implementing, and maintaining SLIs and SLOs aligned with customer experience. Design and instrument SLIs such as latency, error rates, and availability across critical services Manage and enforce error budgets to balance system reliability with product feature v

PythonJavaSQLAWS
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📍 Atlanta, Georgia, United States· Full-time
✓ High-confidence listing

From $116.5K/yr

Quick readStrong listing-quality and freshness signals

Strength in Trust OneTrust’s mission is to enable innovation through the responsible use of data and AI. We believe that ensuring data is trusted shouldn’t slow teams down—it should accelerate what’s possible. This led us to develop the first technology platform for responsible data use in 2016. Today, with AI representing the latest and most impactful expansion of data yet, OneTrust is once again redefining what responsible innovation looks like. OneTrust, the AI‑Ready Governance Platform™, unifies regulatory intelligence, automation, and connected governance workflows so businesses can continue to move at the speed of AI while ensuring good governance to prevent data misuse at scale. Trusted by thousands of organizations worldwide, OneTrust is shaping the future where trusted data becomes a transformative force for business and society. The Challenge We're looking for a Senior Software Engineer that will report to the Development Manager / R&D Head. In this role, you will part of the R&D Team that works on mission-critical applications. Your Mission Engage and partner with various Engineering, Operations, and Product teams to design, deliver, and maintain a highly available and performant application platform. Build and implement application observability and platform monitoring tools to continuously improve the customer experience Eliminate toil by automating processes, tuning alerts, and improving code where it is most needed Frequently evaluate new ideas and trends to identify potentially useful tools and techniques Collaborate with different functional groups to identify gaps, prioritize, and resolve issues Defining, implementing, and maintaining SLIs and SLOs aligned with customer experience. Design and instrument SLIs such as latency, error rates, and availability across critical services Manage and enforce error budgets to balance system reliability with product feature v

PythonJavaSQLAWS
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📍 San Francisco, California, United States· Full-time
✓ High-confidence listingCompany trend -87.4%

$150K – $175K/yr

Quick readStrong listing-quality and freshness signals

Who We Are Notion is the collaborative AI workspace where teams and agents think together . We're building one place where your knowledge, projects, meetings, and AI tools live side by side, so work is faster, clearer, and less fragmented. Millions of individuals, small teams, and large companies run their work on Notion. Notinos (our employees) are customer zero in bringing this future of work to life. We care about craft, building things that last, and the belief that great work is still fundamentally human. Our goal isn’t to ship the next feature. Each and every team of Notinos is working to set the standard for how humans work together in the AI era. From building a business’s system of record to making and managing AI agents to automating away the busy work, we care deeply about giving our customers more time for their life’s work. About the Role This is an opportunity to serve as a key partner and advisor on Notion’s Business Operations team, working primarily with our Engineering, Product, & Design teams. Business Operations is a cross-functional team that partners with senior leaders across the company, focusing on high-impact strategic projects and analysis. In this role, you’ll work hand-in-hand with leadership to identify, structure, and act on the most challenging strategic and operational questions impacting our business. This role is based in San Francisco, CA. We work from our offices on Mondays, Tuesdays and Thursdays (our Anchor Days) because we do our best thinking and building together in person. We’re looking for someone who’s excited to work alongside the team during those days. What You'll Achieve Build trusted relationships with cross-functional leaders to define and implement strategy across all Notion products, driving increased value to our users and our business Structure complex, ambiguous strategic problems for the Notion leadership team, defining clear hypotheses and building detailed business cases and quantitative models that will

SQLRestAIGo
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📍 San Francisco, California, United States· Full-time· Remote
✓ High-confidence listingCompany trend -87.4%

