Informatics Manager Jobs

Opportunity Overview: We’re seeking a Senior Clinical Informatician to serve as a key bridge between clinical expertise and data science. In this advanced role, you’ll apply deep clinical reasoning and informatics expertise to design, evaluate, and optimize data-driven healthcare solutions. You’ll also lead ontology mapping, structured data validation, and annotation quality initiatives supporting our next-generation AI and LLM-enabled healthcare tools. This is a remote-first role that may require travel to Boston, MA for new hire onboarding and occasional in-person team meetings and company events. What you’ll do: Collaborate with clinicians, data scientists, and engineers to design and validate digital health and analytics solutions. Translate clinical workflows into structured data and logic for algorithms and quality measurement. Lead efforts in ontology mapping, terminology management (SNOMED, ICD, LOINC, RxNorm), and interoperability standards (FHIR, HL7). Oversee labeling and abstraction to ensure model safety, accuracy, and clinical integrity. Mentor junior informaticians and specialists in annotation, data validation, and workflow improvement. What you’ll need: BSN or related clinical degree with active RN license required. 4–6+ years of experience in clinical informatics, analytics, or digital health. Advanced understanding of clinical data, EHR systems, and data standards. Experience with data modeling or AI-driven healthcare products preferred. Master’s degree or informatics certification (RN-BC, CPHIMS, ACHIP, etc.) a plus. Pay & Perks: 💻 Fully remote opportunity with about 5% travel 🩺 Medical, dental, vision, life, disability insurance, and Employee Assistance Program 📈 401K retirement plan with company match; flexible spending and health savings account 🏝️ Up to 184 hours (23 days) of PTO per year + company holidays 👶 Up to 14 weeks of paid parental leave 🐶 Pet insurance The salary range for this p

This is an exciting opportunity at Natera (a global leader in precision medicine and genomics testing), to oversee the entire operations of our Extended-Hours Support (ExHS) team, to provide key data analytics services for our lab production operations. As the Director of Operations for ExHS at our Data Science Production Engineering (DSPE) department, you will have the opportunity to work with Natera's diverse and ultra-large data sets (up to PB size), apply innovative solutions built with the latest information and cloud technologies, directly support the most cutting-edge medical diagnostics and genomics applications, and make real & immediate impact to patients and healthcare providers, by ensuring the ExHS team's timely and accurate data analytics support to production teams, e.g., product management team, lab operations teams, lab director teams, and genetic counselor teams. Important Note: This Director needs to be available during the extended hours (e.g., early morning, late evening, and weekend hours) for emergencies or other similar critical events (note: this position does not require general availability during the extended hours, but only during emergencies or other similar critical events during the extended hours). PRIMARY RESPONSIBILITIES: Team Leadership and Operations Direct and mentor a team of 10+ ExHS data science support engineers and analysts providing coverage across standard and extended operational shifts, for the timely and accurate data analytics support for production teams. Enforce operating procedures for compliance, quality, and efficiency. Measure, report, and continuously improve team operational effectiveness. Lead the team during critical production incidents or emergency events during and outside standard business hours. Technical Execution and Infrastructure Develop and maintain technologies for operational visibility (e.g., via AWS QuickSight or Streamlit). Develop and maintain technologies for operational efficiency

This is an exciting opportunity at Natera (a global leader in precision medicine and genomics testing), to oversee the entire operations of our Extended-Hours Support (ExHS) team, to provide key data analytics services for our lab production operations. As the Director of Operations for ExHS at our Data Science Production Engineering (DSPE) department, you will have the opportunity to work with Natera's diverse and ultra-large data sets (up to PB size), apply innovative solutions built with the latest information and cloud technologies, directly support the most cutting-edge medical diagnostics and genomics applications, and make real & immediate impact to patients and healthcare providers, by ensuring the ExHS team's timely and accurate data analytics support to production teams, e.g., product management team, lab operations teams, lab director teams, and genetic counselor teams. Important Note: This Director needs to be available during the extended hours (e.g., early morning, late evening, and weekend hours) for emergencies or other similar critical events (note: this position does not require general availability during the extended hours, but only during emergencies or other similar critical events during the extended hours). PRIMARY RESPONSIBILITIES: Team Leadership and Operations Direct and mentor a team of 10+ ExHS data science support engineers and analysts providing coverage across standard and extended operational shifts, for the timely and accurate data analytics support for production teams. Enforce operating procedures for compliance, quality, and efficiency. Measure, report, and continuously improve team operational effectiveness. Lead the team during critical production incidents or emergency events during and outside standard business hours. Technical Execution and Infrastructure Develop and maintain technologies for operational visibility (e.g., via AWS QuickSight or Streamlit). Develop and maintain technologies for operational efficiency

