Jobs in United States

Lead Senior Python Engineer in United States

2,434 active opportunities · Updated October 2026

Explore current lead senior python engineer jobs across United States. Filter by work mode, employment type, experience, department, date posted and distance.

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📍 New York, New York, United States· Full-time
✓ High-confidence listing

From $145K/yr

Quick readStrong listing-quality and freshness signals

CLEAR is building THE secure identity company of the future. Our mission is to make experiences safer and easier—physically and digitally. With more than 43 million Members and a growing network of partners across the world, CLEAR's secure identity platform is transforming the way people live, work, and travel. Whether it’s at the airport, stadium, or throughout your everyday life, CLEAR unlocks the magic of frictionless experiences. We are seeking a Senior Manager of Industrial Engineering to join CLEAR's Central Operations team. This role is the quantitative backbone of our Experience & Operations Design function — owning the data-driven design standards, labor models, and capacity planning that determine how CLEAR's physical operation is structured and staffed. You will be the analytical engine behind lane design decisions, engineered labor standards, and demand forecasts, ensuring the operation is designed to deliver a consistently excellent member experience efficiently at scale. What you'll do: Develop and own engineered labor standards and staffing models across CLEAR’s physical experiences, including Verifier, Greeter, eGate, Concierge, TSA PreCheck, Enrollment, Sports, and new programs, serving as the operations source of truth for labor and headcount inputs Define physical operating requirements and sizing standards across lane configurations, verification and enrollment experiences, hardware placement, and queue management; lead checkpoint design for new and existing airport locations Lead demand forecasting and capacity planning across CLEAR experiences, modeling throughput, staffing requirements, operating hours, and operational impact for new programs, launches, surge periods, and events Drive operational efficiency through time studies, process analysis, and labor optimization, identifying and developing opportunities to improve productivity, capacity, and the Member experience across the network Partner cross-functionally with Operations,

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📍 San Francisco, CA, United States
✓ Quality checkedCompany trend -100%

The Opportunity Typography is central to how ideas are communicated. If you're passionate about beautifully created design, have deep curiosity about what AI can do, and take personal responsibility for creating products that people love; then this may be the role for you. Adobe Fonts supports millions of creatives in choosing and using typefaces across fonts.adobe.com, Express, Photoshop, Illustrator, Acrobat, and more Creative Cloud platforms. Our Internal Services team provides the platform engineering and deployment backbone for all of these. We manage CI/CD, deployment approaches, the services and data layers our engineers depend on, our observability and security stance, and increasingly the agentic tools that transform how our entire organization delivers software. We're seeking a Senior Software Development Engineer to lead this exciting journey in our San Francisco location. What you'll do Own and evolve our deployment platform. Lead strategy for CI/CD, PR environments, and release safety across a mixed fleet that includes containerized services, serverless services, and static front ends. Build the foundation for AI-accelerated development. Help build our agent factory and grow our internal agentic toolkit and skill library. Ship inference applications at scale. Take greenfield services from spec to production and standardize our ML/inference footprint. Modernize our services for the AI era. Identify where an existing service is held back by its current build and lead the fix. Rethink our security posture for agentic threats. Lead how we secure autonomous agents and their tool use. Expose Adobe Fonts to the agentic ecosystem. Extend our Model Context Protocol (MCP) surface and conversational, intent-based font discovery. Work higher up the stack, too. Contribute directly to search, browse, discovery, and the customer-facing experie

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📍 Denver, Colorado, United States· Full-time
✓ High-confidence listing

