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Lead Enterprise Systems Engineer in San Francisco

609 active opportunities · Updated October 2026

Explore current lead enterprise systems engineer jobs in San Francisco. Filter by work mode, employment type, experience, department, date posted and distance.

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📍 San Francisco, California, United States· Full-time· Remote
✓ High-confidence listingCompany trend -84.1%
Quick readStrong listing-quality and freshness signals

About the Team OpenAI’s Governance team helps shape how the company responsibly develops and deploys increasingly capable AI. We bring together technical evidence, policy, and operational perspectives to help the company address emerging risks, resolve difficult questions, and make well-supported decisions. Our work includes shaping and improving governance practices, supporting effective oversight, developing clear assessments and recommendations, and ensuring that decisions lead to action. We work closely with research, safety, security, legal, and product teams to identify gaps, reconcile different views, and improve our approach as capabilities and circumstances change. About the Role We are looking for a curious, high-agency Research Program Manager who can reason from first principles, make sense of incomplete or conflicting information, and move difficult work forward. You will help shape the substance of governance reviews, connect ideas and evidence across teams, and develop recommendations that are both well-founded and practical. The work requires someone who can use established approaches where they fit, recognize when circumstances call for a different approach, and update their thinking as new evidence emerges. You should bring sound judgment, a willingness to experiment and learn, and the program-management discipline to turn good analysis into action. Depending on your experience and the team’s needs, your work may focus on safety advisory and board-level oversight, deployment governance, or standards and strategic partner commitments. In this role, you will: Bring together technical, policy, and operational inputs to develop coherent assessments, recommendations, and decision materials for governance bodies and senior leaders. Work through emerging or ambiguous questions, test assumptions, identify gaps or conflicting evidence, and help determine what additional analysis or decisions are needed. Engage critically with research, evaluations, safeguar

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Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time· Remote
✓ High-confidence listingCompany trend -84.1%
Quick readStrong listing-quality and freshness signals

About the Team OpenAI’s mission is to ensure that general-purpose artificial intelligence benefits all of humanity. The Design Systems team creates the foundations that help teams across OpenAI build coherent, high-quality experiences at scale. Accessibility is fundamental to that work. We’re building the shared standards, components, tools, and practices that make inclusive experiences the default across OpenAI’s products and platforms. About the Role In this role, you’ll lead OpenAI’s company-wide accessibility program from within Design Foundations. You’ll pair strategy and organizational influence with hands-on product design—advocating for disabled people, removing barriers across complete customer journeys, and establishing durable ownership throughout the company. This is an opportunity to define accessibility for a new generation of products spanning web, mobile, desktop, voice, AI, and hardware. You’ll help teams consider the many ways people perceive, understand, navigate, and interact with technology, going beyond minimum compliance to create experiences that are genuinely useful and inclusive. Working across design, engineering, research, product, go-to-market, and legal, you’ll make accessibility an expected part of product quality—not a final review or the responsibility of a single expert. This role is based in our San Francisco HQ. We offer relocation assistance to new employees. In this role you will: Define OpenAI’s accessibility strategy, roadmap, governance, priorities, and measures of progress. Design and ship accessible experiences while identifying systemic barriers across complete customer journeys. Build accessibility into our design system through inclusive components, tokens, interaction patterns, Figma libraries, documentation, and engineering guardrails. Center disabled people through participatory research, usability studies, and assistive-technology testing rather than relying solely on assumptions, simulations, or automated tools. Des

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📍 San Francisco, California, United States· Full-time· Remote
✓ High-confidence listingCompany trend -80.6%
Quick readStrong listing-quality and freshness signals

