POSITION SUMMARY Natera is seeking a Principal AI Engineer to set technical direction for, and hands-on build of, the Vector Store GenAI Platform that powers document intelligence and retrieval across our Real-World Data (RWD) organization. The platform ingests clinical documents from multiple sources, indexes them for high-quality search, and makes that content available to downstream AI workflows and business use cases across oncology and other clinical domains. This is a principal-level individual contributor role with architecture-plus-build ownership of retrieval, document processing, and ingestion systems. You will define platform strategy and sequencing, ship production code in a cloud environment, raise the reliability and quality of search and retrieval, and prove new approaches through POCs and benchmarks. You will partner with clinical, engineering, and product leaders to turn ambiguous priorities into a clear technical roadmap, establish standards for how retrieval serves agents and re-extraction workflows, and deliver measurable improvements in platform quality and operability—with high autonomy and limited day-to-day direction. The ideal candidate combines deep hands-on engineering with a track record of owning complex AI platforms end to end. You set direction, implement critical path yourself, and elevate the technical bar across the teams that consume and extend the platform. RESPONSIBILITIES Own platform architecture and hands-on delivery for the Vector Store GenAI Platform, including search and retrieval, document processing and chunking, ingestion pipelines, and APIs that serve downstream AI workflows. Set technical direction for hybrid search and retrieval quality; evaluate embedding models and retrieval approaches through working implementations, POCs, and benchmarks, and drive adoption of what works in production. Advance document parsing and chunking so clinical content is indexed in a way that supports accurate, structured, and faceted retri
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POSITION SUMMARY Natera is seeking a highly motivated Scientist, R&D – Immunohistochemistry (IHC) & Histology to join the Oncology Product Development team. This role will focus on the development, optimization, verification, and validation of IHC and tissue-based workflows supporting oncology products and clinical assay development. The ideal candidate will have strong hands-on experience in IHC assay development and optimization, supported by a solid foundation in histology and FFPE tissue workflows. Experience with automated IHC/ISH staining platforms, particularly the Roche BenchMark ULTRA IHC/ISH System, is highly desirable. Experience with NGS and molecular biology workflows is an additional plus. PRIMARY RESPONSIBILITIES Design and execute development, optimization, verification, and validation studies for IHC, histology, and tissue-based workflows. Develop and optimize IHC assays, including antibody selection and titration, antigen retrieval, staining conditions, controls, and assay performance assessment. Evaluate and optimize histology and pre-analytical variables, including tissue fixation, FFPE processing, embedding, sectioning, H&E staining, and slide preparation. Develop and troubleshoot workflows on automated IHC/ISH staining platforms and investigate staining artifacts, reagent performance, tissue quality, and assay variability. Plan and execute moderate- to high-complexity experiments; analyze and interpret results using tools such as Excel, JMP, and image-analysis approaches. Collaborate with Pathology, Clinical Laboratory Operations, Quality, Automation, and other cross-functional teams to transfer R&D methods into robust clinical laboratory workflows. Author study protocols, development/validation reports, SOPs, and transfer documentation, and provide technical guidance and training during implementation. Communicate project progress, experimental findings, risks, and recommendations to project teams and stakeholders. QUALI
Position Summary Pfizer is seeking a motivated Senior Associate Scientist to join the In Vivo Pharmacology group within the Oncology Research Unit, with a focus on antibody-drug conjugate (ADC) programs, but including other large molecule and small molecule programs. This role supports the execution of in vivo oncology studies that enable ADC discovery and preclinical development, including efficacy, tolerability, pharmacodynamic, and sample collection workflows. The ideal candidate will demonstrate strong technical aptitude, careful attention to detail, and a commitment to animal welfare, compliance, and high-quality study execution. The Senior Associate Scientist is expected to contribute as a dependable technical team member while building scientific understanding of oncology pharmacology and ADC-specific study requirements. Position Responsibilities Execute in vivo oncology studies supporting discovery programs using a variety of in vivo models including human cell line- derived, patient-derived xenograft, syngeneic models as appropriate with minimum guidance from study leads. Perform routine and advanced in vivo procedures, including tumor measurements, body weight monitoring, test article administration (IV, PO, subQ, IP dosing), clinical observations, and sample collection. Perform routine in vitro tissue culture procedures Support pharmacology studies evaluating efficacy, tolerability, pharmacodynamic biomarkers, dosing schedules, and combination approaches. Prepare study materials, confirm dosing and sampling schedules, and ensure study activities are performed according to approved protocols and SOPs. Maintain accurate, timely, and compliant study records using approved electronic data capture and documentation systems. Communicate study observations, technical issues, animal welfare concerns, and timeline risks promptly to managers and study line leads. Collabo