This is an exciting opportunity to lead and grow the Data Science and Bioinformatics function supporting Natera's Women's Health and Organ Health product portfolios. In this role, you will build the bioinformatics capability within the Data Science development team, establish scalable AWS cloud infrastructure, and ensure the quality and reproducibility of the genomic algorithms powering our clinical products. PRIMARY RESPONSIBILITIES: Strategy and Vision Build and define the Bioinformatics function within the Data Science development team, identify technical tooling gaps, and execute a roadmap to advance genomics-based algorithm development. Establish and enforce pipeline and algorithm quality standards, including review processes, validation frameworks, and documentation practices Infrastructure and Automation Own and architect scalable AWS-based data science and bioinformatics infrastructure, ensuring quality, reproducibility, and reliable deployment of Next-Generation Sequencing (NGS) algorithms. Implement MLOps tooling and automated validation frameworks to support reliable algorithm deployment into clinical production. Cross-Functional Collaboration Partner with Research, Product Development, Laboratory Operations, Engineering, and Quality teams to implement stable, scalable pipelines and support successful productization Team Leadership Lead, mentor and hire a high-performing team of bioinformaticians and data scientists, establishing technical quality standards and clear operational ownership. Build technical depth within the team to support expanding product roadmaps across Women's Health and Organ Health. QUALIFICATIONS: Master of Science or Ph.D. in a quantitative technical discipline (Biostatistics, Bioinformatics, Computer Science, Physics, Applied Mathematics, or equivalent). Minimum of 10 years of experience in Data Science or Bioinformatics, with at least 5 years of direct people management experience leading technical teams. Hands-on experience archi

This is an exciting opportunity to lead and grow the Data Science and Bioinformatics function supporting Natera's Women's Health and Organ Health product portfolios. In this role, you will build the bioinformatics capability within the Data Science development team, establish scalable AWS cloud infrastructure, and ensure the quality and reproducibility of the genomic algorithms powering our clinical products. PRIMARY RESPONSIBILITIES: Strategy and Vision Build and define the Bioinformatics function within the Data Science development team, identify technical tooling gaps, and execute a roadmap to advance genomics-based algorithm development. Establish and enforce pipeline and algorithm quality standards, including review processes, validation frameworks, and documentation practices Infrastructure and Automation Own and architect scalable AWS-based data science and bioinformatics infrastructure, ensuring quality, reproducibility, and reliable deployment of Next-Generation Sequencing (NGS) algorithms. Implement MLOps tooling and automated validation frameworks to support reliable algorithm deployment into clinical production. Cross-Functional Collaboration Partner with Research, Product Development, Laboratory Operations, Engineering, and Quality teams to implement stable, scalable pipelines and support successful productization Team Leadership Lead, mentor and hire a high-performing team of bioinformaticians and data scientists, establishing technical quality standards and clear operational ownership. Build technical depth within the team to support expanding product roadmaps across Women's Health and Organ Health. QUALIFICATIONS: Master of Science or Ph.D. in a quantitative technical discipline (Biostatistics, Bioinformatics, Computer Science, Physics, Applied Mathematics, or equivalent). Minimum of 10 years of experience in Data Science or Bioinformatics, with at least 5 years of direct people management experience leading technical teams. Hands-on experience archi

Natera is seeking an Associate Director to lead a team of Bioinformatics Scientists in our Women's Health and Organ Health research organization. You will oversee the scientific planning and execution of research and assay-development of diagnostic projects, and you will be responsible for creating production-ready pipeline components. You will manage your team and its professional growth, the research strategy behind new product development, and the handoff of research work into production. The role calls for deep experience in algorithm and assay development, NGS data processing across multiple modalities, and the full life cycle of diagnostic product research and development in a regulated (CLIA) setting. You will evaluate new technologies and NGS assays, implement methods to optimize performance, and help define the product profile from a bioinformatics perspective, with input from R&D, Product, and Laboratory Directors. Primary Responsibilities: Team Leadership and Development: Lead and mentor a team of Bioinformatics Scientists. Own their professional growth, their responsibilities, and the standard the team holds itself to. Research Strategy: Own the research strategy behind new product development, from scoping through execution, working with cross-functional stakeholders on what the team takes on and in what order. Assay Science: Lead bioinformatics analysis for assay development and optimization, and troubleshoot experiments alongside laboratory scientists. This spans multi-omic approaches including methylation and fragmentomics and other cell-free DNA (cfDNA) derived features. It also spans short-read and long-read sequencing and both hybrid-capture and amplicon target enrichment. Study Design and Data Quality: Partner with laboratory teams on study design at the research and feasibility stage, covering new technology assessment, optimization, and performance determination. Make sure the resulting data holds up before anyone builds on it. Analys