From $118.7K/yr

Quick readStrong listing-quality and freshness signals

Healthcare is complex. We're here to change that. RVO Health is a health technology company on a mission to make health easier to navigate, more accessible, and more affordable for everyone. Here, you'll help over 40 million people every month, with a team that genuinely cares about the work and each other. AT A GLANCE The Senior Software Engineer is a crucial role within our organization, requiring work in various capacities and adaptation to different work arrangements based on the needs set by the business. Where You'll Be Location: Denver, CO | Hybrid We believe great collaboration happens when we're together, solving problems, learning from each other, and connecting as a team. That's why we're in our offices Tuesday through Thursday each week. You are welcome to work remotely Mondays and Fridays if you wish. Office Address: 1801 California St. Denver, CO 80202 What You’ll Do Lead the end-to-end design, development, and implementation of sophisticated software applications and systems aligned with business goals. Collaborate closely with stakeholders including product managers, designers, and other engineers to gather requirements and translate them into robust technical designs and solutions. Write high-quality, efficient, maintainable, and scalable code adhering to best practices and company standards. Debug, analyze, and resolve complex software defects and performance bottlenecks to ensure optimal system reliability and user experience. Conduct comprehensive testing and validation including unit, integration, and performance testing to guarantee software quality. Mentor and provide technical guidance to junior and mid-level engineers, fostering professional growth and knowledge sharing. Perform thorough code reviews to maintain high code quality, enforce coding standards, and promote best practices across the team. Continuously improve software development processes, tools, and methodol

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📍 United States· Full-time
✓ Quality checkedCompany trend -100%

At ClickUp, we're building the future of work: the first truly converged AI workspace unifying tasks, docs, chat, calendar, and enterprise search, all supercharged by context-driven AI. We are an AI-native company. Every team member is expected to leverage AI daily, and we evaluate AI fluency as part of our hiring process. Join us and help redefine what's possible. 🚀 Role Overview: We are seeking a skilled and innovative Senior AI Engineer – AI Product to join our ClickUp Engineering team. In this role, you will drive the development of intelligent, user-facing features that leverage the latest advancements in AI and large language models (LLMs). You will work closely with product, design, and engineering teams to deliver seamless, impactful AI-powered experiences that delight our users and differentiate ClickUp in the productivity space. This is a product-focused engineering role requiring deep expertise in AI, LLMs, and building scalable, production-ready applications. Key Responsibilities: Lead the design, development, and deployment of AI-powered features and products that directly impact ClickUp users. Collaborate with product managers, designers, and engineers to identify opportunities for AI-driven innovation and translate user needs into technical solutions. Integrate and orchestrate multiple LLMs and AI models to deliver robust, context-aware, and personalized user experiences. Prototype, test, and iterate on new AI features, leveraging user feedback and data to drive continuous improvement. Ensure the reliability, scalability, and performance of AI-powered features in production environments. Stay at the forefront of AI research and product trends, incorporating the latest advancements into ClickUp’s product roadmap. Address AI privacy, security, and compliance challenges, ensuring responsible and ethical use of AI in user-facing applications. Mentor and guide other engineers in best practices for building AI-powered products. Qualifications: Proven exper

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📍 Bellevue, WA, United States· Full-time
✓ High-confidence listingCompany trend -91.7%
Quick readStrong listing-quality and freshness signals

For over 20 years, Smartsheet has empowered teams to manage work seamlessly and scale solutions smarter. Now, in our most ambitious chapter yet, we are uniting human teams with AI agents. By orchestrating the work agents do best, automating manual tasks and uncovering insights at scale, we create the space for people to focus on what truly matters: judgment, creativity, and big thinking. That is magic at work, and it’s what we show up for every day. Corporate Systems Engineering builds and operates the software platforms, integrations, and automations that power Smartsheet’s core business functions across Finance, Sales/GTM, and People & Culture. Our team owns mission-critical systems and workflows that enable how the company hires, sells, bills, pays, reports, and scales. We operate at the intersection of software engineering, enterprise platforms, and business-critical data, treating internal systems with the same rigor, reliability, and product mindset as customer-facing software. The Automation team builds human-to-system and system-to-system automations that reduce manual effort and friction across the business. We combine cloud-native services, agentic AI, and workflow orchestration to enable employees to interact with enterprise systems through intelligent, secure, and auditable automation. As a Senior Software Engineer I (Automation), you will lead the design, build, and operation of systems and workflows that directly support business execution at scale. You will own complex technical initiatives, partner with Product Managers and stakeholders on technical roadmaps, and mentor junior engineers. This full-time position reports to the Sr. Director, Development and can be located in our Bellevue, WA office, or you may work remotely from anywhere in the US where Smartsheet is a registered employer. You Will: Architect AI Agents: Take a leading role in designing Agentic Workflows using AWS Step Functions and Bedrock Agents that reason

