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Principal Senior Machine Learning Scientist Jobs

2,908 active opportunities · Updated for October 2026

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Explore current principal senior machine learning scientist jobs. Use filters to narrow by work mode, employment type, experience and date posted.

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Zoox
📍 Foster City• Full-time• Hybrid• $349K – $419K/yr
13mo ago

Zoox is on an ambitious journey to develop a full-stack autonomous mobility solution for cities and safely deploy such a robotaxi solution. The System Design and Mission Assurance (SDMA) team plays a foundational role in the company's success, responsible for constructing the safety case and fail-operational design for our autonomous driving robots before public road deployment. We are looking for a Principal Systems Engineer to lead the design and assurance efforts for overall safety and fail-operational initiatives. In this highly visible position, you will lead technical programs with cross-functional teams, defining, developing, and continuously refining the methodology for measuring and optimizing safety and fail-operational metrics. You will serve as a trusted technical partner for the Vice President of System Design and Mission Assurance, at times representing the Vice President in leadership meetings. You will be part of an organization with strong leadership and a transparent, respectful culture that enables you to reach your full potential. This highly visible position offers opportunities for career growth through demonstrated achievement. In this role, you will: Define and refine the strategy and architecture for the Systems Engineering efforts that guide Zoox’s approach to safety and fail-operational initiatives Lead and oversee the definition, development, and evolution of safety and fail-operational metrics that measure the robotaxi’s ability to safely complete customers’ journeys Review and approve mission assurance clearance documents Communicate complex metric concepts, data analyses, and actionable insights to diverse stakeholders and executives Coach and mentor SDMA systems engineers, fostering their career growth and strengthening SDMA’s technical bench Qualifications M.S. or higher degree in an Engineering, Computer Science, or a related field At least 10 years of relevant professi

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Tenstorrent is leading the industry on cutting-edge AI technology, revolutionizing performance expectations, ease of use, and cost efficiency. With AI redefining the computing paradigm, solutions must evolve to unify innovations in software models, compilers, platforms, networking, and semiconductors. Our diverse team of technologists have developed a high performance RISC-V CPU from scratch, and share a passion for AI and a deep desire to build the best AI platform possible. We value collaboration, curiosity, and a commitment to solving hard problems. We are growing our team and looking for contributors of all seniorities. Our Tensix Team is building the future of AI compute with a ground-up architecture centered on scalable RISC-V processors. As we push performance boundaries, we’re reimagining the frontend of our RISC-V cores to deliver major gains in programmability, efficiency, and developer experience. This is a rare opportunity to shape the CPU architecture at the heart of our AI platform and lead one of the most strategic technical efforts at Tenstorrent. This role is hybrid, based out of Toronto, ON, Austin, TX or Santa Clara, CA. We welcome candidates at various experience levels. During the interview process, candidates will be assessed for the appropriate level, and offers will align with that level, which may differ from the one in this posting. Who You Are Experienced Microarchitect: 10+ years of deep expertise in CPU performance modeling and microarchitecture design. AI Workload Expert: Deeply familiar with the computational and memory bottlenecks of modern AI workloads, particularly Large Language Models (LLMs). Hardware-Software Co-Designer: Driven to architect custom instruction set extensions and validate their performance gains against real-world workloads. Ways to stand-out: Familiarity with open-source RISC-V cores, AI-based agentic workflow experience What We Need Profile & Analyze: Dissect cutting-edge AI workloads to identi