$280K – $340K/yr

Quick readStrong listing-quality and freshness signals

Who We Are Notion is the collaborative AI workspace where teams and agents think together . We're building one place where your knowledge, projects, meetings, and AI tools live side by side, so work is faster, clearer, and less fragmented. Millions of individuals, small teams, and large companies run their work on Notion. Notinos (our employees) are customer zero in bringing this future of work to life. We care about craft, building things that last, and the belief that great work is still fundamentally human. Our goal isn’t to ship the next feature. Each and every team of Notinos is working to set the standard for how humans work together in the AI era. From building a business’s system of record to making and managing AI agents to automating away the busy work, we care deeply about giving our customers more time for their life’s work. About the Role: We are looking for an experienced attorney to join our Commercial Counsel team. This senior role will help build and support Notion’s rapidly evolving Enterprise customer sales motions, bringing deep expertise in negotiating complex AI SaaS agreements with enterprise customers, as well as acting as an advisor and coach to our account teams and cross functional partners. Notion is scaling rapidly, and we need people who work well as a tight-knit team with a passion for driving revenue deals to conclusion. If you enjoy using your deep industry and technology transaction expertise to support revenue generating functions, this role is for you. Our Commercial Legal team sits at the center of Notion’s growth. We simplify how customers contract with us, take clear and unambiguous positions on AI, privacy, and security, and drive revenue deals to a fast, predictable close. That means exercising real judgment and finding creative, pragmatic paths forward through complex customer requests and requirements. This role can be based in either San Francisco or New York City. We work from our offices on Mondays, Tuesdays and Thursday

RestAIGoRust
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📍 San Francisco, California, United States· Full-time· Remote
✓ High-confidence listingCompany trend -87.4%

$230K – $257K/yr

Quick readStrong listing-quality and freshness signals

Who We Are Notion is the collaborative AI workspace where teams and agents think together . We're building one place where your knowledge, projects, meetings, and AI tools live side by side, so work is faster, clearer, and less fragmented. Millions of individuals, small teams, and large companies run their work on Notion. Notinos (our employees) are customer zero in bringing this future of work to life. We care about craft, building things that last, and the belief that great work is still fundamentally human. Our goal isn’t to ship the next feature. Each and every team of Notinos is working to set the standard for how humans work together in the AI era. From building a business’s system of record to making and managing AI agents to automating away the busy work, we care deeply about giving our customers more time for their life’s work. About the Role: As our GTM Compensation Lead on Commercial Operations, you’ll own commissions strategy, design, and execution for GTM. This is an opportunity to evolve how GTM Comp supports a growing GTM org through Notion’s AI-era selling motion and Enterprise growth. You’ll set the incentive systems that shape how our sellers focus, partner, and grow with customers. On a typical week, you’ll work with senior GTM leaders — including the Head of Sales and geo leaders — to translate business priorities into clear, accurate, scalable comp programs. What You'll Achieve: By your 90th day, map the current GTM Comp operating model and publish a roadmap for evolving the function as GTM grows. Introduce AI quick wins that improve the quality of work: triage inbound questions, help reps estimate payouts, flag discrepancies across systems, and automate reminders tied to the comp calendar. Build a planning-cycle framework that makes design inputs, trade-offs, decision rights, and timelines clear across GTM, Finance, and Commercial Operations. Provide board-level updates, including clear reporting on plan health, payout accuracy, systems quality

RestAIGoFinance
O
📍 San Francisco, California, United States· Full-time· Remote
✓ Quality checkedCompany trend -82%

About the Team The Industry Marketing team helps OpenAI bring frontier AI to the industries where it can create meaningful, measurable impact. We work across Product, GTM, Communications, Partnerships, Policy, Security, and Research to translate model and product capabilities into industry narratives, field motions, customer proof, and launch programs that help enterprises adopt AI responsibly. About the Role As Product Marketing Manager, Cybersecurity, you will help define how OpenAI brings frontier AI to cyber defenders. This role sits at the center of Daybreak, OpenAI’s cybersecurity initiative to help defenders see risk earlier, act sooner, and build software that is resilient by design. You will shape the market narrative, build the field-facing operating system, and coordinate cross-functional execution across product launches, customer proof, partner moments, events, and account-based campaigns. You will help senior security leaders understand how OpenAI models, Trusted Access for Cyber, Codex Security, and related workflows can support real defensive work. We’re looking for a product marketer who combines strategic narrative, technical curiosity, enterprise go-to-market judgment, and program leadership. The right person can turn fast-moving capabilities into clear positioning, credible assets, and practical field execution. In this role, you will: Own positioning and messaging for OpenAI’s cybersecurity offering, including Daybreak, Trusted Access for Cyber, Codex Security, and related product surfaces. Build field-ready assets for account directors, solutions engineers, security leaders, and executive audiences, including first-call decks, one-pagers, use-case libraries, customer stories, and proof-point packages. Translate frontier model capabilities into simple, accurate, and defensible go-to-market language for senior enterprise buyers and security practitioners. Partner with Product, Research, Security, Policy, Communications, Partnerships, and GTM to c