Natera is seeking an Associate Director to lead a team of Bioinformatics Scientists in our Women's Health and Organ Health research organization. You will oversee the scientific planning and execution of research and assay-development of diagnostic projects, and you will be responsible for creating production-ready pipeline components. You will manage your team and its professional growth, the research strategy behind new product development, and the handoff of research work into production. The role calls for deep experience in algorithm and assay development, NGS data processing across multiple modalities, and the full life cycle of diagnostic product research and development in a regulated (CLIA) setting. You will evaluate new technologies and NGS assays, implement methods to optimize performance, and help define the product profile from a bioinformatics perspective, with input from R&D, Product, and Laboratory Directors. Primary Responsibilities: Team Leadership and Development: Lead and mentor a team of Bioinformatics Scientists. Own their professional growth, their responsibilities, and the standard the team holds itself to. Research Strategy: Own the research strategy behind new product development, from scoping through execution, working with cross-functional stakeholders on what the team takes on and in what order. Assay Science: Lead bioinformatics analysis for assay development and optimization, and troubleshoot experiments alongside laboratory scientists. This spans multi-omic approaches including methylation and fragmentomics and other cell-free DNA (cfDNA) derived features. It also spans short-read and long-read sequencing and both hybrid-capture and amplicon target enrichment. Study Design and Data Quality: Partner with laboratory teams on study design at the research and feasibility stage, covering new technology assessment, optimization, and performance determination. Make sure the resulting data holds up before anyone builds on it. Analys

Natera is seeking a Staff Scientist to join our Early Research Team. The primary focus of this role is to independently lead the research and development of novel next-generation sequencing (NGS) technologies. In this role, you will lead projects from ideation to prototype, specifically designing and optimizing high-complexity NGS methods to advance our oncology diagnostic portfolio. Success in this role requires a deep technical foundation in molecular biology and NGS plus a proven track record of industrial R&D leadership. Primary Responsibilities: Lead and manage the development of innovative NGS-based diagnostic assays from feasibility through optimization. Define project goals and plans with input from stakeholders and manage multiple project streams in parallel. Independently design and execute complex laboratory experiments; analyze and interpret results to guide research direction. Coordinate cross-functional efforts to meet milestones and collaborate closely with bioinformatics, statistics, and data science teams to ensure robust experimental design and data analysis. Mentor and guide junior scientists while promoting scientific rigor and best practices. Author high-quality protocols, technical reports, and study documentation. Communicate progress regularly to stakeholders, including departmental meetings and senior leadership. Contribute to risk management, strategy development, and continuous improvement of scientific workflows. Qualifications: Ph.D. in molecular biology, genomics, or a closely related field. Minimum 8 years of relevant industry experience, or 2+ years postdoctoral research with 6+ years in industry. Proven experience in designing and advancing NGS-based diagnostics, preferably in the field of oncology. Required Expertise: A strong technical foundation in molecular biology or chemistry. Deep mechanistic knowledge of NGS library preparation chemistry. Demonstrated ability to independently design and execute complex experiments (solid