About Formation Bio Formation Bio is a tech and AI driven pharma company differentiated by radically more efficient drug development. Advancements in AI and drug discovery are creating more candidate drugs than the industry can progress because of the high cost and time of clinical trials. Recognizing that this development bottleneck may ultimately limit the number of new medicines that can reach patients, Formation Bio, founded in 2016 as TrialSpark Inc., has built technology platforms, processes, and capabilities to accelerate all aspects of drug development and clinical trials. Formation Bio partners, acquires, or in-licenses drugs from pharma companies, research organizations, and biotechs to develop programs past clinical proof of concept and beyond, ultimately helping to bring new medicines to patients. The company is backed by investors across pharma and tech, including a16z, Sequoia, Sanofi, Thrive Capital, John Doerr, Spark Capital, SV Angel Growth, and others. You can read more at the following links: Our Vision for AI in Pharma Our Current Drug Portfolio Our Technology & Platform At Formation Bio, our values are the driving force behind our mission to revolutionize the pharma industry. Every team and individual at the company shares these same values, and every team and individual plays a key part in our mission to bring new treatments to patients faster and more efficiently. About the Position As a Principal Data Scientist - Medical Imaging at Formation Bio, you will lead our efforts to integrate advanced imaging analytics and AI into our drug development pipeline. In this role, you'll pioneer the application of computer vision and deep learning to medical imaging data (MRI, X-ray, CT, PET) to accelerate clinical trials and improve patient outcomes. You'll develop state-of-the-art models for automated image analysis, disease progression monitoring, and treatment response assessment. Working closely with clinical teams, radiologists, and

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Godaddy
📍 United States• Full-time• $215K – $323K/yr
15mo ago

Location Details: United States, Remote At GoDaddy the future of work looks different for each team. Some teams work in the office full-time; others have a hybrid arrangement (they work remotely some days and in the office some days) and some work entirely remotely. This is a remote position, so you’ll be working remotely from your home. You may occasionally visit a GoDaddy office to meet with your team for events or meetings. This position is not eligible to be performed in Alaska, Mississippi, North Dakota, or the Virgin Islands. Join our team At GoDaddy, we are seeking an exceptional Principal Compliance Engineer - PKI with deep technical expertise to define requirements and guide the evolution of our Certificate Authority (CA) platform. Reporting to GoDaddy's Vice President Engineering Partners, you will translate industry standards into technical requirements, define specifications for compliance automation, and provide technical guidance for next-generation cryptographic systems. This role combines technical leadership with strategic requirements development, focusing on post-quantum cryptography readiness, certificate lifecycle automation, and CA infrastructure resilience. What you'll get to do... Technical Standards & Requirements Leadership Actively participate in standards bodies such as the IETF, representing GoDaddy in working groups for TLS and related SSL standards CA Infrastructure & Systems Requirements Conduct deep-dive technical assessments of CA infrastructure, identifying architectural gaps, security vulnerabilities, and performance bottlenecks Define technical requirements for the evolution of certificate issuance pipelines, HSM integrations, and cryptographic key management systems Specify requirements for automated testing frameworks for compliance validation, including CT

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AC
18mo ago

Here at Appian, our values of Intensity and Excellence define who we are. We set high standards and live up to them, ensuring that everything we do is done with care and quality. We approach every challenge with ambition and commitment, holding ourselves and each other accountable to achieve the best results. When you join Appian, you’ll be part of a passionate team dedicated to accomplishing hard things, together. Principal Consultant Location: Chennai, India | Work Model: In Office Our Customer Success team in Chennai serves as elite technical advisors for global enterprise teams. We bridge deep software architecture with business strategy, building scalable platform environments that leverage AI-Powered Process Automation to solve mission-critical operational challenges. As a Principal Technical Consultant , you will assume architectural leadership for multi-application platform design, execution, and performance optimization. Top engineering talent joins Appian in this role to move beyond basic application maintenance and ensure applications are resilient, scalable, and built to power mission-critical operations at enterprise scale . What You’ll Do Architect Platform Scalability: Build and maintain standards and tools to ensure high performance and resilience with a focus on reusability, schema optimization, data modeling , system performance, and responsive UX/UI . Engineered Integrations: Perform hands-on design, development, and code reviews using SQL views , stored procedures , and high-concurrency REST/SOAP web services/APIs . System-Level Troubleshooting: Rapidly isolate performance bottlenecks, memory leaks, resource contention, and latency spikes across the entire web application stack. Performance Analysis & Profiling: Analyze database execution plans, JVM/memory utilization, and Locust load test outputs to resolve root-cause architectural bottlenecks. Technical Communication & Enablement: Translate complex system diagnostics in

