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Principal Senior Machine Learning Scientist Jobs

2,909 active opportunities · Updated for October 2026

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Explore current principal senior machine learning scientist jobs. Use filters to narrow by work mode, employment type, experience and date posted.

ES
eClinical Solutions
📍 Mansfield• Hybrid• $152K – $190K/yr
1mo ago

About eClinical Solutions eClinical Solutions is transforming clinical development with elluminate®, our Clinical Data Cloud , helping life sciences organizations unify, analyze, and unlock the value of their data faster than ever before. By combining a modern cloud platform with expert data services, we empower smarter decisions across the clinical trial lifecycle—accelerating innovation that ultimately improves patient outcomes. Our engineering teams build enterprise-grade, revenue-generating products at the intersection of cloud, data, analytics, and emerging AI technologies . If you’re excited about building sophisticated software that makes a real-world impact on healthcare, this is the place to do it. You will make an impact: As a Principal Full Stack Software Engineer , you will be a technical leader within the elluminate Product Development team. You’ll help design and build the core services and user experiences of a next-generation clinical data and analytics platform—while influencing architecture, engineering standards, and technical direction. This role is ideal for an experienced engineer who enjoys hands-on development , mentoring others, and bringing modern capabilities—including AI-assisted and agentic workflows—into production-grade systems . Your day to day: Design, develop, test, and deploy scalable, secure, and highly interactive web applications Own and evolve core platform modules , from concept through release and support Influence application and system architecture with a focus on performance, reliability, security, and maintainability Lead by example through clean, well-tested code , thoughtful design reviews, and pragmatic technical decisions Collaborate closely with Product Management, QA, and other engineers throughout the SDLC Provide technical mentorship and guidance to other engineers on the team Diagnoses and resolves complex production issues across distributed systems Ensure solutions meet eClinica

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Glean
📍 United States• $224K – $258K/yr
1mo ago

About Glean: Glean is the Work AI platform that helps everyone work smarter with AI. What began as the industry’s most advanced enterprise search has evolved into a full-scale Work AI ecosystem, powering intelligent Search, an AI Assistant, and scalable AI agents on one secure, open platform. With over 100 enterprise SaaS connectors, flexible LLM choice, and robust APIs, Glean gives organizations the infrastructure to govern, scale, and customize AI across their entire business - without vendor lock-in or costly implementation cycles. At its core, Glean is redefining how enterprises find, use, and act on knowledge. Its Enterprise Graph and Personal Knowledge Graph map the relationships between people, content, and activity, delivering deeply personalized, context-aware responses for every employee. This foundation powers Glean’s agentic capabilities - AI agents that automate real work across teams by accessing the industry’s broadest range of data: enterprise and world, structured and unstructured, historical and real-time. The result: measurable business impact through faster onboarding, hours of productivity gained each week, and smarter, safer decisions at every level. Recognized by Fast Company as one of the World’s Most Innovative Companies (Top 10, 2025), by CNBC’s Disruptor 50, Bloomberg’s AI Startups to Watch (2026), Forbes AI 50, and Gartner’s Tech Innovators in Agentic AI, Glean continues to accelerate its global impact. With customers across 50+ industries and 1,000+ employees in more than 25 countries, we’re helping the world’s largest organizations make every employee AI-fluent, and turning the superintelligent enterprise from concept into reality. If you’re excited to shape how the world works, you’ll help build systems used daily across Microsoft Teams, Zoom, ServiceNow, Zendesk, GitHub, and many more. You'll be deeply embedded where people get things done. You'll ship agentic capabilities on an open, extensible stack, with