About Sentry Software runs the world and the pace is faster than ever. Sentry helps developers fix errors and performance issues before users notice, so teams can spend less time firefighting and more time building. Trusted by 200,000+ organizations, Sentry is today’s application monitoring standard and our team is building its AI-native future. About this role At Sentry, Finance plays a critical role in helping the company understand where we are, where we're going, and how to make better decisions along the way. We are looking for a Director of FP&A to build and own the core financial planning and operating rhythms for the company. You will lead company-wide forecasting and planning, management and Board reporting, headcount planning, and FP&A's partnership with Accounting during the close. You will also be a senior business partner to leaders across Sentry, helping translate company strategy into financial plans and operating decisions. This is a hands-on leadership role. Many of the processes you will own are being rebuilt, so we're looking for someone who has designed great FP&A processes—not just inherited and operated them. You'll be expected to get into the details, build where necessary, and quickly develop enough context and trust to run your areas with a high degree of independence. You will report to the VP of Finance & Strategy and manage an FP&A Manager focused on company spend, including cloud and AI infrastructure costs. In this role you will Own Sentry's company-wide forecasting, annual planning, and long-range planning processes, including the consolidated financial model and corporate roll-up. Build a clear and repeatable operating cadence around forecasts, budget-to-actual performance, variance analysis, and communication of financial results. Partner closely with Accounting during the monthly and quarterly close, providing accrual inputs, budget-to-actual analysis, and variance explanations while Accounting retains ownership

RestAIGoRust
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Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time· Remote
✓ High-confidence listingCompany trend -84.1%
Quick readStrong listing-quality and freshness signals

About the team OpenAI’s mission is to build safe artificial general intelligence (AGI) which benefits all of humanity. This long-term undertaking brings the world’s best scientists, engineers, and business professionals into one lab together to accomplish this. In pursuit of this mission, our Go To Market (GTM) team is responsible for helping customers learn how to leverage and deploy our highly capable AI products across their business. The team is made of Sales, Solutions, Support, Marketing, and Partnership professionals that work together to create valuable solutions that will help bring AI to as many users as possible. About the role Startups are creating many of the most disruptive and category-defining AI applications. The Startup Go To Market team’s mission is to help startups harness the power of AI models to drive these advances. You will lead a team that supports startups building effectively with OpenAI’s APIs, providing access to OpenAI teams and expertise to support their growth. This role is a mixture of technical understanding, vision, partnership, and strategy. This leadership role will be responsible for driving and implementing the sales strategy within our startups segment, recruiting and leading a team of technical sales professionals, and achieving successful deployments with startup customers. The ideal candidate will possess significant sales leadership experience and a comprehensive understanding of AI technologies. This leader will have the capability to adapt to a complex and fast-changing technology environment. Responsibilities will include customer acquisition, account management, owning executive relationships, and more. This individual will need to be a proven leader who can effectively collaborate cross-functionally with product, marketing, developer relations, operations, and core GTM teams, while guiding and mentoring a sales team towards achieving business objectives. This role is based in San Francisco, CA. We use a hybrid work m

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📍 San Francisco, California, United States· Full-time· Remote
✓ High-confidence listingCompany trend -84.1%
Quick readStrong listing-quality and freshness signals

About the Team OpenAI’s mission is to ensure that general-purpose artificial intelligence benefits all of humanity. We believe achieving this goal requires real-world deployment and continuous iteration based on how our products are used—and misused—in practice. The Child Safety team is responsible for detection, review, and enforcement of OpenAI’s Child Safety product policies. We leverage a balanced use of technology and subject matter expertise to scale our operations. We collaborate with internal legal, research, and policy teams, external experts, and other industry stakeholders to keep OpenAI aligned with evolving regulations and industry best practices around child safety. About the Role As a Child Safety Enforcement Specialist on the Intelligence & Investigations, you independently lead defined child safety investigations and projects from triage through documented outcome. You apply strong working knowledge of policy and investigative practice, surface trends in abuse signals, recommend evidence-based mitigations, and coordinate with partners to deliver reliable safety outcomes. The role includes sensitive content review and may involve supporting quality and workflow improvements. You’ll be responsible for: This role supports child safety investigations, enforcement, reporting, and process improvement. The work includes significant review of sensitive content and analysis of user behavior. This role independently owns defined projects, aligns with cross-functional priorities, and escalates complex legal or policy questions through established channels. In this role, you will: Independently review and investigate child safety content and behavior, including CSAM and grooming signals, applying policy consistently and documenting evidence and rationale. Lead well-defined high-risk escalations end to end; anticipate blockers, communicate progress, and make or recommend enforcement decisions within policy and escalation boundaries. Identify potential mandat

