Jobs in San Carlos

POSITION SUMMARY: Performs histological preparations for Signatera Whole Exome/Genome Sequencing PRIMARY RESPONSIBILITIES: • Perform histological preparations for the tissue whole exome/genome sequencing laboratory with little to no errors • Duties may include, but are not limited to: preparation of tissues, stained slides, macrodissection, and supporting workflow tasks • May independently perform testing, reagent, and equipment preparation after completion of training and competency. • Participates in validations • Performs qualifications of reagents • Monitors and performs case management; ensures all cases are processed within department TAT goals and investigates sample processing issues • Actively participate in EH&S initiatives such as safety audits • Participates in updating and creating Standard Operating Procedures • May serve as the general supervisor (Depending on education and years of experience) and perform competencies • Trains staff on department procedures • Participates in Projects and initiatives initiated by the department/external departments • Extensive knowledge in equipment and process troubleshooting • Document all corrective actions taken when test systems deviate from the established performance specifications as needed. Escalates protocol deviation to the lead/supervisor. • Provides general oversight of personnel and the daily operations in the lab. Provides guidance to new team members • Engages with external departments s

Natera is seeking a Bioinformatics Scientist to join our Bioinformatics Research & Development team with a focus on cancer recurrence monitoring. Natera’s mission is to change the management of disease worldwide with a focus on reproductive health, cancer, and organ transplantation. The ideal candidate should have experience in sequencing data analysis, genomics, and/or algorithm development. This individual will analyze large and complex high-throughput cancer genomics datasets. They will also assist in developing novel computational methods, and integrating frameworks developed by our R&D team. PRIMARY RESPONSIBILITIES: Analyze high-throughput DNA sequencing datasets utilizing understanding of cancer biology and genomics. Help implement and validate novel algorithms and statistical methods. Collaborate with molecular biologists and other bioinformatics scientists to answer biological questions Contribute to experimental design and quality control Help develop tools and end-to-end bioinformatics pipelines QUALIFICATIONS: Bachelor's degree in bioinformatics, computational biology, computer science, engineering, molecular biology, or a related field; Master's degree preferred Minimum of 2 years of hands-on experience doing high-throughput genomic sequencing analysis KNOWLEDGE, SKILLS, AND ABILITIES: Experience doing NGS data analysis (e.g. mapping, variant calling, etc.) Strong programming skills in a scientific programming language, Python strongly preferred Knowledge

POSITION SUMMARY: Join Natera as the Senior Director of Development for our Early Cancer Detection (ECD) and Multi-Cancer Early Detection (MCED) portfolio. You will take ownership of product development strategy and execution, guiding Next-Generation Sequencing (NGS) and cell-free DNA-based (cfDNA) In Vitro Diagnostic (IVD) products from feasibility through FDA Premarket Approval (PMA) and post-market support. Every test represents a real person, and you will build an organization of scientific contributors and managers to deliver robust clinical tools. You will establish priorities, allocate resources, and represent development with the FDA and executive leadership, ensuring that scientific rigor and data drive all regulatory and portfolio decisions. PRIMARY RESPONSIBILITIES: Define and own the multi-year assay development strategy and technical lifecycle for the ECD and MCED portfolio, in alignment with corporate and R&D strategy Take accountability for the phase-gated execution of all ECD and MCED programs, overseeing the development, design verification, and validation of NGS-based cancer detection IVD devices using cfDNA, methylation and other analyte classes. Set team priorities, allocate people, budget, and laboratory resources, and make or recommend go/no-go decisions to executive leadership Establish the analytical verification and validation strategy for the portfolio to ensure robust assays transfer seamlessly to commercial manufacturing Partner with clinical,

POSITION SUMMARY Natera is seeking a highly motivated Scientist, R&D – Immunohistochemistry (IHC) & Histology to join the Oncology Product Development team. This role will focus on the development, optimization, verification, and validation of IHC and tissue-based workflows supporting oncology products and clinical assay development. The ideal candidate will have strong hands-on experience in IHC assay development and optimization, supported by a solid foundation in histology and FFPE tissue workflows. Experience with automated IHC/ISH staining platforms, particularly the Roche BenchMark ULTRA IHC/ISH System, is highly desirable. Experience with NGS and molecular biology workflows is an additional plus. PRIMARY RESPONSIBILITIES Design and execute development, optimization, verification, and validation studies for IHC, histology, and tissue-based workflows. Develop and optimize IHC assays, including antibody selection and titration, antigen retrieval, staining conditions, controls, and assay performance assessment. Evaluate and optimize histology and pre-analytical variables, including tissue fixation, FFPE processing, embedding, sectioning, H&E staining, and slide preparation. Develop and troubleshoot workflows on automated IHC/ISH staining platforms and investigate staining artifacts, reagent performance, tissue quality, and assay variability. Plan and execute moderate- to high-complexity experiments; analyze and interpret results using tools such as Excel, JMP,