Artificial IntelligenceAIProcurement
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📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -80.4%

ABOUT BASETEN Baseten powers mission-critical inference for the world's most dynamic AI companies, like Cursor, Notion, OpenEvidence, Abridge, Clay, Gamma and Writer. By uniting applied AI research, flexible infrastructure, and seamless developer tooling, we enable companies operating at the frontier of AI to bring cutting-edge models into production. We're growing quickly and recently raised our $1.5B Series F , led by Altimeter Capital, Conviction Partners, and Spark Capital. Join us and help build the platform engineers turn to to ship AI products. THE OPPORTUNITY We are looking for Senior Software Engineers to join our team. This is a specialized, high-impact role sitting at the intersection of high-performance computing (HPC) and Large Language Model (LLM) engineering. You will not just be building the automated "speedometer and diagnostic" suite for our next-generation AI infrastructure; you will be defining the roadmap, driving key technical decisions, and taking full ownership of the future of this work. RESPONSIBILITIES Benchmarking : Evaluate, run and automate standard LLM quality benchmarks (GSM8K, MMLU) alongside custom performance suites for specific workloads (e.g., long-context window, KV cache reuse, disaggregated serving). DevEx Improvement : Develop and maintain internal GPU-enabled development environments (similar to GitHub Codespaces). You will ensure the team has seamless, high-performance "dev machines" optimized for model experimentation. Tool Development : Build and contribute to open-source tools such as InferenceMAX and genai-bench to automate model evaluation, benchmarking and analysis. System Profiling : Use profilers like PyTorch Profiler, NVIDIA Nsight Systems and py-spy to collect performance profiles, identify bottlenecks, and debug the compute/networking stack. Monitoring & Observability : Develop real-time dashboards and alerts to monitor system health, model startup times, and runtime performance. Continuous Integration : Auto

PythonCI/CDGitRest
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📍 United States· Full-time
✓ Quality checkedCompany trend -100%

About Supabase Supabase is the Postgres development platform, built by developers for developers. We provide a complete backend solution including Database, Auth, Storage, Edge Functions, Realtime, and Vector Search. All services are deeply integrated and designed for growth. About the Role Supabase's Partnerships function is scaling fast - spanning Technology Partners, Solution Partners, Startups, and Cloud Partnerships. We're looking for a Partner Operations & Systems Lead to own the operational and technical backbone that lets this team move quickly and make decisions with good data. This is a senior, hands-on role. You'll design the systems, processes, and reporting that the whole partnerships org runs on - and, increasingly, you'll build the internal tools yourself. Supabase is investing heavily in AI-assisted development to move faster than a traditional ops build cycle allows, and this role is expected to be a leading example of that inside Partnerships. You'll report directly to the Head of Partnerships and sit alongside our regional and functional leads as a peer, with the mandate to build and enforce operational rigor across all teams. Beyond the infrastructure, we want someone who helps shape where Partnerships places its bets - not just the system that reports on them. What You'll Own Systems & Data Infrastructure Own the partner tech stack end-to-end - CRM partner objects, attribution tooling, and partner-facing portals. Design and maintain partner attribution models and the dashboards leadership uses to evaluate performance. Ensure data hygiene and consistency across partner records, deals, and touchpoints spanning all sub-functions. Process & Program Management Design and run partner onboarding, tiering, and certification programs. Own the RFC / DRI decision-making framework for the partnerships team, including how it's used and refined over time. Run deal-registration and "quarterback" account-ownership processes that keep internal teams