G
1mo ago

About Glean: Glean is the Work AI platform that helps everyone work smarter with AI. What began as the industry’s most advanced enterprise search has evolved into a full-scale Work AI ecosystem, powering intelligent Search, an AI Assistant, and scalable AI agents on one secure, open platform. With over 100 enterprise SaaS connectors, flexible LLM choice, and robust APIs, Glean gives organizations the infrastructure to govern, scale, and customize AI across their entire business - without vendor lock-in or costly implementation cycles. At its core, Glean is redefining how enterprises find, use, and act on knowledge. Its Enterprise Graph and Personal Knowledge Graph map the relationships between people, content, and activity, delivering deeply personalized, context-aware responses for every employee. This foundation powers Glean’s agentic capabilities - AI agents that automate real work across teams by accessing the industry’s broadest range of data: enterprise and world, structured and unstructured, historical and real-time. The result: measurable business impact through faster onboarding, hours of productivity gained each week, and smarter, safer decisions at every level. Recognized by Fast Company as one of the World’s Most Innovative Companies (Top 10, 2025), by CNBC’s Disruptor 50, Bloomberg’s AI Startups to Watch (2026), Forbes AI 50, and Gartner’s Tech Innovators in Agentic AI, Glean continues to accelerate its global impact. With customers across 50+ industries and 1,000+ employees in more than 25 countries, we’re helping the world’s largest organizations make every employee AI-fluent, and turning the superintelligent enterprise from concept into reality. If you’re excited to shape how the world works, you’ll help build systems used daily across Microsoft Teams, Zoom, ServiceNow, Zendesk, GitHub, and many more. You'll be deeply embedded where people get things done. You'll ship agentic capabilities on an open, extensible stack, with

Elastic, the Search AI Company, enables everyone to find the answers they need in real time, using all their data, at scale — unleashing the potential of businesses and people. The Elastic Search AI Platform, used by more than 50% of the Fortune 500, brings together the precision of search and the intelligence of AI to enable everyone to accelerate the results that matter. By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI. What is The Role: We're looking for a Principal Software Engineer to join the Elasticsearch - Search Infra team. This globally-distributed team of experienced engineers focuses on delivering a robust and feature-rich search experience, including contributing to improving the search experience in Lucene. This is a principle software engineering role that entails using your vast knowledge in this space in order to define, direct, and build the next generation of Elasticsearch capabilities. This role provides technical vision and direction for Elasticsearch’s core search infrastructure, including indexing, retrieval, and relevance, and requires deep expertise in search internals and cross-team collaboration. Our company is distributed by intention. We hire the best engineers we can find wherever they are, whoever they are. We collaborate across continents every day over email, GitHub, Zoom, and Slack. At our best, we write fast, scalable and intuitive software. We believe that the best way to do that is to empower individual engineers, code review every change, decide big things by consensus, and strive for incremental improvements. What You Will Be Doing: As a full-time Elasticsearch contributor, you will define, lead, and contribute to the evolution of core search and indexing capabilities. You’ll research advances in search infrastructure,

E
1mo ago

Elastic, the Search AI Company, enables everyone to find the answers they need in real time, using all their data, at scale — unleashing the potential of businesses and people. The Elastic Search AI Platform, used by more than 50% of the Fortune 500, brings together the precision of search and the intelligence of AI to enable everyone to accelerate the results that matter. By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI. What is The Role: We're looking for a Principal Software Engineer to join the Elasticsearch - Search Infra team. This globally-distributed team of experienced engineers focuses on delivering a robust and feature-rich search experience, including contributing to improving the search experience in Lucene. This is a principle software engineering role that entails using your vast knowledge in this space in order to define, direct, and build the next generation of Elasticsearch capabilities. This role provides technical vision and direction for Elasticsearch’s core search infrastructure, including indexing, retrieval, and relevance, and requires deep expertise in search internals and cross-team collaboration. Our company is distributed by intention. We hire the best engineers we can find wherever they are, whoever they are. We collaborate across continents every day over email, GitHub, Zoom, and Slack. At our best, we write fast, scalable and intuitive software. We believe that the best way to do that is to empower individual engineers, code review every change, decide big things by consensus, and strive for incremental improvements. What You Will Be Doing: As a full-time Elasticsearch contributor, you will define, lead, and contribute to the evolution of core search and indexing capabilities. You’ll research advances in search infrastructure,

E
1mo ago

Elastic, the Search AI Company, enables everyone to find the answers they need in real time, using all their data, at scale — unleashing the potential of businesses and people. The Elastic Search AI Platform, used by more than 50% of the Fortune 500, brings together the precision of search and the intelligence of AI to enable everyone to accelerate the results that matter. By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI. What is The Role: We're looking for a Principal Software Engineer to join the Elasticsearch - Search Infra team. This globally-distributed team of experienced engineers focuses on delivering a robust and feature-rich search experience, including contributing to improving the search experience in Lucene. This is a principle software engineering role that entails using your vast knowledge in this space in order to define, direct, and build the next generation of Elasticsearch capabilities. This role provides technical vision and direction for Elasticsearch’s core search infrastructure, including indexing, retrieval, and relevance, and requires deep expertise in search internals and cross-team collaboration. Our company is distributed by intention. We hire the best engineers we can find wherever they are, whoever they are. We collaborate across continents every day over email, GitHub, Zoom, and Slack. At our best, we write fast, scalable and intuitive software. We believe that the best way to do that is to empower individual engineers, code review every change, decide big things by consensus, and strive for incremental improvements. What You Will Be Doing: As a full-time Elasticsearch contributor, you will define, lead, and contribute to the evolution of core search and indexing capabilities. You’ll research advances in search infrastructure,