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📍 Foster City, California, United States· Full-time
✓ Quality checkedCompany trend -85.9%

Replit is the agentic software creation platform that enables anyone to build applications using natural language. With millions of users worldwide, Replit is democratizing software development by removing traditional barriers to application creation. The AI Studio is the team responsible for designing, building, and operationalizing internal software platforms across every functional department of the company, including People Operations, Customer Support, Sales, Marketing, Finance, Recruiting, and Executive Operations. We treat each internal department as its own product surface, and in truth as its own startup, with its own customers, its own metrics, and its own reasons for existing. We ship custom software, built on Replit’s own platform, to solve operational problems that off-the-shelf SaaS tools cannot serve well at our scale and pace of growth. Position Summary The Member of Technical Staff (AI Builder) is a full-time builder role with substantial autonomy. You will design, architect, and ship AI-powered internal platforms that run the operations of the company across many departments at once. This is not a role for someone who wants a narrow, well-defined lane. It is a role for someone who wants to walk into an ambiguous business problem, understand it well enough to argue about it with the department lead, and then ship the software that fixes it. We are looking for people who genuinely understand the mechanics of a business: how revenue is actually made, why recruiting velocity matters, what makes support scale or break, how finance closes a month, and why each department is critical to whether the company wins or loses. You do not need to have run every function, but you need to respect why each one exists and be able to reason about it like an operator, not just an engineer. Because we treat each department as its own startup, we strongly favor people who have either run their own business or worked on a fast-scaling startup. You know what it feels like

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LA
📍 New York, United States· Full-time
✓ High-confidence listing
Quick readStrong listing-quality and freshness signals

We are investing in agentic AI and need a Senior AI Engineer to lead the design and delivery of these systems. This is a foundational hire: you will own both the agent-facing workstreams — pipelines, orchestration, conversational interfaces — and the underlying context layer that makes them reliable, including memory management, knowledge graph integration, and retrieval infrastructure. You will work closely with data engineers, project leads, and client stakeholders, and play a key role in shaping how Lynx builds and ships AI solutions at scale. What This Involves: Lead the architecture and delivery of agentic AI systems end-to-end: agents, orchestration, tool use, and multi-step reasoning workflows. Own the context layer: design and implement memory architectures (episodic, semantic, working memory) and integrate GraphRAG and knowledge graph retrieval into agentic pipelines. Build robust RAG systems — including vector retrieval, graph traversal, and hybrid search — and ensure retrieval quality through evaluation frameworks. Translate client requirements into technical designs, presenting approaches and trade-offs to both technical and non-technical stakeholders. Define standards and reusable patterns for agentic AI development that other engineers at Lynx can build on. Set up observability, evaluation, and monitoring pipelines to ensure AI systems perform correctly in production. Requirements: 5–8 years of software or ML engineering experience, with at least 2–3 years building LLM-based or agentic AI systems in production. Deep hands-on experience with agentic frameworks (LangChain, LlamaIndex, AutoGen, CrewAI, or similar) and LLM APIs (OpenAI, Anthropic, etc.). Strong understanding of agent design patterns: ReAct, planning loops, tool use, multi-agent coordination, and memory architectures. Practical experience with GraphRAG or knowledge graph-based retrieval (e.g., Neo4j, Microsoft GraphRAG) and vector databases (Pinecone, Weaviate, Qdrant, etc.). Proficiency in

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📍 Menlo Park, California, United States· Full-time
✓ Quality checkedCompany trend -92.9%

