Co-op, mRNA Process Development

Company Overview: Strand Therapeutics is a clinical-stage biotechnology company pioneering programmable mRNA therapeutics to unlock the full potential of genetic medicines. Strand is applying its proprietary Signal Stack platform, which integrates EverScript circular RNA, AmpliScript self-replicating RNA, SignalPath targeted delivery, and logic-driven SignalLock genetic circuits to enable precise control of therapeutic activity across tissues and cell types and overcome foundational limitations in targeting, durability, and safety. Strand is advancing a pipeline with an initial focus on oncology and autoimmune disease. Its initial program, STX-001, an intratumorally delivered LNP-encapsulated self-replicating RNA expressing IL-12, has demonstrated preliminary evidence of systemic immune activation and anti-tumor activity in patients with advanced solid tumors who have progressed on prior therapies. Building on this early clinical validation, intravenously delivered STX-003 is designed for tumor-targeted expression and avoidance of off-target expression. STX-003, which is expected to enter the clinic in mid-2026, has the potential to be a major step forward for the fields of genetic medicine and oncology. Strand is also advancing STX-005, an in vivo CAR-T program designed to enable controlled, durable expression and repeat dosing. Founded by MIT synthetic biology pioneers, Strand has raised over $250 million and is headquartered in Boston, MA. Become the next standout single strand! Job Summary: Strand is looking for people who have the enthusiasm and motivation to be a highly contributing member of a small but extremely productive team. This opportunity will offer the employee the ability to work in a matrix-based environment and be a part of the future strategy of the company. We are looking for a highly motivated candidate to join as Co-op of the mRNA Process Development team at Strand Therapeutics to support the development, optimization, and scale-up of manufacturing processes for high-quality mRNA therapeutics. This role will provide hands-on experience with mRNA production, purification, analytical characterization, and process improvement activities in a collaborative and fast-paced biotechnology environment. Primary Responsibilities: Execute experiments related to the advancement of Strands mRNA manufacturing and/or process optimization platforms. Carry out the production of IVT synthesized mRNA. Support screening, optimization, and scale-up efforts for enzymatic reactions, chromatographic separations and filtration processes - including ultrafiltration, diafiltration, and sterile filtration. Perform analytical assays and characterization studies to evaluate mRNA quality and process performance. Analyze experimental data and contribute to technical presentations, reports, and team discussions. Maintain accurate and detailed experimental records in electronic laboratory notebooks. Work effectively to support the group's development activities in a fast-paced and collaborative environment. Qualifications: Currently pursuing a B.S. or M.S. in Biochemistry, Chemical Engineering, Molecular Biology, Bioengineering, Molecular Medicine, Genetics or related field. Experience in the biotechnology space is a plus. Experience with nucleic acid workflows, chromatography, filtration processes, or biological analytic techniques is preferred, but not required Ability to follow standard operating procedures, make careful observations, maintain clear and complete records of lab work.‪ Strong collaboration and inter-personal skills. Ability to present scientific context, experimental set up, data interpretation, and big-picture conclusions to a diverse audience. Strand Therapeutics is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law. Strand does not accept unsolicited resumes from any source other than directly from candidates. Job Type: Co-op Hourly Rate: $25 - $28 / hour