POSITION SUMMARY: Performs histological preparations for Signatera Whole Exome/Genome Sequencing PRIMARY RESPONSIBILITIES: • Perform histological preparations for the tissue whole exome sequencing laboratory with little to no errors • Duties may include but not limited to: preparation of tissues, stained slides, microdissection, and supporting workflow tasks • May independently perform testing, reagent and equipment preparation after completion of training and competency. • Participates in validations • Performs qualifications of reagents • Monitors and performs case management; ensures all cases are processed within department TAT goals and investigates sample processing issues • Actively participate in EH&S initiatives such as safety audits • Participates in updating and creating Standard Operating Procedures • May serve as a general supervisor (Depending on education and years of experience) and perform competencies • Trains staff on department procedures • Participates in Projects and initiatives initiated by the department/external departments • May serve as a general supervisor (Depending on education and years of experience) and perform competencies • Extensive knowledge in equipment and process troubleshooting • Document all corrective actions taken when test systems deviate from the established performance specifications as needed. Escalates protocol deviation to lead/supervisor. • Provides general oversight of personnel and the daily operations in the lab.

POSITION SUMMARY: The role of a Laboratory Assistant I has the ability to receive specimens with an ability to exercise independent judgement in the performance of assigned laboratory tasks. This role ensures all workflow stations within the laboratory are given specimens in a timely manner, with turnaround time in consideration. PRIMARY RESPONSIBILITIES: •Assist licensed/certified staff in preparing specimen (i.e. blood tubes, tissue) to be processed for testing •Receive and deliver specimens to the appropriate workflows and/or labs •Maintain organization of samples through physical and electronic sample storage and/or disposal. •Accurately enter patient data into the Laboratory Inventory Management System (LIMS). •Prepares samples for shipment •Maintains organization of inventory, materials, and supplies within the lab •Assists in cleaning lab equipment and benches •Responsible for maintaining an updated understanding and knowledge of methods pertaining to the role •Completes training and other deadlines on time. •Recognizes and escalates issues to the lead/supervisor •Participate in Continuous Improvement Projects (TAG, 5S) •Conducts himself/herself in a professional manner •Adheres to Departmental Expectations •This role works with PHI on a regular basis both in paper and electronic form and has access to various technologies to access PHI (paper and electronic) in order to perform the job •Must maintain a current status on Natera training requirements. •Performs ot

POSITION SUMMARY: Manager, QC Development is responsible for modifying existing methods and/or developing and optimizing new QC methods to support routine lot release of reagents and kits used in the CLIA laboratory. Provides technical and scientific operations support in event of deviations and/or non-conformance issues arising for reagent preparation and/or qualification. PRIMARY RESPONSIBILITIES: Primary responsibilities include leading a team responsible for development and optimization of reagent Quality Control (QC) Tests and associated bio-chemical process optimizations to support routine reagent and kit qualification. Analyze data and prepare documentation for QC method validation, author and revise QC testing SOPs and reports to ensure the successful implementation of assays in the laboratory. Oversee technical transfer of new product QC methods from Research and Development into Operations, addressing process development needs for implementation. Provide technical and scientific operations support in event of deviations and/or non-conformance issues arising for reagent preparation and/or qualification to ensure disposition(s) for impacted material(s) are driven by scientifically rational input. Personnel management includes: provide technical assistance, employee development, coaching and counseling, administering performance appraisals, and enforcing company policies through appropriate disciplinary measures QUALI

Natera’s Research team is building tests that can detect many cancers from a single blood draw. We are looking for a Staff Machine Learning and Bioinformatics Scientist to help design the models at the heart of that effort. You’ll work with large-scale, multi-modal genomic datasets from clinical cohorts and partner closely with molecular biologists and clinical scientists. Your research will advance the state-of-the-art and you will drive new methods from prototype, through scalable implementation, toward clinical validation and, ultimately, to patients. PRIMARY RESPONSIBILITIES: Lead the development of novel statistical and machine learning methods for cancer signal detection on multi-modal genomic data Build interpretable, well-calibrated models, setting the standard for uncertainty estimation and reproducibility across the group Prototype, test and productionize ML models using scalable infrastructure Own key technical deliverables within larger projects and help shape the team’s research roadmap Collaborate closely with molecular biologists and clinical experts on design and analysis of experiments and validation studies Keep raising the bar through code and design reviews across projects Translate complex results into clear stories for technical and non-technical audiences Mentor junior scientists and champion a culture of curiosity, collaboration, and scientific excellence QUALIFICATIONS: PhD in Computer Science, Mathematics, Bioinformatics, or a related quantitative fi