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23mo ago

Systems Technology Inc. (STI) is a private, employee-owned company (ESOP) that provides engineering consulting and product development with a focus on safety. We are a small company that enjoys many of the perks of start-ups, but we have been in business for over sixty years and have an aggressive growth plan. Being part of STI means being a key contributor in the company while working with a team that spans the range of experience from recent graduates to 20+ year tenure. At STI, we look for business partners who want to be part of something special and contribute to a culture built on transparency, friendliness, innovation, ownership and accountability. If you are of a like mind and enthusiastic about solving challenging, real world, relevant problems, we would love to hear from you. As a 100% employee-owned company, STI understands that employees' individual and collective hard work and dedication will lead directly to the success of the company in the long term. An Employee Stock Ownership Plan (ESOP) gives employees an ownership interest in the company that employs them. What You’ll Do: The Principal Research Engineer executes a variety of highly specialized/technical, business development and leadership activities. This individual provides advanced expertise in the areas of modeling, simulation and/or flight control. This person submits government proposals and is involved in commercial client outreach via networking at conferences and meetings. In addition, this person is responsible for leading commercial consulting contracts. The Principal Research Engineer also manages multiple contracts that involve tracking budgets, ensuring successful deliverables, and managing junior engineers. This person actively engages in company process development and participates in BD related activities. This individual may supervise, and mentor select staff engineers. Will report to the Director of Engineering Services. Supports determining top level technical direction

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Fin
📍 London• Full-time
23mo ago

Fin , now part of Salesforce, is on a mission to help businesses provide perfect customer experiences. Our AI Agent Fin is the highest-performing AI Customer Agent on the market today, enabling businesses to deliver impeccable, always-on customer support across the customer journey, from service, to sales, to ecommerce. Powered by our own AI models, Fin resolves complex customer issues end-to-end across every channel, with minimal set-up and integration. Fin can also be combined with our natively integrated Intercom help desk, giving modern support teams one single system. Together with Salesforce, the #1 AI CRM, where humans with agents drive customer success, we're building the future of customer experience. Here, ambition meets action. Tech meets trust. And innovation isn't a buzzword, it's a way of life. The world of work as we know it is changing, and we're looking for Trailblazers who are passionate about bettering business and the world through AI. Ready to level up your career at the company leading workforce transformation in the agentic era? You're in the right place. Agentforce is the future of AI, and you are the future of Salesforce. What's the opportunity? Principal Engineers at Fin have the opportunity to lead the definition and execution of key strategic initiatives. You will work autonomously and be accountable for strategic execution in part of the engineering organization. You will build both back-end and front-end systems, and work closely with designers, product managers, researchers, and data analysts. You will coach and mentor other engineers and partner closely with the Group Engineering Managers on technical strategy and leadership. Learn more about our engineering culture at intercom.engineering What will I be doing? As an experienced engineer you will: Have a mastery of domain knowledge and work as a leader within the R&D org to drive key strategic projects. Provide assessments of project progress, risks and challenges to e

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Fin
📍 Dublin• Full-time
23mo ago