This is an exciting opportunity to advance Natera’s regulated product portfolio of cutting-edge molecular diagnostic tests. As a Staff Biostatistician, you will leverage your strong applied statistics, IVD, and Clinical Research expertise to drive the strategy, design, analysis, and interpretation of clinical validation studies for kidney disease and other high-priority germline projects. PRIMARY RESPONSIBILITIES: Strategic Study Design and Analysis: Independently lead the design, analysis, and interpretation of clinical validation studies to support in vitro diagnostic approvals (e.g., CDx, 510(k), PMA, etc.) Regulatory Compliance: Ensure statistical methodologies and analyses meet the standards set by regulatory agencies such as FDA. Drive statistical interactions with regulatory authorities. Documentation and Reporting : Prepare comprehensive statistical analysis protocols (SAPs), reports, and presentations for cross-functional and external collaborators and stakeholders. Cross-Functional Leadership : Serve as the statistical lead on high-priority project teams. Partner with Clinical Science, Data Management, and Product teams to integrate statistical expertise into project planning and execution. Identify risks, communicate concerns, and champion solutions to interdisciplinary project teams Clinical Research and Beyond: Drive design and execution of high-impact research clinical trials, studies, and publications that push the development of our world-class product portfolio Stay current with advancements in Biostatistics and clinical validation methodology, implementing innovative approaches to support diagnostic product development and regulatory submissions Mentor and provide technical supervision to junior team members QUALIFICATIONS: Education : Ph.D. or Master's degree in Biostatistics, Statistics, or a related field Experience : At least 8 years of relevant industry experience, preferably within molecular diagnostics, biotechnology,

This is an exciting opportunity to advance Natera’s regulated product portfolio of cutting-edge molecular diagnostic tests. As a Staff Biostatistician, you will leverage your strong applied statistics, IVD, and Clinical Research expertise to drive the strategy, design, analysis, and interpretation of clinical validation studies for kidney disease and other high-priority germline projects. PRIMARY RESPONSIBILITIES: Strategic Study Design and Analysis: Independently lead the design, analysis, and interpretation of clinical validation studies to support in vitro diagnostic approvals (e.g., CDx, 510(k), PMA, etc.) Regulatory Compliance: Ensure statistical methodologies and analyses meet the standards set by regulatory agencies such as FDA. Drive statistical interactions with regulatory authorities. Documentation and Reporting : Prepare comprehensive statistical analysis protocols (SAPs), reports, and presentations for cross-functional and external collaborators and stakeholders. Cross-Functional Leadership : Serve as the statistical lead on high-priority project teams. Partner with Clinical Science, Data Management, and Product teams to integrate statistical expertise into project planning and execution. Identify risks, communicate concerns, and champion solutions to interdisciplinary project teams Clinical Research and Beyond: Drive design and execution of high-impact research clinical trials, studies, and publications that push the development of our world-class product portfolio Stay current with advancements in Biostatistics and clinical validation methodology, implementing innovative approaches to support diagnostic product development and regulatory submissions Mentor and provide technical supervision to junior team members QUALIFICATIONS: Education : Ph.D. or Master's degree in Biostatistics, Statistics, or a related field Experience : At least 8 years of relevant industry experience, preferably within molecular diagnostics, biotechnology,

Use Your Power for Purpose The Global Clinical Supply (GCS) Interactive Response Technology (IRT) Implementation Analyst is a position within Global Central Operations Network (GCON) GCS Strategic Hubs (GSH) team and will be based in Philippines. The IRT Implementation Analyst will be reporting to the GSH Team Lead in Philippines, with a matrix reporting relationship to the Engagement Leader, IRT Global Oversight Team (IGOT) within Clinical Supply Informatics & Technology (CSIT). GCS manages the execution of supply chain strategies to deliver Investigational Medicinal Product to patients involved in Pfizer’s clinical research trials across the globe. IGOT is a well-established high performing team within Pfizer's GCS unit striving to deliver best in class IRT systems providing randomization and drug management capabilities in support of Pfizer's dynamic investigational product portfolio. The patients we serve are our number one priority and IGOT aims to employ the highest quality standards across our internal and vendor IRT solutions. As part of an innovative clinical supply chain, we routinely challenge the status quo in efforts to optimize our systems and processes. The IRT Implementation Analyst is an individual contributor who performs defined implementation activities under the direction of an accountable IRT Lead, Design Lead, or functional lead. Responsibility and independence will expand progressively based on completion of required training, demonstrated proficiency, and role readiness. This role requires providing support across other global time zones based on business need, specifically from 8:00 p.m. to 5:00 a.m Philippine Time or 9:00 p.m. to 6:00 a.m. Philippine Time (equivalent to 8:00 a.m. to 5:00 p.m. U. S. Eastern Time). What You Will Achieve The IRT Implementation Analyst is a new role within the IRT IGOT that will support requirements a