Position Summary Pfizer is seeking a highly motivated Scientist to join the In Vivo Pharmacology group within the Oncology Research Unit, with a focus on antibody-drug conjugate (ADC) programs. This role supports the execution of high-quality in vivo efficacy, pharmacodynamic, tolerability, and mechanistic studies that enable preclinical ADC discovery and development. The ideal candidate will demonstrate strong technical capability in oncology animal models, careful attention to study details, and a commitment to animal welfare, compliance, and scientific rigor. The Scientist is expected to contribute as a reliable technical and scientific team member while developing increasing independence in study execution, data interpretation, and cross-functional collaboration. Position Responsibilities Execute in vivo oncology studies supporting ADC discovery programs using a variety of in vivo models including syngeneic, cell line-derived, and patient-derived xenograft models as appropriate. Perform routine and advanced in vivo procedures, including tumor measurements, body weight monitoring, test article administration, clinical observations, and sample collection. Support ADC pharmacology studies assessing efficacy, tolerability, pharmacodynamic biomarkers, dose-response relationships, schedule optimization, and combination strategies. Prepare, review, and follow study protocols, dosing schedules, randomization plans, and sample collection timelines in alignment with project goals and internal standards. Maintain accurate, timely, and compliant study records using electronic data capture systems and approved documentation practices. Coordinate with project line leads, vivarium operations, pathology, toxicology translational scientists, bioanalytical, pharmacodynamic and pharmacokinetic teams, and external partners to enable efficient study execution. Assist with data quality revie
POSITION SUMMARY: The Product Development Sr. Research Associate will contribute to the design, execution and participation in experiments/tasks to support oncology product development and verification and validation (V&V) studies under design control, for next generation sequencing (NGS) assays. We are looking for a meticulous and dedicated candidate with direct laboratory experience in assay development who can work effectively in a fast-paced environment to ensure the highest quality clinical assays are developed and launched for our patients. The ideal candidate will be an enthusiastic and driven professional who is eager to learn, flexible, enjoys multi-tasking and possesses strong wet lab skills. PRIMARY RESPONSIBILITIES : With some supervision, design and execute low to moderate complexity experimental workflows, including cfDNA extraction, library preparation for next-generation sequencing (NGS) using both manual and automated platforms, employing various molecular biology and standard laboratory methods in accordance with standard operating procedures (SOPs) and work instructions Assist with the design, plan and execution of experiments to support the development and V&V of oncology assays Maintain a detailed and organized electronic laboratory notebooks and accurate records of lab work using a variety of software including Google Sheets, Microsoft Excel, and internal databases Analyze and interpret experimental data using appropriate statistical and analytical tools Assist in drafting documentation including study protocols, reports, SOPs and work instructions Coordinate across multiple internal teams to ensure the timely execution of the studies. Adapt to handle multiple tasks and priorities, and perform other duties as assigned Learn the science behind ongoing research projects while actively completing increasingly complex tasks QUALIFICATIONS : Bachelor’s degree in molecular biology, genetics, biochemistry or related field with a minimum
Are you interested in working directly for a single sponsor while having the security and additional career opportunities that working for a global CRO can bring? Our team says it’s the best of both worlds... We are building our talent pipeline for 2027 and expect to have multiple opportunities throughout the year for experienced professionals in Clinical Statistical Programming at the Senior and Principal level. We anticipate hiring for up to 20 positions during calendar year 2027, with openings becoming available at different times based on client demand and business growth. The Senior/Principal Statistical Programmer is responsible for serving as a technical and study programming lead across multiple compounds and/or studies within the Statistical Programming function, supporting Ipsen’s assets within a specific therapeutic area such as Oncology, Rare Disease, or Neuroscience . The role requires strong hands-on statistical programming expertise, study leadership, and technical knowledge to ensure the quality, consistency, and timely delivery of statistical programming activities. The programmer will work closely with statisticians, clinical teams, data management, and other cross-functional stakeholders and may also provide technical oversight of outsourced programming activities. Main Responsibilities & Technical Competencies Serve as a lead statistical programmer for multiple studies and/or compounds, ensuring high-quality and timely delivery of statistical programming activities. Lead and execute statistical programming activities across clinical trials, from study start-up through database lock, reporting, and regulatory submission. Ensure consistency, quality, and executional excellence across programming deliverables for assigned studies. Support programming activities for global regulatory submissions and responses to health authority questions. Provide technical oversight and guidance for outsourced statistical programming ac