Fin , now part of Salesforce, is on a mission to help businesses provide perfect customer experiences. Our AI Agent Fin is the highest-performing AI Customer Agent on the market today, enabling businesses to deliver impeccable, always-on customer support across the customer journey, from service, to sales, to ecommerce. Powered by our own AI models, Fin resolves complex customer issues end-to-end across every channel, with minimal set-up and integration. Fin can also be combined with our natively integrated Intercom help desk, giving modern support teams one single system. Together with Salesforce, the #1 AI CRM, where humans with agents drive customer success, we're building the future of customer experience. Here, ambition meets action. Tech meets trust. And innovation isn't a buzzword, it's a way of life. The world of work as we know it is changing, and we're looking for Trailblazers who are passionate about bettering business and the world through AI. Ready to level up your career at the company leading workforce transformation in the agentic era? You're in the right place. Agentforce is the future of AI, and you are the future of Salesforce. What's the opportunity? Principal Engineers at Fin have the opportunity to lead the definition and execution of key strategic initiatives. You will work autonomously and be accountable for strategic execution in part of the engineering organization. You will build both back-end and front-end systems, and work closely with designers, product managers, researchers, and data analysts. You will coach and mentor other engineers and partner closely with the Group Engineering Managers on technical strategy and leadership. Learn more about our engineering culture at intercom.engineering What will I be doing? As an experienced engineer you will: Have a mastery of domain knowledge and work as a leader within the R&D org to drive key strategic projects. Provide assessments of project progress, risks and challenges to e

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meesho
📍 Bengaluru• Full-time
26mo ago

About the Team Our Data Science team is the Avengers to Meesho’s S.H.I.E.L.D 🛡️. And why not? We are the ones who assemble during the toughest challenges and devise creative solutions, building intelligent systems for millions of our users looking at a thousand different categories of products. We’ve barely scratched the surface, and have amazing challenges in charting the future of commerce for Bharat. About the Role As a Principal Data Scientist in our AdTech team, you’ll drive innovation in our advertising platform using advanced machine learning and statistical methods. You’ll tackle complex problems in real-time bidding, ad ranking optimization, budget efficiency, and performance measurement that directly impact our business’s bottom line. This role requires technical excellence and business acumen and you’ll collaborate with cross-functional teams to transform data insights into actionable strategies that enhance our advertising ecosystem. What you will do Design and develop sophisticated bidding, budget pacing and other algorithms that optimize ad spend or ROI. Create frameworks and experimental design to measure ad effectiveness and ROI. Collaborate with product and engineering teams to translate business requirements into efficient AI/ML solutions. Communicate long-term roadmap, insights and recommendations to tech and business leadership. Mentor junior data scientists and provide technical guidance. Lead research initiatives in machine learning, auction theory and advertising technology. What you will need B.Tech in Computer Science, Machine Learning, or a related field with at least 6+ years of experience in AI/ML research. Experience in auction theory, predictive modelling, causal inference, and reinforcement learning. Expertise in PyTorch or TensorFlow, and proficiency in Python as we

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Alcumus
📍 Texas• Full-time• Remote• $110K – $160K/yr
Just now

At Veriforce, we help companies in high-risk industries keep their people, worksites, and supply chains safe and compliant. As a global leader in contractor and supply chain risk management, our SaaS platform simplifies contractor onboarding, credentialing, and compliance while providing powerful analytics and insights. Beyond software, we offer expert support, training, and consulting so our clients can operate with confidence. Together, we’re making workplaces safer every day. The Principal is a critical change agent on the Sales Performance & Execution team. You will own the design and delivery of enablement programs that directly impact seller readiness, adoption, and productivity, equipping our sales organization to perform at their best. This is not a passive content role. You’re building, reaching out, moving towards the gap You deliver with precision. You scope realistically, communicate proactively, and finish strong Your field communications are clear, concise, and action-oriented You sell the change. You understand that adoption doesn’t happen because a feature went live You stay calm and composed. You adapt, prioritize, and move forward Change Management & Field Communications Own the change management strategy for GTM with adoption plans that anticipate resistance, reinforce behavior, and measure outcomes Draft and distribute clear, timely communications to the sales org: newsletters, launch announcements, process updates, policy changes, and more Act as the connective tissue between Sales, Onboarding, CS, Marketing, Product, and RevOps, embedding early to represent the seller’s perspective Represent enablement priorities in cross-functional planning forums; proactively flag risks or blockers Enablement Program Delivery Design and execute enablement programs, inclusive of tools, messaging, onboarding, products, etc Maintain an enablement calendar and program roadmap with clear milestones, owners, and success criteria in partnership with cross-functional

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Zscaler
📍 Bellevue• Remote• $171.5K – $245K/yr
Just now