SQLAWSRestAI
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📍 San Francisco, California, United States· Full-time· Remote
✓ High-confidence listingCompany trend -83%
Quick readStrong listing-quality and freshness signals

ABOUT BASETEN Baseten powers mission-critical inference for the world's most dynamic AI companies, like Cursor, Notion, OpenEvidence, Abridge, Clay, Gamma, and Writer. By uniting applied AI research, flexible infrastructure, and seamless developer tooling, we enable companies operating at the frontier of AI to bring cutting-edge models into production. We're growing quickly and recently raised our $1.5B Series F , led by Altimeter Capital, Conviction Partners, and Spark Capital. Join us and help build the platform engineers turn to ship AI products. THE ROLE As a Global Capacity Lead at Baseten, you will lead the "engine room" of the company, architecting, securing, and optimizing the global GPU fleet that powers our customers' AI workloads. You’ll own the end-to-end journey of capacity management, from securing multi-million dollar GPU clusters to building the automation that ensures 99.9% uptime across multi-cloud environments. This role is a great fit for entrepreneurial engineers who want to bridge the gap between high-finance asset management and deep infrastructure engineering. You will act as the fleet orchestrator for the world's most advanced chips, ensuring Baseten never experiences a capacity outage while maintaining elite unit economics. To be clear, this is a high-stakes engineering role. You will be hands-on with Kubernetes orchestration while also leading specialized pods focused on the next generation of hardware, like NVIDIA’s Blackwell (B200) architecture. EXAMPLE INITIATIVES The B200 Frontier: Architecting the infrastructure readiness and deployment strategy for Baseten's first Blackwell GPU clusters. Global Workload Orchestration: Building "Multi-cloud Capacity Management" systems to move customer workloads seamlessly across regions to optimize cost and latency. Precision GPU Triage: Developing automated Go-based operators to identify, cordon, and repair unhealthy H100 nodes in under an hour. The Supply Chain of Intelligence: Partnering with lead

PythonAWSAzureGCP
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Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time
✓ High-confidence listingCompany trend -84.1%
Quick readStrong listing-quality and freshness signals

About the Team OpenAI's data and storage infrastructure spans data platforms, online databases, and file/object storage. These systems underpin data ingestion and processing, durable persistence, indexing and retrieval, and product file experiences. As frontier models and agents evolve how they use memory, history and snapshots, the underlying architecture increasingly shapes the capabilities products can deliver—and their latency, reliability, cost and efficiency. About the Role We are looking for a technically deep TPM to independently define and lead multiple programs across data platforms, online databases and storage infrastructure. You will connect model, product and data-consumer requirements to architecture, and work with the relevant engineering teams to take new capabilities through production adoption and repeatable expansion. The design scope is exabyte-scale storage and infrastructure spanning multiple millions of CPU cores. The challenge is not simply forecasting more resources: it is making complete, workload-ready capacity repeatable, with a clear path from product requirements through architecture, deployment and validation. A data pipeline, database query, file operation or execution snapshot can affect whether a product or agent succeeds; you will connect those outcomes to the systems underneath. This role is based in San Francisco, CA. We use a hybrid work model of 3 days in the office per week and offer relocation assistance to new employees. In this role, you will: Translate model, product and data-platform needs into precise access patterns, consistency, durability, freshness, availability and scalability requirements. Connect memory, history, retrieval and resumable work to capability and end-to-end latency. Partner with engineering to transform data and storage architecture into repeatable scale units: standardized provisioning, placement, routing, data movement and readiness checks that bring storage, compute and networking online together.

AWSAzureRestAI
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Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time· Remote
✓ High-confidence listingCompany trend -84.1%
Quick readStrong listing-quality and freshness signals