Are you interested in working directly for a single sponsor while having the security and additional career opportunities that working for a global CRO can bring? Our team says it’s the best of both worlds... We are building our talent pipeline for 2027 and expect to have multiple opportunities throughout the year for experienced professionals in Clinical Statistical Programming at the Senior and Principal level. We anticipate hiring for up to 20 positions during calendar year 2027, with openings becoming available at different times based on client demand and business growth. The Senior/Principal Statistical Programmer is responsible for serving as a technical and study programming lead across multiple compounds and/or studies within the Statistical Programming function, supporting Ipsen’s assets within a specific therapeutic area such as Oncology, Rare Disease, or Neuroscience . The role requires strong hands-on statistical programming expertise, study leadership, and technical knowledge to ensure the quality, consistency, and timely delivery of statistical programming activities. The programmer will work closely with statisticians, clinical teams, data management, and other cross-functional stakeholders and may also provide technical oversight of outsourced programming activities. Main Responsibilities & Technical Competencies Serve as a lead statistical programmer for multiple studies and/or compounds, ensuring high-quality and timely delivery of statistical programming activities. Lead and execute statistical programming activities across clinical trials, from study start-up through database lock, reporting, and regulatory submission. Ensure consistency, quality, and executional excellence across programming deliverables for assigned studies. Support programming activities for global regulatory submissions and responses to health authority questions. Provide technical oversight and guidance for outsourced statistical programming activitie
POSITION SUMMARY: Natera is hiring a Machine Learning Scientist to join our AI and computational biology team. This role develops and deploys deep learning models across digital pathology, genomics, transcriptomics, and cell-free DNA (cfDNA) modalities. You will build multimodal AI systems that integrate imaging, molecular, and clinical data, leveraging proprietary genomic and clinical datasets. You will collaborate with scientists, pathologists, bioinformaticians, and software engineers to scale machine learning approaches that advance personalized oncology diagnostics and tumor-informed minimal residual disease (MRD) testing. PRIMARY RESPONSIBILITIES: Design, implement, and evaluate deep learning models across biomedical data modalities, including histopathology imaging, genomic sequencing, transcriptomics, and cfDNA features Develop multimodal AI architectures that integrate H&E whole-slide imaging data with molecular and clinical data sources Build scalable, production-quality machine learning workflows and pipelines using cloud infrastructure (AWS) Apply modern machine learning techniques including convolutional neural networks (CNNs), vision transformers (ViTs), sequence transformers, representation learning, and foundation model fine-tuning Collaborate across technical and clinical teams to translate machine learning prototypes into validated tools Analyze model outputs to generate reproducible biological and clinical insights Document pipelines thoroughly and communicate data-driven findings clearly to cross-functional stakeholders QUALIFICATIONS: PhD in Computer Science, Computational Biology, Biomedical Engineering, Bioinformatics, Statistics, or a related quantitative discipline with a focus on machine learning or AI Core experience developing machine learning models for biomedical applications, specifically in medical imaging, computational pathology, genomics, transcriptomics, multi-omics, or molecular diagnostics Hands-on expertise with PyTorch and
Primary Responsibilities: Awareness and understanding of relevant GVP modules. Perform medical review of non-serious & serious ICSRs with emphasis on seriousness, expectedness, causality & narrative etc. without missing on quality & compliance. Experience of medical review of ICSRs received from sources such as Spontaneous, Literature, Regulatory Authority, Solicited and Clinical trials. Experience across multiple therapeutic areas such as Oncology, Respiratory, Immunology, Neuroscience, Rare diseases etc. Support triage of cases and determine seriousness and relatedness across products as assigned. Review and verify appropriate selection of adverse events from source documents, assign appropriate MedDRA code, assess labelling and review narrative. Acquire and maintain current knowledge of product portfolio and safety profiles for products across therapeutic areas. Involve in process improvement activities such as implementation of quality control process. Provide medical guidance and expert opinion on the cases to the data entry associates and quality reviewers to help resolve queries. Identify and resolve case issues, coordinate with client therapeutic teams and within functional team and manage as appropriate. Maintain PV expertise and understanding of international safety regulations and guidelines. Responsible for completing the MR activities in the safety database within the stipulated time to comply with service level agreements and regulatory timelines. Provide timely feedback to case processors on the errors/ discrepancies noted. Assist in training/mentoring of other case processing/medical review personnel as necessitated. Adapt to different client case processing conventions and multi-task as per business needs. Perform ad-hoc tasks as advised by the team lead/manager with quality and compliance as per project requirement. Participate in organizational activities to meet objectives suitable for the role/area of expertise. Candidate Profile: Me