E
1mo ago

Elastic, the Search AI Company, enables everyone to find the answers they need in real time, using all their data, at scale — unleashing the potential of businesses and people. The Elastic Search AI Platform, used by more than 50% of the Fortune 500, brings together the precision of search and the intelligence of AI to enable everyone to accelerate the results that matter. By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI. What is The Role: We're looking for a Principal Software Engineer to join the Elasticsearch - Search Infra team. This globally-distributed team of experienced engineers focuses on delivering a robust and feature-rich search experience, including contributing to improving the search experience in Lucene. This is a principle software engineering role that entails using your vast knowledge in this space in order to define, direct, and build the next generation of Elasticsearch capabilities. This role provides technical vision and direction for Elasticsearch’s core search infrastructure, including indexing, retrieval, and relevance, and requires deep expertise in search internals and cross-team collaboration. Our company is distributed by intention. We hire the best engineers we can find wherever they are, whoever they are. We collaborate across continents every day over email, GitHub, Zoom, and Slack. At our best, we write fast, scalable and intuitive software. We believe that the best way to do that is to empower individual engineers, code review every change, decide big things by consensus, and strive for incremental improvements. What You Will Be Doing: As a full-time Elasticsearch contributor, you will define, lead, and contribute to the evolution of core search and indexing capabilities. You’ll research advances in search infrastructure,

E
1mo ago

Elastic, the Search AI Company, enables everyone to find the answers they need in real time, using all their data, at scale — unleashing the potential of businesses and people. The Elastic Search AI Platform, used by more than 50% of the Fortune 500, brings together the precision of search and the intelligence of AI to enable everyone to accelerate the results that matter. By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI. What is The Role: We're looking for a Principal Software Developer to join the Elasticsearch - Search Infra team. This globally-distributed team of experienced engineers focuses on delivering a robust and feature-rich search experience, including contributing to improving the search experience in Lucene. This is a principle software engineering role that entails using your vast knowledge in this space in order to define, direct, and build the next generation of Elasticsearch capabilities. This role provides technical vision and direction for Elasticsearch’s core search infrastructure, including indexing, retrieval, and relevance, and requires deep expertise in search internals and cross-team collaboration. Our company is distributed by intention. We hire the best engineers we can find wherever they are, whoever they are. We collaborate across continents every day over email, GitHub, Zoom, and Slack. At our best, we write fast, scalable and intuitive software. We believe that the best way to do that is to empower individual engineers, code review every change, decide big things by consensus, and strive for incremental improvements. What You Will Be Doing: As a full-time Elasticsearch contributor, you will define, lead, and contribute to the evolution of core search and indexing capabilities. You’ll research advances in search infrastructure,

E
1mo ago

Elastic, the Search AI Company, enables everyone to find the answers they need in real time, using all their data, at scale — unleashing the potential of businesses and people. The Elastic Search AI Platform, used by more than 50% of the Fortune 500, brings together the precision of search and the intelligence of AI to enable everyone to accelerate the results that matter. By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI. What is The Role: We're looking for a Principal Software Engineer to join the Elasticsearch - Search Infra team. This globally-distributed team of experienced engineers focuses on delivering a robust and feature-rich search experience, including contributing to improving the search experience in Lucene. This is a principle software engineering role that entails using your vast knowledge in this space in order to define, direct, and build the next generation of Elasticsearch capabilities. This role provides technical vision and direction for Elasticsearch’s core search infrastructure, including indexing, retrieval, and relevance, and requires deep expertise in search internals and cross-team collaboration. Our company is distributed by intention. We hire the best engineers we can find wherever they are, whoever they are. We collaborate across continents every day over email, GitHub, Zoom, and Slack. At our best, we write fast, scalable and intuitive software. We believe that the best way to do that is to empower individual engineers, code review every change, decide big things by consensus, and strive for incremental improvements. What You Will Be Doing: As a full-time Elasticsearch contributor, you will define, lead, and contribute to the evolution of core search and indexing capabilities. You’ll research advances in search infrastructure,