About the Team OpenAI’s Client Platform Engineering (CPE) team delivers trusted devices at scale: secure by default, reliable by design, and effortless to use. We own platform capabilities across macOS, Windows, iOS, Android, and Linux, spanning endpoint posture and device trust, application delivery, onboarding, updates, telemetry, workflow orchestration, and employee-facing remediation. The team partners deeply with Security, Research, Applied, and specialized engineering groups to enable and protect OpenAI while reducing friction for the people advancing our mission. About the Role As an Engineering Manager for CPE, you will lead a team of engineers responsible for the strategy, delivery, and operation of OpenAI’s cross-platform client foundation. You will combine people leadership with strong technical judgment: setting direction, developing engineers, reviewing architecture and tradeoffs, and creating the operating mechanisms that turn ambiguous needs into durable platform outcomes. This is a high-leverage role at the intersection of security, reliability, developer velocity, and employee experience. CPE is a highly technical platform engineering organization delivering first-party services, automation, observability, and safe fleet operations. We’re looking for a leader who can guide its next chapter, scaling the team and its systems, partnering across the company, and raising the bar for secure, reliable, low-friction experiences across every supported platform. In this role, you will: Lead and develop a high-performing engineering team; hire thoughtfully, coach engineers, create clarity, and foster an inclusive, high-accountability culture that pushes perceived limits. Define and execute a multi-year client-platform strategy and roadmap across macOS, Windows, iOS, Android, and Linux, including how Codex and agents can reshape employee computing. Provide technical direction for endpoint posture, device trust, application delivery, device onboarding, updates,

AWSKubernetesCI/CDGit
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Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time· Remote
✓ Quality checkedCompany trend -84.1%

About the Team The Statsig team is responsible for the experimentation, feature rollout, dynamic configuration, and analytics systems that help OpenAI ship products with speed, safety, and evidence. Teams across ChatGPT, Codex, model measurement, monetization, business subscriptions, developer products, and shared infrastructure rely on Statsig to introduce capabilities safely, measure their impact, and make high-confidence product decisions. About the Role As a Product Lead on the Statsig team, you will define how experimentation, rollout, configuration, and analytics become a simple, reliable, and trusted part of how every OpenAI product team ships. You will set strategy across multiple product and platform workstreams, translate company-wide needs into durable capabilities, and help Statsig become a core part of OpenAI’s product development system. We’re looking for a product leader who combines strong product judgment, technical fluency, and deep analytical thinking. You should be comfortable navigating ambiguous customer needs, influencing teams across the company, and balancing rapid adoption with reliability, usability, and measurement quality. This role is based in San Francisco, CA. We use a hybrid work model of 3 days in the office per week and offer relocation assistance to new employees. Travel requirements should be confirmed with the recruiter before publishing. In this role, you will: Define the product vision, strategy, and roadmap for experimentation, feature management, dynamic configuration, rollout safety, and analytics. Partner with product, engineering, research, data, design, and infrastructure leaders to turn recurring launch and measurement needs into reusable platform capabilities. Develop a deep understanding of workflows across ChatGPT, Codex, model measurement, monetization, subscriptions, and developer products, then establish clear priorities across competing needs. Drive adoption by making sophisticated experimentation and analytics c

AWSRestAIGo
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📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -84.1%

Technical Program Manager – Applied Infrastructure About the Team The Applied team safely brings OpenAI’s technology to the world, powering products like ChatGPT, and the APIs for GPT and more. Behind these products is a complex and rapidly evolving infrastructure platform that enables scale, performance, and safety. The Applied Infrastructure TPM team partners across engineering to lead foundational programs that ensure OpenAI’s infrastructure can meet current and future demand. About the Role We’re looking for a seasoned Technical Program Manager to drive critical infrastructure programs across the Applied organization. This TPM will focus on cross-cutting initiatives such as general compute capacity planning, process transformation, cost and quota attribution and optimization, and coordination across infrastructure and product stakeholders. There will also be focus on evolving OpenAI’s infrastructure to support growth, scale and new products. This work is core to how OpenAI manages and grows its infrastructure footprint in a disciplined, scalable way. Location: San Francisco, CA (Hybrid – 3 days/week in-office) In this role, you will: Serve as the DRI for complex infrastructure programs spanning CPU planning, orchestration, and other resource management domains (e.g. networking, storage). Build and operationalize systems to capture demand signals, model future capacity needs, and align infrastructure planning across internal teams and partners external to the company. Partner closely with Infrastructure, Product and Finance teams to forecast infrastructure usage patterns and ensure supply/demand alignment. Lead cost attribution and quota enforcement programs to promote stability and ensure equitable access to resources across teams. Drive simplification and standardization of infrastructure tooling and processes across Applied and Infra organizations. Drive cross functional programs to evolve our infrastructure to support new growth and scale Work with external v