Band 7 Locum Senior Dosimetrist Job Title: Senior Dosimetrist Banding: 7 Location: London Working Hours: Monday to Friday 0900-1700 Rate: £32.00 - £33.00 We are currently seeking an experienced Band 7 Locum Senior Dosimetrist to join a leading oncology department in London. This role offers an excellent opportunity to work in a state-of-the-art radiotherapy centre, contributing to high-quality cancer treatment planning. The ideal candidate will have a strong background in radiotherapy dosimetry and treatment planning, working collaboratively with clinical oncologists, radiographers, and physicists. Responsibilities : As a Senior Dosimetrist, you will be responsible for the accurate planning and calculation of radiation treatment dose s for cancer patients, ensuring optimal treatment delivery while minimising exposure to surrounding healthy tissues. You will work with advanced radiotherapy techniques such as IMRT, VMAT, and IGRT, using the latest treatment planning systems. You will liaise closely with oncologists, radiographers, and medical physicists to develop personalised treatment plans, adhering to strict safety protocols and quality assurance standards. Additionally, you will contribute to workflow optimisation, protocol development, and continuous improvement initiatives within the radiotherapy department. Requirements: BSc in Radiotherapy, Medical Physics, or a relevant field. Significant experience in radiotherapy treatment planning and dosimetry. Proficiency with treatment planning systems such as Eclipse, Monaco, or RayStation. Strong understanding of IMRT, VMAT, IGRT, and other advanced radiotherapy techniques. HCPC registration (or equivalent). Ability to work effectively in a multidisciplinary team. Excellent problem-solving skills and attention to detail. Familiarity with quality assurance procedures and radiation safety guidelines. Why work with Pulse? From the moment you register with us, our focus is entirely on you.
Are you interested in working directly for a single sponsor while having the security and additional career opportunities that working for a global CRO can bring? Our team says it’s the best of both worlds…. ClinChoice is searching for a Senior Statistical Programmer Consultant to join one of our clients. ClinChoice is a global full-service CRO with a strong focus on quality, professional development, and supportive culture. As a client-facing role, we are looking for confident candidates with the ability to work independently whilst establishing a high-trust environment with the client’s counterparts. We are seeking an experienced Senior Statistical Programmer with hands-on experience in Gene Therapy clinical trials to lead study-level statistical programming activities. The ideal candidate will have strong SAS programming expertise, a solid understanding of clinical trial data and regulatory requirements, and the ability to independently manage programming deliverables in collaboration with Biostatisticians and cross-functional teams. Experience in Gene Therapy clinical development is essential. Experience in Oncology or Internal Medicine is also valuable. Key Responsibilities Lead statistical programming activities for Gene Therapy clinical trials from study start-up through database lock, analysis, and reporting. Develop, review, and validate SAS programs for SDTM, ADaM, Tables, Listings, and Figures (TLFs). Collaborate with Biostatisticians to interpret study protocols, Statistical Analysis Plans (SAPs), and programming specifications. Develop and validate clinical datasets and statistical outputs for safety and efficacy analyses. Support interim and final analyses, database lock activities, and Clinical Study Report preparation. Ensure programming deliverables comply with CDISC standards and applicable regulatory requirements. Perform independent validation and quality control of datasets, TLFs, and other programming outputs. S
What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Illumina is seeking an experienced and highly motivated Staff Scientist to help advance molecular diagnostics and precision oncology through the development of next-generation sequencing (NGS) assays. In this role, you will serve as a technical leader within a multidisciplinary product development environment, driving the design, optimization, verification, and validation of innovative oncology assays intended for research and/or clinical applications. The ideal candidate combines deep expertise in molecular biology, assay development, and NGS technologies with a proven track record of leading complex technical initiatives in a fast-paced product development environment. This individual will operate with a high degree of independence, influence cross-functional decision-making, mentor scientists, and contribute to the technical and business strategy of key oncology programs. As a Staff Scientist, you will lead critical technical workstreams, provide subject matter expertise, and partner closely with teams across Quality, Bioinformatics, Biostatistics, Software Development, Operations, Product Marketing, and Commercial organizations to deliv