Job Title Product Support Engineer (Open) Job Description As a Product Support Engineer, you will be responsible for providing advanced technical support for Philips healthcare solutions and medical informatics platforms. The role focuses on diagnosing and resolving complex technical issues, supporting customer escalations, and contributing to continuous improvements in product support processes to enhance customer satisfaction and operational performance. Your role: Provide advanced technical support for healthcare products and solutions, diagnosing and troubleshooting software, hardware, network, and system-related issues. Act as a subject matter expert for internal teams, field engineers, and customers, supporting complex technical investigations and escalations. Collaborate with global teams, including R&D, Product Management, Service, and Field Service organizations to drive issue resolution and product improvements. Advocate for customer needs throughout the product lifecycle while promoting service excellence and customer satisfaction. Lead technical troubleshooting efforts and provide Level 3 escalation support for critical customer issues. Support service process improvements, reliability initiatives, technical communications, and knowledge-sharing activities. Participate in the development of training materials and technical documentation for internal and external stakeholders. Drive continuous improvement initiatives focused on product performance, supportability, and customer experience. You're the right fit if: You have experience in Healthcare IT, Biomedical Engineering, Medical Informatics, Clinical Informatics, Technical Product Support, or related fields. You have experience diagnosing and troubleshooting complex hardware, software, networking, or system integration issues. Yo

We’re building a world of health around every individual — shaping a more connected, convenient and compassionate health experience. At CVS Health®, you’ll be surrounded by passionate colleagues who care deeply, innovate with purpose, hold ourselves accountable and prioritize safety and quality in everything we do. Join us and be part of something bigger – helping to simplify health care one person, one family and one community at a time. Executive Director, Business Operations & Strategy Position Summary The Executive Director, Business Operations & Strategy is the senior enterprise leader, accountable for the strategy, financial performance, governance, quality and safety, and operational execution of Clinical Informatics and Clinical Care Delivery products initiatives across all CVS Health Care Delivery businesses. Serving as the CHIO's trusted executive proxy, this leader connects each business unit to its clinical technology strategy, and enterprise Epic and third-party contracts, and owns the relationship and stakeholder management that allows a highly matrixed organization to deliver reliably and at scale. Executive Stakeholder & Business Partnership • Serve as the senior executive point of contact and trusted advisor for Clinical Informatics strategy, governance, and operations across all healthcare delivery businesses, including C-suite and board-level engagement. • Forge and maintain strategic relationships with physician executives, operational leadership, and business partners across Oak Street

We’re building a world of health around every individual — shaping a more connected, convenient and compassionate health experience. At CVS Health®, you’ll be surrounded by passionate colleagues who care deeply, innovate with purpose, hold ourselves accountable and prioritize safety and quality in everything we do. Join us and be part of something bigger – helping to simplify health care one person, one family and one community at a time. Company: Oak Street Health Title: Medical Scribe (Clinical Informatics Specialist) Location: 1113 Carlisle Rd, York, PA 17404 Role Description: At Oak Street Health, Clinical Informatics Specialists (CIS), or Medical Scribes, serve as vital clinical documentation assistants, supporting our primary care providers. Each Scribe is paired with a single provider, joining them in the exam room, during team huddles, and conducting post-visit summaries to ensure accurate, specific, and timely documentation. Our Scribes receive extensive training to become experts in our value-based care model, ICD-10 and CPT coding, electronic medical records, and population health. Their contributions allow our interdisciplinary team to proactively identify and help close care gaps, provide preventative measures for chronic conditions, and provide great patient experiences. This role is designed for individuals seeking significant clinical exposure, particularly those on a pre-med or healthcare administration track. Because providers and patients rely heavily on this partnership, successful candidates should expect a 1 - 2 year commitment. This opportunity offers an immersive, paid position to gain clinical experience, chronic disease management, and a deep understanding of patient care workflows before advancing to MD, PA, Nursing, or other professional hea

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. The Director, Bioinformatics will provide strategic leadership for Illumina's multiomics bioinformatics portfolio, spanning single cell, spatial biology, proteomics, epigenomics, and emerging multiomics technologies. Leading a team of bioinformatics scientists and engineers, this leader will define and execute informatics strategies that enable end-to-end customer multiomics workflows. The role will involve partnering closely with Product Management, Assay Development, Software Engineering, Clinical Development, and Commercial organizations to align bioinformatics capabilities with product roadmaps, customer needs, and business objectives. Responsibilities: Strategy -- define and drive bioinformatics strategy across Illumina's multiomics portfolio, including single cell, spatial biology, proteomics, epigenomics, and emerging multiomics technologies Vision -- establish the long-term vision for customer-facing informatics experiences and end-to-end product workflows Innovation -- drive innovation in analysis methods, AI-enabled workflows, and next-generation multiomics capabilities <