AWSAzureRestAI
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📍 San Francisco, California, United States· Full-time· Remote
✓ Quality checkedCompany trend -84.1%

About the Team The Search research team focuses on building the systems that help AI systems find, retrieve, and use information from the world. We aim to make answers more useful and grounded for more than a billion ChatGPT users. About the Role We’re looking for a Technical Program Manager to lead a broad portfolio of research and engineering programs that power search. You’ll partner closely with researchers, engineers, and product leaders to turn ambitious goals into clear plans, resolve dependencies, and move complex technical work forward. This role combines technical depth, product judgment, and hands-on execution. You’ll work across retrieval, indexing, and model improvements, while collaborating with policy, legal, and external data partners. You’ll help teams make informed tradeoffs and build practical ways of working that support a fast-moving research environment. This role is based in San Francisco, CA. In this role, you will: Lead programs across model training, retrieval, large-scale indexing, and search infrastructure. Translate evolving goals into prioritized workstreams with clear owners, milestones, dependencies, and resource needs. Partner with research, engineering, and product leads to define requirements and make tradeoffs across scope, quality, performance, timelines, and cost. Establish program success metrics and use them to guide priorities and track improvements in coverage, answer quality, responsiveness, and trust. Identify technical and cross-functional risks early, drive blockers to resolution, and communicate progress and decisions clearly to teams and leadership. Coordinate with product, policy, legal, and external partners on data access, use, and presentation, helping teams resolve decisions that span technical and non-technical domains. Manage dependencies with data providers and build repeatable processes that help research and engineering teams execute effectively as the search effort grows. You might thrive in this role if you

AWSRestAIGo
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📍 San Francisco, California, United States· Full-time· Remote
✓ Quality checkedCompany trend -84.1%

About the Role OpenAI is seeking a senior individual contributor to help shape and execute some of our most complex and high-impact commercial opportunities. As AI becomes increasingly important to how organizations operate, the ability to translate sophisticated products and commercial structures into clear, compelling customer narratives is a strategic advantage. In this role, you will serve as an embedded strategic partner to AMER account teams, with a particular focus on high-value, complex, and first-of-kind deals. You will work directly with sellers and cross-functional partners to lead the overall deal strategy, structuring, value narrative, negotiations, and business cases that bring business terms to contractual closure. You will also translate insights and patterns from individual deals into practical frameworks, tools, and resources that improve the quality and consistency of deal execution across the field. This role partners closely with Sales, Pricing, Deal Desk, Strategy, Revenue Operations, Finance, Product, and Legal to help OpenAI move quickly, strengthen proposal quality, and navigate complex commercial opportunities effectively. This role will report to the Americas Deal Strategy Leader. In this role, you will: Partner directly with AMER account teams on complex, high-value, and strategic opportunities, from initial deal strategy through customer proposal, negotiation, and deal closure. Develop deal strategies that bring together customer priorities, commercial considerations, competitive positioning, and OpenAI’s broader business objectives. Create executive- and CFO-ready proposals, ROI analyses, value narratives, and business cases for highly complex and/or first-of-kind deals. Support critical customer and executive conversations by presenting recommendations, business cases, and the rationale behind proposed commercial approaches. Build and maintain practical ROI frameworks, calculators, proposal templates, and value narratives that account

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📍 San Francisco, California, United States· Full-time· Remote
✓ Quality checkedCompany trend -84.1%