Natera’s Research team is building tests that can detect many cancers from a single blood draw. We are looking for a Senior or Lead Bioinformatics Scientist to join the team building the technology at the heart of that effort. You will work with large-scale, multi-modal genomic datasets from clinical cohorts and partner closely with molecular biologists and clinical scientists. You will help advance the state-of-the-art and drive new methods from prototype, through scalable implementation, toward clinical validation and, ultimately, to patients. PRIMARY RESPONSIBILITIES: Develop and validate new algorithms to analyze large multimodal epigenomic datasets Drive research analyses through implementation, testing and performance evaluation, including developing new features within existing pipelines Work with sequencing and clinical data from large cohorts, ensuring data integrity and quality control Partner with molecular biologists and clinical scientists to solve challenging, open-ended problems Visualize results and present complex findings to both technical and non-technical audiences Contribute to the team’s standards for code quality and reproducibility QUALIFICATIONS: Ph.D. in Bioinformatics, Computer Science, Biology, or a related field; alternatively a Bachelor’s or Master’s degree with at least 4 years of professional experience Track record developing and validating analysis workflows for high-throughput sequencing data Experience applying and evaluating statisti

POSITION SUMMARY: The Senior Director, Laboratory Operations is responsible for the management and oversight of all aspects of operations in order to provide the highest quality service including: clinical laboratory and laboratory operations. Knowledge of CAP, CLIA, California, and New York state regulations. PRIMARY RESPONSIBILITIES: Develop policies, procedures, and performance standards to ensure efficiency and quality. Ensure efficient and customer-friendly service. Oversee all clinical and technical functions of laboratory, which includes: day-to-day production, equipment and reagent qualification, and training. Lead trouble-shooting teams to address urgent issues. Ensure that operations maintain all personnel, equipment and consumable resources necessary to match the demand and projections. Maintain and expand laboratory infrastructure, including personnel, equipment, and inventory. Ensure efficient and effective use of resources and personnel within laboratory. Lead process improvements throughout the laboratory. Operationalize and implement new product launches. Maintain the resources required for effective turnaround times for all patient testing. Organize training and development programs for laboratory and support staff. Work with senior leadership to execute on short and long-term strategy. Recruit, retain, train, and develop employees and conduct performance management activities. Develop a team-oriented culture within and between departments. This role wo

POSITION SUMMARY: The Histology Lab Operator I is a member of the Histopathy Department responsible for assisting HT/HTLs in analyzing specimens and maintaining equipment in good condition. PRIMARY RESPONSIBILITIES: • Assists certified/licensed personnel in clinical patient testing in accordance with the SOP • Perform histological preparations for the tissue whole exome sequencing laboratory with little to no errors • Duties may include but not limited to: preparation of tissues, stained slides, macrodissection and supporting workflow tasks • Sets up equipment and assists with automated lab procedures, as applicable • Assist and complete daily tasks • Maintains equipment and instruments in good operating condition • Maintain sufficient inventory of material, supplies, and equipment in the laboratory for the performance of duties • Documents information accurately and in accordance with Good Documentation Practices (GDP) • Performs other duties as assigned QUALIFICATIONS: • 0-2 years of experience • An associate's, or higher, degree in a histotechnician program OR An associate's degree, or higher, in one of the chemical or biological sciences AND one year of experience and/or training in histology within the past 5 years OR - completion of a course of training of at least nine months in a histotechnician program OR A bachelor's, or higher, degree in one of the chemical or biological sciences, including a combination of thirty (30) hours in