We’re building a world of health around every individual — shaping a more connected, convenient and compassionate health experience. At CVS Health®, you’ll be surrounded by passionate colleagues who care deeply, innovate with purpose, hold ourselves accountable and prioritize safety and quality in everything we do. Join us and be part of something bigger – helping to simplify health care one person, one family and one community at a time. CVS Health, a Fortune 6 company, has an outstanding opportunity for a Medical Director (Medical Affairs). This is a full-time, remote based, work from home opportunity. The Medical Affairs department provides clinical business support to the entire enterprise and provides clinical oversight and mentorship for CVS Health clinical programs, PBM Clinical Quality activities, consultative support to the P&T process, formulary development, drug information services and pipeline activities, and clinical leadership to various internal departments (e.g., specialty pharmacy services, clinical product development, Enterprise Analytics, Compliance, Legal, Accreditation) and clients. Job Description Medical Directors at CVS Health are encouraged to model the highest levels of clinical integrity, knowledge and cross functional thinking, and decision making. Medical Directors represent the clinical decision making and professional thought process of the prescriber as a partner across the enterprise’s decisions and planning. Medical Directors are responsible for reviewing a broad range of clinical cases and coverage requests, including specialty medications, oncology therapies, biologics, and newly marketed drugs. Success in this role requires a strong clinical foundation, sound medical judgment, and the ability to efficiently identify, evaluate, and apply current medical
About Iovance Biotherapeutics, Inc. Iovance Biotherapeutics , Inc. is the global leader in innovating, developing, and delivering tumor infiltrating lymphocyte (TIL) cell therapies for patients with solid tumors. Amtagvi® (lifileucel) is the first FDA-approved, one-time treatment for previously treated advanced melanoma, now approved in three global markets and available at more than 95 authorized treatment centers. The Iovance TIL platform spans registrational trials and next-generation programs in additional solid tumors, including gene-edited and IL-12 tethered TIL therapies, next-generation IL-2, and precision immuno-oncology approaches. As the first and only company to take TIL therapy from concept to a broadly accessible commercial treatment, Iovance operates as an end-to-end cell therapy company, anchored by fully owned, centralized U.S.-based manufacturing that is scaled to serve thousands of cancer patients worldwide each year. For more information, please visit www.iovance.com . Amtagvi® and its accompanying design marks, Proleukin ® , Iovance ® , and IovanceCares™ are trademarks and registered trademarks of Iovance Biotherapeutics, Inc. or its subsidiaries. All other trademarks and registered trademarks are the property of their respective owners. Information on Iovance’s broad, industry-leading patent portfolio is available on the Intellectual Property page on www.iovance.com . Overview The Production Planner is the owner and responsible for managing and scheduling production plans for sampling, testing, issuance, bulk manufacturing, and final product shipments at Iovance Cell Therapy Center (iCTC) located in Navy Yard, PA and third-party manufacturing contractors as required. The Production Planner is key communication link between Manufacturing, Materials, Quality, Logistics, Maintenance, MSAT, Commercial, Clinical, and other teams to address additions, changes, substit
ClinChoice is a global full-service CRO committed to professional growth and a quality-driven “one-team” culture. We are seeking a Principal Statistician to join our in-house team and support projects across a diverse client portfolio, including pharmaceutical, biotechnology, medical device, and consumer health companies of varying sizes. We are seeking a highly skilled Principal Statistician to lead statistical activities for clinical trials. This role requires hands-on statistical expertise, strong communication skills, and the ability to independently lead projects while collaborating closely with cross-functional teams. Join our team: you can be part of making a difference in peoples' lives and experience a fulfilling and rewarding career! Key Responsibilities Lead and provide statistical support for clinical studies. Act as the lead statistician on assigned studies, overseeing statistical strategy and deliverables Author and review key statistical documents, including: Statistical Analysis Plans (SAPs) Analysis Database Specifications (ADS) Statistical sections of clinical study reports Review and interpret analysis outputs, ensuring accuracy, quality, and regulatory compliance Collaborate with cross-functional teams including Clinical, Programming, Data Management, and Regulatory Provide guidance and oversight to statistical programmers as needed Communicate statistical concepts, results, and risks clearly to both technical and non-technical stakeholders Ensure adherence to regulatory standards (FDA, ICH, GCP) and company SOPs Required Qualifications MS or PhD in Statistics, Biostatistics, or a related field There are no specific therapeutic area requirements; however, experience in Oncology, Rare Disease, or Neuroscience would be advantageous. Strong oral and written communication skills, with the ability to effectively communicate internally and with clients. Demonstrated understanding and insight in statistics, drug
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