About the Role As an Account Director for Higher Education in AMER, you will own strategic relationships with colleges, universities, and higher education systems as they move from AI experimentation to responsible, institution-wide transformation. You will work with presidents, provosts, CIOs, CTOs, academic and administrative leaders, researchers, security teams, and procurement stakeholders to define priority use cases, build the technical and governance foundation for deployment, and translate institutional goals into a multi-year AI transformation roadmap. You will own the commercial and customer journey end to end—from territory strategy, pipeline creation, and executive alignment through evaluation, procurement, deployment, adoption, consumption, value realization, and expansion. This is a deeply technical, consultative sales role. You will be expected to understand AI capabilities and limitations, integration patterns, data governance, privacy, security, and change management; partner effectively with technical experts; and remain accountable for measurable customer and revenue outcomes after signature. In this role, you will: Own and execute the AMER higher education territory and account strategy, prioritizing institutions where OpenAI can support meaningful, responsible, and scalable transformation. Create pipeline and lead complex, multi-threaded new-business and expansion opportunities from first engagement through procurement, deployment, adoption, and value realization. Engage credibly with presidents, provosts, CIOs, CTOs, academic leaders, researchers, administrators, security teams, legal, procurement, finance, and end-user champions. Lead cross-functional pursuit and account teams across Solutions Engineering, Customer Success, Product, Research, Security, Legal, and other functions to design evaluations, pilots, technical validation, executive business cases, production deployments, and adoption plans. Translate AI model and platform capabilities

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Relocation support. Relocation assistance is stated. This does not establish visa sponsorship.
📍 San Francisco, California, United States· Full-time
✓ Quality checkedCompany trend -84.1%

About the Team The Core Services organization builds and runs the mission-critical online services that product teams rely on in production. We own foundational distributed systems and platform capabilities that enable reliable execution, high-performance services, and large-scale file/data needs across our products. This team is distinct from developer infrastructure and data infrastructure—our focus is production service foundations and core runtime services. About the Role We’re hiring an Engineering Manager, Core Services to help lead teams responsible for highly reliable, high-scale distributed systems that sit on the critical path for OpenAI products. Your team will own foundational production systems that OpenAI’s product engineering teams build on. You’ll collaborate closely with product and infrastructure partners to ship reliable services quickly, and help scale systems and teams as OpenAI grows. You’ll partner closely with senior engineering leaders to scale the org, mature operations, and drive major platform initiatives. This role requires strong technical ability. You’ll be responsible for: Managing and growing a high-performing team of infrastructure engineers. Leading teams building and operating large, critical production platforms, including cluster reliability, scaling, and rollout safety. Building and operating mission-critical distributed systems with strong operational rigor (SLOs, incident response, capacity planning, reliability). Setting technical direction for platform foundations such as workflow/orchestration capabilities, large-scale file/blob/storage services, and core service foundations. Partnering with a broad set of stakeholders, including product engineering, adjacent infrastructure teams, and (where relevant) finance/cost partners. Coaching, mentoring, and developing engineers and emerging leaders. You might thrive in this role if you: Have significant experience leading teams that run mission-critical infrastructure in production

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📍 San Francisco, California, United States· Full-time· Remote
✓ Quality checkedCompany trend -84.1%

About the Team The Applied AI Engineering team partners closely with customers to help them move from experimentation to production with OpenAI’s technologies. We act as trusted technical advisors, working across customer strategy, architecture, deployment, and adoption to help organizations realize meaningful impact from frontier AI. The Startups segment serves fast-moving, high-growth companies that are often building new products, workflows, and businesses directly on top of AI. These customers move quickly, operate with high ambiguity, and expect practical, creative, and technically rigorous partnership. About the Role We are looking for an Applied AI Engineering Manager, Startups to lead and scale the Startups Applied AI Engineering motion. This team helps high-growth startups move quickly from experimentation to production, unlock meaningful usage, and build durable technical partnerships with OpenAI. This leader will operate in a high-velocity customer segment where founders, CTOs, and technical teams expect speed, judgment, and hands-on problem-solving. They will balance team leadership, technical depth, customer prioritization, and cross-functional influence across Sales, Product, Engineering, Research, and broader go-to-market teams. In this role, you will define how OpenAI supports startup customers at scale: identifying where deep technical engagement can unlock outsized impact, building repeatable deployment mechanisms, and ensuring the team can serve a broad and dynamic customer base without losing quality or strategic focus. In this role, you will: Craft and continuously refine the strategic vision and operating model for the Startups Applied AI Engineering team, aligning it with OpenAI’s broader company objectives and the evolving needs of high-growth startup customers. Lead, mentor, and grow a team of high-performing technical ICs supporting startup customers across AI-native, developer-led, and product-led companies. Help startups move from early e

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