At Snowflake, we are powering the era of the agentic enterprise. To usher in this new era, we seek AI-native thinkers across every function who are energized by the opportunity to reinvent how they work. You don’t just use tools; you possess an innate curiosity, treating AI as a high-trust collaborator that is core to how you solve problems and accelerate your impact. We look for low-ego individuals who thrive in dynamic and fast-moving environments and move with an experimental mindset — who rapidly test emerging capabilities to discover simpler, more powerful ways to deliver results. At Snowflake, your role isn't just to execute a function, but to help redefine the future of how work gets done. We’re looking for a Senior Manager to lead our App Experience & Marketplace Data Science team in the Product organization. You will lead a team covering app experience (UI, growth platform, analyst/admin/data engineer tools and experience) and data marketplace areas. Well designed high value apps are essential to make it simple for our customers to complete billions of SQL queries, deploy python, and use powerful AI tools every day Data marketplace makes it easy with a click of a button to get access to a wide range of 3rd party data instead of having to contact a sales representative at a data vendor and setup and maintain a complex API. All the projects above allow the data scientist to work on very large datasets, and a variety of diverse interesting projects that span the domains of data engineering, analytics, statistics, and machine learning. In this role, you will both lead a team, and be hands-on as a tech lead in this area. The manager will interact frequently with senior management, product managers, and engineering managers. The ability to effectively communicate complex technical ideas to a wide audience is crucial. IN THIS ROLE YOU WILL: Serve as the tech lead/manager of a Data Science team in the Product organization, leveraging AI tools and functions (e.g

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📍 Tampa Florida United States, United States
✓ High-confidence listingCompany trend +800%
Quick readStrong listing-quality and freshness signals

We are seeking an experienced Senior Generative AI Developer to help drive the design, development, and integration of state-of-the-art Generative AI and agentic AI solutions across our enterprise Controls Technology platform. You will collaborate with cross-functional teams, contribute deep technical expertise in context engineering, retrieval systems, knowledge graphs, and multi-agent orchestration, and play a key role in delivering scalable, grounded AI solutions to enhance automation and operational efficiency. This role centers on architecting robust applications and agent systems on top of pre-trained and hosted foundation models — not on training or fine-tuning models. Key Responsibilities Collaborate with AI architects, leads, and stakeholders to design and implement generative and agentic AI solutions that address business challenges. Architect advanced context engineering strategies — context layering, chaining, compression, pruning/offloading, and memory management — to maximize reliability, provenance, and token efficiency in production. Design and implement advanced generative AI methods, including sophisticated prompt engineering and Retrieval-Augmented Generation (RAG) . Build and optimize RAG systems , including hybrid search, multi-vector retrieval, and re-ranking pipelines. Design and implement knowledge graphs and Graph RAG architectures to enable multi-hop reasoning, explainability, and traceable, grounded responses for high-value business domains. Architect agentic workflows and multi-agent systems using Google Agent Development Kit (ADK) and comparable frameworks (LangGraph, Microsoft Agent Framework, CrewAI), applying orchestration patterns such as supervisor/worker, hierarchical, and peer-to-peer. Design robust agent harnesses — governance, constraints, feedback loops, state/session management, and

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📍 United States· Full-time
✓ Quality checkedCompany trend -98.8%

Airbnb was born in 2007 when two hosts welcomed three guests to their San Francisco home, and has since grown to over 5 million hosts who have welcomed over 2 billion guest arrivals in almost every country across the globe. Every day, hosts offer unique stays and experiences that make it possible for guests to connect with communities in a more authentic way. The Community You Will Join: MarTech Data Science Measurement empowers Airbnb to optimize marketing ROI by generating data-driven recommendations. We lead the way in defining and advancing best practices for measuring and optimizing marketing impact. We collaborate with Marketing, Finance, and Engineering to provide actionable recommendations and tools based on effective, timely, and granular measurements. Our team’s tenets are: Actionable: Deliver insights that drive confident business decisions. Impactful: Prioritize projects based on their expected value to Airbnb. Balanced: Adapt methods to business questions and data realities, acknowledging limitations. Rigorous: Maintain methodological integrity and quantify the sensitivity of findings. Innovative: Invest in advancing measurement science and developing new methods. Influential: Share learnings across Airbnb and the broader data science community. The Difference You Will Make: We are seeking an experienced (Contract) Sr. Data Scientist for a 24 month contract with deep expertise in marketing measurement, with a particular focus on Marketing Mix Modeling (MMM) and geo-based causal inference. The ideal candidate brings strong statistical intuition and hands-on modeling experience to quantify the incremental impact of Airbnb's marketing investments across channels and geographies. They are fluent in Python, comfortable working with Bayesian frameworks, and can translate complex measurement findings into clear, actionable recommendations for senior stakeholders. A Typical Day: Marketing Mix Modeling: Design, build, and maintain MMM models that est