Elastic, the Search AI Company, enables everyone to find the answers they need in real time, using all their data, at scale — unleashing the potential of businesses and people. The Elastic Search AI Platform, used by more than 50% of the Fortune 500, brings together the precision of search and the intelligence of AI to enable everyone to accelerate the results that matter. By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI. What is The Role: We're looking for a Principal Software Engineer to join the Elasticsearch - Search Infra team. This globally-distributed team of experienced engineers focuses on delivering a robust and feature-rich search experience, including contributing to improving the search experience in Lucene. This is a principle software engineering role that entails using your vast knowledge in this space in order to define, direct, and build the next generation of Elasticsearch capabilities. This role provides technical vision and direction for Elasticsearch’s core search infrastructure, including indexing, retrieval, and relevance, and requires deep expertise in search internals and cross-team collaboration. Our company is distributed by intention. We hire the best engineers we can find wherever they are, whoever they are. We collaborate across continents every day over email, GitHub, Zoom, and Slack. At our best, we write fast, scalable and intuitive software. We believe that the best way to do that is to empower individual engineers, code review every change, decide big things by consensus, and strive for incremental improvements. What You Will Be Doing: As a full-time Elasticsearch contributor, you will define, lead, and contribute to the evolution of core search and indexing capabilities. You’ll research advances in search infrastructure,

E
1mo ago

Elastic, the Search AI Company, enables everyone to find the answers they need in real time, using all their data, at scale — unleashing the potential of businesses and people. The Elastic Search AI Platform, used by more than 50% of the Fortune 500, brings together the precision of search and the intelligence of AI to enable everyone to accelerate the results that matter. By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI. What is The Role: We're looking for a Principal Software Engineer to join the Elasticsearch - Search Infra team. This globally-distributed team of experienced engineers focuses on delivering a robust and feature-rich search experience, including contributing to improving the search experience in Lucene. This is a principle software engineering role that entails using your vast knowledge in this space in order to define, direct, and build the next generation of Elasticsearch capabilities. This role provides technical vision and direction for Elasticsearch’s core search infrastructure, including indexing, retrieval, and relevance, and requires deep expertise in search internals and cross-team collaboration. Our company is distributed by intention. We hire the best engineers we can find wherever they are, whoever they are. We collaborate across continents every day over email, GitHub, Zoom, and Slack. At our best, we write fast, scalable and intuitive software. We believe that the best way to do that is to empower individual engineers, code review every change, decide big things by consensus, and strive for incremental improvements. What You Will Be Doing: As a full-time Elasticsearch contributor, you will define, lead, and contribute to the evolution of core search and indexing capabilities. You’ll research advances in search infrastructure,

E
1mo ago

Elastic, the Search AI Company, enables everyone to find the answers they need in real time, using all their data, at scale — unleashing the potential of businesses and people. The Elastic Search AI Platform, used by more than 50% of the Fortune 500, brings together the precision of search and the intelligence of AI to enable everyone to accelerate the results that matter. By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI. What is The Role: We're looking for a Principal Software Engineer to join the Elasticsearch - Search Infra team. This globally-distributed team of experienced engineers focuses on delivering a robust and feature-rich search experience, including contributing to improving the search experience in Lucene. This is a principle software engineering role that entails using your vast knowledge in this space in order to define, direct, and build the next generation of Elasticsearch capabilities. This role provides technical vision and direction for Elasticsearch’s core search infrastructure, including indexing, retrieval, and relevance, and requires deep expertise in search internals and cross-team collaboration. Our company is distributed by intention. We hire the best engineers we can find wherever they are, whoever they are. We collaborate across continents every day over email, GitHub, Zoom, and Slack. At our best, we write fast, scalable and intuitive software. We believe that the best way to do that is to empower individual engineers, code review every change, decide big things by consensus, and strive for incremental improvements. What You Will Be Doing: As a full-time Elasticsearch contributor, you will define, lead, and contribute to the evolution of core search and indexing capabilities. You’ll research advances in search infrastructure,