Zscaler (NASDAQ: ZS) accelerates digital transformation so customers can be more agile, efficient, resilient, and secure. The Zscaler Zero Trust Exchange platform protects thousands of customers from cyberattacks and data loss by securely connecting users, devices, and applications in any location. Distributed across 200+ public data centers globally and thousands of private sites at the edge, the SASE-based Zero Trust Exchange is the world’s largest in-line cloud security platform. We believe the future of work is Human + AI and are building an AI-native enterprise where human potential is amplified by machine intelligence to solve the world’s hardest security challenges. Driven by deep customer obsession, we are committed to the mission, outcome, and to each other. We bring these commitments to life through three core behaviors: ownership and collaboration, trust through outcomes and impact, and a challenge culture with ongoing feedback. Ready to make an impact at the company pioneering security transformation in the AI era? Join us at Zscaler. Role We are looking for a Principal Threat Researcher to join our team. This is a remote role, reporting to the Manager Threat Research in the Threat Research Team. As our Principal Threat Researcher, you will serve as the definitive subject matter expert on adversary behavior across Endpoint and Cloud environments. You will dissect, replicate, and outmaneuver sophisticated cyber attack techniques to understand exactly how they operate and how to defeat them. By translating complex threat research into concrete, scalable detection recommendations, you will act as the innovation driver for our defensive capabilities. In this pivotal role, your insights won't just live in a whitepaper—they will directly prioritize our engineering efforts, shape product strategy, influence vendor telemetry, and ensure robust, industry-leading protection for our entire customer base. What you’ll do (Role Expectations) Scope and continuously ref

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Toast
📍 United States• Remote• $230K – $368K/yr
Just now

Toast creates technology to help restaurants and local businesses succeed in a digital world, helping business owners operate, increase sales, engage customers, and keep employees happy. We help restaurants streamline operations, increase revenue, and deliver amazing guest experiences through our platform that combines restaurant point of sale, team management, guest-facing technology, and award-winning customer support. As a Toaster, you will be challenged to take on meaningful projects to help craft the company's future. Join us as we empower the restaurant community to delight guests, do what they love, and thrive. Your mission is to lead the architectural design, technical execution, and implementation across the foundational domains of Toast’s Team Suite products, Payroll and Team Management. The Payroll product delivers daily value to its users - enabling restaurant owners to pay their staff and pay their taxes, and enabling transparency for wages and tips for restaurant employees. The Team Management suite allows restaurants to hire, manage, and schedule their staff. As a Principal Engineer, you will serve as a key technical leader in the group, driving modern architectural patterns—including spec-driven development and agentic workflows—to deliver high-impact software. A day in the life (Responsibilities) Lead fellow developers, product managers, designers, and user researchers to build a strong tech infrastructure that enables amazing features Own the architecture for authentication, authorization, and organizational hierarchy — driving technical direction in these domains across the organization Help us transform a traditional SasS platform into an agentic, system-of-action Flex your full-stack muscles by driving challenging large end-to-end initiatives or core architecture changes in a supportive, collaborative team environment Define and drive technical strategy for problems that affect multiple parts of the business Mentor developers across multip

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Just now

Zscaler (NASDAQ: ZS) accelerates digital transformation so customers can be more agile, efficient, resilient, and secure. The Zscaler Zero Trust Exchange platform protects thousands of customers from cyberattacks and data loss by securely connecting users, devices, and applications in any location. Distributed across 200+ public data centers globally and thousands of private sites at the edge, the SASE-based Zero Trust Exchange is the world’s largest in-line cloud security platform. We believe the future of work is Human + AI and are building an AI-native enterprise where human potential is amplified by machine intelligence to solve the world’s hardest security challenges. Driven by deep customer obsession, we are committed to the mission, outcome, and to each other. We bring these commitments to life through three core behaviors: ownership and collaboration, trust through outcomes and impact, and a challenge culture with ongoing feedback. Ready to make an impact at the company pioneering security transformation in the AI era? Join us at Zscaler. Role We are looking for a Principal Software Development Engineer to join our team. This is a Hybrid role, reporting to the Director, Software Development Engineering ZIdentity team in the Identity and Access Management department. Identity is the new security perimeter. Come help manage digital risk by applying security through identity integration and controls. You will be responsible for the design and development of enterprise-grade Identity Management Products for Zscaler, leveraging your deep expertise in IAM and public cloud environments to drive hands-on development and provide technical leadership. What you’ll do (Role Expectations) Practice technical leadership in the design, development, and optimization of the Identity platform, focusing on strategy for cost-effective product growth and expansion Spearhead the technical roadmap for the Kubernetes platform, architecting centralized identity and access management