R
📍 Foster City, California, United States· Full-time
✓ Quality checkedCompany trend -85.9%

Replit is the agentic software creation platform that enables anyone to build applications using natural language. With millions of users worldwide, Replit is democratizing software development by removing traditional barriers to application creation. About the Role We are seeking a mid-level AppSec Vulnerability Management Engineer with a strong software development background. In this role, you will bridge the gap between security, compliance, and engineering teams. You will identify application vulnerabilities, maintain software supply chain security, and drive tracking to satisfy strict regulatory compliance frameworks. You will also serve as a technical responder during security incidents, deploying real-time countermeasures to protect our software ecosystem. What You'll Do Core Responsibilities Vulnerability Scanning & Triage: Perform periodic application security scanning activities. Review results and prioritize flaws based on CVSS scores, real-world exploitability, and system exposure. Compliance-Driven Tracking: Track, document, and manage vulnerabilities according to strict compliance SLAs (e.g., SOC 2, ISO 27001, PCI-DSS). Maintain audit-ready evidence of remediation timelines and exception approvals. Executive Reporting & Alerting: Escalate and report critical exposures directly to the CISO and senior leadership. Maintain dashboards and alerting mechanisms that visualize vulnerability status, risk trends, and compliance posture. Software Supply Chain Security: Ownership of the organization's Software Bill of Materials (SBOM). Continually update SBOM inventories to ensure compliance with modern regulatory requirements and dependency tracking. Help Replit mature through various SLSA levels for supply chain security. Remediation Collaboration: Partner with development teams to provide clear mitigation paths. Review, write, and patch code directly when necessary to resolve security flaws. Tooling Integration: Configure and tune automated security te

JavaScriptTypeScriptPythonJava
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📍 United States· Full-time
✓ Quality checkedCompany trend -82%

About the Team OpenAI’s Agentic Data Science team helps shape how AI agents are built, deployed, and improved across our products. We partner with product, engineering, research, and security teams to define meaningful measures of success, understand how our systems behave in the real world, and translate evidence into better decisions. As AI agents become more capable, they can write and execute code, access sensitive systems, and complete increasingly complex tasks with greater autonomy. These capabilities create powerful opportunities to improve cybersecurity, but they also introduce risks that traditional security tools and processes were not designed to address. Meeting this moment requires new ways to measure security, evaluate defenses, and distinguish genuine risk reduction from friction that slows users down. About the Role We are looking for a senior data scientist to help define what effective cybersecurity looks like in the age of AI agents. You will work across OpenAI’s Security organization and cybersecurity product teams to measure emerging risks, improve internal security controls, and shape AI-powered security products. The problems are foundational: How do we know whether an agent’s security controls are effective? Which safeguards meaningfully reduce risk, and which create unnecessary friction? When an AI system identifies a potential vulnerability, how do we determine whether the finding is accurate, actionable, and ultimately resolved? How do we detect anomalous behavior or risky access when the systems themselves are changing rapidly? You will report into Data Science while partnering closely with Security, Cyber Product, Engineering, and Research. This is a high-ownership role for someone who can establish a new analytical discipline, operate across organizational boundaries, and turn ambiguous security challenges into measurable improvements. In This Role You Will Define how we measure AI-agent security. Establish metrics and evaluation frame

PythonSQLAWSRest
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📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -82%

About the Team Like every team at OpenAI, the Marketing team contributes to our broader mission of ensuring responsible and widespread adoption of artificial intelligence. With that aim in mind, we are responsible for developing and executing strategies that drive awareness, engagement, and usage for OpenAI’s products and platform amongst our core audiences. Our focus extends beyond just promoting product features; we aim to provide valuable insights and resources that help our users make the most out of AI technologies. About the Role As an Industry PMM, you will help define how OpenAI brings frontier AI to priority industries. This role sits at the center of OpenAI’s industry marketing motion, helping customers understand where AI can create practical value, improve workflows, and support responsible adoption. You will shape the market narrative, build the field-facing operating system, and coordinate cross-functional execution across product launches, customer proof, partner moments, events, and account-based campaigns. You will help senior industry leaders understand how OpenAI models, products, and workflows can support meaningful work in either Life Sciences, Banking, or Healthcare. We’re looking for a product marketer who can combine strategic narrative, technical curiosity, enterprise GTM judgment, and program leadership. The right person can turn fast-moving capability into clear positioning, credible assets, and practical field execution. This role is based in San Francisco, CA. We use a hybrid work model of 3 days in the office per week and offer relocation assistance to new employees. In this role, you will: Own positioning and messaging for OpenAI’s industry offering for either Life Sciences, Banking, or Healthcare. Build field-ready assets for account directors, solution engineers, industry leaders, and executive audiences, including first-call decks, one-pagers, use-case libraries, customer stories, and proof-point packages Translate frontier model ca