This is an exciting opportunity to participate in advancing Natera’s oncology product portfolio of cutting-edge diagnostic tests. As Manager of Statistical Programming, you will leverage your strong R programming skills and clinical trials background to contribute to the analysis and reporting of clinical trials supporting multiple regulatory submissions. Primary Responsibilities: Lead and oversee statistical programming deliverables, including ADS (Analysis Datasets) and TLF (Table, Listings and Figures), ensuring data integrity and regulatory compliance with ICH, GCP, and FDA 21 CFR Part 11. May manage a team of statistical programmers, taking responsibility for their technical and professional development, while contributing hands-on to programming work. Act as primary programming lead for regulatory submissions (e.g., 510(k), CTA/CDx, and PMA), ensuring all deliverables meet rigorous global standards. Maintain programming infrastructure, including R package development, validation, and maintenance in a controlled environment. Develop R Shiny dashboards that support data review, study monitoring, and exploration of analysis results. Promote statistical programming development and validation best practices. Work cross-functionally with Biostats, Data Management, Clinical Science, and other functions as necessary. Qualifications: Bachelor’s in Statistics, Mathematics, Computer Science, or a related field. 5+ years of related experience, with at least 3 years of experience in

Important: This position will work in one of the following three Extended-Hours Support (ExHS) shift teams: 1. Weekend Shift Team 1a. Rotation 1: Sunday to Thursday (9AM–5PM), Friday and Saturday off 1b. Rotation 2: Tuesday to Saturday (9AM–5PM), Sunday and Monday off 2. Early-Morning Shift Team 2a. Rotation 1: Monday to Friday (4AM–12PM Pacific Time), Saturday and Sunday off 2b. Rotation 2: Tuesday to Saturday (4AM–12PM Pacific Time), Sunday and Monday off 3. Late-Evening Shift Team 3a. Rotation 1: Monday to Friday (3PM–11PM Pacific Time), Saturday and Sunday off 3b. Rotation 2: Sunday to Thursday (3PM–11PM Pacific Time), Friday and Saturday off Important notes: During hiring, candidates will select and commit to one shift team (Weekend, Early-Morning, or Late-Evening). Once hired and onboarded, the team member will work exclusively within that shift team. ExHS team members rotate quarterly (every three months) between their team's two rotations. There are no rotations between shift teams. This is an exciting opportunity in our Data Science Production Engineering (DSPE) department at Natera (a global leader in precision medicine and genomics testing), to lead a team providing key data analytics services for our lab production operations. As a Manager of Data Analysis for Lab Production Support, you will work in one of the above three DSPE Extended-Hours Support (ExHS) shift teams, during the specified rotation hours. You will have the opportunity to apply innovative data ana

POSITION SUMMARY: Join Natera as the Director of Development for our Early Cancer Detection (ECD) In Vitro Diagnostic (IVD) products. You will take ownership of the development, verification, and validation of our early cancer detection (ECD) Next Generation Sequencing products from feasibility exit through regulatory submission and post-market support. Every test represents a real person, and you will lead a team of scientists and managers to execute the performance data packages supporting PMA submissions. You will serve as the technical subject matter expert in FDA interactions, partnering across functions to deliver design-controlled diagnostic products that directly impact patient care. PRIMARY RESPONSIBILITIES: Own the execution of the technical strategy and phase-gated process of of development, design verification, and validation studies for ECD IVD devices utilizing cfDNA, methylation and other potential analytes Ensure rigorous compliance with applicable FDA Class III (PMA) design and development requirements Take ownership of the analytical performance strategy (limit of blank/detection, precision, linearity, interference, stability) for ECD assays, partnering directly with Regulatory Affairs (RA), biostatistics, bioinformatics and research teams Contribute to the robust transfer of assays to the commercial laboratory and manufacturing in support of the design transfer and operations teams Partner with clinical and biostatistics leaders on statistical analysi

Position Overview: The Temporary Lab Support Associate plays a vital role in supporting fast-paced Research and Development (R&D) and large-scale development laboratories. As part of the Laboratory Operations team, this role ensures the laboratory operates safely, efficiently, and without interruption to enable ongoing scientific advancements. The ideal candidate is a proactive, detail-oriented professional who thrives in dynamic environments and actively anticipates laboratory needs. Key Responsibilities: Inventory & Procurement Management: Manage the end-to-end lifecycle of laboratory supplies, including the procurement, receiving, auditing, and restocking of consumables, reagents, high-value assets, and safety supplies. Prepare and aliquot critical reagents as needed while maintaining optimal inventory levels to ensure uninterrupted laboratory operations. Operational & Logistics Support: Monitor and manage the daily laboratory ticketing queue, fulfilling diverse requests from research personnel in a timely manner. Manage facility package flow, including receiving, breaking down, sorting, and transporting pallets and incoming shipments across buildings. EHS & Safety Compliance: Conduct routine lab safety walkthroughs and inspections to ensure strict adherence to Environmental Health & Safety (EHS) guidelines and Good Laboratory Practices (GLP). Set up, monitor, and handle satellite waste streams, including biohazardous and hazardous