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📍 Dallas, United States
✓ High-confidence listingCompany trend +340.2%
Quick readStrong listing-quality and freshness signals

We’re building a world of health around every individual — shaping a more connected, convenient and compassionate health experience. At CVS Health®, you’ll be surrounded by passionate colleagues who care deeply, innovate with purpose, hold ourselves accountable and prioritize safety and quality in everything we do. Join us and be part of something bigger – helping to simplify health care one person, one family and one community at a time. Position Summary We are seeking a skilled and analytical Senior Product Analytics Associate to lead the development and execution of a data-driven product roadmap. The ideal candidate will have a deep understanding of product analytics, strong problem-solving skills, and experience working with cross-functional teams to support strategic initiatives. As a Senior Product Analytics Associate, you will work closely with cross-functional teams including engineering, product, and clinical operations. Roles and Responsibilities: Define, track, and report on product metrics including performance and profitability Build and maintain robust data transformation models using dbt (or similar frameworks like Dataform or SQL-based ETL tools) to ensure analytics-ready datasets Design and interpret A/B tests; when A/B testing is not feasible, apply causal inference methods (e.g., Diff-in-Diff, Propensity Score Matching) to determine product efficacy. Develop ROI projections for analytics projects to prioritize deliverables by business impact Tell compelling stories through data, articulating technical information to a non-technical audience Build and maintain Power BI dashboards to

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📍 United States· Remote
✓ High-confidence listingCompany trend +340.2%
Quick readStrong listing-quality and freshness signals

We’re building a world of health around every individual — shaping a more connected, convenient and compassionate health experience. At CVS Health®, you’ll be surrounded by passionate colleagues who care deeply, innovate with purpose, hold ourselves accountable and prioritize safety and quality in everything we do. Join us and be part of something bigger – helping to simplify health care one person, one family and one community at a time. POSITION SUMMARY CVS Health Digital is looking for hands-on, passionate people who want to join a high energy and growing team to make a difference in customers lives and who want to be on the forefront of digital innovation that aims to reinvent what a pharmacy and a health care company can be in the digital world. Currently, we are seeking a Staff Software Development Engineer, who will serve as a senior technical leader on a cross-functional product team responsible for designing, developing, and delivering scalable healthcare technology solutions. You will play a critical role in driving architecture decisions, mentoring engineers, and partnering with product, UX, and business stakeholders to build secure, cloud-native applications that enhance the digital healthcare experience. In this role, you will lead the development of distributed systems and microservices leveraging Java, Spring Boot, event-driven architectures, and modern cloud technologies. This Staff Engineer will also guide data migration and interoperability initiatives, supporting healthcare integrations that enable seamless and secure exchange of clinical data across platforms. The ideal candidate combines strong software engineering expertise with a passion for innovation, technical leadership, and delivering high-quality solutions in an Agile environment. Expectations for the Role Software

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📍 Austin, Texas, United States· Full-time
✓ High-confidence listing
Quick readStrong listing-quality and freshness signals