AWSRestAIGo
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📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -82%

About the Team Our Safety Systems team is at the forefront of OpenAI's mission to build and deploy safe AGI, driving our commitment to AI safety and fostering a culture of trust and transparency. The Model Policy team aligns model behavior with desired human values and norms. We co-design policy with models and for models by driving rapid policy taxonomy iteration based on data and defining evaluation criteria for foundational models’ ability to reason about safety. Key focus areas include: catastrophic risk, mental health, teen safety and multimodal safety. About the Role Providing access to frontier AI systems raises complex questions around dual-use science and catastrophic risk. How should models respond to requests involving chemical synthesis, biological experimentation, or pathogen research? Where is the boundary between legitimate scientific inquiry and information that could enable misuse? How do we design policies that meaningfully reduce risk without unnecessarily restricting beneficial research? This is a senior role in which you’ll help shape policy creation and development at OpenAI for addressing biological and chemical risks. You will develop structured policy frameworks and taxonomies to guide safe model behavior. This role sits at the intersection of biosecurity expertise, AI safety research, and policy design. You will help ensure that frontier AI systems can support beneficial life sciences research, such as drug discovery, public health, and biosafety, while reducing the risk that these capabilities could be misused. Our relevant publications: Preparedness framework Preparing for future AI capabilities in biology Safety evaluations hub OpenAI GPT5 System Card Evaluating Fairness in ChatGPT Improving Model Safety Behavior with Rule-Based Rewards OpenAI Model Spec Your Responsibilities: Design and maintain model policies governing chemical and biological risk, defining how models should safely handle dual-use scenarios. Develop structured taxonomi

AWSGitRestMachine Learning
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📍 San Francisco, California, United States· Full-time
✓ High-confidence listingCompany trend -87.4%

From $245K/yr

Quick readStrong listing-quality and freshness signals

Who We Are Notion is the collaborative AI workspace where teams and agents think together . We're building one place where your knowledge, projects, meetings, and AI tools live side by side, so work is faster, clearer, and less fragmented. Millions of individuals, small teams, and large companies run their work on Notion. Notinos (our employees) are customer zero in bringing this future of work to life. We care about craft, building things that last, and the belief that great work is still fundamentally human. Our goal isn’t to ship the next feature. Each and every team of Notinos is working to set the standard for how humans work together in the AI era. From building a business’s system of record to making and managing AI agents to automating away the busy work, we care deeply about giving our customers more time for their life’s work. About the Role Notion is looking for a Head of Demand Engine to build the engine that turns our best product stories, customer proof, and market opportunities into scaled pipeline. You’ll lead demand programs across campaigns, digital, paid strategy, webinars, email, web, and emerging channels. You’ll partner closely with Product Marketing on audience and offer strategy, with Performance Marketing on paid execution, and with Field Marketing & Events on the moments that benefit from in-person activation. This is a senior leadership role with both AMER and global scope. You’ll help set the global standard for how Notion plans, runs, tests, and measures demand programs, while learning from strong regional teams and making the best ideas repeatable across markets. You’ll lead a growing team spanning demand programs and digital demand, with room to expand into areas like partner marketing over time. This is a build job as much as a run job. We’re looking for someone with real taste who can spot a strong idea, turn it into a sharp program, and build a repeatable engine around what works. You should care about quality and craft, but als

GitRestAIGo
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