javaawsgcp
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Zscaler (NASDAQ: ZS) accelerates digital transformation so customers can be more agile, efficient, resilient, and secure. The Zscaler Zero Trust Exchange platform protects thousands of customers from cyberattacks and data loss by securely connecting users, devices, and applications in any location. Distributed across 200+ public data centers globally and thousands of private sites at the edge, the SASE-based Zero Trust Exchange is the world’s largest in-line cloud security platform. We believe the future of work is Human + AI and are building an AI-native enterprise where human potential is amplified by machine intelligence to solve the world’s hardest security challenges. Driven by deep customer obsession, we are committed to the mission, outcome, and to each other. We bring these commitments to life through three core behaviors: ownership and collaboration, trust through outcomes and impact, and a challenge culture with ongoing feedback. Ready to make an impact at the company pioneering security transformation in the AI era? Join us at Zscaler. Principal Specialist Sales Engineer - Sec Ops Location: Tokyo, Japan (Hybrid) Department: Global Speciality Sales Employment Type: Full-Time About the Role We are looking for a Principal Specialist Sales Engineer to join our growing Japan Go-to-Market team, based out of our Tokyo office (Hybrid) . In this high-impact specialist role, you will report to the Sales Engineering leadership within the Security Operations team, acting as a domain expert for our Exposure Management portfolio. The Zscaler Sales and Go-to-Market team is a global group of professionals who are passionate about delighting our customers, nurturing trusted partnerships, and driving a secure, cloud-enabled digital transformation across Japan and the broader APJ region. You will partner closely with Enterprise Account Executives, Solution Architects, Customer Success, and our local channel partner ecosystem to demonstrate the value of Zscaler's cutting-edg

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Toast creates technology to help restaurants and local businesses succeed in a digital world, helping business owners operate, increase sales, engage customers, and keep employees happy. As a Principal Engineer / architect you will be responsible for creating a technical strategy and coordinating the designs for meeting the needs of Toast’s largest restaurant brands. You will partner with Product Managers to develop the technology roadmap that enables enterprise customers to leverage the power of Toast. You will also work closely with technical leaders and implementation teams across the organization to deliver robust, scalable solutions with integrations to customers’ external systems. While the role is primarily internally-facing, it requires infrequent interactions with enterprise customers, listening to their requirements and providing expert guidance as they deploy Toast. If you’re a technical leader or a solutions architect, experienced with enterprise SaaS, passionate about customer value, and a great collaborator, read on! A day in the life (Responsibilities) Lead the evolution of Toast’s backend architecture , frameworks, and data models with a strong focus on delivery efficiency, system scalability, and resilience. Design and build the next generation of accounting and financial systems using Java, Kotlin, DynamoDB, Pulsar, GraphQL, Big Data tools , and more. Define and implement scalable engineering practices , delivery frameworks, and coding standards that raise the technical bar across the org. Collaborate cross-functionally with Product, UX, QA , and multiple engineering teams to deliver robust, customer-facing solutions. Build and maintain strong partnerships across business units, aligning technology strategies with key company objectives. Champion data-driven decision making by developing strategies and prioritizing initiatives with high impact on user and business outcomes. Mentor and grow engineers across levels, promoting a culture of inclu

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