Power and Performance Validation Engineer About us Graphcore is one of the world’s leading innovators in Artificial Intelligence compute. It is developing hardware, software and systems infrastructure that will unlock the next generation of AI breakthroughs and power the widespread adoption of AI solutions across every industry. As part of the SoftBank Group, Graphcore is a member of an elite family of companies responsible for some of the world’s most transformative technologies. Together, they share a bold vision: to enable Artificial Super Intelligence and ensure its benefits are accessible to everyone. Graphcore’s teams are drawn from diverse backgrounds and bring a broad range of skills and perspectives. A melting pot of AI research specialists, silicon designers, software engineers and systems architects, Graphcore enjoys a culture of continuous learning and constant innovation. Job Summary Reporting to senior leadership within Architecture and Validation, the Power and Performance Validation Lead will drive validation strategy and execution for advanced AI compute silicon and systems. The role is responsible for leading power, thermal and performance validation activities across pre-silicon and post-silicon environments to ensure products meet efficiency, reliability and scalability expectations. This role requires strong technical expertise and collaboration across multiple engineering disciplines to deliver robust validation methodologies, scalable automation frameworks and actionable performance insights. The Team The Power and Performance Validation team sits within the Architecture and Validation organisation and is responsible for validating the performance, efficiency and thermal behaviour of Graphcore silicon and systems. The team supports the full product lifecycle, from early architectural modelling through to first silicon bring-up, characterization and production readiness. Engineers work closely with cross-functional teams globally to debug compl

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📍 Dallas 8000 Frankford Road, United States
✓ Quality checkedCompany trend +340.2%

We’re building a world of health around every individual — shaping a more connected, convenient and compassionate health experience. At CVS Health®, you’ll be surrounded by passionate colleagues who care deeply, innovate with purpose, hold ourselves accountable and prioritize safety and quality in everything we do. Join us and be part of something bigger – helping to simplify health care one person, one family and one community at a time. Position Summary We are seeking a highly experienced Principal / Director-level Full-Stack Software Development Engineer to join our Digital Caremark organization and lead the architecture, design, and delivery of next-generation digital solutions. This role spans AI-enabled applications, scalable digital platforms, and enterprise integrations that power critical healthcare and pharmacy experiences. This is a senior technical leadership role for a hands-on engineer who can operate across the full stack—from intuitive front-end applications to resilient backend services—while setting architectural direction, influencing engineering standards, and mentoring teams. The ideal candidate combines deep technical expertise, platform thinking, and strong collaboration skills to build secure, scalable, API-first solutions in a highly regulated environment. Key Responsibilities: Architecture & System Design • Define and drive architecture for large-scale distributed systems and digital platforms • Lead design reviews and set architecture standards and best practices • Champion API-first, microservices, and event-driven architecture patterns • Ensure systems meet scalability, reliability, security, and compliance requirements • Balance performance, cost, and speed in technical decision-making Fu

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📍 Menlo Park, California, United States· Full-time
✓ Quality checkedCompany trend -92.9%

At Snowflake, we are powering the era of the agentic enterprise. To usher in this new era, we seek AI-native thinkers across every function who are energized by the opportunity to reinvent how they work. You don’t just use tools; you possess an innate curiosity, treating AI as a high-trust collaborator that is core to how you solve problems and accelerate your impact. We look for low-ego individuals who thrive in dynamic and fast-moving environments and move with an experimental mindset — who rapidly test emerging capabilities to discover simpler, more powerful ways to deliver results. At Snowflake, your role isn't just to execute a function, but to help redefine the future of how work gets done. Staff Network Engineer Location: MPK/Bellevue/Dublin Snowflake's Enterprise Technology Network Services team is looking for a Senior Network Engineer to lead the design, operation, and optimization of our Zero Trust and secure-access platform. This role is Zscaler-centric — you will own the health, performance, and roadmap of our ZIA/ZPA deployment — while working across a modern, multi-cloud network stack that supports a global workforce of 10,000+ users. You'll be the escalation point for the most complex connectivity issues and a driver of automation and observability across the environment. What You'll Do Own and operate the Zscaler platform (ZIA, ZPA, ZDX, ZCC) end-to-end, including policy frameworks, app-segmentation models, PAC/traffic-forwarding standards, App Connector topology, and NSS/log-streaming design. Troubleshoot secure-access incidents like tunnel flapping, broker/connector health, SSL inspection edge cases, DNS/DTLS failures, and lead root-cause analysis for systemic issues. Manage Palo Alto firewalls, Panorama and GlobalProtect VPN, while planning migration toward Zscaler solutions. Support Aruba (Central) Wireless, Ekahau and Cisco Catalyst switches globally. Design, install, and configure network devices and ISP circuits at new offices. Build automatio

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