We are looking for an experienced Partner Sales Manager to ignite partnerships by identifying and recruiting new partners for long-term success and nurture ongoing relationships with key strategic Global Systems Integrator partners. Our ultimate goal is building channels and alliances that drive new customer adoption and revenue. This is a great opportunity for you to join a high-growth cloud software company and help blaze the path for our company's expansion. At Datadog, we place value in our office culture - the relationships and collaboration it builds and the creativity it brings to the table. We operate as a hybrid workplace to ensure our Datadogs can create a work-life harmony that best fits them. What You’ll Do: Identify and recruit new strategic Global SI partners to drive revenue growth Enable and activate existing GSI partners through training, planning and joint selling activities Coordinate the technical and marketing aspects of integrated partnership launches Host regular business reviews with partners to drive accountability and report on success metrics Work hand-in-hand with Datadog’s regional enterprise and commercial sales organizations Generate partner-sourced net-new sales pipeline and revenue Who You Are: 10+ years of partner-facing, quota-carrying experience in business development, strategic alliances, or channel sales at a cloud services or software as a service organization Proven experience in driving sales opportunities from lead generation to closure, effectively negotiating agreements and building long-lasting partnerships Understanding of, and exposure to working with, the leading Global and regional SIs Ability to quickly understand technical concepts and architectural scenarios, and explain them to others verbally and in writing Willingness to travel 40-50% of the time Entrepreneurial mindset with a passion for taking initiatives from ideation to impact Passion for fast-paced, sometimes unpredictable growth culture and environ

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Baxter
📍 Skaneateles• $120K – $165K/yr
1mo ago

This is where your work makes a difference. At Baxter, we believe every person—regardless of who they are or where they are from—deserves a chance to live a healthy life. It was our founding belief in 1931 and continues to be our guiding principle. We are redefining healthcare delivery to make a greater impact today, tomorrow, and beyond. Our Baxter colleagues are united by our Mission to Save and Sustain Lives. Together, our community is driven by a culture of courage, trust, and collaboration. Every individual is empowered to take ownership and make a meaningful impact. We strive for efficient and effective operations, and we hold each other accountable for delivering exceptional results. Here, you will find more than just a job—you will find purpose and pride. This is where your work saves lives As a Principal Android Software Engineer, you will lead architecture and delivery of shared Android capabilities that power multiple clinical product applications worldwide. You will own significant portions of the Android system design—reusable services and libraries, hybrid WebView/React UI foundations, device connectivity patterns, and common clinical workflows—while mentoring engineers and raising the bar for quality in a regulated medical-device environment. An ideal candidate brings deep hands-on Android expertise, a clear technical vision for multi-product platform software, and the ability to drive complex cross-team decisions independently. Strong communication and collaboration with product teams, systems, hardware, and other platform partners are essential. What you'll be doing: Lead Platform Android Architecture and Delivery: Define and evolve shared Android platform architecture (Kotlin services, DI, WebView/JS bridge patterns, messaging/broker integr

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Humana
📍 New York• $206.6K – $284.3K/yr
1mo ago

Become a part of our caring community Every large organization is making critical decisions today about how it will leverage AI over the next decade. Few have leaders who can both define that vision and demonstrate its viability through hands-on engineering. This role requires both. We build the platform that transforms millions of clinical documents into trusted, actionable data. Our systems use large language models (LLMs) to read medical records, extract structured facts, answer complex questions with citations to source documents, and route difficult cases to human experts. These capabilities support decisions that impact real healthcare outcomes for members. As a Principal AI Applied Engineer, you will define the technical strategy, architectural standards, and long-term vision for AI-enabled products across the organization. You will influence enterprise-wide decisions regarding AI platforms, model strategies, engineering standards, and technology investments while remaining deeply hands-on in prototyping, experimentation, architecture, and software development. This is the highest-level individual contributor role within the AI Applied Engineering organization. Success requires exceptional technical depth, organizational influence, strategic thinking, and the ability to translate emerging AI capabilities into scalable, reliable, and responsible production systems. Why Join Us Shape the long-term AI architecture and engineering direction for a large enterprise healthcare organization. Influence how AI-enabled products are designed, built, evaluated, deployed, and governed across multiple teams. Drive strategic decisions involving models, vendors, platforms, infrastructure, and shared capabilities. Prototype and validate emerging technologies before the organization invests at scale.</

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